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Acute toxicity and chromosomal aberration toxicity of insect wax and its policosanol
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作者 Jinju Ma Kun Li +5 位作者 Wenwen Zhang Liyi Ma Juan Xu Lanxiang Liu Xiaoming Chen Hong Zhang 《Food Science and Human Wellness》 SCIE 2022年第2期356-365,共10页
An acute toxicity test in Sprague Dawley(SD)rats and a chromosomal aberration toxicity test in Chinese hamster lung(CHL)fibroblasts were conducted to promote the application of insect wax and its policosanol.Results o... An acute toxicity test in Sprague Dawley(SD)rats and a chromosomal aberration toxicity test in Chinese hamster lung(CHL)fibroblasts were conducted to promote the application of insect wax and its policosanol.Results of oral acute toxicity test showed that the LD;values of insect wax and its policosanol were higher than 5000 mg/kg.The rats showed no obvious toxic symptoms and survived,suggesting that these substances were not toxic.The chromosomal aberration rates of the CHL cells incubated with insect wax for 3-6 h under metabolic activation conditions and for 3-6 h and 24 h under non-metabolic activation conditions were lower than 5%.No significant difference was found compared with the negative control group.Also,no significant difference in chromosomal aberration rates was found between each dose group of policosanol under metabolic or non-metabolic activation conditions and the negative control group.Therefore,the chromosomal aberration rates of CHL cells treated with insect wax and its policosanol were negative regardless of metabolic activation conditions.These results indicate the absence of acute toxicity and potential chromosomal aberration in the tested dose range of insect wax and its policosanol. 展开更多
关键词 insect wax policosanol from insect wax Acute toxicity Chromosomal aberration
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锐孔-凝固浴法制备虫白蜡源高级烷醇微囊 被引量:1
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作者 刘晓丽 罗秀梅 +4 位作者 张锦砚 杜绍辉 刘佳佳 孙昂 马金菊 《生物化工》 2021年第6期95-98,共4页
以海藻酸钠为囊材,研究不同实验参数对锐孔-凝固浴法制备虫白蜡源高级烷醇微囊成球效果及包封率的影响。确定最佳工艺条件:CaCl_(2)溶液浓度6%,固化液温度70℃,搅拌速度200 r/min,针头孔径0.49 mm,下滴高度2 cm,虫白蜡源高级烷醇添加量0... 以海藻酸钠为囊材,研究不同实验参数对锐孔-凝固浴法制备虫白蜡源高级烷醇微囊成球效果及包封率的影响。确定最佳工艺条件:CaCl_(2)溶液浓度6%,固化液温度70℃,搅拌速度200 r/min,针头孔径0.49 mm,下滴高度2 cm,虫白蜡源高级烷醇添加量0.10 g。制备的微囊球形较圆,包封率75.50%,颗粒大小均匀,干燥前D90粒径为120~140μm,干燥后D90粒径为50~70μm。 展开更多
关键词 虫白蜡源高级烷醇 微胶囊 锐孔-凝固浴法 工艺
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