SAP、铁氧体与硫酸铁对水泥早强性能的影响

目的为提高瓦斯抽采效果,解决传统封孔水泥早期强度发展缓慢的问题。方法选用高吸水树脂(SAP)、纳米铁氧体和硫酸铁来制备新型封孔材料。通过抗压强度试验、流动度测试、凝结时间测试、X射线衍射(XRD)、热重分析、扫描电子显微镜(SEM)等手段对水泥试样进行结构分析及性能测试,研究三元早强剂对水泥基封孔材料的影响。结果与空白组相比,三元早强剂缩短了水泥的凝结时间,提高了水泥早期强度。1d抗压强度为10.13MPa,与空白组相比提高了51.87%。结论SAP的自养护效应和纳米铁氧体的晶核效应,可以促进水泥水化产物的生成,同时硫酸铁和纳米铁氧体中的铁离子为高价阳离子,对C-S-H形成的双电子层具有压缩作用,可以进一步促进C-S-H凝胶的生成,加快水泥水化速率,生成更多水化产物,填充孔隙,增加水泥密实度,提高早强性能,为水泥早强剂的设计提供了新思路。

SAP合并急性肾损伤患者的血液灌流结合CVVHDF治疗效果观察

SAP合并急性肾损伤,制定血液灌流、CVVHDF治疗方案,评比疗效。方法 为探索新型、高效治疗SAP合并急性肾损伤措施,以两种方案对30例患者干预,即参照组(CVVHDF治疗15例)与干预组(参照组基础上结合血液灌流治疗15例)评估方案治疗价值差异。结果 两组依据康复指标、肝肾功能、炎性指标、APACHEⅡ和MODS评分而言干预组更优(P<0.05)。结论 SAP合并急性肾损伤具有较高的死亡风险,临床建议尽早采用血液灌流+CVVHDF治疗方案对该病干预,其可发挥多方位治疗目的,降低死亡风险,利于提升治疗效果。

基于纳米二氧化硅改性下SAP内养护混凝土的基本性能研究

研究纳米二氧化硅(NS)改性SAP内养护混凝土的物理力学性能以及抗氯离子渗透性能,提出该混凝土的配合比设计。复掺0.08%SAP和1.5%NS能提高混凝土抗折强度;复掺0.08%SAP和1.0%NS能提高其抗压强度;复掺0.24%SAP和1.5%NS氯离子抗渗透性能最佳;复掺0.24%SAP和0.5%NS能显著减小干燥收缩率。

基于SAP的财务共享中心运营管理能力评估研究

运营管理能力是财务共享中心优劣的最直观体现,当前针对财务共享中心运营管理能力评估的研究较少,文中提出一种基于卷积神经网络的财务共享中心运营管理能力评估方法。先通过调研、查阅相关资料等方式了解CM公司财务共享中心的现状,并选取其运营管理的关键性要素建立评估指标体系;随后,将数据进行归一化处理以便于评估模型的建立;再基于各指标权重采用卷积神经网络法建立评估模型。将该方法运用于CM公司财务共享中心2021-2022年度运营管理能力评估中,该方法具有可行性,有助于提高企业财务共享中心运营管理的质量。

基于Python的SAP2000向ANSYS模型转化技术及软件开发研究

工程人员常通过对比设计软件与有限元软件的分析结果,以验算和校核结构设计的合理性。然而,由于软件分析内核的差异,设计软件与有限元软件之间的模型信息往往难以直接传递并转化。针对SAP2000结构设计分析软件向ANSYS有限元分析软件的模型转化问题,基于Python语言和APDL参数化设计语言,编译并开发了STAMT V1.0(SAP2000 To ANSYS Model Transformation V1.0)模型转化程序。相比已有转化程序,STAMT程序实现了更多单元类型、材料属性、截面类型、荷载形式的转化,提高了模型转化的通用性。其次,其涵盖了节点坐标系变换、梁单元坐标系变换、梁端自由度释放、创建刚性域等必备功能,进一步满足了模型转化过程中的功能性需求。然后,采用先建立几何模型后生成有限元模型的转化思路,实现了梁单元网格数量的自定义以及板壳荷载向梁的传递,软件操作界面简洁,便于工程人员的使用。最后,通过单层工业厂房和多层框架结构的两个算例分析,得到转化后模型的质量与原模型一致,前5阶周期的平均误差不超过3%,满足精度要求。研究分析验证了STAMT程序可实现SAP2000模型向ANSYS模型的准确、快速转化。

KCNQ1 rs2237895 gene polymorphism increases susceptibility to type 2 diabetes mellitus in Asian populations

BACKGROUND The association of single nucleotide polymorphism of KCNQ1 gene rs2237895 with type 2 diabetes mellitus(T2DM)is currently controversial.It is unknown whether this association can be gene realized across different populations.AIM To determine the association of KCNQ1 rs2237895 with T2DM and provide reliable evidence for genetic susceptibility to T2DM.METHODS We searched PubMed,Embase,Web of Science,Cochrane Library,Medline,Baidu Academic,China National Knowledge Infrastructure,China Biomedical Literature Database,and Wanfang to investigate the association between KCNQ1 gene rs2237895 and the risk of T2DM up to January 12,2022.Review Manager 5.4 was used to analyze the association of the KCNQ1 gene rs2237895 polymorphism with T2DM and to evaluate the publication bias of the selected literature.RESULTS Twelve case–control studies(including 11273 cases and 11654 controls)met our inclusion criteria.In the full population,allelic model[odds ratio(OR):1.19;95%confidence interval(95%CI):1.09–1.29;P<0.0001],recessive model(OR:1.20;95%CI:1.11–1.29;P<0.0001),dominant model(OR:1.27.95%CI:1.14–1.42;P<0.0001),and codominant model(OR:1.36;95%CI:1.15–1.60;P=0.0003)(OR:1.22;95%CI:1.10–1.36;P=0.0002)indicated that the KCNQ1 gene rs2237895 polymorphism was significantly correlated with susceptibility to T2DM.In stratified analysis,this association was confirmed in Asian populations:allelic model(OR:1.25;95%CI:1.13–1.37;P<0.0001),recessive model(OR:1.29;95%CI:1.11–1.49;P=0.0007),dominant model(OR:1.35;95%CI:1.20–1.52;P<0.0001),codominant model(OR:1.49;95%CI:1.22–1.81;P<0.0001)(OR:1.26;95%CI:1.16–1.36;P<0.0001).In non-Asian populations,this association was not significant:Allelic model(OR:1.06,95%CI:0.98–1.14;P=0.12),recessive model(OR:1.04;95%CI:0.75–1.42;P=0.83),dominant model(OR:1.06;95%CI:0.98–1.15;P=0.15),codominant model(OR:1.08;95%CI:0.82–1.42;P=0.60.OR:1.15;95%CI:0.95–1.39;P=0.14).CONCLUSION KCNQ1 gene rs2237895 was significantly associated with susceptibility to T2DM in an Asian population.Carriers of the C allele had a higher risk of T2DM.This association was not significant in non-Asian populations.

基于“SPOC+SAP”的“运营管理”课程混合教学模式探析

教育数字化转型是利用数字技术改进教学理念和构建教学场景。本文研究利用数字技术,基于建构主义理论,以学生为中心,对“运营管理”课程进行教学改革,对教学模式和教学过程进行重新设计。以培养数字化综合型运营管理人才为目的,结合SPOC在线教学手段和SAP数字化运营平台,充分利用线上和线下教学优势,构建“运营管理”课程混合教学模式,并提出了具体的建设方案。

SAP和聚丙烯纤维双掺对混凝土抗压强度及抗渗性能的影响

隧道等地下工程混凝土主体结构渗漏为常见质量问题,严重影响结构的安全、正常使用功能及耐久性,因此混凝土的抗渗性能成为研究焦点。采用双掺SAP和聚丙烯纤维提高混凝土的抗渗性能,在混凝土中分别掺入质量比为胶凝材料0.1%,0.3%,0.5%的SAP,并同时分别加入1,2,3kg/m3的聚丙烯纤维,进行抗压与抗渗试验。结果表明:单掺0.1%~0.3%SAP时几乎不影响混凝土的抗压强度,但掺量为0.5%时,抗压强度会显著降低;双掺0.1%SAP和0~2kg/m3聚丙烯纤维可略微提升混凝土抗压强度,并且显著改善其抗渗性能;经对比,掺入0.1%~0.3%SAP和0~2kg/m3聚丙烯纤维时,可保证混凝土的抗压强度,提高抗渗性能,有效降低混凝土的渗水风险。

含SAP水泥基材料动态力学性能演变规律研究

关于高应变速率下含高吸水树脂(SAP)水泥基材料力学行为的研究较少,本文通过压汞法和图像法研究了含SAP水泥基材料的总孔隙率和宏观孔(>100μm)孔隙率;分析了SAP粒径和补偿水对改性材料准静态(10~(-5)s^(-1))和动态(60~110 s^(-1))力学性能的影响;基于裂缝扩展行为的研究,解析了高应变速率下水泥基材料的破坏行为。结果表明:添加补偿水和增大SAP粒径均会提升材料的宏观孔孔隙率和总孔隙率,从而降低准静态和动态压缩作用下试样的抗压强度和弹性模量;添加补偿水和增大SAP粒径还会提高水泥基材料的抗压强度动态增加因子和弹性模量动态增加因子,这是由于总孔隙率和宏观孔孔隙率的增加会引起裂缝扩展路径的改变、破碎程度的增加以及应变响应的延迟。

Relationship between the rs2241766 ADIPOQ Polymorphism in a Black African Population and the Occurrence of Type 2 Diabetes

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disease, characterized by chronic hyperglycemia. This pathology is linked to various genes whose interaction with the environment promotes its development. The aim of this work was to determine the relationship between the rs2241766 (T/G) polymorphism of the ADIPOQ gene with type 2 diabetes in the black population. Material and Methods: This work was a case-control study, involving type 2 diabetics subjects (n = 94) and controls (n = 82). The study took place from September 2022 to September 2023. Patients were recruited in the Endocrinology Department of the Libreville University Hospital Center. Analysis was performed in the Biochemistry laboratory of the University of Health Sciences in Libreville and at the Research Institute of Health Sciences of Bobodioulasso. Genomic DNA was extracted using the protocol Qiagen kit and the PCR-RFLP method was used to determine the rs2241766 (T/G) polymorphism of the ADIPOQ gene. Results: Only 2 genotypes were found in this population, the TT genotype and the GT genotype. The proportions were not different between the two groups (p = 0.1095) neither the distribution of G and T alleles (p = 0.1095). On the other hand, the HDL hypocholesterolemia was frequent in subjects with the GT genotype compared to TT heterozygous (51.1% vs 48.9%, p = 0.0280;OR = 0.55 [0.30 - 1.01]). Conclusion: There was no association between the rs2241766 (T/G) variant of the ADIPOQ gene and the occurrence of type 2 diabetes in this population. On the other hand, a relationship between HDL hypocholesterolemia and the GT genotype has been established.

Single nucleotide polymorphism within chromosome 8q24 is associated with prostate cancer development in Saudi Arabia

Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that the incidence of PCa in Saudi males is low but is probably familial or genetically related.Methods: To identify any possible association of SNP with PCa development in Saudi patients, we investigated a group of SNPs in Saudi PCa patients (n=85) and compared the outcomes to healthy normal controls (n=115) and nodular hyperplasia patients (n=120). DNA was extracted from paraffin-embedded formalin fixed tissue or whole blood from both patients’ groups and healthy control group. A total of thirteen SNPs were genotyped using TaqMan® minor groove binder polymerase chain reaction assay.Results: The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequency in PCa patients than controls (p< 0.05). The rs16901979 CA genotype was found at significantly greater frequency in PCa patients than in healthy controls (43% vs. 14%, odds ratio=4.6, p=0.0001) and benign hyperplasia group (43% vs. 25%, odds ratio=2.2, p=0.009).Conclusion: Our study has highlighted the association of rs16901979 SNP with PCa in Saudi males. Such findings have important implications in the PCa diagnosis and in screening unaffected family members of Saudi patients.

Nucleotide excision repair gene polymorphisms and hepatoblastoma susceptibility in Eastern Chinese children:A five-center case-control study

Objective:Nucleotide excision repair(NER)plays a vital role in maintaining genome stability,and the effect of NER gene polymorphisms on hepatoblastoma susceptibility is still under investigation.This study aimed to evaluate the relationship between NER gene polymorphisms and the risk of hepatoblastoma in Eastern Chinese Han children.Methods:In this five-center case-control study,we enrolled 966 subjects from East China(193 hepatoblastoma patients and 773 healthy controls).The TaqMan method was used to genotype 19 single nucleotide polymorphisms(SNPs)in NER pathway genes,including ERCC1,XPA,XPC,XPD,XPF,and XPG.Then,multivariate logistic regression analysis was performed,and odds ratios(ORs)and 95%confidence intervals(95%CIs)were utilized to assess the strength of associations.Results:Three SNPs were related to hepatoblastoma risk.XPC rs2229090 and XPD rs3810366 significantly contributed to hepatoblastoma risk according to the dominant model(adjusted OR=1.49,95%CI=1.07−2.08,P=0.019;adjusted OR=1.66,95%CI=1.12−2.45,P=0.012,respectively).However,XPD rs238406 conferred a significantly decreased risk of hepatoblastoma under the dominant model(adjusted OR=0.68,95%CI=0.49−0.95;P=0.024).Stratified analysis demonstrated that these significant associations were more prominent in certain subgroups.Moreover,there was evidence of functional implications of these significant SNPs suggested by online expression quantitative trait loci(eQTLs)and splicing quantitative trait loci(sQTLs)analysis.Conclusions:In summary,NER pathway gene polymorphisms(XPC rs2229090,XPD rs3810366,and XPD rs238406)are significantly associated with hepatoblastoma risk,and further research is required to verify these findings.

Quantitative Study on Morphological Change Characteristics of Tonle Sap Lake Based on DEM

Lake is an important part of the natural ecosystem, and its morphological characteristics reflect the capacity of lake regulation and storage, the strength of material migration, and the characteristics of shoreline development. In most existing studies, remote sensing images are used to quantify the morphological characteristics of lakes. However, the extraction accuracy of lake water is greatly affected by cloud cover and vegetation cover, and the inversion accuracy of lake elevation data is poor, which cannot accurately describe the response relationship of lake landscape morphology with water level change. Therefore, this paper takes Tonle Sap Lake as the research object, which is the largest natural freshwater lake in Southeast Asia. DEM is constructed based on high-resolution measured topographic data, and morphological indicators such as lake area, lake shoreline length, perimeter area ratio, longest axis length, maximum width, shoreline development index, lake shape complexity, compactness ratio and form ratio are adopted to researching the evolution law of high water overflows and low water outbursts quantitatively, and clarifying the variation characteristics of landscape morphology with water level gradient in Tonle Sap Lake. The research results have important theoretical significance for the scientific utilization of Tonle Sap Lake water resources and the protection of the lake ecosystem.

SAP环境下物料移动合规提升研究

标准化建设能够带动产业链提档升级,而数据标准化是其重要组成部分。文章着力于对SAP系统中移动类型的合规研究,运用矩阵分析及帕累托模型工具,剖析物资移动在SAP环境下的应用现状,并以“模型先行、多维验证、成果导向”为研究主线,基于现实案例,将大数据分析法、德尔菲法、层级分析法等科学方法论与SAP移动类型优化策略相结合,为企业优化SAP移动类型提供了较为全面且可行的提升思路,帮助企业在仓储作业合规的前提下,制定与自身仓储业务需求相匹配的移动类型使用清单,以实现降本增效,保障财务记账顺畅,为管理者提供有益参考。

基于SAP系统企业财务管理信息化存在的问题与对策

分析了SAP系统在企业财务管理信息化方面存在的问题和解决对策。SAP系统为企业提供了全面的财务管理功能,但部分企业存在管理理念落后、系统功能不适应需求、数据集成共享困难、专业人才匮乏等问题。针对这些问题,提出了创新管理理念、满足企业个性化需求、推动数据集成共享、提高员工技能水平等对策。

Lipid concentration and composition in xylem sap of woody angiosperms from a tropical savanna and a seasonal rainforest

Lipids may play an important role in preventing gas embolisms by coating nanobubbles in xylem sap.Few studies on xylem sap lipids have been reported for temperate plants,and it remain unclear whether sap lipids have adaptational significance in tropical plants.In this study,we quantify the lipid composition of xylem sap for angiosperm species from a tropical savanna(seven species)and a seasonal rainforest(five species)using mass spectrometry.We found that all twelve species studied contained lipids in their xylem sap,including galactolipids,phospholipids and triacylglycerol,with a total lipid concentration ranging from 0.09 to 0.26 nmol/L.There was no difference in lipid concentration or composition between plants from the two sites,and the lipid concentration was negatively related to species’open vessel volume.Furthermore,savanna species showed little variation in lipid composition between the dry and the rainy season.These results support the hypothesis that xylem sap lipids are derived from the cytoplasm of individual conduit cells,remain trapped inside individual conduits,and undergo few changes in composition over consecutive seasons.A xylem sap lipidomic data set,which includes 12 tropical tree species from this study and 11 temperate tree species from literature,revealed no phylogenetic signals in lipid composition for these species.This study fills a knowledge gap in the lipid content of xylem sap in tropical trees and provides additional support for their common distribution in xylem sap of woody angiosperms.It appears that xylem sap lipids have no adaptive significance.

Heterosis Analysis in Endogenous Substances in Root Bleeding Sap of Sorghum

Despite hybrid dominance contributing to the genetic improvement of crops,little is known about heterosis and inheritance patterns of endogenous substances in sorghum(Sorghum bicolor(L.)Moench)root bleeding sap.In this study,six sterile and six restorer lines of sorghum and 36 hybrid sorghum combinations formulated as incomplete double-row crosses were selected as test materials,and heterosis,combining ability,heritability,and their interrelationships of root bleeding sap endogenous substances in different hybrid sorghum combinations and their parents were investigated.The results showed that the root bleeding sap of the F1 generation of hybrid sorghum had a high heterosis in both soluble sugar content and amino acid content at the flowering stage,and the average high-parent heterosis was 129.34%and 74.57%,respectively.Indole-3-acetic acid(IAA),cytokinins(CTK),gibberellic acid(GA_(3)),abscisic acid(ABA),soluble sugar,amino acid,and root bleeding intensity were mainly affected by non-additive genetic effects of the genes.Soluble protein was affected by additive genetic effects of the genes and had a high narrow heritability(75.50%),which could be selected at low generations in breeding.The combining ability analyses showed that the sterile lines 521A and 170A,and the restorer lines Ji318R and 0–30 were promising parents with high general combining ability.Correlation analysis showed that all endogenous substances of root bleeding sap were positively correlated with the sum of parental general combining ability(GCA)at highly significant levels,and IAA,CTK,GA_(3),ABA,soluble sugar,amino acid,and root bleeding intensity were positively correlated with male GCA at significant or highly significant levels.Therefore,the GCA of the restorer lines root bleeding sap endogenous material or the sum of both parents’GCA can be used to predict the performance of wounding endogenous material in the F1 generation of hybrid sorghum.Overall,this study results can help elucidate heterosis mechanisms of root bleeding sap endogenous material and improve sorghum quality.

Toll-like receptors 2 polymorphism is associated with psoriasis: A case-control study in the northern Chinese population

Background:Psoriasis is a disease caused by genetics and immune system dysfunction,affecting the skin and joints.Toll-like receptors(TLRs)play an important role in triggering the innate immune response and controlling adaptive immunity.The role of TLR2 in the progression of psoriasis is not well understood.Methods:A case-control study was conducted on a northern Chinese Han population,consisting of psoriasis patients and healthy control subjects.Genotyping was performed using the tetra-primer amplification refractory mutation system-polymerase chain reaction(ARMS-PCR),and allele and genotype frequencies of four SNPs in TLR2 were analyzed in 270 psoriasis patients and 246 healthy controls.Results:Four TLR2 SNPs(rs11938228,rs4696480,rs3804099,rs5743699)were genotyped and found to be in linkage disequilibrium.The genotype distributions of rs11938228 and rs4696480 in two groups were in Hardy-Weinberg equilibrium and statistically significant except for the overdominance model.The haplotypes ATTC and ATCC were found to be protective against psoriasis.Conclusion:Our study found a correlation between TLR2 genetic variations and the likelihood of psoriasis in northern China.

Distribution of gene polymorphisms associated with aspirin antiplatelet in the Han NSTEMI population

Objective:To analyze the genotype and allele distribution characteristics of GPⅢa PLA2(rs5918),PEAR1(rs12041331),and PTGS1(rs10306114)genes related to the antiplatelet pharmacological effects of aspirin,providing reference for individualized treatment of Chinese Han NSTEMI patients.Methods:A total of 107 Han patients with NSTEMI in Beijing Luhe Hospital affiliated to Capital Medical University from January 2016 to December 2022 were selected as the research subjects.The genotypes of GPⅢa PLA2(rs5918),PEAR1(rs12041331)and PTGS1(rs10306114)were detected by fluorescence staining in situ hybridization.The frequency distribution and allele distribution of genotype were analyzed.The results were analyzed whether there were statistical differences in the distribution of related alleles between the Han NSTEMI population and some populations in the 1000 Genomes database.Results:In the Han NSTEMI population,the genotype frequencies of GPⅢa PLA2(rs5918)locus were TT 97.20%,TC 2.80%and CC 0%,the allele frequencies were T 98.60%and C 1.40%.The genotype frequencies of PEAR1(rs12041331)locus were GG 42.06%,GA 44.86%and AA 13.08%,the allele frequencies were G 64.49%and A 35.51%.The genotypes at the PTGS1(rs10306114)locus were all AA(100%),no AG or GG genotype was found.Conclusion:In the NSTEMI population of Han nationality,the mutation at GPⅢa PLA2(rs5918)site related to aspirin antiplatelet pharmacology is rare,and there is no mutation at PTGS1(rs10306114)site.Wild homozygotes are dominant in these two gene loci,while mutations in PEAR1(rs12041331)are more common.Some of the findings in this study are similar to those in previous reports or other populations included in the relevant database;however,some results differ from previous reports or other populations。

SAP/S4系统下的企业成本管控研究

为助力企业成本管控高效开展,以达到降本增效的目的,文章以SAP/S4系统下的企业成本管控为研究课题,在明确SAP/S4系统较传统SAP系统具有先进性,能够减少系统冗余性和复杂性的基础上,设计了SAP/S4系统下的企业成本管控方案;进一步依托于案例企业展开深入分析,SAP/S4系统下的成本管控工作充分发挥信息系统自动化、智能化成本核算和管控作用,提升了海量成本数据采集、核算、处理的效率与准确性,极大地缓解了参与成本核算和管理工作人员的工作量压力,提高了沟通效率和质量,充分发挥了作业成本法和标准成本法结合优势,取得了一定的成本管控成效。