Advanced biophysical wound healing therapies can apply mechanical, electrical, or light energy to re-stimulate healing processes in chronic wounds. Despite the growing evidence of the clinical efficacy of these therap...Advanced biophysical wound healing therapies can apply mechanical, electrical, or light energy to re-stimulate healing processes in chronic wounds. Despite the growing evidence of the clinical efficacy of these therapies, the optimal treatment stimulation parameters remain unknown and there are no standard treatment protocols. We introduce a closed-loop control design as an experimental system to study the dose-response of wound healing therapy treatment within a prescribed multidimensional and multimodal stimulation parameter space. Systems engineering approaches are applied to the control problem for estimation of a transfer function and model equations derived for use in optimal model-based control. The experimental control system design consisted of simultaneous application of biophysical energies inputted into a wound system. A study design set up including the use of negative pressure wound therapy, electrical stimulation therapy, and photobiomodulation device systems was described. Treatment stimulation parameters were selected from experimental ranges used in the scientific literature. Classical control methods and model-based control were suggested for model selection and evaluation and design of the overall control system. An experimental design for multimodal biophysical wound healing therapy control system is introduced to establish the dose-response interactions for development of therapeutic applications and device design.展开更多
恒频直接功率控制(constant switching frequency direct power control,CSF-DPC)具有开关频率固定、动态性能好、系统采样频率较低等优点。电网电压不平衡会在脉宽调制(pulse width modulation,PWM)型整流器交流侧产生大量谐波电流,使...恒频直接功率控制(constant switching frequency direct power control,CSF-DPC)具有开关频率固定、动态性能好、系统采样频率较低等优点。电网电压不平衡会在脉宽调制(pulse width modulation,PWM)型整流器交流侧产生大量谐波电流,使系统有功功率大幅波动,恶化系统性能。针对上述情况,提出一种新型恒频直接功率控制策略。该策略首先分离出电网电压和电流正、负序分量;然后在正、负序双旋转坐标系下计算瞬时功率与参考值之间的误差,根据误差生成整流器正、负序参考电压;合成后采用空间矢量调制(spacevector modulation,SVM)算法产生整流器电压,对功率进行补偿。该策略可有效抑制交流侧电流谐波,减小系统无功功率直流分量,稳定系统输出的有功功率,改善系统稳态性能。仿真与实验结果证明了该策略的正确性和有效性。展开更多
文摘Advanced biophysical wound healing therapies can apply mechanical, electrical, or light energy to re-stimulate healing processes in chronic wounds. Despite the growing evidence of the clinical efficacy of these therapies, the optimal treatment stimulation parameters remain unknown and there are no standard treatment protocols. We introduce a closed-loop control design as an experimental system to study the dose-response of wound healing therapy treatment within a prescribed multidimensional and multimodal stimulation parameter space. Systems engineering approaches are applied to the control problem for estimation of a transfer function and model equations derived for use in optimal model-based control. The experimental control system design consisted of simultaneous application of biophysical energies inputted into a wound system. A study design set up including the use of negative pressure wound therapy, electrical stimulation therapy, and photobiomodulation device systems was described. Treatment stimulation parameters were selected from experimental ranges used in the scientific literature. Classical control methods and model-based control were suggested for model selection and evaluation and design of the overall control system. An experimental design for multimodal biophysical wound healing therapy control system is introduced to establish the dose-response interactions for development of therapeutic applications and device design.
文摘恒频直接功率控制(constant switching frequency direct power control,CSF-DPC)具有开关频率固定、动态性能好、系统采样频率较低等优点。电网电压不平衡会在脉宽调制(pulse width modulation,PWM)型整流器交流侧产生大量谐波电流,使系统有功功率大幅波动,恶化系统性能。针对上述情况,提出一种新型恒频直接功率控制策略。该策略首先分离出电网电压和电流正、负序分量;然后在正、负序双旋转坐标系下计算瞬时功率与参考值之间的误差,根据误差生成整流器正、负序参考电压;合成后采用空间矢量调制(spacevector modulation,SVM)算法产生整流器电压,对功率进行补偿。该策略可有效抑制交流侧电流谐波,减小系统无功功率直流分量,稳定系统输出的有功功率,改善系统稳态性能。仿真与实验结果证明了该策略的正确性和有效性。