Gastrointestinal stromal tumors （GISTs） are rare neoplasms （1%） of the gastrointestinal tract and to our knowledge only rare cases of synchronous presentation of gastric carcinomas and GISTs are reported in the li...Gastrointestinal stromal tumors （GISTs） are rare neoplasms （1%） of the gastrointestinal tract and to our knowledge only rare cases of synchronous presentation of gastric carcinomas and GISTs are reported in the literature. A 72-year-old female with a simultaneous presentation of gastric adenocarcinoma and GIST is presented. Moreover, due to polymyalgia rheumatica the patient received corticosteroids as treatment for the last 3 years. The concomitant occurrence of these neoplasms may involve common carcinogenic factors and there could be an association with polymyalgia rheumatica either as a paraneoplastic presentation or due to its treatment with corticosteroids.展开更多
The aim of this observational study was to biochemically characterize the anaemia in GCA (giant cell arteritis) and PMR (polymyalgia rheumatica) patients. Values for mean corpuscular volume, mean corpuscular hemoglobi...The aim of this observational study was to biochemically characterize the anaemia in GCA (giant cell arteritis) and PMR (polymyalgia rheumatica) patients. Values for mean corpuscular volume, mean corpuscular hemoglobin and soluble transferrin receptor were normal, whereas serum iron and total iron binding capacity (TIBC) were subnormal, and mean ferritin was above the upper reference limit. Iron-restricted erythropoiesis (IRE), defined as a bone marrow smear staining positive for iron in combination with transferrin saturation less than 20%, was present in all patients. All patients exhibited clinical and biochemical signs of active inflammation with elevated C-reactive protein and an increased erythrocyte sedimentation rate.展开更多
Background::Polymyalgia rheumatica (PMR) is an inflammatory disease that affects the older adult population. The aim of this study was to investigate the risk and prognosis associated with the coronavirus disease 2019...Background::Polymyalgia rheumatica (PMR) is an inflammatory disease that affects the older adult population. The aim of this study was to investigate the risk and prognosis associated with the coronavirus disease 2019 (COVID-19) infection among patients diagnosed with PMR during the predominance of the Omicron variant.Methods::In this retrospective study, we included a cohort of patients with PMR who met the 2012 European League Against Rheumatism/American College of Rheumatology classification criteria or the 1982 PMR diagnostic criteria and tracked their progress over time. The diagnosis of COVID-19 was based on the clinical manifestations and laboratory tests. We collected demographic information, PMR disease activity, treatment data, and clinical data related to COVID-19.Results::In total, 101 patients diagnosed with PMR were enrolled. Most patients with PMR exhibited low disease activity. Of the total cohort, 81 patients (80.2%) were categorized as individuals diagnosed with COVID-19, while the remaining 20 (19.8%) were not diagnosed with COVID-19. Among the patients with PMR diagnosed with COVID-19, 65 (80.2%) exhibited the presence of the COVID-19 antigen, while 16 (19.8%) tested positive for COVID-19 RNA. Most COVID-19 patients with PMR were classified as having mild disease (72, 88.9%). Two cases were identified within the confirmed infected group, resulting in a recurrence rate of 2.5% (2/81). Conversely, no relapses were observed in the non-infected group (0/20). In our multivariate logistic regression analysis, we found that pre-COVID-19 PMR disease activity was an independent risk factor for COVID-19 infection (odds ratio = 30.00, 95% confidence interval: 2.137-421.117, p = 0.012). Conclusion::The increased susceptibility to COVID-19 may be influenced by the pre-existing disease activity of PMR.展开更多
文摘Gastrointestinal stromal tumors （GISTs） are rare neoplasms （1%） of the gastrointestinal tract and to our knowledge only rare cases of synchronous presentation of gastric carcinomas and GISTs are reported in the literature. A 72-year-old female with a simultaneous presentation of gastric adenocarcinoma and GIST is presented. Moreover, due to polymyalgia rheumatica the patient received corticosteroids as treatment for the last 3 years. The concomitant occurrence of these neoplasms may involve common carcinogenic factors and there could be an association with polymyalgia rheumatica either as a paraneoplastic presentation or due to its treatment with corticosteroids.
文摘The aim of this observational study was to biochemically characterize the anaemia in GCA (giant cell arteritis) and PMR (polymyalgia rheumatica) patients. Values for mean corpuscular volume, mean corpuscular hemoglobin and soluble transferrin receptor were normal, whereas serum iron and total iron binding capacity (TIBC) were subnormal, and mean ferritin was above the upper reference limit. Iron-restricted erythropoiesis (IRE), defined as a bone marrow smear staining positive for iron in combination with transferrin saturation less than 20%, was present in all patients. All patients exhibited clinical and biochemical signs of active inflammation with elevated C-reactive protein and an increased erythrocyte sedimentation rate.
基金Natural Science Foundation of China,Grant/Award Number:82171768National Key Research and Development Program of China,Grant/Award Number:2022YFC3602000Zhejiang Province Excellent Young Talent Fund for Traditional Chinese Medicine,Grant/Award Number:2022ZQ051.
文摘Background::Polymyalgia rheumatica (PMR) is an inflammatory disease that affects the older adult population. The aim of this study was to investigate the risk and prognosis associated with the coronavirus disease 2019 (COVID-19) infection among patients diagnosed with PMR during the predominance of the Omicron variant.Methods::In this retrospective study, we included a cohort of patients with PMR who met the 2012 European League Against Rheumatism/American College of Rheumatology classification criteria or the 1982 PMR diagnostic criteria and tracked their progress over time. The diagnosis of COVID-19 was based on the clinical manifestations and laboratory tests. We collected demographic information, PMR disease activity, treatment data, and clinical data related to COVID-19.Results::In total, 101 patients diagnosed with PMR were enrolled. Most patients with PMR exhibited low disease activity. Of the total cohort, 81 patients (80.2%) were categorized as individuals diagnosed with COVID-19, while the remaining 20 (19.8%) were not diagnosed with COVID-19. Among the patients with PMR diagnosed with COVID-19, 65 (80.2%) exhibited the presence of the COVID-19 antigen, while 16 (19.8%) tested positive for COVID-19 RNA. Most COVID-19 patients with PMR were classified as having mild disease (72, 88.9%). Two cases were identified within the confirmed infected group, resulting in a recurrence rate of 2.5% (2/81). Conversely, no relapses were observed in the non-infected group (0/20). In our multivariate logistic regression analysis, we found that pre-COVID-19 PMR disease activity was an independent risk factor for COVID-19 infection (odds ratio = 30.00, 95% confidence interval: 2.137-421.117, p = 0.012). Conclusion::The increased susceptibility to COVID-19 may be influenced by the pre-existing disease activity of PMR.
