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Diagnosis of poorly differentiated adenocarcinoma of the stomach by confocal laser endomicroscopy:A case report 被引量:3
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作者 Jia-Xin Lou Yong Wu +3 位作者 Muren Huhe Jing-Jie Zhang Dong-Wu Jia Zhen-Yu Jiang 《World Journal of Clinical Cases》 SCIE 2024年第8期1481-1486,共6页
BACKGROUND In recent years,confocal laser endomicroscopy(CLE)has become a new endoscopic imaging technology at the microscopic level,which is extensively performed for real-time in vivo histological examination.CLE ca... BACKGROUND In recent years,confocal laser endomicroscopy(CLE)has become a new endoscopic imaging technology at the microscopic level,which is extensively performed for real-time in vivo histological examination.CLE can be performed to distinguish benign from malignant lesions.In this study,we diagnosed using CLE an asymptomatic patient with poorly differentiated gastric adenocarcinoma.CASE SUMMARY A 63-year-old woman was diagnosed with gastric mucosal lesions,which may be gastric cancer,in the small curvature of the stomach by gastroscopy.She consented to undergo CLE for morphological observation of the gastric mucosa.Through the combination of CLE diagnosis and postoperative pathology,the intraoperative CLE diagnosis was considered to be reliable.According to our experience,CLE can be performed as the first choice for the diagnosis of gastric cancer.CONCLUSION CLE has several advantages over pathological diagnosis.We believe that CLE has great potential in the diagnosis of benign and malignant gastric lesions. 展开更多
关键词 Confocal laser endomicroscopy Poorly differentiated gastric adenocarcinoma DIAGNOSIS Early stage Case report
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Systematic review of risk factors,prognosis,and management of colorectal signet-ring cell carcinoma 被引量:1
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作者 Frederiek Nuytens Vincent Drubay +2 位作者 Clarisse Eveno Florence Renaud Guillaume Piessen 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第5期2141-2158,共18页
BACKGROUND Colorectal signet-ring cell carcinoma(CSRCC)is a rare clinical entity which accounts for approximately 1%of all colorectal cancers.Although multiple studies concerning this specific topic have been publishe... BACKGROUND Colorectal signet-ring cell carcinoma(CSRCC)is a rare clinical entity which accounts for approximately 1%of all colorectal cancers.Although multiple studies concerning this specific topic have been published in the past decades,the pathogenesis,associated risk factors,and potential implications on treatment are still poorly understood.Besides the low incidence,historically confusing histological criteria have resulted in confusing data.Nevertheless,the rising incidence of CSRCC along with relatively young age at presentation and associated dismal prognosis,highlight the actual interest to synthesize the known literature regarding CSRCC.AIM To provide an updated overview of risk factors,prognosis,and management of CSRCC.METHODS A literature search in the MEDLINE/PubMed database was conducted with the following search terms used:‘Signet ring cell carcinoma’and‘colorectal’.Studies in English language,published after January 1980,were included.Studies included in the qualitative synthesis were evaluated for content concerning epidemiology,risk factors,and clinical,diagnostic,histological,and molecular features,as well as metastatic pattern and therapeutic management.If possible,presented data was extracted in order to present a more detailed overview of the literature.RESULTS In total,67 articles were included for qualitative analysis,of which 54 were eligible for detailed data extraction.CSRCC has a reported incidence between 0.1%-2.4%and frequently presents with advanced disease stage at the time of diagnosis.CSRCC is associated with an impaired overall survival(5-year OS:0%-46%)and a worse stagecorrected outcome compared to mucinous and not otherwise specified adenocarcinoma.The systematic use of exploratory laparoscopy to determine the presence of peritoneal metastases has been advised.Surgery is the mainstay of treatment,although the rates of curative resection in CSRCC(21%-82%)are lower compared to those in other histological types.In case of peritoneal metastasis,cytoreductive surgery with hyperthermic intraperitoneal chemotherapy should only be proposed in selected patients.CONCLUSION CSRCC is a rare clinical entity most often characterized by young age and advanced disease at presentation.As such,diagnostic modalities and therapeutic approach should be tailored accordingly. 展开更多
关键词 Colorectal cancer Signet-ring cell histology Poorly cohesive cells Systematic review Risk factors PROGNOSIS Therapeutic management
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Gallbladder carcinosarcoma with a poor prognosis: A case report
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作者 Yi Dai Min Meng +3 位作者 Qi-Zhi Luo Yuan-Jun Liu Fan Xiao Chun-Hua Wang 《World Journal of Clinical Cases》 SCIE 2024年第10期1817-1823,共7页
BACKGROUND Carcinosarcoma of the gallbladder is a rare malignant tumor with a very poor prognosis.To date,only approximately 100 patients have been reported in the English literature.The prognosis of this tumor type i... BACKGROUND Carcinosarcoma of the gallbladder is a rare malignant tumor with a very poor prognosis.To date,only approximately 100 patients have been reported in the English literature.The prognosis of this tumor type is poor,the preoperative diagnosis is difficult,and there is a possibility of a misdiagnosis.We present an unsuccessful case of carcinosarcoma of the gallbladder with a preoperative misdiagnosis and rapid early postoperative recurrence.Therefore,we have a deeper understanding of the poor prognosis of gallbladder carcinosarcoma(GBC)patients.CASE SUMMARY The patient is a 65-year-old male.He was admitted to the hospital because of right upper abdomen distending pain and discomfort for half a month.Abdominal magnetic resonance imaging revealed a polycystic mass in the right lobe of the liver and the fossa of the gallbladder.After admission,the patient was diagnosed with a liver abscess,which was treated by abscess puncture drainage.Obviously,this treatment was unsuccessful.Hepatectomy and cholecystectomy were performed one month after the puncture.Postoperative pathologic examination revealed carcinosarcoma of the gallbladder,and the resected specimen contained two tumor components.One month after surgery,the patient's tumor recurred in situ and started to compress the duodenum,resulting in duodenal obstruction and bleeding.The treatment was not effective.The patient died of gastrointestinal hemorrhage and hypovolemic shock.CONCLUSION Carcinosarcoma of the gallbladder is a rare malignant tumor that is easily misdiagnosed preoperatively and has a poor prognosis. 展开更多
关键词 Gallbladder disease CARCINOSARCOMA MISDIAGNOSIS Poor prognosis Pathological diagnosis RECURRENCE Case report
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Gastroesophageal signet ring cell carcinoma morbidity and mortality: A retrospective review
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作者 Megan Grinlinton Chris Furkert +2 位作者 Andrew Maurice Neville Angelo Michael Booth 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第6期1629-1636,共8页
BACKGROUND Upper gastrointestinal(GI)signet ring cell carcinomas(SRCC)confer a poor prognosis.The benefit of operative intervention for this patient group is contro-versial in terms of overall survival.AIM To investig... BACKGROUND Upper gastrointestinal(GI)signet ring cell carcinomas(SRCC)confer a poor prognosis.The benefit of operative intervention for this patient group is contro-versial in terms of overall survival.AIM To investigate factors relating to survival in patients with upper GI SRCC.METHODS A retrospective,tertiary,single-centre review of patients who were diagnosed with oesophageal,gastroesophageal junction and gastric SRCC was performed.The primary outcome was to compare mortality of patients who underwent operative management with those who had nonoperative management.Secon-dary outcomes included assessing the relationship between demographic and histopathological factors,and survival.RESULTS One hundred and thirty-one patients were included.The one-year survival for the operative group was 81%and for the nonoperative group was 19.1%.The five-year survival in the operative group was 28.6%vs 1.5%in the nonoperative group.The difference in overall survival between groups was statistically significant(HR 0.19,95%CI(0.13-0.30),P<0.001).There was no difference in survival when ad-justing for age,smoking status or gender.On multivariate analysis,patients who underwent surgical management,those with a lower stage of disease,and those with a lower Charlson Comorbidity Index(CCI)had significantly improved sur-vival.CONCLUSION Well-selected patients with upper GI SRCC appear to have reasonable medium-term survival following surgery.Offering surgery to a carefully selected patient group may improve the outcome for this disease. 展开更多
关键词 Signet ring cell carcinoma Gastric cancer Oesophageal cancer Poorly cohesive gastric cancer Diffuse gastric cancer
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Pharmacological Treatment for Atrial Fibrillation—Modalities in Equines and Companion Animals
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作者 Ina Cojoaca 《Open Journal of Veterinary Medicine》 CAS 2024年第10期257-303,共47页
Cardiac arrhythmias are probably more common in horses than in any other domestic animal species where poor performance and exercise intolerance is the most frequent clinical complaint. Atrial fibrillation is a type o... Cardiac arrhythmias are probably more common in horses than in any other domestic animal species where poor performance and exercise intolerance is the most frequent clinical complaint. Atrial fibrillation is a type of cardiac arrhythmia that appears as a common finding during medical examinations in humans, large breed dogs and horses. Clinical presentations are of a particular value in racehorses in high performing activities. Atrial fibrillation is characterized by an irregular heart rhythm, secondary to a primary disease or without any sign of comorbidity. The generation and maintenance of Atrial Fibrillation requires a substrate. Some breeds have a genetic predisposition to developing Atrial Fibrillation. Most cases of Atrial Fibrillation are of the paroxysmal type and self-regulate within a few hours to days without the need for treatment. The focus of this study is on the arrhythmic agents that are used for the treatment of Atrial Fibrillation, therefore other arrhythmic agents may not be included, or are included to demonstrate their effect on increasing, inhibiting or decreasing efficacy when used together with medications for the treatment of Atrial Fibrillation. The “working horse” for the pharmacological treatment of Atrial Fibrillation is Quinidine. 展开更多
关键词 Atrial Fibrillation ARRYTHMIA Equine Cardiology Poor Performance Pharmacological Treatment QUINIDINE Genetic Predisposition Sinus Rhythm
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Associated Factors to Poor Blood Pressure Control in Hypertensives Followed Up at the Campus University Hospital of Lome (Togo)
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作者 Soulemane Pessinaba Yaovi Mignazonzon Afassinou +9 位作者 Wiyao Dieudonné Kaziga Komlavi Yayehd Kolani Lamboni Sélim Bolarinwa Mohamed Kpélafia Ekpe Togbossi Akpe Adzodo Machihude Pio Soodougoua Baragou Findibé Damorou 《World Journal of Cardiovascular Diseases》 CAS 2024年第6期374-380,共7页
Introduction: Hypertension is a real public health issue and its control is very difficult. We aim to determine the frequency of uncontrolled hypertension in hypertensive patients followed up as an outpatient at the c... Introduction: Hypertension is a real public health issue and its control is very difficult. We aim to determine the frequency of uncontrolled hypertension in hypertensive patients followed up as an outpatient at the campus university hospital of Lome (Togo) and to search for the associated factors. Methodology: The study was cross-sectional, descriptive and analytical, carried out from February (2022) to August 2022 in 260 hypertensive patients aged 22 years old, followed up (on an) as an outpatient for at least 3 months at the Lome University Hospital campus. A univariate then multivariate analysis were conducted in order to highlight the most common factors significantly linked to uncontrolled. Results: The mean age of hypertensives was 56.4 ± 12.7 years, the sex ratio (M/F) was 0.59. Prevalence of uncontrolled blood pressure was 42%. Associated Factors to poor blood pressure control in our study were age > 60 years (OR = 1.6 CI [1.17 - 2.50]), low socio-economic level (OR = 2.2 CI [1.96 - 4.33]), high cardiovascular risk level (OR = 3.1 CI [2.18 - 4.52]), non-adherence to regular blood pressure monitoring (OR = 3.3 CI [2.21 - 5.55]), low compliance to treatment (OR = 4.1 CI [2.33 - 6.76]) and a chronic renal failure (OR = 2.1 CI [1.21 - 3.10]). Conclusion: Nearly half of the hypertensives in our study had poorly controlled blood pressure by antihypertensive treatment medication. The factors of this poor control were age > 60 years, low socio-economic level, high or very high level of cardiovascular risk, low compliance to treatment, and renal failure. 展开更多
关键词 HYPERTENSION Poor Control Associated factors TOGO
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Acute Stent Thrombosis: A Case at the Montlucon Hospital Center
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作者 Wiyaou Dieu-Donné Kaziga Sana Samoura +10 位作者 Yaovi Mignazonzon Afassinou Soulemane Pessinaba Machihude Pio Lao-Abalo Sodou Fetoutou M’badia Simwetare Michelline Mambue Nouhoum Diallo Sami Assi Jean-Bertrand Irakoze Enver Hilic Sylvain Chanseaume 《World Journal of Cardiovascular Diseases》 CAS 2024年第10期681-687,共7页
Background and objective: Coronary angioplasty is one of the techniques introduced in 1976 by Andreas Grüntzig in Zurich. It is a revolutionary procedure that allows coronary circulation to be restored by inserti... Background and objective: Coronary angioplasty is one of the techniques introduced in 1976 by Andreas Grüntzig in Zurich. It is a revolutionary procedure that allows coronary circulation to be restored by inserting a stent. This new technique has considerably evolved over time, but sometimes has limitations, such as the development of neo-pathologies like stent thrombosis. The aim of our case report is to highlight one of the limitations of coronary angioplasty, although rare, and to encourage greater clinical and electrical monitoring after each procedure. Case report: We report the case of a patient who presented with early stent thrombosis barely an hour after placement of a pharmacoactive stent. Chest pain reported by the patient after the procedure and electrical changes prompted an urgent repeat procedure. Aetiologies of stent thrombosis are multifactorial, including patient-, procedure- and stent-dependent factors. Conclusion: Although rare, there is a risk of stent thrombosis after coronary angioplasty. Careful monitoring and rigorous follow-up of patients after coronary angioplasty are therefore required, as the prognosis for stent thrombosis is fairly poor. 展开更多
关键词 Coronary Angioplasty Acute Stent Thrombosis MULTIFACTORIAL Poor Prognosis
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How secure can we expect the surveillance policies to be after the implementation in T1 polyps with carcinoma?
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作者 Cristina Mateos Sanchez Elvira Quintanilla Lazaro Luis Ramon Rabago 《World Journal of Gastrointestinal Endoscopy》 2024年第9期502-508,共7页
Approximately 7%of the polyps resected endoscopically have an adenocarcinoma focus,with no previous endoscopic evidence of malignancy.This raises the question of whether endoscopic resection has been curative.Furtherm... Approximately 7%of the polyps resected endoscopically have an adenocarcinoma focus,with no previous endoscopic evidence of malignancy.This raises the question of whether endoscopic resection has been curative.Furthermore,there is no consensus on what the endoscopic and histological criteria for good prognosis are,the appropriate follow-up strategy and what are the long-term results.The aim of the retrospective study by Fábián et al was to evaluate the occurrence of local relapse or distant metastasis in those tumors that were resected endoscopically compared to those that underwent oncologic surgery.They concluded that,regardless of the treatment strategy chosen,there was a higher recurrence rate than described in the literature and that adherence to follow-up was poor.The management approach for an endoscopically benign polyp histologically confirmed as adenocarcinoma depends on the presence of any of the previously described poor prognostic histological factors.If none of these factors are present and the polyp has been completely resected en bloc(R0),active surveillance is considered appropriate as endoscopic resection is deemed curative.These results highlight,once again,the need for further multicentric clinical practice studies to obtain more evidence for the purpose of establishing appropriate treatment and follow-up strategies. 展开更多
关键词 pT1 adenocarcinoma polyps pT1 follow up management Histological recurrence rate of pT1 adenocarcinoma Endoscopic and histologic poor prognostic criteria
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Autosomal Dominant Polycystic Kidney Disease: Epidemiological, Clinical Aspects and Predictive Factors of Poor Renal Prognosis (About 300 Cases)
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作者 Rihab Dkhissi Nada El Kadiri +2 位作者 Tarik Bouattar Loubna Benamar Naima Ouzeddoun 《Open Journal of Nephrology》 2024年第2期275-293,共19页
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a common, multisystemic, and progressive hereditary disease. It accounts for 6 to 8% of incident cases of end-stage chronic renal disease (ESRD) in... Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a common, multisystemic, and progressive hereditary disease. It accounts for 6 to 8% of incident cases of end-stage chronic renal disease (ESRD) in developed countries. The aim of this study is to describe the predictive factors for the development of end-stage chronic kidney disease (CKD) in the course of this disease. Material and Methods: This is a retrospective, descriptive, and analytical study including 300 cases of ADPKD collected at the Nephrology Department of Ibn-Sina Hospital in Rabat over a period of 30 years (1993 to 2023). Included in the study are all patients with ADPKD meeting the ultrasound diagnostic criteria. The analysis focused on demographic, clinical, paraclinical, evolutionary data, as well as prognostic factors associated with renal function deterioration. Results: The mean age of patients at diagnosis is 51.53 +/− 17 years [16 - 93] with a male predominance. The median serum creatinine at diagnosis is 15.5 mg/l [10 - 34]. 21% of patients had ESRD (eGFR 300 mg/24h (21%). The most common cystic complication is hemorrhage (12.3%). 21.3% of patients had hepatorenal polycystic disease. In adjusted analysis, the predictive risk factors for the occurrence of ESRD were smoking (p = 0.019), anemia (p Conclusion: ADPKD can progress insidiously to ESRD. Identification and early treatment of predictive factors for poor renal prognosis could contribute to a better outcome for this disease. 展开更多
关键词 ADPKD ESRD Factors of Poor Renal Prognosis Renal and Extra-Renal Manifestations
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Metropolitan Housing Development in Urban Fringe Areas-A Case Study of Three Metropolitan Cities of South Africa: Johannesburg, Ekurhuleni and Tshwane
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作者 Aurobindo Ogra 《Journal of Civil Engineering and Architecture》 2024年第5期244-253,共10页
Purpose:The metropolitan cities of Johannesburg,Ekurhuleni and Tshwane play an important role in the economy of the Gauteng province in South Africa.The region constitutes to 22.4 percent of the total population of So... Purpose:The metropolitan cities of Johannesburg,Ekurhuleni and Tshwane play an important role in the economy of the Gauteng province in South Africa.The region constitutes to 22.4 percent of the total population of South Africa and has a strong presence and contributes in areas of manufacturing sector,financial and business services,retail and wholesale trade,etc.The rapid urban population,increase in the informal settlements and socio-economic opportunities has resulted in considerable urban sprawl in and around the urban fringe areas of these metropolitan cities.The urban fringe areas of these metros often come under the influence of rapid urbanization process and pressures.Coupled with the economical and potential land dynamics and lack of priority of spatial development guidelines,these areas attract rapid and haphazard development from communities and developers.Research Design/Methodology:This research is based on a qualitative approach through a comprehensive literature review that included content analysis of key documents on housing sector such as IDPs(Integrated Development Plans),Municipal Annual Reports,Growth Development Strategies,and among other sectoral documents on housing sector.Some of the key priority issues considered in the housing sector included:eradication of housing backlogs,spatial restructuring of housing,provision of choice in terms of location,tenure and housing typology.Findings:The current paper discusses the approaches of metropolitan housing development processes in three metropolitan cities of South Africa from Gauteng region,namely:Johannesburg,Ekurhuleni and Tshwane.The paper discusses the existing housing sectoral scenario along with the fringe areas in three cities with focus on:formal and informal settlements,housing segregation and the backlogs,current institutional arrangements,role of public private participation,and scope for alternate mechanisms.The paper concludes in discussion on sustainable development options for housing development in urban fringe areas. 展开更多
关键词 Metropolitan housing development urban fringe areas housing backlog informal settlements urban poor land dynamics housing infrastructure PPP(public private partnership)
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最新关注
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《中学生英语》 2024年第14期9-9,共1页
World will see first trillionaire in next 10 years○未来10年,世界将出现第一个万亿富翁。A report says in the next ten years,the world will have its first trillionaire.The report said the wealth1 gap2?between the rich a... World will see first trillionaire in next 10 years○未来10年,世界将出现第一个万亿富翁。A report says in the next ten years,the world will have its first trillionaire.The report said the wealth1 gap2?between the rich and poor is growing.And it said we will have a trillionaire within ten years,while to fight poverty,we need more than 200 years. 展开更多
关键词 FIGHT POVERTY POOR
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Discussion on the Ideological and Political Education for Poor College Students
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作者 Jie Li Yang Liu +1 位作者 Shuang Liu Cen Yan 《Journal of Contemporary Educational Research》 2024年第1期133-139,共7页
At present,ideological and political education is significant for poor college students.The focus of funding for poor students has gradually transformed from providing economic support for them to ideological and spir... At present,ideological and political education is significant for poor college students.The focus of funding for poor students has gradually transformed from providing economic support for them to ideological and spiritual help,which puts forward higher requirements on how to carry out ideological and political work.It also requires us to advance the work of ideological and moral education and put it in the most important position in the ideological and educational work for poor college students.Combined with the reality of poor college students,we will adhere to the idea of being student-oriented and endeavor to enhance the effectiveness,pertinence,and relevance of the work of ideological and political education.This paper analyzes the significance and problems of ideological and political education for poor college students and puts forward effective ways to solve the problems from the levels of ideology,cognition,and teaching staff. 展开更多
关键词 Ideological and political education Poor college students Mechanism improvement
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Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment 被引量:4
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作者 Ejlal Abu-El-Rub Fatimah Almahasneh +9 位作者 Ramada R Khasawneh Ayman Alzu'bi Doaa Ghorab Rawan Almazari Huthaifa Magableh Ahmad Sanajleh Haitham Shlool Mohammad Mazari Noor S Bader Joud Al-Momani 《World Journal of Stem Cells》 SCIE 2023年第12期1093-1103,共11页
BACKGROUND Mesenchymal stem cells(MSCs)are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic diseases.Diabetes mellitus(DM)is a frequently diagnosed chronic diseas... BACKGROUND Mesenchymal stem cells(MSCs)are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic diseases.Diabetes mellitus(DM)is a frequently diagnosed chronic disease characterized by hyperglycemia which initiates many multisystem complications in the long-run.DM patients can benefit from MSCs transplantation to curb down the pathological consequences associated with hyperglycemia persistence and restore the function of damaged tissues.MSCs therapeutic outcomes are found to last for short period of time and ultimately these regenerative cells are eradicated and died in DM disease model.AIM To investigate the impact of high glucose or hyperglycemia on the cellular and molecular characteristics of MSCs.METHODS Human adipose tissue-derived MSCs(hAD-MSCs)were seeded in low(5.6 mmol/L of glucose)and high glucose(25 mmol/L of glucose)for 7 d.Cytotoxicity,viability,mitochondrial dynamics,and apoptosis were deplored using specific kits.Western blotting was performed to measure the protein expression of phosphatidylinositol 3-kinase(PI3K),TSC1,and mammalian target of rapamycin(mTOR)in these cells.RESULTS hAD-MSCs cultured in high glucose for 7 d demonstrated marked decrease in their viability,as shown by a significant increase in lactate dehydrogenase(P<0.01)and a significant decrease in Trypan blue(P<0.05)in these cells compared to low glucose control.Mitochondrial membrane potential,indicated by tetramethylrhodamine ethyl ester(TMRE)fluorescence intensity,and nicotinamide adenine dinucleotide(NAD+)/NADH ratio were significantly dropped(P<0.05 for TMRE and P<0.01 for NAD+/NADH)in high glucose exposed hAD-MSCs,indicating disturbed mitochondrial function.PI3K protein expression significantly decreased in high glucose culture MSCs(P<0.05 compared to low glucose)and it was coupled with significant upregulation in TSC1(P<0.05)and downregulation in mTOR protein expression(P<0.05).Mitochondrial complexes I,IV,and V were downregulated profoundly in high glucose(P<0.05 compared to low glucose).Apoptosis was induced as a result of mitochondrial impairment and explained the poor survival of MSCs in high glucose.CONCLUSION High glucose impaired the mitochondrial dynamics and regulatory proteins in hAD-MSCs ensuing their poor survival and high apoptosis rate in hyperglycemic microenvironment. 展开更多
关键词 Mesenchymal stem cells High glucose Mitochondrial dynamics Apoptosis Poor survival Phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway
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Performance of RC buildings after Kahramanmaraş Earthquakes: lessons toward performance based design 被引量:2
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作者 Baris Binici Ahmet Yakut +7 位作者 Koray Kadas Ozan Demirel Ugur Akpinar Afsin Canbolat Firat Yurtseven Orkun Oztaskin Selin Aktas Erdem Canbay 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2023年第4期883-894,共12页
Two simultaneous earthquakes occurred in the Kahramanmaraş-Pazarcık and Kahramanmaraş-Elbistan districts of Turkey on February 6,2023,and with magnitudes of 7.7 and 7.6,respectively.These events caused the highest est... Two simultaneous earthquakes occurred in the Kahramanmaraş-Pazarcık and Kahramanmaraş-Elbistan districts of Turkey on February 6,2023,and with magnitudes of 7.7 and 7.6,respectively.These events caused the highest estimated loss recorded in Turkey within the last century from natural disasters.The key reason for the extensive loss was the proximity of eleven cities to the earthquake epicenters.Middle East Technical University teams investigated the building sites in Gaziantep,Kahramanmaras,Hatay,Adiyaman and Adana.The ground motion recordings revealed that in certain locations of Gaziantep,Kahramanmaraşand Hatay,the ground motion levels exceeded the maximum credible earthquake level defined for a return period of 2,475 years in the Turkish Earthquake Code.Residential building performance was investigated with respect to the construction year,which is a good indicator of compliance with modern seismic codes and inspection procedures.About 97%of the collapsed buildings were constructed prior to 2000,whereas over 5,000 buildings,which were built after 2000,collapsed or required urgent demolition.Most of the buildings with minor or greater structural damage sustained heavy infill wall damage rendering occupancy impossible.Aside from damage in older construction with significant structural deficiencies,the damage in some of the more recent and better constructed buildings was observed to be surprisingly poor.This can be attributed to the level of ground motion,significant ductility demands,poor material and workmanship and damage to non-structural elements.With the estimated total loss of above 100 billion dollars and over 50,000 casualties,the current seismic design criterion based on ductility and acceptance of structural damage should be re-evaluated to ensure a more resilient urban environment in high seismic regions. 展开更多
关键词 earthquake damage Kahramanmaras earthquake RC Building seismic codes poor performance
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Increased MAD2L2 expression predicts poor clinical outcome in Colon Adenocarcinoma 被引量:1
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作者 HAOTONG SUN HEYING WANG +5 位作者 XIN LI YANJIE HAO JUN LING HUAN WANG FEIMIAO WANG FANG XU 《BIOCELL》 SCIE 2023年第3期607-618,共12页
Background:Colon adenocarcinoma(COAD)is the second leading cause of cancer death worldwide thus,identification of COAD biomarkers is critical.Mitotic Arrest Deficient 2 Like 2(MAD2L2)is a key factor in mammalian DNA d... Background:Colon adenocarcinoma(COAD)is the second leading cause of cancer death worldwide thus,identification of COAD biomarkers is critical.Mitotic Arrest Deficient 2 Like 2(MAD2L2)is a key factor in mammalian DNA damage repair and is highly expressed in many malignant tumors.This is a comprehensive study of MAD2L2 expression,its diagnostic value,prognostic analysis,potential biological function,and impact on the immune system of patients with COAD.Methods:Gene expression,clinical relevance,prognostic analysis,diagnostic value,GO/KEGG cluster analysis,data obtained from TCGA,and bioinformatics statistical analysis were performed using the R package.Immune responses to MAD2L2 expression in COAD were analyzed using TIMER.The expression of MAD2L2 in HCT116 cells induced by the inflammatory factor TNF-αwas detected using Western blot.Results:Our results underscore the clinical diagnostic value and potential biological significance of MAD2L2 in patients with COAD.A high level of MAD2L2 expression has been found in COAD and correlated with tumor status and colon polyps.ROC curve analysis showed that MAD2L2 expression has high diagnostic value in COAD.Analysis of immune infiltration results showed that MAD2L2 expression was positively correlated with neutrophil levels.The western blot results demonstrated that MAD2L2 was dose-dependently present with TNF-α.GO/KEGG revealed that MAD2L2 overexpressed and coexpressed genes were mostly involved in biological functions,including hypoxia response,response to reduced oxygen levels,mitochondrial translation elongation,and other processes.Conclusion:MAD2L2 as a new COAD biomarker contributes to our understanding of how alterations in gene expression and the immunological environment contribute to the development of colon cancer.Following further investigation,MAD2L2 may prove to be a viable target factor for clinical diagnosis and therapy of COAD. 展开更多
关键词 MAD2L2 COAD Poor prognosis Immune infiltration TCGA
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Tumor budding in gastric cancer 被引量:1
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作者 Shuo-Meng Xiao Jian Li 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第4期578-591,共14页
The tumor,nodes,metastasis(TNM)staging system has long been the gold standard for the classification and prognosis of solid tumors.However,the TNM staging system is not without limitations.Prognostic heterogeneity exi... The tumor,nodes,metastasis(TNM)staging system has long been the gold standard for the classification and prognosis of solid tumors.However,the TNM staging system is not without limitations.Prognostic heterogeneity exists within patients at the same stage.Therefore,the pursuit of other biomarkers with the potential to classify patients with cancer has never stopped.One of them,tumor budding(TB),has gained much success in colorectal cancer.In recent years,TB in gastric cancer has attracted much attention from researchers,beginning to reveal the molecular and biological aspects of this phenomenon in gastric cancer,and has emerged as a promising prognostic biomarker in gastric cancer,predicting disease progression and unfavorable survival.Therefore,it is time and essential to provide a holistic overview of TB in gastric cancer,which has not been achieved and is the aim of this review. 展开更多
关键词 Tumor budding Gastric cancer Poorly differentiated cluster PROGNOSIS Lymph node metastasis
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Long term outcomes of Cohen’s cross trigonal reimplantation for primary vesicoureteral reflux in poorly functioning kidney
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作者 Mohd Sualeh Ansari Ravi Banthia +3 位作者 Shrey Jain Vinay N Kaushik Nayab Danish Priyank Yadav 《World Journal of Clinical Cases》 SCIE 2023年第16期3750-3755,共6页
BACKGROUND Open ureteric reimplantation by cross trigonal technique described by Cohen is considered a common surgical option for correction of vesicoureteral reflux(VUR). There is a lack of evidence in literature tho... BACKGROUND Open ureteric reimplantation by cross trigonal technique described by Cohen is considered a common surgical option for correction of vesicoureteral reflux(VUR). There is a lack of evidence in literature though for what happens to such kidneys, in the long run, particularly those which are poorly functioning.AIM To assess the long-term outcomes of ureteric reimplantation in poorly functioning kidneys in children with unilateral primary VUR.METHODS Children with unilateral primary VUR and a relative renal function of less than 35% who underwent open or laparoscopic ureteric reimplantation between January 2005 and January 2017 were included in the study. Patients who had a follow up of less than five years were excluded. Preoperative evaluation consisted of a voiding cystourethrogram and Dimercaptosuccinic acid(DMSA) scan. In the follow-up period, patients underwent a diuretic scan at 6 weeks and 6 months.Follow up ultrasound was done for change in grade of hydronephrosis and retrovesical ureteric diameter. Subsequent follow up was done at 6 monthly intervals with evaluation for proteinuria and hypertension and any recurrent urinary tract infection(UTI). For assessment of cortical function, DMSA was repeated annually for 5 years after surgery. A paired-samples t-test was used to test the mean difference of DMSA between pre-post observations.RESULTS During this period, 36 children underwent ureteric reimplantation for unilateral primary VUR. After excluding those with insufficient follow-up, 31 were included in the analysis. Most of the patients were males(n = 26/31, 83.8%). Patient’s age(mean ± SD, range) was 5.21 ± 3.71, 1-18 years. The grades of VUR were grade Ⅱ(1patient), grade Ⅲ(8 patients), grade Ⅳ(10 patients), and grade Ⅴ(12 patients). The pre and postoperative DMSA was 24.064 ± 12.02 and 24.06 ± 10.93, which was almost the same(statistically equal, paired-samples t-test: P = 0.873). The median(range) follow-up duration was 82(60-120)mo. One patient had persistent reflux after surgery(preoperative: grade Ⅳ, postoperative: grade Ⅲ), and the very same patient developed recurrent UTI. The difference in the preoperative and postoperative DRF was less than 10% in 29 patients. In one patient, the DRF decreased by 17%(22% to 05%) while in another patient, the DRF increased by 12%(25% to 37%) after surgery. None of the patients had an increase in scarring after surgery. 15% of patients were hypertensive before surgery and all of them continued to be hypertensive after surgery while none developed hypertension after surgery. None of the patients had significant proteinuria(> 150 mg/d) during the follow-up period.CONCLUSION Children with unilateral primary VUR and poorly functioning kidney maintain the renal function over the long term in most cases. Hypertension and proteinuria do not progress over time in these patients. 展开更多
关键词 Vesicoureteral reflux Ureteric reimplantation Relative renal function Poorly functioning kidney UNILATERAL Long term
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Poor hygienic conditions of butcheries and high level of microbiological contamination of meat sold in Nampula city,Mozambique
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作者 Ndjate Kinyamba-Junior Cátia Salamandane +2 位作者 Vanito Frei Acacio Salamandane Pompílio Vintuar 《Food and Health》 2023年第2期6-12,共7页
The present study aimed to evaluate the hygiene practices and the quality of meat sold in butcheries in the city of Nampula,Mozambique.Of the twelve butcheries in the city,only seven participated in the study,which wa... The present study aimed to evaluate the hygiene practices and the quality of meat sold in butcheries in the city of Nampula,Mozambique.Of the twelve butcheries in the city,only seven participated in the study,which was divided into four categories:hygienic conditions of buildings and facilities,equipment,furniture and utensils,good handling practices for handlers,and microbiological quality of meat products.Results showed that most of the butcheries(71%)had poor hygiene conditions,such as walls with cracks and holes and lack of washbasins in the production area.In addition,the majority(71%)of butcheries used a reusable dirty cloth to clean equipment and utensils,and only 43%had a cold room or refrigerated chamber for meat conservation.Regarding personal hygiene,100%of the handlers washed and changed their clothes daily,but 71%did not properly wash their hands before handling food.Microbiological analysis revealed that 86%of the cutting tables swabs and 43%of the hand blades had E.coli counts above 4 Log,and the presence of Salmonella was observed in 71%of meat samples.Overall,the study highlights the need for improvement in hygiene practices and the quality of meat sold in butcheries in Nampula. 展开更多
关键词 Salmonella spp poor hygienic conditions butcheries facilities Nampula meat handling
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Selection of Cotton Variety Suitable for Cottonwheat Intercropping in Rainy and Poor Sunshine Years
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作者 王树林 刘文艺 +5 位作者 祁虹 王燕 张谦 冯国艺 林永增 梁青龙 《Agricultural Science & Technology》 CAS 2016年第9期2008-2011,2036,共5页
The year of 2013 is a typical rainy and poor sunshine year, and the monthly sunshine hours from May to October were all lower than the average, which from July to September was only 69.3%,71.1% and 56.2% of average, r... The year of 2013 is a typical rainy and poor sunshine year, and the monthly sunshine hours from May to October were all lower than the average, which from July to September was only 69.3%,71.1% and 56.2% of average, respectively. In cotton-wheat system 10 cotton varieties (lines) were planted to select the most suitable varieties for cotton-wheat system in rainy and poor sunshine years through investigating cotton growing traits in 2013. The results showed that in cotton-wheat system the vegetative growth of cotton was mainly from late June to middle July especially in rainy and poor sunshine years. And with the increase of the cotton growth period the peak of vegetative growth delayed, the ratio of the autumn bolls increased, and the ratio of pre-frost yield decreased. In all the varieties unginned cottonyield of Zhongmiansuo 50 with shorter growth period, higher rate of summer bolls and better fiber quality, seed yield reached 3 814.1 kg/hm2, higher than that of other varieties (lines) significantly, and the rate of pre-frost yield reached 83.4%, which was the most suitable variety for cotton-wheat system in rainy and poor sunshine years. 展开更多
关键词 Rainy and poor sunshine Cotton-wheat intercropping Cotton Variety selection
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Research on the Mistakes Made by College English Teachers in Pronunciation of /n/&/l/
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作者 刘斌 桂严捷 《海外英语》 2014年第18期251-252,共2页
As an old saying goes that"once you open mouth, you are decided". Thus, there is no doubt about the fact that English pronunciation is of great importance, especially for English teachers whose pronunciation... As an old saying goes that"once you open mouth, you are decided". Thus, there is no doubt about the fact that English pronunciation is of great importance, especially for English teachers whose pronunciation exerts far-reaching and direct influences on that of students. Some of College English teachers, however, have poor pronunciation; most of them cannot distinguish/n/ from /l/. Therefore, it is of huge practical value to commit to the research on the mistakes made by College English teachers in pronunciation of /n/ &/l/ and analyze the underlying causes in the hope of helping teachers to improve their poor pronunciation. 展开更多
关键词 POOR PRONUNCIATION /n/ & /l/ COLLEGE English TEACH
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