Walt Disney’s USD 5.5 billion theme park in China had a really successful year after opening in June 2016.According to its annual financial report,the Shanghai theme park had already gained profit in its first full y...Walt Disney’s USD 5.5 billion theme park in China had a really successful year after opening in June 2016.According to its annual financial report,the Shanghai theme park had already gained profit in its first full year of operations,much better than what its American headquarters had expected.“That’s an extraordinary achievement.I’m not sure we’ve ever done that.It’s a mark none of its resorts has been able to hit in the last 30 years,”said Chief Executive Officer Bob Iger.“After the first year,I’m pleased to say that prospects are really strong for continued success and continued growth,”he added.展开更多
Subthalamic nucleus deep brain stimulation (STN DBS) is an effective treatment for medically refractory Parkinson’s disease (PD). However, a minority of patients develop cognitive problems, particularly a decline of ...Subthalamic nucleus deep brain stimulation (STN DBS) is an effective treatment for medically refractory Parkinson’s disease (PD). However, a minority of patients develop cognitive problems, particularly a decline of executive function in the early period after STN DBS. Although this problem is usually transient, it may cause social maladjustment. We investigated factors affecting early decline of executive function after STN-DBS. Fifty-seven patients whose preoperative global cognitive screening was normal (MMSE score;28 or more) were enrolled in this study. Executive function was evaluated with the Trail-Making Test (TMT) preoperatively and 1-month after surgery. We considered a patient to have decline in executive function if the TMT (B-A) was prolonged more than 30 seconds after STN DBS. Among 57 patients, 25 patients were categorized as having decline of executive function. Univariate analysis revealed that high preoperative UPDRS III motor score in the medication-off period and a depressive state evaluated with BDI-II correlated significantly with decline in executive function. Multiple logistic regression analysis revealed that the only significant independent variable related to early decline of executive function was the preoperative BDI-II score. Postoperative factors such as active contact location or dopaminergic medication reduction had no relation with the decline of executive function. Even in cognitively well-selected patients, STN DBS causes early decline in executive function in a significant number of patients. Preoperative simple cognitive screening alone could not predict early decline in executive function. More detailed neuropsychological evaluation, including mood status, should be undertaken before surgery.展开更多
Macroeconomic Overview:The U.S.dollar has fallen 4%against a broad collection of widely circulated currencies since January.While the magnitude of the decline may not appear large,it does signal an important reversal ...Macroeconomic Overview:The U.S.dollar has fallen 4%against a broad collection of widely circulated currencies since January.While the magnitude of the decline may not appear large,it does signal an important reversal relative to recent years.Against the same broad collection of currencies,the U.S.dollar had consistently strengthened since 2013。展开更多
文摘Walt Disney’s USD 5.5 billion theme park in China had a really successful year after opening in June 2016.According to its annual financial report,the Shanghai theme park had already gained profit in its first full year of operations,much better than what its American headquarters had expected.“That’s an extraordinary achievement.I’m not sure we’ve ever done that.It’s a mark none of its resorts has been able to hit in the last 30 years,”said Chief Executive Officer Bob Iger.“After the first year,I’m pleased to say that prospects are really strong for continued success and continued growth,”he added.
文摘Subthalamic nucleus deep brain stimulation (STN DBS) is an effective treatment for medically refractory Parkinson’s disease (PD). However, a minority of patients develop cognitive problems, particularly a decline of executive function in the early period after STN DBS. Although this problem is usually transient, it may cause social maladjustment. We investigated factors affecting early decline of executive function after STN-DBS. Fifty-seven patients whose preoperative global cognitive screening was normal (MMSE score;28 or more) were enrolled in this study. Executive function was evaluated with the Trail-Making Test (TMT) preoperatively and 1-month after surgery. We considered a patient to have decline in executive function if the TMT (B-A) was prolonged more than 30 seconds after STN DBS. Among 57 patients, 25 patients were categorized as having decline of executive function. Univariate analysis revealed that high preoperative UPDRS III motor score in the medication-off period and a depressive state evaluated with BDI-II correlated significantly with decline in executive function. Multiple logistic regression analysis revealed that the only significant independent variable related to early decline of executive function was the preoperative BDI-II score. Postoperative factors such as active contact location or dopaminergic medication reduction had no relation with the decline of executive function. Even in cognitively well-selected patients, STN DBS causes early decline in executive function in a significant number of patients. Preoperative simple cognitive screening alone could not predict early decline in executive function. More detailed neuropsychological evaluation, including mood status, should be undertaken before surgery.
文摘Macroeconomic Overview:The U.S.dollar has fallen 4%against a broad collection of widely circulated currencies since January.While the magnitude of the decline may not appear large,it does signal an important reversal relative to recent years.Against the same broad collection of currencies,the U.S.dollar had consistently strengthened since 2013。
