Microglial cells are the key innate immune cells in the brain and they are crucial in maintaining brain parenchyma homeostasis.Under physiological conditions,microglial cells assume a ramified morphology with a small ...Microglial cells are the key innate immune cells in the brain and they are crucial in maintaining brain parenchyma homeostasis.Under physiological conditions,microglial cells assume a ramified morphology with a small cell body and an extensive network of fine processes,which secrete neurotrophic factors and patrol the surroundings in search for pathogens and eliminate cellular debris via phagocytosis.Microglial cells express a repertoire of pattern recognition receptors(PRRs)that enable them to detect diverse danger-associated molecular patterns(DAMPs)released from damaged cells or cells under stress,or pathogen-associated molecular patterns generated by pathogens during infection.展开更多
Sulfur dioxide(SO_(2))is a typical pollutant that affects human health,climate,and environmental and ecological conditions.China has been experiencing high concentrations of SO_(2),particularly in urban areas,since th...Sulfur dioxide(SO_(2))is a typical pollutant that affects human health,climate,and environmental and ecological conditions.China has been experiencing high concentrations of SO_(2),particularly in urban areas,since the 1990s.In 2010,a"joint prevention and control"(JPC)policy was issued to address air pollution problems and strengthen the regulation of SO_(2)emissions.This study aimed to describe the mitigation effects of this policy on SO_(2)emissions in 116 Chinese cities from 2003 to 2017.We applied global and local Moran's I indices to confirm the presence of significant spatial autocorrelation in SO_(2)emissions and constructed four spatial models to assess the effect of the JPC policy in reducing SO_(2)emissions and its transmission mechanism.We found that the policy decreased SO_(2)emissions by 1.89×10^(4)tons,S0_(2)intensity by 1.70 tons per km^(2),and S0_(2)per capita of 158.49 tons per 10,000 people in each city,on average,all of which are significant changes.The empirical results also show that population growth,economic structure,and environmental protection significantly decrease SO_(2)emissions.Finally,we recommended policies to encourage regional cooperation under the JPC policy,with the aim of promoting furtherreductions in SO_(2)emissions.展开更多
基金supported in part by grants from the Disciplinary Group of Psychology and Neuroscience Xinxiang Medical University(2016PN-KFKT-06)a visiting professorship from University of Tours(to LHJ)
文摘Microglial cells are the key innate immune cells in the brain and they are crucial in maintaining brain parenchyma homeostasis.Under physiological conditions,microglial cells assume a ramified morphology with a small cell body and an extensive network of fine processes,which secrete neurotrophic factors and patrol the surroundings in search for pathogens and eliminate cellular debris via phagocytosis.Microglial cells express a repertoire of pattern recognition receptors(PRRs)that enable them to detect diverse danger-associated molecular patterns(DAMPs)released from damaged cells or cells under stress,or pathogen-associated molecular patterns generated by pathogens during infection.
基金Shaanxi Social Science Project(2022YA14)Xi'an Social Science Planning Project(23JX66)+1 种基金Fundamental Research Funds for the Central Universities(KYFZ23008)Proof of Concept Foundation of Xidian University Hangzhou Institute of Technology under Grant No.GNYZ2023ZC0503.
文摘Sulfur dioxide(SO_(2))is a typical pollutant that affects human health,climate,and environmental and ecological conditions.China has been experiencing high concentrations of SO_(2),particularly in urban areas,since the 1990s.In 2010,a"joint prevention and control"(JPC)policy was issued to address air pollution problems and strengthen the regulation of SO_(2)emissions.This study aimed to describe the mitigation effects of this policy on SO_(2)emissions in 116 Chinese cities from 2003 to 2017.We applied global and local Moran's I indices to confirm the presence of significant spatial autocorrelation in SO_(2)emissions and constructed four spatial models to assess the effect of the JPC policy in reducing SO_(2)emissions and its transmission mechanism.We found that the policy decreased SO_(2)emissions by 1.89×10^(4)tons,S0_(2)intensity by 1.70 tons per km^(2),and S0_(2)per capita of 158.49 tons per 10,000 people in each city,on average,all of which are significant changes.The empirical results also show that population growth,economic structure,and environmental protection significantly decrease SO_(2)emissions.Finally,we recommended policies to encourage regional cooperation under the JPC policy,with the aim of promoting furtherreductions in SO_(2)emissions.
