Surfaces with hydrophilic and antimicrobial properties are very attractive for cardio-vascular device-associated applications.The aim of this study was to prepare and coat a hydrophilic polymer containing a functional...Surfaces with hydrophilic and antimicrobial properties are very attractive for cardio-vascular device-associated applications.The aim of this study was to prepare and coat a hydrophilic polymer containing a functional group capable of forming triazole functionality onto the surface of polyurethane(PU).The modified surfaces were assessed with cell adhesion,bacterial adhesion and bacterial viability.Mouse fibroblast cells(NIH-3T3)and three bacterial species were used for assessment.The results showed that the modified surface not only exhibited a significant reduction in cell adhesion with a 25%-59%decrease to mouse fibroblast but also showed a sig-nificant reduction in bacterial attachment with 26%-67%,24%-61%and 23%-57%decrease to Staphylococcus aureus,Escherichia coli and Pseudomonas aeruginosa,respectively,as compared with original PU.Furthermore,the polymer-modified surface exhibited a significant antibacterial function by inhibiting bacterial growth with reduction of 49%-84%,44%-79%and 53%-79%to S.aureus,E.coli and P.aeru-ginosa,respectively,as compared with original PU.These results indicate that covalent polymer attachment enhanced the antibacterial and antifouling properties of the PU surface.展开更多
基金Indiana University-Purdue University IndianapolisMajmaah University。
文摘Surfaces with hydrophilic and antimicrobial properties are very attractive for cardio-vascular device-associated applications.The aim of this study was to prepare and coat a hydrophilic polymer containing a functional group capable of forming triazole functionality onto the surface of polyurethane(PU).The modified surfaces were assessed with cell adhesion,bacterial adhesion and bacterial viability.Mouse fibroblast cells(NIH-3T3)and three bacterial species were used for assessment.The results showed that the modified surface not only exhibited a significant reduction in cell adhesion with a 25%-59%decrease to mouse fibroblast but also showed a sig-nificant reduction in bacterial attachment with 26%-67%,24%-61%and 23%-57%decrease to Staphylococcus aureus,Escherichia coli and Pseudomonas aeruginosa,respectively,as compared with original PU.Furthermore,the polymer-modified surface exhibited a significant antibacterial function by inhibiting bacterial growth with reduction of 49%-84%,44%-79%and 53%-79%to S.aureus,E.coli and P.aeru-ginosa,respectively,as compared with original PU.These results indicate that covalent polymer attachment enhanced the antibacterial and antifouling properties of the PU surface.
