Erythropoietin（EPO） is a circulating glycosylated protein hormone and has been implicated in the development and progression of non-hematopoietic tissue tumors.The objective of the present study was to determine if ...Erythropoietin（EPO） is a circulating glycosylated protein hormone and has been implicated in the development and progression of non-hematopoietic tissue tumors.The objective of the present study was to determine if the EPO rs576236 polymorphism was associated with the risk of adrenal tumors.We genotyped the EPO rs576236 polymorphism in a case-control study of 288 adrenal tumor patients and 456 cancer-free controls by using the TaqMan method,and assessed the association between the polymorphism and the adrenal tumor risk by logistic regression.Furthermore,95%confidence interval（CI） was used to assess the genetic association between the polymorphism and the risk of adrenal tumor.Compared with the TT genotype,the TC genotype had a significantly increased risk of adrenal tumor[adjusted odds ratio（OR） = 1.24,95%CI = 1.12-2.22].Furthermore a significantly increased risk of adrenal tumor was found in the combined variant genotypes TC＋CC compared with the TT genotype（adjusted OR = 1.17,95%CI = 1.12-2.21）.Our present study suggests that the rs576236 polymorphism of EPO confers susceptibility to adrenal tumor in the Chinese population.展开更多
目的探讨微粒体环氧化物水解酶（EPHX1）编码基因多态性与泌尿系恶性肿瘤的遗传易感性的关系。方法按照制定的检索策略,检索相关数据库中的文献,获取有关EPHX1基因多态性与泌尿系恶性肿瘤易感性的病例-对照研究,提取相关数据进行Meta分...目的探讨微粒体环氧化物水解酶（EPHX1）编码基因多态性与泌尿系恶性肿瘤的遗传易感性的关系。方法按照制定的检索策略,检索相关数据库中的文献,获取有关EPHX1基因多态性与泌尿系恶性肿瘤易感性的病例-对照研究,提取相关数据进行Meta分析。以病例组和对照组基因型分布的比值比（OR）及其95%可信区间（CI）作为效应指标。结果共纳入EPHX1 Y113H多态位点的6篇文献,累计病例806例,对照1 156例。纳入的结果使用Meta分析显示EPHX1 Y113H基因多态性与泌尿系恶性肿瘤易感性无相关性[（CC vs TT：OR=1.33,95%CI：0.87~2.05,P〉0.05）;（CT vs TT：OR=1.11,95%CI：0.93~1.33,P〉0.05）;（CC/CT vs TT：OR=1.11,95%CI：0.95~1.30,P〉0.05）;（CC vs CT/TT：OR=1.24,95%CI：0.86~1.78,P〉0.05）]。EPHX1 H139R多态位点共4篇文献,累计病例491例,对照760例。Meta分析显示EPHX1 H139R基因多态性与泌尿系恶性肿瘤易感性无相关性[（GG vs AA：OR=0.74,95%CI：0.40~1.08,P〉0.05）;（AG vs AA：OR=1.04,95%CI：0.83~1.32,P〉0.05）;（GG/AG vs AA：OR=1.00,95%CI：0.79~1.27,P〉0.05）;（GG vs AG/AA：OR=0.72,95%CI：0.41~1.27,P〉0.05）]。结论 EPHX1 Y113H或H139R基因多态性与泌尿系恶性肿瘤易感性无明显相关性。展开更多
目的探讨肿瘤坏死因子-α(TNF-α)启动子基因5个单核苷酸多态性(SNP)位点(rs361525、rs1800629、rs1800750、rs1799964、rs673)的基因型、等位基因频率与山东省汉族妇女宫颈癌发病易感性的相关性。方法采用Taq M an探针法对选取的TNF-...目的探讨肿瘤坏死因子-α(TNF-α)启动子基因5个单核苷酸多态性(SNP)位点(rs361525、rs1800629、rs1800750、rs1799964、rs673)的基因型、等位基因频率与山东省汉族妇女宫颈癌发病易感性的相关性。方法采用Taq M an探针法对选取的TNF-α启动子5个SNP位点进行基因分型,分析比较宫颈癌组452例(其中原位癌组104例和浸润癌组348例)和对照组494例的基因类型与基因频率,并对两组进行流行病学调查与人乳头瘤病毒(HPV)亚型分析。结果与对照组比较,宫颈癌组rs361525(CT)、rs1800629(AG)和rs17999645(AG)基因型增加宫颈癌遗传风险倍数分别为3.040(95%CI:1.761~5.248,P=0.001)、2.580(95%CI:1.867~3.564,P=0.001)、3.162(95%CI:2.332~4.187,P=0.001)。rs1800750、rs673基因型频率在宫颈癌组及对照组之间差异无统计学意义(P=0.929,0.670)。5个SNP位点基因分型频率在浸润癌组与原位癌组间差异无统计学意义(P=0.124,0.455,0.437,0.809,0.868)。宫颈癌组HPV感染率(91.4%)高于对照组(10.3%)(P=0.001),浸润癌组(95.4%)HPV感染率高于原位癌组(77.9%)(P=0.001)。结论 TNF-α启动子rs361525、rs1800629、rs17999645单核苷酸基因多态性可能是山东省汉族妇女宫颈癌的遗传危险因素,rs1800750、rs673位点与山东省汉族妇女宫颈癌发生无明显相关性。展开更多
基金supported by the Program for Development of Innovative Research Team in the First Affiliated Hospital of Nanjing Medical University,Provincial Initiative Program for Excellency Disciplines of Jiangsu Province,by the National Natural Science Foundation of China(No.81171963,81102089,and 81201998)the Natural Science Foundation of Jiangsu Province(No.BK2011773)
文摘Erythropoietin（EPO） is a circulating glycosylated protein hormone and has been implicated in the development and progression of non-hematopoietic tissue tumors.The objective of the present study was to determine if the EPO rs576236 polymorphism was associated with the risk of adrenal tumors.We genotyped the EPO rs576236 polymorphism in a case-control study of 288 adrenal tumor patients and 456 cancer-free controls by using the TaqMan method,and assessed the association between the polymorphism and the adrenal tumor risk by logistic regression.Furthermore,95%confidence interval（CI） was used to assess the genetic association between the polymorphism and the risk of adrenal tumor.Compared with the TT genotype,the TC genotype had a significantly increased risk of adrenal tumor[adjusted odds ratio（OR） = 1.24,95%CI = 1.12-2.22].Furthermore a significantly increased risk of adrenal tumor was found in the combined variant genotypes TC＋CC compared with the TT genotype（adjusted OR = 1.17,95%CI = 1.12-2.21）.Our present study suggests that the rs576236 polymorphism of EPO confers susceptibility to adrenal tumor in the Chinese population.
文摘目的探讨微粒体环氧化物水解酶（EPHX1）编码基因多态性与泌尿系恶性肿瘤的遗传易感性的关系。方法按照制定的检索策略,检索相关数据库中的文献,获取有关EPHX1基因多态性与泌尿系恶性肿瘤易感性的病例-对照研究,提取相关数据进行Meta分析。以病例组和对照组基因型分布的比值比（OR）及其95%可信区间（CI）作为效应指标。结果共纳入EPHX1 Y113H多态位点的6篇文献,累计病例806例,对照1 156例。纳入的结果使用Meta分析显示EPHX1 Y113H基因多态性与泌尿系恶性肿瘤易感性无相关性[（CC vs TT：OR=1.33,95%CI：0.87~2.05,P〉0.05）;（CT vs TT：OR=1.11,95%CI：0.93~1.33,P〉0.05）;（CC/CT vs TT：OR=1.11,95%CI：0.95~1.30,P〉0.05）;（CC vs CT/TT：OR=1.24,95%CI：0.86~1.78,P〉0.05）]。EPHX1 H139R多态位点共4篇文献,累计病例491例,对照760例。Meta分析显示EPHX1 H139R基因多态性与泌尿系恶性肿瘤易感性无相关性[（GG vs AA：OR=0.74,95%CI：0.40~1.08,P〉0.05）;（AG vs AA：OR=1.04,95%CI：0.83~1.32,P〉0.05）;（GG/AG vs AA：OR=1.00,95%CI：0.79~1.27,P〉0.05）;（GG vs AG/AA：OR=0.72,95%CI：0.41~1.27,P〉0.05）]。结论 EPHX1 Y113H或H139R基因多态性与泌尿系恶性肿瘤易感性无明显相关性。
文摘目的探讨肿瘤坏死因子-α(TNF-α)启动子基因5个单核苷酸多态性(SNP)位点(rs361525、rs1800629、rs1800750、rs1799964、rs673)的基因型、等位基因频率与山东省汉族妇女宫颈癌发病易感性的相关性。方法采用Taq M an探针法对选取的TNF-α启动子5个SNP位点进行基因分型,分析比较宫颈癌组452例(其中原位癌组104例和浸润癌组348例)和对照组494例的基因类型与基因频率,并对两组进行流行病学调查与人乳头瘤病毒(HPV)亚型分析。结果与对照组比较,宫颈癌组rs361525(CT)、rs1800629(AG)和rs17999645(AG)基因型增加宫颈癌遗传风险倍数分别为3.040(95%CI:1.761~5.248,P=0.001)、2.580(95%CI:1.867~3.564,P=0.001)、3.162(95%CI:2.332~4.187,P=0.001)。rs1800750、rs673基因型频率在宫颈癌组及对照组之间差异无统计学意义(P=0.929,0.670)。5个SNP位点基因分型频率在浸润癌组与原位癌组间差异无统计学意义(P=0.124,0.455,0.437,0.809,0.868)。宫颈癌组HPV感染率(91.4%)高于对照组(10.3%)(P=0.001),浸润癌组(95.4%)HPV感染率高于原位癌组(77.9%)(P=0.001)。结论 TNF-α启动子rs361525、rs1800629、rs17999645单核苷酸基因多态性可能是山东省汉族妇女宫颈癌的遗传危险因素,rs1800750、rs673位点与山东省汉族妇女宫颈癌发生无明显相关性。
