The post-cure kinetics of electron beam (EB) curing of epoxy resin initiated by diaryiodinium was investigated. The post-cure reaction fits first order reaction kinetics. The reaction rate constant increases with incr...The post-cure kinetics of electron beam (EB) curing of epoxy resin initiated by diaryiodinium was investigated. The post-cure reaction fits first order reaction kinetics. The reaction rate constant increases with increasing treatment temperature of post-cure. The reaction rate of post-cure is much lower than the rate of its reaction on electron beam treatment.展开更多
Elimination of visceral leishmaniasis is a priority programme in Indian subcontinent.The World Health Organization has set a new target to eliminate kala-azar by the year 2020 as previous target elimination year(2015)...Elimination of visceral leishmaniasis is a priority programme in Indian subcontinent.The World Health Organization has set a new target to eliminate kala-azar by the year 2020 as previous target elimination year(2015) has passed.The elimination programme has successfully curbed the rate of infection in endemic regions; however, there are still few challenges in its route.The current drug control regime is extremely limited and comprises only two(amphotericin B and miltefosine) drugs, which are also susceptible for parasites resistance.Moreover, these drugs do not produce sterile cure, and cured patients may develop post kala-azar dermal leishmaniasis even after a decade of cure leaving behind a potent source of parasitic reservoirs for further disease transmission.A significant proportion of endemic population remain seropositive but aymptomatic for many years without any clinical symptom that serve as latent parasitic reservoirs.The lack of tools to identify live parasites in asymptomatic infections and there association in disease transmission, parameters of sterile cure along with post kala-azar dermal leishmaniasis progression remain a major threat in its elimination.In this review, we discuss the potential of host immune inhibitory mechanisms to identify immune correlates of protective immunity to understand the mystery of asymptomatic infections, sterile cure and post kala azar dermal leishmaniasis.展开更多
基金This work was financially supported by the National Natural Science Foundation of China (No. 59833110).
文摘The post-cure kinetics of electron beam (EB) curing of epoxy resin initiated by diaryiodinium was investigated. The post-cure reaction fits first order reaction kinetics. The reaction rate constant increases with increasing treatment temperature of post-cure. The reaction rate of post-cure is much lower than the rate of its reaction on electron beam treatment.
基金A part of the grant received from Science and Engineering Research Board,Department of Science and Technology,New Delhi(SB/SO/HS/0091/2013) was utilized in this work
文摘Elimination of visceral leishmaniasis is a priority programme in Indian subcontinent.The World Health Organization has set a new target to eliminate kala-azar by the year 2020 as previous target elimination year(2015) has passed.The elimination programme has successfully curbed the rate of infection in endemic regions; however, there are still few challenges in its route.The current drug control regime is extremely limited and comprises only two(amphotericin B and miltefosine) drugs, which are also susceptible for parasites resistance.Moreover, these drugs do not produce sterile cure, and cured patients may develop post kala-azar dermal leishmaniasis even after a decade of cure leaving behind a potent source of parasitic reservoirs for further disease transmission.A significant proportion of endemic population remain seropositive but aymptomatic for many years without any clinical symptom that serve as latent parasitic reservoirs.The lack of tools to identify live parasites in asymptomatic infections and there association in disease transmission, parameters of sterile cure along with post kala-azar dermal leishmaniasis progression remain a major threat in its elimination.In this review, we discuss the potential of host immune inhibitory mechanisms to identify immune correlates of protective immunity to understand the mystery of asymptomatic infections, sterile cure and post kala azar dermal leishmaniasis.
