This paper described the development of chitosan composites containing precipitated hydroxyapatite particles for potential applications in orthopaedic surgery or waste water treatment.The synthetic process and morphol...This paper described the development of chitosan composites containing precipitated hydroxyapatite particles for potential applications in orthopaedic surgery or waste water treatment.The synthetic process and morphology of hydroxyapatite were reported.The effects of hydroxyapatite content on the microstructure and mechanical properties of composites were investigated.It was found that the Young’s Modulus of the composites decreases with hydroxyapatite content while the failure strength and strain increase with the hydroxyapatite content.展开更多
In an effort to develop biomaterials to meet guided tissue regeneration （GTR） standards for periodontal tissue recovery, a homogeneous and transparent chitosan （CS）/hydroxyapatite （HA） membrane with potential ap...In an effort to develop biomaterials to meet guided tissue regeneration （GTR） standards for periodontal tissue recovery, a homogeneous and transparent chitosan （CS）/hydroxyapatite （HA） membrane with potential applications as GTR barrier in periodontal therapy has been prepared via in situ compositing. The membrane has been designed to have a smoothrough asymmetric structure that meets the demand for GTR. Component and morphology of the membrane are characterized by XRD and SEM. It can be indicated that HA was in situ synthesized uniformly in the CS membrane. Mechanical experiments of the membranes with various HA contents show that their tensile strengths are adequate for periodontal therapy. Biological properties of the membrane have been performed by cell toxicity assays, hemolysis tests and animal experiments. Results indicate that the membrane has good biocompatibility and inductive effect for cell growth. Therefore this membrane can be potentially applied as GTR barrier membrane for periodontal tissue regeneration.展开更多
文摘This paper described the development of chitosan composites containing precipitated hydroxyapatite particles for potential applications in orthopaedic surgery or waste water treatment.The synthetic process and morphology of hydroxyapatite were reported.The effects of hydroxyapatite content on the microstructure and mechanical properties of composites were investigated.It was found that the Young’s Modulus of the composites decreases with hydroxyapatite content while the failure strength and strain increase with the hydroxyapatite content.
基金supported by the National Natural Science Foundation of China(No.50773070)the Key Basic Research Development Plan(Project 973) of China(No.2005CB623902)+1 种基金Grand Science and Technology Special Project of Zhejiang Province(No.2008C11087)Science and Technology Project of Zhejiang Province(No.2006C33067)
文摘In an effort to develop biomaterials to meet guided tissue regeneration （GTR） standards for periodontal tissue recovery, a homogeneous and transparent chitosan （CS）/hydroxyapatite （HA） membrane with potential applications as GTR barrier in periodontal therapy has been prepared via in situ compositing. The membrane has been designed to have a smoothrough asymmetric structure that meets the demand for GTR. Component and morphology of the membrane are characterized by XRD and SEM. It can be indicated that HA was in situ synthesized uniformly in the CS membrane. Mechanical experiments of the membranes with various HA contents show that their tensile strengths are adequate for periodontal therapy. Biological properties of the membrane have been performed by cell toxicity assays, hemolysis tests and animal experiments. Results indicate that the membrane has good biocompatibility and inductive effect for cell growth. Therefore this membrane can be potentially applied as GTR barrier membrane for periodontal tissue regeneration.
