Asymmetric membranes present better separation and service characteristics than the symmetric ones. In our preliminary studies the possibility of obtaining sintered porous materials with gradual structure by sedimenta...Asymmetric membranes present better separation and service characteristics than the symmetric ones. In our preliminary studies the possibility of obtaining sintered porous materials with gradual structure by sedimentation of metallic and ceramic powders was demonstrated. Zirconium silicate （ZrSiO4） particles were used for the manufacturing of the porous supports, and mullite powder was deposited by sedimentation in order to achieve the active layer with pores size gradient. The used powders and the obtained structures were characterized by laser scattering particle size analyzer, scanning electron microscopy and mercury porosimetry. The permeability and the filtration fineness of the structures were also determined. By using a thin active layer made of small particles deposited onto a macro-porous support, one can achieve membranes with high flow rates and filtration fineness in the microfiltration area.展开更多
Despite quantum leaps,the biomimetic regeneration of cartilage and osteochondral regeneration remains a major challenge,owing to the complex and hierarchical nature of compositional,structural and functional propertie...Despite quantum leaps,the biomimetic regeneration of cartilage and osteochondral regeneration remains a major challenge,owing to the complex and hierarchical nature of compositional,structural and functional properties.In this review,an account of the prevailing challenges in biomimicking the gradients in porous microstructure,cells and extracellular matrix(ECM)orientation is presented.Further,the spatial arrangement of the cues in inducing vascularization in the subchondral bone region while maintaining the avascular nature of the adjacent cartilage layer is highlighted.With rapid advancement in biomaterials science,biofabrication tools and strategies,the state-of-the-art in osteochondral regeneration since the last decade has expansively elaborated.This includes conventional and additive manufacturing of synthetic/natural/ECM-based biomaterials,tissue-specific/mesenchymal/progenitor cells,growth factors and/or signaling biomolecules.Beyond the laboratory-based research and development,the underlying challenges in translational research are also provided in a dedicated section.A new generation of biomaterial-based acellular scaffold systems with uncompromised biocompatibility and osteochondral regenerative capability is necessary to bridge the clinical demand and commercial supply.Encompassing the basic elements of osteochondral research,this review is believed to serve as a standalone guide for early career researchers,in expanding the research horizon to improve the quality of life of osteoarthritic patients affordably.展开更多
基金supported by CNCSIS–UEFISCSU(Project No. PNII – IDEI 749/2009)
文摘Asymmetric membranes present better separation and service characteristics than the symmetric ones. In our preliminary studies the possibility of obtaining sintered porous materials with gradual structure by sedimentation of metallic and ceramic powders was demonstrated. Zirconium silicate （ZrSiO4） particles were used for the manufacturing of the porous supports, and mullite powder was deposited by sedimentation in order to achieve the active layer with pores size gradient. The used powders and the obtained structures were characterized by laser scattering particle size analyzer, scanning electron microscopy and mercury porosimetry. The permeability and the filtration fineness of the structures were also determined. By using a thin active layer made of small particles deposited onto a macro-porous support, one can achieve membranes with high flow rates and filtration fineness in the microfiltration area.
基金supported by the Raymond and Beverly Sackler Center for Biomedical,Biological,Physical and Engineering Sciences.
文摘Despite quantum leaps,the biomimetic regeneration of cartilage and osteochondral regeneration remains a major challenge,owing to the complex and hierarchical nature of compositional,structural and functional properties.In this review,an account of the prevailing challenges in biomimicking the gradients in porous microstructure,cells and extracellular matrix(ECM)orientation is presented.Further,the spatial arrangement of the cues in inducing vascularization in the subchondral bone region while maintaining the avascular nature of the adjacent cartilage layer is highlighted.With rapid advancement in biomaterials science,biofabrication tools and strategies,the state-of-the-art in osteochondral regeneration since the last decade has expansively elaborated.This includes conventional and additive manufacturing of synthetic/natural/ECM-based biomaterials,tissue-specific/mesenchymal/progenitor cells,growth factors and/or signaling biomolecules.Beyond the laboratory-based research and development,the underlying challenges in translational research are also provided in a dedicated section.A new generation of biomaterial-based acellular scaffold systems with uncompromised biocompatibility and osteochondral regenerative capability is necessary to bridge the clinical demand and commercial supply.Encompassing the basic elements of osteochondral research,this review is believed to serve as a standalone guide for early career researchers,in expanding the research horizon to improve the quality of life of osteoarthritic patients affordably.
