Amphiphilic block copolymers of poly（5-benzyloxy trimethylene carbonate） （PBTMC） and poly（ethylene glycol） （PEG） were synthesized through enzymatic polymerization using immobilized porcine pancreas lipase （I...Amphiphilic block copolymers of poly（5-benzyloxy trimethylene carbonate） （PBTMC） and poly（ethylene glycol） （PEG） were synthesized through enzymatic polymerization using immobilized porcine pancreas lipase （IPPL）. The obtained copolymers with different compositions were characterized by GPC and IH NMR. The copolymer composition was in agreement with the feed ratio. The molecular weight of the copolymers showed an increasing trend with the decrease of PEG contents. MiceUes of the copolymers were formed by dialysis procedure, and characterized by transmission electron microscopy （TEM）.展开更多
A smart polycarbonate（PCA） copolymer-based nanoparticle（NanoPCA） with pH-responsive, long-term stability, and tumor targeting ability was successfully developed by synthesizing and assembling a series of functiona...A smart polycarbonate（PCA） copolymer-based nanoparticle（NanoPCA） with pH-responsive, long-term stability, and tumor targeting ability was successfully developed by synthesizing and assembling a series of functional PCA-based copolymers including poly（2-amino-l,3-propanediol carbonate-co-L-lactide）[P（CA-co-LA）], poly（2- amino-1,3-propanediol carbonate-co-L-lactide）-g-methoxy-poly（ethylene glycol）[P（CA-co-LA）-g-MPEG], and poly（2-amino-1,3-propanediol carbonate-co-L-lactide）-g-poly（ethylene glycol）-cyclic（Arg-Gly-Asp-D-Phe-Lys） [P（CA-co-LA）-g-PEG-cRGD] for targeted anticancer drug delivery, pH-Responsive studies demonstrated that the loading doxorubicin（DOX） released faster from NanoPCA at acidic conditions due to protonation effects of P（CA-co-LA） copolymers. Furthermore, the in vitro and in vivo investigations demonstrate that the DOX-loaded NanoPCA exhibited significant tumor targeting ability, outstanding antitumor effect and excellent biological safety in the treatment of oral squamous cell carcinoma（OSCC）. Therefore, this work provides a promising drug delivery plat-form for cancer therapy and other applications.展开更多
通过熔体流动速率、热变形温度和力学性能等指标变化评价了ASA胶含量及用量对PC/ASA合金性能的影响。结果表明,随着ASA用量的增加,合金的热变形温度下降;可以通过ASA胶含量和用量调节合金的流动性;不论合金的组成,ASA胶含量为30%的PC/AS...通过熔体流动速率、热变形温度和力学性能等指标变化评价了ASA胶含量及用量对PC/ASA合金性能的影响。结果表明,随着ASA用量的增加,合金的热变形温度下降;可以通过ASA胶含量和用量调节合金的流动性;不论合金的组成,ASA胶含量为30%的PC/ASA合金的低温冲击强度最高;当PC/ASA比例为7∶3,ASA胶含量为30%时,PC/ASA合金的低温冲击强度最高为36 k J/m^(2)。展开更多
The compatibitily and morphology of HIPS/PC and HIPS g GMA/PC blends were studied.The compatibility and morphology of HIPS/PC blends were characterized by DSC and SEM,respectively.The result of DSC shows that T g of P...The compatibitily and morphology of HIPS/PC and HIPS g GMA/PC blends were studied.The compatibility and morphology of HIPS/PC blends were characterized by DSC and SEM,respectively.The result of DSC shows that T g of PS doesn’t change with the blend composition,and T g of PC decreases with the increase in weight fraction of HIPS,which indicates that the PC/HIPS blend is a partially miscible system.Results of SEM indicate that the decrease in T g of PC results from PS interpenetrating into the phase of PC,and no change in T g of PS results from PC not interpenetrating into the phase of PS.The copolymer of HIPS g GMA was prepared by reactive grafting method.The IR spectrum shows that GMA is grafted on the chain of HIPS.The compatibility and morphology of HIPS g GMA(35)/PC(65) were studied by DSC and SEM.PC(65)/HIPS g GMA(35) blend exhibits reduced size of disperse phase,enhanced interface adhesion and lower T g of PC phase as compared with the PC(65)/HIPS(35) blend.It implies that HIPS g GMA is an effective compatibilizer of the HIPS/PC blend.展开更多
综述和讨论了芳香族磷酸酯阻燃聚碳酸酯(PC)/丙烯腈-丁二烯-苯乙烯共聚物、硅化合物和硫化合物阻燃 PC 的阻燃机理以及 PC 的热分解机理。涉及的反应有碳酸酯基的重排、羟基化合物与 PC 的作用、Fries 重排、异亚丙基键的断裂及 PC 的...综述和讨论了芳香族磷酸酯阻燃聚碳酸酯(PC)/丙烯腈-丁二烯-苯乙烯共聚物、硅化合物和硫化合物阻燃 PC 的阻燃机理以及 PC 的热分解机理。涉及的反应有碳酸酯基的重排、羟基化合物与 PC 的作用、Fries 重排、异亚丙基键的断裂及 PC 的热氧化等。今后的研究重点之一是应取得更多证据支持已提出的机理,使其日趋完善。展开更多
文摘Amphiphilic block copolymers of poly（5-benzyloxy trimethylene carbonate） （PBTMC） and poly（ethylene glycol） （PEG） were synthesized through enzymatic polymerization using immobilized porcine pancreas lipase （IPPL）. The obtained copolymers with different compositions were characterized by GPC and IH NMR. The copolymer composition was in agreement with the feed ratio. The molecular weight of the copolymers showed an increasing trend with the decrease of PEG contents. MiceUes of the copolymers were formed by dialysis procedure, and characterized by transmission electron microscopy （TEM）.
基金Supported by the National High Technolgy Researeh and Development Program of China（No.2013AA032201）, the National Natural Science Foundation of China（Nos.81703003, 51303009, 21476018, 21622601） and the National Key R＆D Program of China（No.2015CB932101 ）.
文摘A smart polycarbonate（PCA） copolymer-based nanoparticle（NanoPCA） with pH-responsive, long-term stability, and tumor targeting ability was successfully developed by synthesizing and assembling a series of functional PCA-based copolymers including poly（2-amino-l,3-propanediol carbonate-co-L-lactide）[P（CA-co-LA）], poly（2- amino-1,3-propanediol carbonate-co-L-lactide）-g-methoxy-poly（ethylene glycol）[P（CA-co-LA）-g-MPEG], and poly（2-amino-1,3-propanediol carbonate-co-L-lactide）-g-poly（ethylene glycol）-cyclic（Arg-Gly-Asp-D-Phe-Lys） [P（CA-co-LA）-g-PEG-cRGD] for targeted anticancer drug delivery, pH-Responsive studies demonstrated that the loading doxorubicin（DOX） released faster from NanoPCA at acidic conditions due to protonation effects of P（CA-co-LA） copolymers. Furthermore, the in vitro and in vivo investigations demonstrate that the DOX-loaded NanoPCA exhibited significant tumor targeting ability, outstanding antitumor effect and excellent biological safety in the treatment of oral squamous cell carcinoma（OSCC）. Therefore, this work provides a promising drug delivery plat-form for cancer therapy and other applications.
文摘通过熔体流动速率、热变形温度和力学性能等指标变化评价了ASA胶含量及用量对PC/ASA合金性能的影响。结果表明,随着ASA用量的增加,合金的热变形温度下降;可以通过ASA胶含量和用量调节合金的流动性;不论合金的组成,ASA胶含量为30%的PC/ASA合金的低温冲击强度最高;当PC/ASA比例为7∶3,ASA胶含量为30%时,PC/ASA合金的低温冲击强度最高为36 k J/m^(2)。
文摘The compatibitily and morphology of HIPS/PC and HIPS g GMA/PC blends were studied.The compatibility and morphology of HIPS/PC blends were characterized by DSC and SEM,respectively.The result of DSC shows that T g of PS doesn’t change with the blend composition,and T g of PC decreases with the increase in weight fraction of HIPS,which indicates that the PC/HIPS blend is a partially miscible system.Results of SEM indicate that the decrease in T g of PC results from PS interpenetrating into the phase of PC,and no change in T g of PS results from PC not interpenetrating into the phase of PS.The copolymer of HIPS g GMA was prepared by reactive grafting method.The IR spectrum shows that GMA is grafted on the chain of HIPS.The compatibility and morphology of HIPS g GMA(35)/PC(65) were studied by DSC and SEM.PC(65)/HIPS g GMA(35) blend exhibits reduced size of disperse phase,enhanced interface adhesion and lower T g of PC phase as compared with the PC(65)/HIPS(35) blend.It implies that HIPS g GMA is an effective compatibilizer of the HIPS/PC blend.
文摘综述和讨论了芳香族磷酸酯阻燃聚碳酸酯(PC)/丙烯腈-丁二烯-苯乙烯共聚物、硅化合物和硫化合物阻燃 PC 的阻燃机理以及 PC 的热分解机理。涉及的反应有碳酸酯基的重排、羟基化合物与 PC 的作用、Fries 重排、异亚丙基键的断裂及 PC 的热氧化等。今后的研究重点之一是应取得更多证据支持已提出的机理,使其日趋完善。
