Progress in diagnosis and treatment of small cell lung cancer with integrated traditional Chinese and Western medicine

Lung cancer is one of the most common major diseases that seriously threaten human health,lung cancer includes small cell lung cancer(SCLC)and non-small cell lung cancer(NSCLC).Although patients with SCLC account for about 20%of the total number of patients with lung cancer,the mortality rate is much higher than that of patients with NSCLC.Integrated traditional Chinese and Western medicine has obvious advantages in the treatment of patients with SCLC.According to the relevant literature reports on the treatment of SCLC in recent years,this article will summarize the research progress of integrated traditional Chinese and western medicine in the treatmentof SCLC from the aspects of traditional Chinese medicine(TCM)combined with surgery,chemotherapy,radiotherapy,and molecular targeted therapy.

An Expert Consensus of Integrated Chinese and Western Medicine Treatment on Lung Cancer

Lung cancer is a malignant tumor of the lung originating from the bronchial mucosa,glands or alveolar epithelium.With the population aging and environmental pollution getting increasingly severe,lung cancer has become the malignant tumor with the highest incidence and mortality rate in China,seriously endangering people’s life and health.However,there is no standardized guideline for the integrated Chinese and Western medicine treatment of lung cancer in China.In order to standardize and improve integrated Chinese and Western medicine diagnosis and treatment of lung cancer in China,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,together with oncologists from the Sun Yat-sen University Cancer Center,compiled this consensus under the coordination of the Medical Policy Department of the National Administration of Traditional Chinese Medicine,taking into account the main results of the pilot project of Chinese and Western Medicine Clinical Collaboration for Major Difficult Diseases(lung cancer).

Preparation of NIR-II-excited Drug-loaded Liposomes and Their Antitumor Activity and in Vitro Imaging Studies

In recent years,with the rapid development of nano-technology,the combination of diagnosis and treatment by nanotechnologyhas brought new hope for mankind to overcome cancer.The Near-infrared two-region(NIR-II)imaging technology hasdeveloped rapidly in recent years because of its non-invasive nature,strong tissue penetration and overall imaging of small animals.In this study,a novel nano-drug delivery system(DOX-IR1061 cationic liposomes)was prepared,loaded with doxorubicin(DOX)as a chemotherapeutic drug and NIR-II-excited fluorescent probe IR1061 as an imaging agent,and the uptake ability of tumor cellswas enhanced by octadecylamine.DOX-IR1061 cationic liposomes have good NIR-II imaging ability,clear imaging and obvioussignal.Cell uptake indicated that palamine could enhance the uptake efficiency of cationic liposomes by tumor cells,while in vitroanti-tumor experiments revealed that the enhancement of uptake efficiency would enhance the anti-tumor effect of DOX.Therefore,DOX-IR1061 cationic liposomes we prepared have the potential to realize both tumor imaging and therapy,and to realize theintegration of rapid diagnosis and treatment,and provide new ideas for cancer cure and the development of the field of diagnosis andtreatment integration.

Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment

Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and drug release rates at different p H values to assess the biodistribution and drug delivery pathways in vivo. Here, we established a strategy to integrate Bi-doped carbon quantum dots(CQDs)with liposomes to produce fluorescence visualization and therapeutic effects, namely lipo/Bi-doped CQDs.Lipo/Bi-doped CQDs show good water solubility and physicochemical properties, which can be used for in vitro labeling of colon cancer(CT26) cells and in vivo imaging localization tracking tumors for monitoring. Simultaneously, thanks to the excellent p H sensitivity and ion doping characteristic of Bi-doped CQDs, lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different p H values and exhibit potential effects in vivo antitumor therapy.

Randomized controlled study of a diagnosis and treatment plan for moderate coronavirus disease 2019 that integrates Traditional Chinese and Western Medicine

OBJECTIVE:To investigate the clinical efficacy and safety of a diagnosis and treatment plan for moderate coronavirus disease 2019(COVID-19)that integrates traditional Chinese(TCM)and western medicine.METHODS:One hundred twenty patients with moderate COVID-19 were randomized 1∶2 to the control group(n=40)and experimental group(n=80).Both groups received conventional western medicine treatment,and the experimental group also received TCM decoction.Over a 2-week period from diagnosis,we observed the time to clinical recovery(TTCR),rate of improvement on lung computed tomography(CT)imaging,time to defervescence,cough remission time,hospital discharge rate,average hospitalization stay,modified Medical Research Council(m MRC)scale score,clinical cure rate,laboratory findings,incidence of progression to severe or critical disease,and adverse events.RESULTS:Among 120 enrolled patients,108 completed the study.The baseline data did not differ between the experimental and control groups(all P>0.05).After treatment,the TTCR,rate of lung CT imaging improvement,time to defervescence,cough remission time,hospital discharge rate,average hospitalization stay(among discharged patients),m MRC scale score,clinical cure rate,and rates of normal values for laboratory findings were better in the experimental group than in the control group(P<0.05 or<0.01).The incidence of progression to severe or critical disease and the incidence of adverse events did not differ between the two groups(P>0.05).CONCLUSION:The diagnosis and treatment plan integrating Chinese and western medicine showed improved clinical efficacy compared with western medicine alone for patients with moderate COVID-19 and is worthy of clinical promotion and application.

Thinking and Strategy on the Diagnosis and Treatment of Functional Gastrointestinal Disorders with Integrative Medicine

The functional gastrointestinal disorders (FGIDs) are a group of diseases mainly manifested as gastrointestinal functional disorders,including 45 kinds of different diseases,such as functional dyspepsia(FD), irritable bowel syndrome (IBS),functional constipation

Experiences on the Integrative Medical Diagnosis and Treatment of Acute Kidney Injury

The definition of acute renal failure（ARF） has not gotten common understanding yet in a long time,which leads to the difficulty in comparing the outcomes of some different studies,and has impacted the advance of diagnosis and treatment on the illness to certain extents. Most of the scholars hold that the attention paid to the early diagnosis and intervention of ARF was insufficient in recent years. Lots of clinical researchers indicated that even a slight impairment of renal function could result in the increasing of the morbidity and mortality of ARF.

中西医结合诊治妊娠胚物残留专家共识(2024年版)

妊娠胚物残留(RPOC)是指流产或分娩后,胚胎组织或胎盘未能完全排出而残留子宫内,可引起出血、感染,甚至宫腔粘连等。目前RPOC的治疗策略主要分为药物治疗和手术治疗两类,但国内外对此尚未形成科学、规范的指导意见。中西医联合诊治一直是我国诊治RPOC的特色手段,为推广中西医结合协同诊疗理念,促进RPOC中西医结合诊疗技术发展,山东中医药学会妇科专业委员会、山东中西医结合学会生殖外科专业委员会、山东省疼痛医学会妇产科专业委员会共同牵头成立共识专家组,讨论形成《中西医结合诊治妊娠胚物残留专家共识(2024年版)》,从RPOC的高危因素、临床表现、诊断、治疗等方面阐述中西医结合协同诊疗理念,并提供专家共识,以改善RPOC患者预后,提高其生活质量。

Effect of integrated Traditional Chinese and Western Medicine on Gout

OBJECTIVE:To evaluate the curative effect of integrated Traditional Chinese and Western Medicine on gout,and to investigate the therapy timing and exact treatment options of integrated medicine.METHODS:Totally 860 patients were enrolled,including 460 patients with intermittent gout,200 patients with active Traditional Chinese Medicine(TCM)syndrome(TCM syndrome score≥6)and200 patients with stable TCM syndrome(score<6).They were randomly divided into intervention and control groups.The control group was treated according to Western Medicine guidelines.The intervention group was treated with integrated Traditional Chinese and Western Medicine.The efficacy of TCM syndrome,joint pain score,joint swelling score,ESR,C-reactive protein,serum uric acid,liver and kidney function,and the duration of remission of TCM syndrome were compared between the two groups before and after treatments.RESULTS:For the patients with stable TCM syndrome,there was no significant difference in the effective rate and inefficiency between the intervention group and the control group.For the active type,the effective rate of the intervention group is better than the control group significantly.For the stable type,there was no significant difference between the intervention group and the control group in improving the scores of joint pain and swelling,reducing the level of ESR,C-reactive protein,serum uric acid and improving liver and kidney function.For the active type,the differences between the two groups were significant.The stable stage of gout in the intervention group was longer than the control group.CONCLUSION:For the gout patients with stable TCM syndrome in the acute stage of gout,we can use TCM treatment or Western Medicine alternatively;for the patients with active TCM syndrome,the scheme of combination of Traditional Chinese and Western Medicine can be applied,with the better curative effect than any medicine alone.

儿童流行性感冒中西医结合诊疗指南

儿童是流行性感冒的高发人群及重症病例的高危人群。流行性感冒早期干预,特别是在轻症阶段给予中西医结合的干预措施对疾病的预后具有重要意义。本指南基于文献检索及评价、专家访谈、组内讨论、专家论证会、公开征求意见等制订流程,形成《儿童流行性感冒中西医结合诊疗指南》。此次制订提出指南适用范围、规范性引用文件、术语和定义、诊断、治疗,旨在为儿童流行性感冒中西医结合临床实践、诊疗规范和质量评价提供重要参考。

2型糖尿病中西医结合诊疗指南

2型糖尿病(T2DM)是全球性的公共卫生问题,目前我国患病总人数已超过1亿。为指导2型糖尿病规范化中西医诊疗,中国中西医结合学会联合中华中医药学会、中华医学会共同开展中西医结合诊疗方案制订工作,本指南组织国内22位内分泌及相关领域中西医专家,通过前期调研、专家访谈、共识会议,结合循证医学证据,最终形成了2型糖尿病中西医结合诊疗指南。主要内容包括2型糖尿病的诊断标准、高危人群筛查、中医证候分型、治疗原则和方法。治疗方案涵盖健康教育与管理、营养与药膳、运动与功法、心理调节与情志疗法,以及中药辨证论治、中成药、中医外治法等中医疗法与西药的联合干预。强调以患者为中心,注重个体化治疗,旨在改善血糖控制,减少并发症,提高生活质量。本指南适用于中医、中西医结合医疗机构的临床医师及相关护理人员,也可供西医临床医师和健康管理相关专业人员参考。

儿童功能性消化不良中西医结合诊疗指南

功能性消化不良作为临床最常见的上消化道功能性疾病之一,严重影响我国儿童的生活质量和生长发育。由于儿童功能性消化不良定义和症状谱的不断改变,导致其在诊治方面存在较大争议。为规范儿童功能性消化不良中西医结合诊治,切实解决儿童功能性消化不良诊疗中的临床问题,故制定本指南以指导儿童功能性消化不良中西医结合规范诊疗。

卵巢癌中西医结合诊疗指南

卵巢癌病死率位于女性生殖系统恶性肿瘤之首,严重威胁女性健康。本指南工作组在遵循循证医学原则的基础上,参考国际国内最新临床实践指南制订方法,客观评价卵巢癌中西医结合诊治证据,广泛征求中医学、临床医学、方法学等多学科专家的意见,最终形成本指南,旨在为中西医结合诊治卵巢癌的临床实践提供参考。

三级公立医院紧密型城市医疗集团建设的探索与思考

加强紧密型城市医疗集团一体化管理,助力分级诊疗政策落地,对提升基层医院医疗水平具有促进作用。以某市级三甲公立医院为例,对紧密型城市医疗集团成员单位在医、教、研、防及管理上实施一体化管理,通过责权协同、资源协同、业务协同等方法,以资源下沉共享为核心,搭建联盟平台,通过网格化布局,构建分级诊疗服务新格局。针对医疗集团基层单位,建立定期反馈机制,针对基层医疗集团运营中的难点,帮助基层单位找准定位,促进医疗集团内部协同发展,通过深化创新实践,推动医防融合。紧密型城市医疗集团实施一体化管理后,集团成员单位社会影响力扩大,医疗服务能力得到提升,医疗科研技术水平也得到不同程度的提高,基层医院获得百姓的认可。

《抑郁症中西医结合诊疗指南》制定的思考

规范抑郁症中西医结合诊疗,发挥中西医结合治疗优势,是困扰神志病领域中西医结合工作的难题。通过规范抑郁症中西医结合循证和标准化工作,制定和发布《抑郁症中西医结合诊疗指南》(以下简称《指南》),形成系统的中西医结合治疗方案,为临床提供客观、具体、且可操作的建议,从而指导临床实践。本文从制定背景、亮点、总结和展望等方面对《指南》进行解读,解释相关问题,从而加强《指南》的落地、实践与推广。

中医急危重症诊疗知识融合路径探析

知识融合技术能将诊疗决策医师群体的知识融合成集群体智慧的综合诊疗知识,实现更加科学准确的诊疗决策,从而提高中医急危重症临床诊疗效率。本研究结合中医急危重症诊疗知识的复杂性和模糊不确定性提出构建中医急危重症诊疗知识表示模型、建立中医急危重症诊疗知识模糊不确定性测度模型、构建中医急危重症诊疗知识融合框架的知识融合的实现路径,为实现中医急危重症诊疗知识融合提供参考,为提高中医急危重症诊疗效率提供思路。

双心诊疗模式中西医研究现状

在临床诊治过程中,心血管疾病常常伴有复杂的心理社会因素,具有较高的精神心理障碍发病率,即“双心疾病”。防治这类心血管病要从心脏、心理两方面入手,即双心诊疗模式。目前部分临床医生及患者对于双心疾病认识不足,医生接诊时重视客观检查,缺乏与患者的实际沟通,患者则不能正确分辨其与器质类心脏病的区别。这些情况要求临床的医务人员在重视药物、物理治疗的基础上,还要对患者的心理状况采用个体化心理评估以及干预,以维持机体整体平衡,追求心血管和心理整体健康。目前现代医学对其研究与治疗已经有了坚实的基础,临床医生对于此类疾病有了更加清楚的认识。中医学对双心疾病也有深刻的见解,以整体观念与辨证论治,通过中药内服及特色外治疗法(针灸、穴位贴敷、导引、五音疗法等)可明显缓解心脏病伴有心理障碍患者的临床症状,同时无服用抗抑郁、焦虑药物带来的心理排斥,在双心疾病的干预治疗中发挥着更加重要的作用。中西医结合治疗对于双心疾病意义重大,取长补短,各尽其用,真正达到了“身心同治”的临床治疗目的,做到了以人为本的诊疗理念,患者的认可和接受程度越来越高,具有广阔的发展空间。

老年性骨质疏松症中西医结合诊疗指南

随着我国人口老龄化日益严重,老年性骨质疏松症已成为严重影响老年人群健康的慢病之一。中西医结合治疗可以取长补短、优化诊疗方案、提高诊疗效果,近年来在老年性骨质疏松症的临床和科研中的应用越来越广。为了更好地规范中西医结合疗法在老年性骨质疏松症诊疗中的应用,中华中医药学会骨质疏松防治发展共同体联合浙江中医药大学附属第二医院,依据循证医学标准,组织多学科专家形成指南制订专家组,经过指南立项与注册、临床问题筛选与确定、证据检索及评价、推荐意见形成等流程,制订老年性骨质疏松症中西医结合诊疗指南。该指南涵盖了老年性骨质疏松症中西医结合诊断及治疗,旨在规范和提高我国老年性骨质疏松症中西医结合的临床诊疗水平,保障我国老年人群的健康。

川北医学院附属医院医联体协同平台建设与应用

目的:建设医联体平台,实现川北地区区域内医疗数据信息互联互通,促进分级诊疗服务有效落地。方法:基于标准体系及安全体系,结合各医疗卫生机构信息系统情况,建设以川北医学院附属医院为牵头单位、覆盖南充市10家县域医院的医联体平台。结果:川北医联体平台具备双向转诊、就诊预约、标本送检、基础数据管理四大业务功能。平台的构建和应用,规范了医疗服务行为,提升了区域医疗服务能力,提高了群众接受医疗卫生服务的可及性、便捷性。结论:建设区域医疗信息共享与服务协同平台、覆盖远程医疗服务的协作网络有助于区域医疗一体化发展体系的建立,是对分级诊疗、区域医疗一体化发展的有益尝试。

肺癌中西医结合诊疗指南

肺癌在我国是发病率和死亡率均居首位的恶行肿瘤。中西医结合治疗肺癌在此疾病的各个阶段均具有显著的临床疗效,如减轻现代抗肿瘤治疗相关毒副反应、减少术后复发转移、延长晚期患者生存期、改善患者生活质量等。为贯彻落实《中共中央国务院关于促进中医药传承创新发展的意见》,中国中西医结合学会联合中华中医药学会、中华医学会制定并发布了《肺癌中西医结合诊疗指南》,旨在提高我国肺癌的中西医结合诊疗肺癌的水平。