期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Green Tea Polyphenols Attenuate High-Fat Diet-Induced Renal Oxidative Stress through SIRT3-Dependent Deacetylation 被引量:4
1
作者 YANG Hui ZUO Xue Zhi +6 位作者 TIAN Chong HE Dong Liang YI Wei Jie CHEN Zhuo ZHANG Pi Wei DING Shi Bin YING Chen Jiang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2015年第6期455-459,共5页
Fifty male Wistar rats were fed a standard chow diet or a high-fat (HF) diet, and different concentrations of green tea polyphenols (GTPs) (0.8, 1.6, and 3.2 g/L) were administered in the drinking water. We foun... Fifty male Wistar rats were fed a standard chow diet or a high-fat (HF) diet, and different concentrations of green tea polyphenols (GTPs) (0.8, 1.6, and 3.2 g/L) were administered in the drinking water. We found that the malondialdehyde (MDA) level in the HF diet group was significantly higher than that in the control (CON) group (P〈0.05). Decreased peroxisome proliferato r-activated receptor (PPAR)-α and sirtuin 3 (SlRT3) expression, and increased manganese superoxide dismutase (MnSOD) acetylation levels were also detected in the HF diet group (P〈0.05). GTP treatment upregulated SlRT3 and PPARa expression, increased the ppora mRNA level, reduced the MnSOD acetylation level, and decreased MDA production in rats fed a HF diet (P〈0.05). No significant differences in total renal MnSOD and PPAR-y coactivator-1α (PGCI-α) expression were detected. The reduced oxidative stress detected in kidney tissues after GTP treatment was partly due to the higher SIRT3 expression, which was likely mediated by PPARα. 展开更多
关键词 polyphenols drinking PPAR Figure mitochondria metabolism superoxide peroxisome oxidative homeostasis
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部