This review provides a glimpse of the potential of the biodegradable phos-phoryl-containing polymers in medical applications. Undoubtedly these polymerspossess unique properties that are yet to be fully understood. Ma...This review provides a glimpse of the potential of the biodegradable phos-phoryl-containing polymers in medical applications. Undoubtedly these polymerspossess unique properties that are yet to be fully understood. Many areas warrantfurther investigation and much optimization remains to be done. The fascinatingchemistry of phosphorus poses interesting hurdles but at the same time leavesample room for polymer scientists to exercise their creativity in designinginteresting biomaterials. As the mutual understanding between basic and clinicalscientists on the need of medical devices and the capabilities of these newbiomaterials expands, imaginative application of new biomaterials to other medi-cal applications can be expected.展开更多
Multi-responsive hydrogels,or‘intelligent’hydrogels that respond to more than one environmental stimulus,have demonstrated great utility as a regenerative biomaterial in recent years.They are structured biocompatibl...Multi-responsive hydrogels,or‘intelligent’hydrogels that respond to more than one environmental stimulus,have demonstrated great utility as a regenerative biomaterial in recent years.They are structured biocompatible materials that provide specific and distinct responses to varied physiological or externally applied stimuli.As evidenced by a burgeoning number of investigators,multi-responsive hydrogels are endowed with tunable,controllable and even biomimetic behavior well-suited for drug delivery and tissue engineering or regenerative growth applications.This article encompasses recent developments and challenges regarding supramolecular,layer-by-layer assembled and covalently cross-linked multi-responsive hydrogel networks and their application to drug delivery and tissue engineering.展开更多
文摘This review provides a glimpse of the potential of the biodegradable phos-phoryl-containing polymers in medical applications. Undoubtedly these polymerspossess unique properties that are yet to be fully understood. Many areas warrantfurther investigation and much optimization remains to be done. The fascinatingchemistry of phosphorus poses interesting hurdles but at the same time leavesample room for polymer scientists to exercise their creativity in designinginteresting biomaterials. As the mutual understanding between basic and clinicalscientists on the need of medical devices and the capabilities of these newbiomaterials expands, imaginative application of new biomaterials to other medi-cal applications can be expected.
基金Preparation of this review article was supported in part by the National Science Foundation Graduate Research Fellowship Program[DGE-1110007 to J.M.K.].
文摘Multi-responsive hydrogels,or‘intelligent’hydrogels that respond to more than one environmental stimulus,have demonstrated great utility as a regenerative biomaterial in recent years.They are structured biocompatible materials that provide specific and distinct responses to varied physiological or externally applied stimuli.As evidenced by a burgeoning number of investigators,multi-responsive hydrogels are endowed with tunable,controllable and even biomimetic behavior well-suited for drug delivery and tissue engineering or regenerative growth applications.This article encompasses recent developments and challenges regarding supramolecular,layer-by-layer assembled and covalently cross-linked multi-responsive hydrogel networks and their application to drug delivery and tissue engineering.
