Population synthesis studies into planet formation have suggested that distributions consistent with observations can only be reproduced if the actual Type Ⅰ migration timescale is at least an order of magnitude long...Population synthesis studies into planet formation have suggested that distributions consistent with observations can only be reproduced if the actual Type Ⅰ migration timescale is at least an order of magnitude longer than that deduced from linear theories.Although past studies considered the effect of the Type I migration of protoplanetary embryos,in most cases they used a conventional formula based on static torques in isothermal disks,and employed a reduction factor to account for uncertainty in the mechanism details.However,in addition to static torques,a migrating planet experiences dynamic torques that are proportional to the migration rate.These dynamic torques can impact on planet migration and predicted planetary populations.In this study,we derived a new torque formula for Type Ⅰ migration by taking into account dynamic corrections.This formula was used to perform population synthesis simulations with and without the effect of dynamic torques.In many cases,inward migration was slowed significantly by the dynamic effects.For the static torque case,gas giant formation was effectively suppressed by Type I migration;however,when dynamic effects were considered,a substantial fraction of cores survived and grew into gas giants.展开更多
The association of gluckinase (GCK) gene with type 2 (non-insulin-dependent) diabetes mellitus was investigated in 168 Chinese subjects (85 unrelated type 2 diabetics and 83 non-diabetic controls), The microsatellite ...The association of gluckinase (GCK) gene with type 2 (non-insulin-dependent) diabetes mellitus was investigated in 168 Chinese subjects (85 unrelated type 2 diabetics and 83 non-diabetic controls), The microsatellite polymorphism marker, GCK-5', was amplified with polymerase chain reaction. Four alleles were observed in Chinese population with length varying from 137bp to 143bp and the most common one being the 139bp allele 3. In comparison with non-diabetics, allele 4 was significantly increased in type 2 diabetes (10% versus 38, respectively; X(2)=6.773, P=0.009); genotype 44 and 4X (X denotes any allele other than allele 4) were significantly increased in type 2 diabetes (16% versus 6% respectively; X(2)=6.439, P=0.011), The frequency difference was also shown in overweight / obese subgroup comparison (X(2)=7.718, P=0.021), but not in lean / normal-weight subgroup comparison, No differences of age of onset and frequency of positive family history were observed between type 2 diabetic patients with genotype 44 or 4X and those with XX. The risk for type 2 diabetes in Chinese with genotype 44 or 4X was about 3.5 times higher than in Chinese with genotype XX. Therefore, GCK gene was associated with Chinese type 2 diabetes.展开更多
基金supported by Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education,Culture,Sports, Science and Technology(MEXTGrant No.26106006)+1 种基金supported by a Grand-in-Aid for Young Scientists(KAKENHI B) from the Japan Society for the Promotion of Science(JSPSGrant No. 24740120)
文摘Population synthesis studies into planet formation have suggested that distributions consistent with observations can only be reproduced if the actual Type Ⅰ migration timescale is at least an order of magnitude longer than that deduced from linear theories.Although past studies considered the effect of the Type I migration of protoplanetary embryos,in most cases they used a conventional formula based on static torques in isothermal disks,and employed a reduction factor to account for uncertainty in the mechanism details.However,in addition to static torques,a migrating planet experiences dynamic torques that are proportional to the migration rate.These dynamic torques can impact on planet migration and predicted planetary populations.In this study,we derived a new torque formula for Type Ⅰ migration by taking into account dynamic corrections.This formula was used to perform population synthesis simulations with and without the effect of dynamic torques.In many cases,inward migration was slowed significantly by the dynamic effects.For the static torque case,gas giant formation was effectively suppressed by Type I migration;however,when dynamic effects were considered,a substantial fraction of cores survived and grew into gas giants.
文摘The association of gluckinase (GCK) gene with type 2 (non-insulin-dependent) diabetes mellitus was investigated in 168 Chinese subjects (85 unrelated type 2 diabetics and 83 non-diabetic controls), The microsatellite polymorphism marker, GCK-5', was amplified with polymerase chain reaction. Four alleles were observed in Chinese population with length varying from 137bp to 143bp and the most common one being the 139bp allele 3. In comparison with non-diabetics, allele 4 was significantly increased in type 2 diabetes (10% versus 38, respectively; X(2)=6.773, P=0.009); genotype 44 and 4X (X denotes any allele other than allele 4) were significantly increased in type 2 diabetes (16% versus 6% respectively; X(2)=6.439, P=0.011), The frequency difference was also shown in overweight / obese subgroup comparison (X(2)=7.718, P=0.021), but not in lean / normal-weight subgroup comparison, No differences of age of onset and frequency of positive family history were observed between type 2 diabetic patients with genotype 44 or 4X and those with XX. The risk for type 2 diabetes in Chinese with genotype 44 or 4X was about 3.5 times higher than in Chinese with genotype XX. Therefore, GCK gene was associated with Chinese type 2 diabetes.
