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Aqueous Self-Assembly of Block Copolymers to Form Manganese Oxide-Based Polymeric Vesicles for Tumor Microenvironment-Activated Drug Delivery 被引量:2
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作者 Yalei Miao Yudian Qiu +6 位作者 Mengna Zhang Ke Yan Panke Zhang Siyu Lu Zhongyi Liu Xiaojing Shi Xubo Zhao 《Nano-Micro Letters》 SCIE EI CAS CSCD 2020年第9期324-338,共15页
Molecular self-assembly is crucially fundamental to nature.However,the aqueous self-assembly of polymers is still a challenge.To achieve self-assembly of block copolymers [(polyacrylic acid-block-polyethylene glycol-b... Molecular self-assembly is crucially fundamental to nature.However,the aqueous self-assembly of polymers is still a challenge.To achieve self-assembly of block copolymers [(polyacrylic acid-block-polyethylene glycol-block-polyacrylic acid(PAA68-b-PEG86-b-PAA68)] in an aqueous phase,manganese oxide(MnO2) is first generated to drive phase separation of the PAA block to form the PAA68-b-PEG68-b-PAA68/MnO2 polymeric assembly that exhibits a stable structure in a physiological medium.The polymeric assembly exhibits vesicular morphology with a diameter of approximately 30 nm and high doxorubicin(DOX) loading capacity of approximately 94%.The transformation from MnO2 to Mn2+caused by endogenous glutathione(GSH)facilitates the disassembly of PAA68-b-PEG68-b-PAA68/MnO2 to enable its drug delivery at the tumor sites.The toxicity of DOXloaded PAA68-b-PEG68-b-PAA69/MnO2 to tumor cells has been verified in vitro and in vivo.Notably,drug-loaded polymeric vesicles have been demonstrated,especially in in vivo studies,to overcome the cardiotoxicity of DOX.We expect this work to encourage the potential application of polymer self-assembly. 展开更多
关键词 POLYMER Aqueous self-assembly vesicles Tumor microenvironment Drug delivery system
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LHRH/TAT dual peptides-conjugated polymeric vesicles for PTT enhanced chemotherapy to overcome hepatocellular carcinoma 被引量:2
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作者 Yu Qin Qing Guo +5 位作者 Shengjie Wu Chenlu Huang Zhiming Zhang Li Zhang Linhua Zhang Dunwan Zhu 《Chinese Chemical Letters》 SCIE CAS CSCD 2020年第12期3121-3126,共6页
Combination therapy such as photothermal therapy(PTT)enhanced chemotherapy is regarded as a promising strategy for cancer treatment.Herein,we developed redox-responsive polymeric vesicles based on the amphiphilic trib... Combination therapy such as photothermal therapy(PTT)enhanced chemotherapy is regarded as a promising strategy for cancer treatment.Herein,we developed redox-responsive polymeric vesicles based on the amphiphilic triblock copolymer PCL-ss-PEG-ss-PCL.To avoid the limited therapeutic effect of chemotherapeutic drugs caused by systemic exposures and drug resistance,the redox-sensitive polymeric vesicles were cargoed with two chemotherapeutics:doxorubicin(DOX)and paclitaxel(PTX).Besides,indocyanine green(ICG)was encapsulated,and cell-penetrating peptides and LHRH targeting molecule were modified on the surface of polymeric vesicles.The results indicated that the polymeric vesicles can load different kinds of drugs with high drug loading content,trigger drug release in responsive to the reductive environment,realize high cellular uptake via dual peptides and laser irradiation,and achieve higher cytotoxicity via chemo-photothermal combination therapy.Hence,the redox-responsive LHRH/TAT dual peptides-conjugated PTX/DOX/ICG co-loaded polymeric micelles exhibited great potential in tumor-targeting and chemo-photothermal therapy. 展开更多
关键词 Redox-responsive polymeric vesicles CHEMOTHERAPY Photothermal therapy Combination therapy
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CO_2-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle
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作者 Xian-Wu Jing Zhi-Yu Huang +1 位作者 Hong-Sheng Lu Bao-Gang Wang 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2018年第1期18-24,共7页
A series of triblock copolymers, containing a CO_2-switchable block poly(2-(dimethylamino)ethyl methacrylate)(PDM) block and two symmetrical hydrophilic blocks polyacrylamide(PAM), were synthesized using atom ... A series of triblock copolymers, containing a CO_2-switchable block poly(2-(dimethylamino)ethyl methacrylate)(PDM) block and two symmetrical hydrophilic blocks polyacrylamide(PAM), were synthesized using atom transfer radical polymerization(ATRP) method. The p H and conductivity tests showed that the triblock copolymer exhibited switchable responsiveness to CO_2, i.e. a relatively low conductivity of solution could be switched on and off by bubbling and removing of CO_2, and the triblock copolymer aqueous solution displayed a CO_2-switchable viscosity variation. The changes were all attributed to protonation of tertiary amine groups in PDM blocks and proven by 1 H-NMR. Cryogenic transmission electron microscopy and dynamic light scattering characterization demonstrated that the viscosity variation was the result of a unilamellar vesicle-network aggregate structure transition. The release of rhodamine B from the vesicles with and without CO_2 stimuli showed the potential application in drug delivery domains; after CO_2 bubbling, the drug release rate could be accelerated. Finally, reasonable mechanism of CO_2-switchable morphology changes and CO_2-induced drug release was proposed. 展开更多
关键词 ATRP CO_2-sensitive polymeric vesicles Drug release
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Synchronous Synthesis of Polymeric Vesicles with Controllable Size and Low-Polydispersity by Polymerization-Induced Self-Assembly
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作者 Ren-Man Zhu Cheng-Lin Yang +3 位作者 Zi-Xuan Chang Cai-Yuan Pan Wen-Jian Zhang Chun-Yan Hong 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2022年第4期453-459,共7页
Comprehensive Summary The size and size distribution of polymeric nanoparticles have great impact on their physicochemical and biological properties.Polymerization-induced self-assembly(PISA)has been demonstrated to b... Comprehensive Summary The size and size distribution of polymeric nanoparticles have great impact on their physicochemical and biological properties.Polymerization-induced self-assembly(PISA)has been demonstrated to be an efficient method to fabricate various polymeric nanoparticles,among which polymeric vesicles have attracted great interest due to their unique hollow structure. 展开更多
关键词 Polymerization-induced self-assembly RAFT dispersion polymerization vesicles Block copolymers Nanoparticles
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Order-Disorder Transition of Carboxyl Terminated Chains in Polydiacetylenes Vesicles Probed by Second Harmonic Generation and Two-Photon Fluorescence
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作者 Shun-li Chen Xue-feng Zhu +3 位作者 Fang-yuan Yang Xue-cong Pan Wei Gan Qun-hui Yuan 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2018年第3期269-276,367,共9页
To understand and control the interfacial properties of polydiacetylenes(PDAs)vesicles withπ-conjugated backbone is very important for their colorimetric sensing of chemical and biological targets.In this work,we ado... To understand and control the interfacial properties of polydiacetylenes(PDAs)vesicles withπ-conjugated backbone is very important for their colorimetric sensing of chemical and biological targets.In this work,we adopted 10,12-pentacosadiynoic acid(PCDA)as the model molecule to prepare PDAs vesicles in aqueous solution with different forms(from monomer to blue-to-purple-to-red phase)by controlling the UV irradiation dose.The variations of the interfacial conformation of PDAs vesicles during chromatic transitions were inspected by the adsorption behaviors of probe molecules(4-(4-diethylaminostyry)-1-methylpyridinium iodide,D289)on vesicle surface with surface-specific second harmonic generation(SHG)and zeta potential measurements.Resonant SHG signal from D289 adsorbed on vesicle surface attenuated sharply,and the adsorption free energy as well as the corresponding two-photon fluorescence signal decreased slightly in chromatic transitions.While,the change in the surface density of the adsorbed D289 molecules for PDAs vesicles with different forms was relatively small as estimated from zeta potential measurements.The attenuation of the SHG intensity was thus attributed to the overall order-disorder transition and the changed orientation of D289 molecules caused by the gradual distortion of carboxyl head group driven by backbone perturbation. 展开更多
关键词 POLYDIACETYLENES vesicle POLYMERIZATION interfacial adsorption Second harmonic generation ORDER-DISORDER transition
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POLYELEOSTEARIC ACID VESICLES
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作者 李子臣 谢希明 +1 位作者 范青华 方一非 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1992年第1期26-31,共6页
α-Eleostearic acid and β-eleostearic acid formed vesicles in aqueous medium when an ethanol solution of eleostearic acid was injected rapidly into a vigorously vortexed aqueous phase. Formation of the vesicles was d... α-Eleostearic acid and β-eleostearic acid formed vesicles in aqueous medium when an ethanol solution of eleostearic acid was injected rapidly into a vigorously vortexed aqueous phase. Formation of the vesicles was demonstrated by electron microscopic observation and bromothymol blue encapsulation experiments. Polymerizations of the eleostearic acids in the formed vesicles carried out by UV irradiation produced poly-α-eleostearic acid and poly-β-eleostearic acid vesicles. 展开更多
关键词 Eleostearic acid UV irradiated polymerization vesicle
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Mechanisms of Cup-Shaped Vesicle Formation Using Amphiphilic Diblock Copolymer
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作者 Eri Yoshida 《Open Journal of Polymer Chemistry》 CAS 2022年第2期43-54,共12页
A cup shape is a dynamic morphology of cells and organelles. With the aim of elucidating the formation of the biotic cup-shaped morphology, this study investigated cup-shaped vesicles consisting of an amphiphilic dibl... A cup shape is a dynamic morphology of cells and organelles. With the aim of elucidating the formation of the biotic cup-shaped morphology, this study investigated cup-shaped vesicles consisting of an amphiphilic diblock copolymer from the aspect of synthetic polymer chemistry. Cup-shaped vesicles were obtained by the polymerization-induced self-assembly of poly(methacrylic acid)-block-poly(n-butyl methacrylate-random-methacrylic acid), PMAA-b-P(BMA-r-MAA), in an aqueous methanol solution using the photo nitroxide-mediated controlled/living radical polymerization technique. Field emission scanning electron microscopic observations demonstrated that the cup-shaped vesicles were suddenly formed during the late stage of the polymerization due to the extension of the hydrophobic P(BMA-r-MAA) block chain. During the early stage, the polymerization produced spherical vesicles rather than a cup shape. As the hydrophobic block chain was extended by the polymerization progress, the spherical vesicles reduced the size and were accompanied by the generation of small particles that were attached to the vesicles. The vesicles continued to reduce the size due to further extension of the hydrophobic chain;however, they suddenly grew into cup-shaped vesicles. This growth was accounted for by a change in the critical packing shape of the copolymer due to the hydrophobic chain extension. These findings are helpful for a better understanding of the biotic cup-shaped vesicle formation. 展开更多
关键词 Cup-Shaped vesicles Polymerization-Induced Self-Assembly Poly(methacrylic acid)-block-poly(n-butyl methacrylate-random-methacrylic acid) Critical Packing Shape
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Polymer Vesicle Sensor through the Self-assembly of Hyperbranched Polymeric Ionic Liquids for the Detection of SO2 Derivatives 被引量:4
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作者 Zhi-lin Hou Tong Huang +4 位作者 Cai-yun Cai Tahir Resheed 于春阳 Yong-feng Zhou De-yue Yan 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2017年第5期602-610,共9页
This work reports a SO2 derivative-detecting and colorful hyperbranched polymeric ionic liquid (HBPIL) vesicle through aqueous self-assembly. By a simple anion-exchange, we achieved the combination of functional sma... This work reports a SO2 derivative-detecting and colorful hyperbranched polymeric ionic liquid (HBPIL) vesicle through aqueous self-assembly. By a simple anion-exchange, we achieved the combination of functional small-molecule probe of acid fuchsin with HBPILs. The obtained HBPIL vesicle displayed ultraviolet absorption at 544 nm, and was used as a novel SO2 derivative sensor with high sensitivity and visualization. Due to the functional ion pairs enriching on the surface, the SO32 detection limit of the HBPILs vesicles was as low as 0.138 gmol/L, which was about 1.5 orders of magnitude lower than that of acid fuchsin. 展开更多
关键词 SO2 SELF-ASSEMBLY polymeric ionic liquids vesicles
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聚合脂质体 被引量:4
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作者 孙彦 刘敬义 +1 位作者 于凯 周秀中 《有机化学》 SCIE CAS CSCD 北大核心 1994年第5期468-479,共12页
本文综述了聚合脂质体的结构类型、制备及应用前景。
关键词 聚合脂体 化学结构 聚合泡囊 制备
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CTAB/SDBS囊泡的自发形成与聚合 被引量:4
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作者 余娜 孙丹 +3 位作者 韩兆让 刘春丽 李玉 崔琳琳 《化学学报》 SCIE CAS CSCD 北大核心 2008年第3期315-320,共6页
讨论了十六烷基三甲基溴化铵/十二烷基苯磺酸钠(CTAB/SDBS)复配比例、体系浓度对其囊泡自发形成的影响和不同制备方法与放置时间对囊泡尺寸的影响,同时用TEM考察了囊泡的结构与形态.通过TEM发现囊泡之间有相互聚集融合变大的趋势,粒径... 讨论了十六烷基三甲基溴化铵/十二烷基苯磺酸钠(CTAB/SDBS)复配比例、体系浓度对其囊泡自发形成的影响和不同制备方法与放置时间对囊泡尺寸的影响,同时用TEM考察了囊泡的结构与形态.通过TEM发现囊泡之间有相互聚集融合变大的趋势,粒径分析也发现随放置时间延长囊泡尺寸增大.所以这里采用聚合法来改善囊泡的稳定性.经粒径分析证实经聚合法处理的囊泡其尺寸明显比未处理的稳定. 展开更多
关键词 囊泡 自发形成 聚合 稳定
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聚合物构筑的囊泡及应用 被引量:5
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作者 朱玥珺 谭业邦 +1 位作者 张翼 侯昭升 《日用化学工业》 CAS CSCD 北大核心 2005年第2期94-96,132,共4页
综述了形成囊泡的两亲聚合物的结构,如双链两亲聚合物、单链两亲聚合物、正/负离子复合聚合物、聚合物与小分子化合物及可聚合化两亲聚合物;介绍了这些聚合物形成囊泡的特点和形成条件;概括了囊泡在反应微环境、药物释放、基因载体和生... 综述了形成囊泡的两亲聚合物的结构,如双链两亲聚合物、单链两亲聚合物、正/负离子复合聚合物、聚合物与小分子化合物及可聚合化两亲聚合物;介绍了这些聚合物形成囊泡的特点和形成条件;概括了囊泡在反应微环境、药物释放、基因载体和生物矿化等方面的潜在应用;并提出了聚合物构筑囊泡的发展前景。 展开更多
关键词 表面活性剂 聚合物囊泡 聚集体 自组装
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聚硼酸酯表面活性剂囊泡自发形成 被引量:3
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作者 王海鹰 李斌栋 +1 位作者 户安军 吕春绪 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2007年第2期358-361,共4页
通过直接引发聚合,以偶氮二异丁腈为引发剂,用N-羟甲基丙烯酰胺、硼酸三乙酯和N,N-二羟乙基十二烷基胺制备了聚硼酸酯(PMBE)表面活性剂,用红外光谱、核磁共振谱和凝胶色谱对其结构进行了表征;用透射电镜(TEM)研究了PMBE在纯水... 通过直接引发聚合,以偶氮二异丁腈为引发剂,用N-羟甲基丙烯酰胺、硼酸三乙酯和N,N-二羟乙基十二烷基胺制备了聚硼酸酯(PMBE)表面活性剂,用红外光谱、核磁共振谱和凝胶色谱对其结构进行了表征;用透射电镜(TEM)研究了PMBE在纯水和0.1mol/LNaCI水溶液中的自组装形态.结果表明,PMBE在水和0.1mol/LNaCI溶液中皆可自发形成聚合囊泡;在水溶液中PMBE囊泡粒径约为20nm,而NaCI溶液中囊泡直径增大,在150-250nm之间,分布较为均匀;结合两亲性分子排列参数理论和一定的近似处理方法对PMBE聚合囊泡的形成机理进行了初步探讨. 展开更多
关键词 囊泡 聚硼酸酯表面活性剂 排列参数
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反应性H形嵌段共聚物的合成和自组装 被引量:11
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作者 邹鹏 潘才元 《高分子学报》 SCIE CAS CSCD 北大核心 2007年第10期974-978,共5页
以2,2′-(α-溴异丁酰氧基甲基)丙酰氯与Mn分别为4000和2×104的双端羟基聚乙二醇(PEG)进行酯化反应,制得了含4个端溴的PEG大分子引发剂.它在溴化亚铜/2,2′-联吡啶的存在下,在甲醇中,引发甲基丙烯酸3-三甲氧基硅丙酯(TMSPMA)单体... 以2,2′-(α-溴异丁酰氧基甲基)丙酰氯与Mn分别为4000和2×104的双端羟基聚乙二醇(PEG)进行酯化反应,制得了含4个端溴的PEG大分子引发剂.它在溴化亚铜/2,2′-联吡啶的存在下,在甲醇中,引发甲基丙烯酸3-三甲氧基硅丙酯(TMSPMA)单体进行原子转移自由基聚合(ATRP),得到两个不同分子量的H形嵌段共聚物Sam 1和Sam 2.其结构和分子量及分布用核磁共振氢谱及GPC表征.用TEM研究它们在N,N-二甲基甲酰胺和水混合溶剂中的自组装行为.组成为(EG)91-b-(TMSPMA)92的Sam 1生成复合囊泡;组成为(EG)455-b-(TMSPMA)176的Sam 2形成大的囊泡聚集体. 展开更多
关键词 大分子引发剂 原子转移自由基聚合 自组装 囊泡 聚集体
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浸矿细菌表面性质研究 被引量:7
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作者 傅建华 邱冠周 胡岳华 《金属矿山》 CAS 北大核心 2004年第9期19-24,39,共7页
为了探索浸矿细菌的吸附机理 ,提高生物冶金运作中的金属回收率 ,对浸矿细菌的表面性质进行了研究。在对硫培养的T .f(Thiobacillusferrooxidans)进行透射电镜 (TEM )观察时发现在它们的吸附面形成了外膜泡 ,而在铁培养的细菌中未观察... 为了探索浸矿细菌的吸附机理 ,提高生物冶金运作中的金属回收率 ,对浸矿细菌的表面性质进行了研究。在对硫培养的T .f(Thiobacillusferrooxidans)进行透射电镜 (TEM )观察时发现在它们的吸附面形成了外膜泡 ,而在铁培养的细菌中未观察到外膜泡。外膜泡仅在存在固体矿物的基质中形成 ,说明它在浸矿细菌吸附至矿物过程中起着十分重要的作用 ;用电镜细胞化学方法证实了浸矿细菌表面存在着脂类、多糖和蛋白质等物质 ,并阐明了它们在吸附过程中的作用 ;用FTIR法证实了T .f表面存在着—CONH—、OH、CH3 、CH2 等基团及C -O键。分析了这些基团在吸附过程中的作用。 展开更多
关键词 浸矿细菌 吸附机理 生物冶金 金属回收率
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热聚合法自交联共轭亚油酸囊泡的制备与释药性能 被引量:2
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作者 高迪 樊晔 +1 位作者 方云 李张宜 《精细化工》 EI CAS CSCD 北大核心 2016年第5期509-513,556,共6页
为考察以热聚合法取代紫外辐照法在较高浓度下制备稳定的脂肪酸囊泡的可行性,以可聚合单体共轭亚油酸(CLA)及其钠盐混合物为原料,在水溶液中经p H响应自组装得到共轭亚油酸囊泡(CLA-Ufasome),再通过热聚合法对高浓度CLA-Ufasome自... 为考察以热聚合法取代紫外辐照法在较高浓度下制备稳定的脂肪酸囊泡的可行性,以可聚合单体共轭亚油酸(CLA)及其钠盐混合物为原料,在水溶液中经p H响应自组装得到共轭亚油酸囊泡(CLA-Ufasome),再通过热聚合法对高浓度CLA-Ufasome自交联进行化学绑定,制备稳定的自交联共轭亚油酸囊泡(CLA-FAV),并采用透射电子显微镜(TEM)和动态激光光散射(DLS)对其进行表征。结果表明,在p H=8.6的条件下,在3~100mmol/L〔cvc(CLA)的500倍〕的浓度范围内均得到粒径为10~20 nm的CLA-FAV。说明经简单的热聚合法制备的CLA-FAV形貌与紫外法基本一致;该热聚合法CLA-FAV对5-氟尿嘧啶(5-FU)具有良好的包载缓释效果。 展开更多
关键词 脂肪酸囊泡 不饱和脂肪酸囊泡 共轭亚油酸 热聚合 形貌 包载缓释 功能材料
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在大孔硅基囊泡材料孔道内原位接枝有机聚合物
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作者 任申勇 张卡 +4 位作者 闫慧 张建华 曾鹏晖 郭巧霞 申宝剑 《化工学报》 EI CAS CSCD 北大核心 2016年第8期3507-3514,共8页
以聚环氧乙烷-聚环氧丙烷-聚环氧乙烷三嵌段共聚物(P123)为模板剂、正硅酸甲酯(TMOS)为硅源,采用水热法合成出孔径大于100 nm的硅基囊泡材料。同时采用两步法合成出带有硅烷偶联基团的有机自由基引发剂2-溴-2-甲基丙酸丁酯基三乙氧基硅... 以聚环氧乙烷-聚环氧丙烷-聚环氧乙烷三嵌段共聚物(P123)为模板剂、正硅酸甲酯(TMOS)为硅源,采用水热法合成出孔径大于100 nm的硅基囊泡材料。同时采用两步法合成出带有硅烷偶联基团的有机自由基引发剂2-溴-2-甲基丙酸丁酯基三乙氧基硅烷(BPE)和2-溴-2甲基丙酸丁酯基二甲基氯硅烷(BPCM)。再利用偶联基团与囊泡材料孔道内表面的硅羟基偶联反应将自由基引发剂BPE和BPCM分别接枝到囊泡内表面,元素分析发现BPCM具有更高的接枝效率。然后在囊泡孔道内分别引发烯烃单体甲基丙烯酸甲酯(MMA)和甲基丙烯酸丁酯(BMA)的原子转移自由基聚合(ATRP)反应,使单体在表面自由基上逐一反应形成聚合物刷。透射电镜(TEM)表征结果表明,孔道内表面接枝上了聚合物后囊泡保持较为完好。通过化学方法将聚合物切割下来,凝胶渗透色谱(GPC)分析发现接枝的PMMA和PBMA的数均分子量(Mn)分别为7600和11400,分子量分布指数(PDI)均为1.25。 展开更多
关键词 囊泡材料 孔道 原位接枝 自由基 聚合 复合材料
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CO_2/N_2可逆单层囊泡-网状结构转变研究
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作者 敬显武 黄志宇 鲁红升 《精细化工》 EI CAS CSCD 北大核心 2017年第12期1345-1349,1369,共6页
以聚乙二醇6000与α-溴代异丁酰溴进行酯化反应得到大分子引发剂PEG6000-Br,使用原子转移自由基聚合(ATRP)法合成了对称三嵌段且聚合度相等的聚甲基丙烯酸二甲胺乙酯-聚乙二醇-聚甲基丙烯酸二甲胺乙酯(PDM_(165)-PEG_(165)-PDM_(165))... 以聚乙二醇6000与α-溴代异丁酰溴进行酯化反应得到大分子引发剂PEG6000-Br,使用原子转移自由基聚合(ATRP)法合成了对称三嵌段且聚合度相等的聚甲基丙烯酸二甲胺乙酯-聚乙二醇-聚甲基丙烯酸二甲胺乙酯(PDM_(165)-PEG_(165)-PDM_(165))。利用FTIR和~1HNMR对其结构进行了表征。以p H、电导率测试证明了聚合物溶液的CO_2/N_2循环可逆性,聚合物溶液中通入CO_2后,5 min内,溶液p H值即从7.74下降至5.47,溶液电导率从0.176 m S/cm迅速上升至0.405 m S/cm;继而向溶液中通入N_2,经过30 min后,溶液的p H值和电导率都恢复到初始值。冷冻透射电镜(Cryo-TEM)观察得知,聚合物在水中可自组装形成单层囊泡,通入CO_2后,叔胺被质子化,囊泡解离形成网状结构,导致溶液黏度从3 m Pa·s上升至12 m Pa·s,叔胺质子化由~1HNMR证明,N原子附近的氢位移从δ2.3、2.7、4.1向低场分别移动至δ2.8、3.2、4.3。 展开更多
关键词 原子转移自由基聚合 嵌段聚合物 单层囊泡 质子化 功能材料
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高分子微泡体系中光解水的研究——(Ⅱ)聚卵磷脂微泡在光解水中的应用 被引量:2
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作者 周荣才 梁玉增 +2 位作者 陈志良 管爱国 赵德仁 《功能高分子学报》 CAS CSCD 1990年第2期127-130,共4页
本文研究以卵磷脂为单体形成的微泡体系,以Co^(60)辐照为聚合方式,通过超声波作用将联吡啶钌和EDTA,甲基紫精和铂溶胶等光解水的试剂置于微泡的不同区域,从而获得不同的光解水效果。
关键词 光解 聚卵磷脂 高分子微泡
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规整链球型含C_(60)聚(丙烯酸β-羟乙酯)的合成及其在水中的自组装 被引量:2
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作者 黎淳昭 张炜程 +3 位作者 魏柳荷 杜福胜 李子臣 李福绵 《高分子学报》 SCIE CAS CSCD 北大核心 2002年第1期120-122,共3页
Atom transfer radical polymerization of protected 2 hydroxyethyl acrylate (HEA\|TMS) was conducted to prepare well\|defined bromo\|terminated macroinitiators,which were further allowed to react with large excess amoun... Atom transfer radical polymerization of protected 2 hydroxyethyl acrylate (HEA\|TMS) was conducted to prepare well\|defined bromo\|terminated macroinitiators,which were further allowed to react with large excess amount of C 60 under ATRP condition.A well defined hammer shaped C 60 PHEA was then obtained by hydrolysis of C 60 PHEA TMS under mild conditions.A TEM observation of the association behavior of these well defined hammer like C 60 PHEA macromolecules showed that they assemble into spherical vesicles in water.Their characteristic inner water phase was further confirmed by fluorescence probe method.Also,it was found that the size of vesicles decreased as the increase of molecular weight of PHEA. 展开更多
关键词 碳60 聚(丙烯酸β-羟乙酯) 原子转移自由基聚合 衍生物 链球型含C60聚合物 囊泡 透射电镜 荧光 自组装
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新型载药高分子囊泡的制备与抗菌性能研究 被引量:2
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作者 曹冰 胡祥龙 《激光生物学报》 CAS 2016年第5期413-417,共5页
相对于小分子抗菌剂,高分子抗菌材料会对细菌的胞膜产生物理破坏,从而降低病原体产生耐药性的可能;另外,高分子抗菌材料不但具有较高的抗菌性能,抗菌作用时效长,环境污染小,而且对人体伤害小,具有更好的选择性。因此,高分子抗菌材料的... 相对于小分子抗菌剂,高分子抗菌材料会对细菌的胞膜产生物理破坏,从而降低病原体产生耐药性的可能;另外,高分子抗菌材料不但具有较高的抗菌性能,抗菌作用时效长,环境污染小,而且对人体伤害小,具有更好的选择性。因此,高分子抗菌材料的研究受到广泛关注。此外,还可以将小分子抗生素负载到高分子纳米载体中,实现小分子抗菌剂的传输与协同抗菌。本文构筑了两亲性高分子聚(N,N-二甲氨基乙酯-嵌段-聚苯氧异丙醇)(PDMAEMA-b-PPOPMA),自组装得到纳米囊泡,被用来物理包埋万古霉素(Vancomycin),对金黄色葡萄球菌(S.aureus)表现出良好的抗菌活性。 展开更多
关键词 高分子抗菌剂 囊泡 万古霉素 金黄色葡萄球菌 抗菌活性
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