Poly methyl methacrylate(PMMA)bone cement is used in augmenting and stabilizing fractured vertebral bodies through percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP).However,applications of PMMA bone ce...Poly methyl methacrylate(PMMA)bone cement is used in augmenting and stabilizing fractured vertebral bodies through percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP).However,applications of PMMA bone cement are limited by the high elasticity modulus of PMMA,its low biodegradability,and its limited ability to regenerate bone.To improve PMMA bio activity and biodegradability and to modify its elasticity modulus,we mixed PMMA bone cement with oxidized hyaluronic acid and carboxymethyl chitosan in situ cross-linking hydrogel loaded with bone morphogenetic protein-2(BMP-2)to achieve novel hybrid cement.These fabric ated PMMA-hydrogel hybrid cements exhibited lower setting temperatures,a lower elasticity modulus,and better biodegradability and biocompatibility than that of pure PMMA cement,while retaining acceptable setting times,mechanical strength,and inj ectability.In addition,we detected release of BMP-2 from the PMMA-hydrogel hybrid cements,significantly enhancing in vitro osteogenesis of bone marrow mesenchymal stem cells by up-regulating the gene expression of Runx2,Coll,and OPN.Use of PMMA-hydrogel hybrid cements loaded with BMP-2 on rabbit femoral condyle bone-defect models revealed their biodegradability and enhanced bone formation.Our study demonstrated the favorable mechanical properties,biocompatibility,and biodegradability of fabricated PMMA-hydrogel hybrid cements loaded with BMP-2,as well as their ability to improve osteogenesis,making them a promising material for use in PKP and PVP.展开更多
Phytochemical investigation of the MeOH extract of twigs and leaves of Baeckea frutescens led to the isolation of seven new polymethylated phloroglucinol meroterpenoids(PPMs),named baeckfrutones M-S(1-7).Their structu...Phytochemical investigation of the MeOH extract of twigs and leaves of Baeckea frutescens led to the isolation of seven new polymethylated phloroglucinol meroterpenoids(PPMs),named baeckfrutones M-S(1-7).Their structures and absolute configurations were determined by spectroscopic analyses,chiral-phase HPLC analysis,and electronic circular dichroism(ECD)calculations.PPM 1 is a novel meroterpenoid possessing a 6/6/5/3 tetracyclic skeleton in PPMs,whereas 3 and 4 are the first hydroxytasmanone type phloroglucinol-monoterpene hybrids.(+)-2 and 7 displayed potent antiinflammatory activity with IC50 values of 20.86±0.60 and 36.21±1.18 lL,respectively.展开更多
We report on a novel and convenient method of measuring secondary electron spectra for insulators in a secondary electron yield measurement system with a planar grid analyzer configuration and a metal mesh probe. In t...We report on a novel and convenient method of measuring secondary electron spectra for insulators in a secondary electron yield measurement system with a planar grid analyzer configuration and a metal mesh probe. In this measurement, the planar grid is negatively biased to force some emitted secondary electrons to return to the sample surface and to neutralize charges accumulated on the sample during the previous beam irradiation. The surface potential of the sample is then measured by use of a metal mesh probe. The grid bias for neutralization corresponding to the zero surface potential is determined based on the linear relationship between the surface potential and the grid bias. Once the surface potential equals zero, the secondary electron spectra of polymethyl methacrylate(PMMA) are studied experimentally by measuring the -curve and then fitting it to Everhart's formula. The measurement results show that the peak energy and the full width at half maximum of the spectra are 4.26 eV and 14.06 eV, respectively.展开更多
Polymethyl methacrylate (PMMA) microspheres with clear surface and diameter close to 1 祄 were synthesized by newly soap-free emulsion polymerization. The results showed that the presence of ethanol and NaCl made the...Polymethyl methacrylate (PMMA) microspheres with clear surface and diameter close to 1 祄 were synthesized by newly soap-free emulsion polymerization. The results showed that the presence of ethanol and NaCl made the increase of diameter and distribution, while the presence of toluene could avoid the problem of the increase of distribution, resulting a harvest of PMMA microspheres with a diameter close to 1 祄.展开更多
BACKGROUND In children with osteosarcoma around the knee joint without epiphysis involvement,joint-sparing surgery seems to be an ideal way to retain knee joint function.However,there are two points of debate with reg...BACKGROUND In children with osteosarcoma around the knee joint without epiphysis involvement,joint-sparing surgery seems to be an ideal way to retain knee joint function.However,there are two points of debate with regard to the technique:How to accurately achieve a safe surgical margin,and how to achieve intercalary reconstruction of the massive bone defect following resection of the tumor.CASE SUMMARY We present the case of an 8-year-old girl with osteosarcoma of the distal femur without involvement of the epiphysis.Epiphyseal distraction was applied to separate the epiphysis and metaphysis,and this provided a safe surgical margin.The massive bone defect was reconstructed with a custom-made antibioticloaded polymethyl methacrylate(PMMA)construct combined with a free nonvascularized fibular graft.Six months after surgery,bone union between the autograft and host bone was confirmed in both the proximal and distal femur by computer tomography(CT)examination.Moreover,considerable callus formation was found around the PMMA construct.After 28 mo of follow-up,there was no sign of recurrence or metastasis.The patient could walk without any aid and carry out her daily life activities satisfactorily.CONCLUSION In cases of osteosarcoma without epiphysis involvement,epiphyseal distraction can be easily applied to obtain a safe margin.Hybrid reconstruction with an antibiotic-loaded PMMA construct combined with a free non-vascularized fibular graft has the advantages of being easy to manufacture,less time-consuming to place,and less likely to get infected,while also ensuring bone union.Our case provides an alternative technique for biological reconstruction after joint-sparing surgery in patients with osteosarcoma around the knee without epiphyseal involvement.展开更多
Based on the strong fluorescence and the highly thermal stability of sodium tris (pyridine dicarboxylato) europate (Na 3Eu(DPA) 3), polymethyl methacrylate (PMMA) composite material incorporated with the complex, P...Based on the strong fluorescence and the highly thermal stability of sodium tris (pyridine dicarboxylato) europate (Na 3Eu(DPA) 3), polymethyl methacrylate (PMMA) composite material incorporated with the complex, PMMA: Na 3Eu(DPA) 3, was prepared at 250 ℃. The fluorescence behavior of PMMA: Na 3Eu(DPA) 3 material was examined. The results show that the composite material keeps the luminescent characteristics of the Eu 3+ chelate after PMMA is incorporated with Na 3Eu(DPA) 3, and strong orange-red emission of the composite was observed. The fluorescence intensity of the composite material increases with the increase of the weight ratio of Na 3Eu(DPA) 3 to PMMA, but the relationship is not linear.展开更多
A new kind of polymethyl methacrylate (PMMA)-TiO2 nanocomposite was synthesized through polymerization. The thermal and photic stability of this PMMA TiO2 nanocomposites were investigated. The as prepared samples we...A new kind of polymethyl methacrylate (PMMA)-TiO2 nanocomposite was synthesized through polymerization. The thermal and photic stability of this PMMA TiO2 nanocomposites were investigated. The as prepared samples were characterized by scanning electron microscopy (SEM), UV-Vis spectroscopy, differential thermal analysis (DTA) and the photo-induced weight loss, The results show that the photostability of the PMMA-TiO2 nanocomposite is higher than that of the pure PMMA under UV-light irradiation, The weight loss of the pure PMMA reaches 30 % after 300 h UVirradiation, while the composite only 0.3% under the identical experimental condition. The glass transition temperature (TR) of pure PMMA is only 80℃, while the Tg of the composite reaches 258℃. Compared with pure PMMA, the thermal stability of the composite is greatly enhanced.展开更多
Background:Massage is generally believed to be a simple and effective method for preventing necrosis when intravascular injection emboli are suspected.Due to its good dispersive properties,polymethyl methacrylate(PMMA...Background:Massage is generally believed to be a simple and effective method for preventing necrosis when intravascular injection emboli are suspected.Due to its good dispersive properties,polymethyl methacrylate(PMMA)was used as the test filler.The main purpose of this study was to observe whether local massage as a simple remedial measure can promote the diffusion of filler and reduce the necrosis rate for intra-arterial embolism.Methods:Rabbit ears with the central ear artery(CEA)main trunk totally or segmentally obstructed 5 min after PMMA injection were studied.In order to simulate the massage effect of the fingers,the massage group was treated with a small beauty massage bar with a fixed vibration frequency along the direction of the blood flow.CEA blood flow and skin lesions were also analyzed.Results:The baseline data were similar between the control and massage groups.Compared to the control group,the recanalization rate of the CEA trunk in the treatment group increased significantly after massage.However,there was no significant difference in the visible rate of transparent embolus on the 1st day after treatment,nor in the necrosis degree or area of soft tissue damage on the 7th day after treatment.Further analysis showed that massage tended to have a positive effect on segmentally obstructed cases at 5 min after injection but a negative effect on totally obstructed ears at 5 min.Conclusion:Local massage cannot reduce the complications of tissue necrosis after intra-arterial PMMA injection.Prevention is key to reducing complications.展开更多
Comprehensive Summary,Polymethyl methacrylate(PMMA)has been widely applied in diverse fields such as medicine and engineering materials due to its good hydrophilicity and biocompatibility.However,another term for PMMA...Comprehensive Summary,Polymethyl methacrylate(PMMA)has been widely applied in diverse fields such as medicine and engineering materials due to its good hydrophilicity and biocompatibility.However,another term for PMMA,Plexiglas,means that it is water insoluble.These features of PMMA are valuable but seem paradoxical.To explore the underlying mechanism of the paradoxical properties,the interactions between PMMA and water have been investigated by atomic force microscopy(AFM)-based single-molecule force spectroscopy(SMFS).The single-chain elasticity of PMMA obtained in aqueous solutions is significantly different from that obtained in non-aqueous environments,implying that PMMA can form hydrogen bonds with water molecules.展开更多
粒子速度是分析固体介质中应力波传播规律的一个重要参数。结合激光多普勒效应和全光纤干涉测速系统,提出了一种基于光纤镀膜探针的固体介质中应力波粒子速度的测量方法。将光纤镀膜探针嵌入有机玻璃(PMMA)中,距爆心同一半径处,采用0.12...粒子速度是分析固体介质中应力波传播规律的一个重要参数。结合激光多普勒效应和全光纤干涉测速系统,提出了一种基于光纤镀膜探针的固体介质中应力波粒子速度的测量方法。将光纤镀膜探针嵌入有机玻璃(PMMA)中,距爆心同一半径处,采用0.125 g TNT当量的微型炸药球作为爆炸源,进行填实爆炸产生应力波,通过采集光纤探针端面的运动信息,基于短时傅里叶变换的时频分析方法,解调出端面运动速度,进而反推出粒子速度。实验结果表明:不同光纤镀膜探针测得的速度分别为22.648 m/s、23.505 m/s,将反推的粒子速度与传统的圆环型电磁粒子速度计方法获取到的数据进行对比,两者的相对偏差低于5.00%,验证了光纤镀膜探针测量固体介质中应力波粒子速度的可行性。展开更多
PMMA matrices were doped with nano-crystalline neodymium oxides synthesized by thermal decomposition process. X-ray diffraction and high-resolution transmission electron microscopy measurements were carried out to inv...PMMA matrices were doped with nano-crystalline neodymium oxides synthesized by thermal decomposition process. X-ray diffraction and high-resolution transmission electron microscopy measurements were carried out to investigate the structure, phase, and the morphology of the Nd_2O_3 nanocrystals and those embedded in the PMMA matrix. The average grain sizes were estimated 35 ± 6 nm and 46 ± 4 nm for non-annealed and annealed Nd_2O_3 particles, respectively. The grain size distributions(GSD) were calculated from the diffraction peaks of the annealed and non-annealed Nd_2O_3 powders and doped PMMA samples. The mass density, refractive index. UV-Visible absorption spectra were measured and the data were analyzed using the Judd-Ofelt approach to determine the oscillator strengths, the spontaneous emission probabilities and the branching ratios as a function of the nano-crystalline Nd_2O_3 content in the range of 0.1 wt.%-20 wt.% of MMA. Luminescence spectra upon 808 nm diode laser excitation were carried out in the wavelength range of 850-1550 nm at room temperature. The photoluminescence study has shown that the reasonably sharp emission peaks were observed upon heat treatment at 800 ℃ for 24 h for all concentrations of Nd_2O_3 nanopowders in PMMA. The infrared laser transition of Nd^(3+) ions at about 1.06 μm due to the ~4F_(3/2)→~4I_(11/2) transition was analyzed and discussed in Nd_2O_3 system for their possible applications in the photonic technology.展开更多
Diamond cutting is a popular method to fabricate microlens array (MLA) on polymethyl methacrylate (PMMA);however, it is limited by brittle fracture, which is formed easily on the surface of MLA during the cutting proc...Diamond cutting is a popular method to fabricate microlens array (MLA) on polymethyl methacrylate (PMMA);however, it is limited by brittle fracture, which is formed easily on the surface of MLA during the cutting process. In this paper, the formation mechanism of the brittle fracture is studied via a series of experiments including the slow tool servo (STS) cutting experiment of MLA, surface scratching experiment and suddenstop cutting experiment. The effects of undeformed chip thickness, feed rate, and machining track on brittle fracture formation are investigated in detail. In addition, based on the fracture formation mechanism, a bi-directional cutting approach is proposed to eliminate the regional brittle fracture of the microlens during diamond cutting. An experiment was then conducted to verify the method;the results demonstrated that bi-directional cutting could eliminate brittle fracture entirely. Finally, a spherical MLA with the form error (vPV) of 60 nm and the surface roughness (Ra) of 8 nm was successfully fabricated.展开更多
The optical properties of polymethyl methacrylate(PMMA)with varying degrees of artificial scratches have been studied with the aim of reproducing the change of visibility of an aircraft’s PMMA optical windows after b...The optical properties of polymethyl methacrylate(PMMA)with varying degrees of artificial scratches have been studied with the aim of reproducing the change of visibility of an aircraft’s PMMA optical windows after being damaged in their service environment.A novel maintenance method that can perfectly restore the optical property of PMMA has been identified and employed in the repair of the scratches that are formed on the surface of PMMA.This convenient and low-cost method entails polishing PMMA with different types of sandpaper to remove the scratches,and then spin-coating the repair solution in order to restore the optical properties of PMMA.The effect of this repair mechanism and parameters of the repair process were studied.The results indicated that the optical performance of PMMA is closely related to the mesh size of sandpaper,and improper parameter selection destroys the general effect of the repair.When the number of sandpaper mesh is low,the size of the abrasive particle is relatively larger,which can cause deeper friction marks on the surface of PMMA optical windows.Surface treatment using 5000 mesh sandpaper lowers surface roughness(R——a=0.566 nm),and optical transmittance in visible range can be restored to more than 88%.展开更多
In this research,bone cement was prepared by mixing 2 g of magnesium hydroxyapatite(laboratory synthesized),12 g of polymethyl methacrylate,4 g of methyl methacrylate,and collagen(1,3,and 6 g).The samples were molded ...In this research,bone cement was prepared by mixing 2 g of magnesium hydroxyapatite(laboratory synthesized),12 g of polymethyl methacrylate,4 g of methyl methacrylate,and collagen(1,3,and 6 g).The samples were molded in a circular shape.They were inspected by visual microscopy,FTIR,XRD,and FESEM.They were engrossed in synthesized simulated body fluid for 1 month and then inspected by visual microscopy,FTIR,XRD,and FESEM.The samples prepared from 6 g of collagen showed the highest hydroxyapatite formation(high osseointegration)than the other samples.展开更多
背景:聚甲基丙烯酸甲酯(PMMA)骨水泥具有良好的稳定性、可塑性和空间占位能力,是目前临床上最常用的抗生素载体之一。局部应用抗生素骨水泥可以预防、延缓甚至根除骨骼肌肉系统的感染,是目前解决骨关节感染难题的常用手段。但是,抗生素...背景:聚甲基丙烯酸甲酯(PMMA)骨水泥具有良好的稳定性、可塑性和空间占位能力,是目前临床上最常用的抗生素载体之一。局部应用抗生素骨水泥可以预防、延缓甚至根除骨骼肌肉系统的感染,是目前解决骨关节感染难题的常用手段。但是,抗生素的加入会显著影响聚甲基丙烯酸甲酯骨水泥的机械性能,并且有引发不良反应的可能。另外,有学者发现抗生素骨水泥的抗生素释放率很低,局部应用抗生素骨水泥并不能有效消灭细菌,且有引起细菌耐药的可能。因此,他们对抗生素骨水泥在控制感染方面的有效性提出了质疑,并引起了广泛热议。目的:综述抗生素骨水泥的优势与问题,并总结其在临床使用中的注意事项。方法:通过计算机在PubMed、万方、中国知网数据库中以“抗生素骨水泥、聚甲基丙烯酸甲酯、PMMA;Bone Cements、Anti-Bacterial Agents、Bone and Bones、joints、elution、release、Mechanical”为中、英文检索词,检索2017-01-01/2021-12-31发表的相关文献。排除与文章内容无关的、创新性差、重复的文献后,最终纳入68篇文献进行综述。结果与结论:目前,抗生素骨水泥仍是治疗骨关节感染的最佳选择之一。随着对抗生素骨水泥研究的不断深入,许多能改善其抗生素释放方式、抗菌能力和力学性能的新方法不断涌现出来,同时其在临床上的使用也得到了拓展。但仍然有许多问题尚未得到解决,还需进一步的研究,如抗生素的选择、剂量以及最佳的混合方法等。另外,通过对可加入聚甲基丙烯酸甲酯骨水泥的改性材料和抗生素替代物的开发与局部应用有望解决细菌耐药问题。相信随着医学、药学和生物材料科学的发展,抗生素骨水泥会在临床上得到更加广泛的应用。展开更多
基金supported by the National Key R&D Program of China(No.2018YFA0703000)the National Natural Science Foundation of China(Nos.82071564,82072412,and 81772326)+1 种基金the Fundamental Research Program Funding of Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(No.JYZZ070)Project of Shanghai Science and Technology Commission(No.19XD1434200/18431903700)。
文摘Poly methyl methacrylate(PMMA)bone cement is used in augmenting and stabilizing fractured vertebral bodies through percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP).However,applications of PMMA bone cement are limited by the high elasticity modulus of PMMA,its low biodegradability,and its limited ability to regenerate bone.To improve PMMA bio activity and biodegradability and to modify its elasticity modulus,we mixed PMMA bone cement with oxidized hyaluronic acid and carboxymethyl chitosan in situ cross-linking hydrogel loaded with bone morphogenetic protein-2(BMP-2)to achieve novel hybrid cement.These fabric ated PMMA-hydrogel hybrid cements exhibited lower setting temperatures,a lower elasticity modulus,and better biodegradability and biocompatibility than that of pure PMMA cement,while retaining acceptable setting times,mechanical strength,and inj ectability.In addition,we detected release of BMP-2 from the PMMA-hydrogel hybrid cements,significantly enhancing in vitro osteogenesis of bone marrow mesenchymal stem cells by up-regulating the gene expression of Runx2,Coll,and OPN.Use of PMMA-hydrogel hybrid cements loaded with BMP-2 on rabbit femoral condyle bone-defect models revealed their biodegradability and enhanced bone formation.Our study demonstrated the favorable mechanical properties,biocompatibility,and biodegradability of fabricated PMMA-hydrogel hybrid cements loaded with BMP-2,as well as their ability to improve osteogenesis,making them a promising material for use in PKP and PVP.
基金This work was financially supported by the National Natural Science Foundation of China(Nos.31570363 and 31770391)Key Research and Development Plan of Yunnan Province–Special Project of Science and Technology in Yunnan Province(2017IB007)+2 种基金Major Biomedical Project of Yunnan Province(2018ZF005)Innovation Team of the Ministry of Education(No.IRT-17R49)the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2017-ZZ04 and P2017-KF06),Kunming Institute of Botany,Chinese Academy of Sciences.
文摘Phytochemical investigation of the MeOH extract of twigs and leaves of Baeckea frutescens led to the isolation of seven new polymethylated phloroglucinol meroterpenoids(PPMs),named baeckfrutones M-S(1-7).Their structures and absolute configurations were determined by spectroscopic analyses,chiral-phase HPLC analysis,and electronic circular dichroism(ECD)calculations.PPM 1 is a novel meroterpenoid possessing a 6/6/5/3 tetracyclic skeleton in PPMs,whereas 3 and 4 are the first hydroxytasmanone type phloroglucinol-monoterpene hybrids.(+)-2 and 7 displayed potent antiinflammatory activity with IC50 values of 20.86±0.60 and 36.21±1.18 lL,respectively.
基金Supported by the National Natural Science Foundation of China under Grant Nos U1537210 and 11375139the National Key Laboratory of Space Microwave Technology China under Grant No 9140C530101130C53013
文摘We report on a novel and convenient method of measuring secondary electron spectra for insulators in a secondary electron yield measurement system with a planar grid analyzer configuration and a metal mesh probe. In this measurement, the planar grid is negatively biased to force some emitted secondary electrons to return to the sample surface and to neutralize charges accumulated on the sample during the previous beam irradiation. The surface potential of the sample is then measured by use of a metal mesh probe. The grid bias for neutralization corresponding to the zero surface potential is determined based on the linear relationship between the surface potential and the grid bias. Once the surface potential equals zero, the secondary electron spectra of polymethyl methacrylate(PMMA) are studied experimentally by measuring the -curve and then fitting it to Everhart's formula. The measurement results show that the peak energy and the full width at half maximum of the spectra are 4.26 eV and 14.06 eV, respectively.
文摘Polymethyl methacrylate (PMMA) microspheres with clear surface and diameter close to 1 祄 were synthesized by newly soap-free emulsion polymerization. The results showed that the presence of ethanol and NaCl made the increase of diameter and distribution, while the presence of toluene could avoid the problem of the increase of distribution, resulting a harvest of PMMA microspheres with a diameter close to 1 祄.
基金Supported by National Natural Science Foundation of China,No.81301671
文摘BACKGROUND In children with osteosarcoma around the knee joint without epiphysis involvement,joint-sparing surgery seems to be an ideal way to retain knee joint function.However,there are two points of debate with regard to the technique:How to accurately achieve a safe surgical margin,and how to achieve intercalary reconstruction of the massive bone defect following resection of the tumor.CASE SUMMARY We present the case of an 8-year-old girl with osteosarcoma of the distal femur without involvement of the epiphysis.Epiphyseal distraction was applied to separate the epiphysis and metaphysis,and this provided a safe surgical margin.The massive bone defect was reconstructed with a custom-made antibioticloaded polymethyl methacrylate(PMMA)construct combined with a free nonvascularized fibular graft.Six months after surgery,bone union between the autograft and host bone was confirmed in both the proximal and distal femur by computer tomography(CT)examination.Moreover,considerable callus formation was found around the PMMA construct.After 28 mo of follow-up,there was no sign of recurrence or metastasis.The patient could walk without any aid and carry out her daily life activities satisfactorily.CONCLUSION In cases of osteosarcoma without epiphysis involvement,epiphyseal distraction can be easily applied to obtain a safe margin.Hybrid reconstruction with an antibiotic-loaded PMMA construct combined with a free non-vascularized fibular graft has the advantages of being easy to manufacture,less time-consuming to place,and less likely to get infected,while also ensuring bone union.Our case provides an alternative technique for biological reconstruction after joint-sparing surgery in patients with osteosarcoma around the knee without epiphyseal involvement.
文摘Based on the strong fluorescence and the highly thermal stability of sodium tris (pyridine dicarboxylato) europate (Na 3Eu(DPA) 3), polymethyl methacrylate (PMMA) composite material incorporated with the complex, PMMA: Na 3Eu(DPA) 3, was prepared at 250 ℃. The fluorescence behavior of PMMA: Na 3Eu(DPA) 3 material was examined. The results show that the composite material keeps the luminescent characteristics of the Eu 3+ chelate after PMMA is incorporated with Na 3Eu(DPA) 3, and strong orange-red emission of the composite was observed. The fluorescence intensity of the composite material increases with the increase of the weight ratio of Na 3Eu(DPA) 3 to PMMA, but the relationship is not linear.
文摘A new kind of polymethyl methacrylate (PMMA)-TiO2 nanocomposite was synthesized through polymerization. The thermal and photic stability of this PMMA TiO2 nanocomposites were investigated. The as prepared samples were characterized by scanning electron microscopy (SEM), UV-Vis spectroscopy, differential thermal analysis (DTA) and the photo-induced weight loss, The results show that the photostability of the PMMA-TiO2 nanocomposite is higher than that of the pure PMMA under UV-light irradiation, The weight loss of the pure PMMA reaches 30 % after 300 h UVirradiation, while the composite only 0.3% under the identical experimental condition. The glass transition temperature (TR) of pure PMMA is only 80℃, while the Tg of the composite reaches 258℃. Compared with pure PMMA, the thermal stability of the composite is greatly enhanced.
基金funded by Hafod Bioscience B.V., which also provided Artecoll products for this experiment
文摘Background:Massage is generally believed to be a simple and effective method for preventing necrosis when intravascular injection emboli are suspected.Due to its good dispersive properties,polymethyl methacrylate(PMMA)was used as the test filler.The main purpose of this study was to observe whether local massage as a simple remedial measure can promote the diffusion of filler and reduce the necrosis rate for intra-arterial embolism.Methods:Rabbit ears with the central ear artery(CEA)main trunk totally or segmentally obstructed 5 min after PMMA injection were studied.In order to simulate the massage effect of the fingers,the massage group was treated with a small beauty massage bar with a fixed vibration frequency along the direction of the blood flow.CEA blood flow and skin lesions were also analyzed.Results:The baseline data were similar between the control and massage groups.Compared to the control group,the recanalization rate of the CEA trunk in the treatment group increased significantly after massage.However,there was no significant difference in the visible rate of transparent embolus on the 1st day after treatment,nor in the necrosis degree or area of soft tissue damage on the 7th day after treatment.Further analysis showed that massage tended to have a positive effect on segmentally obstructed cases at 5 min after injection but a negative effect on totally obstructed ears at 5 min.Conclusion:Local massage cannot reduce the complications of tissue necrosis after intra-arterial PMMA injection.Prevention is key to reducing complications.
基金supported by the National Natural Science Foundation of China(22273079)the Natural Science Foundation of Sichuan Province(2022NSFSC1204)the Central Government Guiding Local Science and Technology Development Project of Sichuan Province(2022ZYD0043).
文摘Comprehensive Summary,Polymethyl methacrylate(PMMA)has been widely applied in diverse fields such as medicine and engineering materials due to its good hydrophilicity and biocompatibility.However,another term for PMMA,Plexiglas,means that it is water insoluble.These features of PMMA are valuable but seem paradoxical.To explore the underlying mechanism of the paradoxical properties,the interactions between PMMA and water have been investigated by atomic force microscopy(AFM)-based single-molecule force spectroscopy(SMFS).The single-chain elasticity of PMMA obtained in aqueous solutions is significantly different from that obtained in non-aqueous environments,implying that PMMA can form hydrogen bonds with water molecules.
文摘粒子速度是分析固体介质中应力波传播规律的一个重要参数。结合激光多普勒效应和全光纤干涉测速系统,提出了一种基于光纤镀膜探针的固体介质中应力波粒子速度的测量方法。将光纤镀膜探针嵌入有机玻璃(PMMA)中,距爆心同一半径处,采用0.125 g TNT当量的微型炸药球作为爆炸源,进行填实爆炸产生应力波,通过采集光纤探针端面的运动信息,基于短时傅里叶变换的时频分析方法,解调出端面运动速度,进而反推出粒子速度。实验结果表明:不同光纤镀膜探针测得的速度分别为22.648 m/s、23.505 m/s,将反推的粒子速度与传统的圆环型电磁粒子速度计方法获取到的数据进行对比,两者的相对偏差低于5.00%,验证了光纤镀膜探针测量固体介质中应力波粒子速度的可行性。
基金Project supported by Istanbul Technical University Scientific Research Projects Department(ITU BAP,project number 39283)
文摘PMMA matrices were doped with nano-crystalline neodymium oxides synthesized by thermal decomposition process. X-ray diffraction and high-resolution transmission electron microscopy measurements were carried out to investigate the structure, phase, and the morphology of the Nd_2O_3 nanocrystals and those embedded in the PMMA matrix. The average grain sizes were estimated 35 ± 6 nm and 46 ± 4 nm for non-annealed and annealed Nd_2O_3 particles, respectively. The grain size distributions(GSD) were calculated from the diffraction peaks of the annealed and non-annealed Nd_2O_3 powders and doped PMMA samples. The mass density, refractive index. UV-Visible absorption spectra were measured and the data were analyzed using the Judd-Ofelt approach to determine the oscillator strengths, the spontaneous emission probabilities and the branching ratios as a function of the nano-crystalline Nd_2O_3 content in the range of 0.1 wt.%-20 wt.% of MMA. Luminescence spectra upon 808 nm diode laser excitation were carried out in the wavelength range of 850-1550 nm at room temperature. The photoluminescence study has shown that the reasonably sharp emission peaks were observed upon heat treatment at 800 ℃ for 24 h for all concentrations of Nd_2O_3 nanopowders in PMMA. The infrared laser transition of Nd^(3+) ions at about 1.06 μm due to the ~4F_(3/2)→~4I_(11/2) transition was analyzed and discussed in Nd_2O_3 system for their possible applications in the photonic technology.
基金the National Key Basic Research Program of China (Grant No. 2015CB059900)the National Natural Science Foundation of China (Grant No. 51775046)The authors would also like to acknowledge the support from the Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China (Grant No. 151052).
文摘Diamond cutting is a popular method to fabricate microlens array (MLA) on polymethyl methacrylate (PMMA);however, it is limited by brittle fracture, which is formed easily on the surface of MLA during the cutting process. In this paper, the formation mechanism of the brittle fracture is studied via a series of experiments including the slow tool servo (STS) cutting experiment of MLA, surface scratching experiment and suddenstop cutting experiment. The effects of undeformed chip thickness, feed rate, and machining track on brittle fracture formation are investigated in detail. In addition, based on the fracture formation mechanism, a bi-directional cutting approach is proposed to eliminate the regional brittle fracture of the microlens during diamond cutting. An experiment was then conducted to verify the method;the results demonstrated that bi-directional cutting could eliminate brittle fracture entirely. Finally, a spherical MLA with the form error (vPV) of 60 nm and the surface roughness (Ra) of 8 nm was successfully fabricated.
基金supported by the National Science Fund for Distinguished Young Scholars(Grant No.51625201)the National Key Research and Development Program of China(Grant No.2016YFE0201600)+2 种基金the National Natural Science Foundation of China(Grant No.51702066)the Open Fund of Key Laboratory of Micro-systems and Micro-structures Manufacturing,Ministry of Education(Grant No.2016KM001)the Major State Basic Search Program(Grant No.2014CB46505)。
文摘The optical properties of polymethyl methacrylate(PMMA)with varying degrees of artificial scratches have been studied with the aim of reproducing the change of visibility of an aircraft’s PMMA optical windows after being damaged in their service environment.A novel maintenance method that can perfectly restore the optical property of PMMA has been identified and employed in the repair of the scratches that are formed on the surface of PMMA.This convenient and low-cost method entails polishing PMMA with different types of sandpaper to remove the scratches,and then spin-coating the repair solution in order to restore the optical properties of PMMA.The effect of this repair mechanism and parameters of the repair process were studied.The results indicated that the optical performance of PMMA is closely related to the mesh size of sandpaper,and improper parameter selection destroys the general effect of the repair.When the number of sandpaper mesh is low,the size of the abrasive particle is relatively larger,which can cause deeper friction marks on the surface of PMMA optical windows.Surface treatment using 5000 mesh sandpaper lowers surface roughness(R——a=0.566 nm),and optical transmittance in visible range can be restored to more than 88%.
文摘In this research,bone cement was prepared by mixing 2 g of magnesium hydroxyapatite(laboratory synthesized),12 g of polymethyl methacrylate,4 g of methyl methacrylate,and collagen(1,3,and 6 g).The samples were molded in a circular shape.They were inspected by visual microscopy,FTIR,XRD,and FESEM.They were engrossed in synthesized simulated body fluid for 1 month and then inspected by visual microscopy,FTIR,XRD,and FESEM.The samples prepared from 6 g of collagen showed the highest hydroxyapatite formation(high osseointegration)than the other samples.
文摘背景:聚甲基丙烯酸甲酯(PMMA)骨水泥具有良好的稳定性、可塑性和空间占位能力,是目前临床上最常用的抗生素载体之一。局部应用抗生素骨水泥可以预防、延缓甚至根除骨骼肌肉系统的感染,是目前解决骨关节感染难题的常用手段。但是,抗生素的加入会显著影响聚甲基丙烯酸甲酯骨水泥的机械性能,并且有引发不良反应的可能。另外,有学者发现抗生素骨水泥的抗生素释放率很低,局部应用抗生素骨水泥并不能有效消灭细菌,且有引起细菌耐药的可能。因此,他们对抗生素骨水泥在控制感染方面的有效性提出了质疑,并引起了广泛热议。目的:综述抗生素骨水泥的优势与问题,并总结其在临床使用中的注意事项。方法:通过计算机在PubMed、万方、中国知网数据库中以“抗生素骨水泥、聚甲基丙烯酸甲酯、PMMA;Bone Cements、Anti-Bacterial Agents、Bone and Bones、joints、elution、release、Mechanical”为中、英文检索词,检索2017-01-01/2021-12-31发表的相关文献。排除与文章内容无关的、创新性差、重复的文献后,最终纳入68篇文献进行综述。结果与结论:目前,抗生素骨水泥仍是治疗骨关节感染的最佳选择之一。随着对抗生素骨水泥研究的不断深入,许多能改善其抗生素释放方式、抗菌能力和力学性能的新方法不断涌现出来,同时其在临床上的使用也得到了拓展。但仍然有许多问题尚未得到解决,还需进一步的研究,如抗生素的选择、剂量以及最佳的混合方法等。另外,通过对可加入聚甲基丙烯酸甲酯骨水泥的改性材料和抗生素替代物的开发与局部应用有望解决细菌耐药问题。相信随着医学、药学和生物材料科学的发展,抗生素骨水泥会在临床上得到更加广泛的应用。