Objective： To observe the comprehensive curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain for post stroke depression associated with anxiety.Methods： Sixty-four patients ...Objective： To observe the comprehensive curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain for post stroke depression associated with anxiety.Methods： Sixty-four patients with post stroke depression associated with anxiety were randomly divided into 2 groups according to the random numbers generated by spss16.0 software, the group of acupuncture manipulation of regulating governor vessel and unblocking brain（group A） and medication group（group B）, with 32 patients in each group. Acupuncture manipulation of regulating governor vessel and unblocking brain was performed in group A.Bǎihuì（百会GV 20）, Shéntíng（神庭GV 24）, Yǎmén（哑门GV 15） and Dànzhōng（膻中CV 17）, Gānshū（肝俞BL 18）. Xīnshū（心俞BL 15）. Shènshū（肾俞BL 23）,Tàichōng（太冲LR 3）, Tàixī（太溪KI 3）, Shénmén（神门HT 7） and Nèiguān（内关PC 6） were selected. The treatment was conducted for once a day, and 5 times a week. Escitalopram oxalate tablets were given orally to the patients in group B for once a day. The treatment was conducted for 8 consecutive weeks in each group. The scores of Hamilton depression scale（HAMD）, Hamilton anxiety scale（HAMA）, Barthel index（BI） and Fugl-Meyer assessment（FMA） in the two groups before and after treatment were compared.Results： Comparison with the same group before treatment, HAMD score and HAMA sore in the two groups after treatment for 4 weeks and 8 weeks were all obviously lower than that in the same group before treatment（all P〈0.01）; after treatment for 8 weeks, B1 score and FMA score in the two groups were all significantly higher than that in the same group before treatment（all P〈0.01）. Comparison between two groups after treatment. HAMD score and HAMA sore in group A after treatment for 4 weeks were significantly lower than that in group B（both P〈0.05）; only the HAMA sore in group A after treatment for 8 weeks was lower than that in group B（P〈0.05）, and there was no significant difference in HAMD score in the two groups（P〉0.05）; after treatment for 8 weeks, FMA score in group A was obviously higher than that in group B（P〈0.05）, and there was no significant difference in BI score in the two groups（P〉 0.05）.Conclusion： The curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain on the anxiety state and motor function of the patients with post stroke depression is superior to that of escitalopram. With regard to the improvement of depression, this acupuncture manipulation was provided with the characteristic of rapid onset, and its long-term efficacy is equivalent to that of escitalopram. In terms of the improvement of activities of daily living, the curative effect of the two methods is equally well.展开更多
目的探讨脑卒中后抑郁-焦虑共病(post-stroke anxiety combined with depression,PSCAD)患者合用安神合剂与黛力新治疗对其神经功能缺损、负性心理及不良反应的影响。方法选取2019年8月—2021年5月医院收治PSCAD患者146例,随机数字表法...目的探讨脑卒中后抑郁-焦虑共病(post-stroke anxiety combined with depression,PSCAD)患者合用安神合剂与黛力新治疗对其神经功能缺损、负性心理及不良反应的影响。方法选取2019年8月—2021年5月医院收治PSCAD患者146例,随机数字表法分对照组及观察组,各73例。对照组予以黛力新治疗,观察组在对照组基础之上联用安神合剂;比较治疗前与治疗4周后两组中医证候相关积分,酶联免疫分析仪检测血清5-羟色胺(5-hydroxytryptamine,5-HT)、盐酸多巴胺(Dopamine hydrochloride,DA)以及去甲肾上腺素(Norepinephrine,NE)水平,美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评估神经功能缺损现象,选取特质焦虑分量表(Trait anxiety invento⁃ry,T-AI)、状态焦虑分量表(S-AI)和汉密尔顿抑郁量表与(Hamilton Depression Scale,HAMD)进行负性心理评估;比较两组治疗后不良反应的发生率。结果治疗后,观察组中医症候相关积分皆明显优于对照组(P<0.05);治疗后,观察组血清5-HT、DA及NE水平显著高于对照组,观察组NIHSS评分明显低于对照组(P<0.05);治疗后,观察组T-AI、S-AI和HAMD评分皆明显低于对照组(P<0.05)。观察组不良反应发生率低于对照组,但差异不存在统计学意义(P>0.05)。结论安神合剂与黛力新联用改善PSCAD患者神经功能缺损状况,有效调节负性心理,不增加不良反应发生率。展开更多
基金Supported by Project of Hebei Provincial Science and Technology Department:Clinical study of the acupuncture manipulation of regulating governor vessel andunblocking brain for treatment of dominant diseases of acupuncture-moxibustion":14277706D~~
文摘Objective： To observe the comprehensive curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain for post stroke depression associated with anxiety.Methods： Sixty-four patients with post stroke depression associated with anxiety were randomly divided into 2 groups according to the random numbers generated by spss16.0 software, the group of acupuncture manipulation of regulating governor vessel and unblocking brain（group A） and medication group（group B）, with 32 patients in each group. Acupuncture manipulation of regulating governor vessel and unblocking brain was performed in group A.Bǎihuì（百会GV 20）, Shéntíng（神庭GV 24）, Yǎmén（哑门GV 15） and Dànzhōng（膻中CV 17）, Gānshū（肝俞BL 18）. Xīnshū（心俞BL 15）. Shènshū（肾俞BL 23）,Tàichōng（太冲LR 3）, Tàixī（太溪KI 3）, Shénmén（神门HT 7） and Nèiguān（内关PC 6） were selected. The treatment was conducted for once a day, and 5 times a week. Escitalopram oxalate tablets were given orally to the patients in group B for once a day. The treatment was conducted for 8 consecutive weeks in each group. The scores of Hamilton depression scale（HAMD）, Hamilton anxiety scale（HAMA）, Barthel index（BI） and Fugl-Meyer assessment（FMA） in the two groups before and after treatment were compared.Results： Comparison with the same group before treatment, HAMD score and HAMA sore in the two groups after treatment for 4 weeks and 8 weeks were all obviously lower than that in the same group before treatment（all P〈0.01）; after treatment for 8 weeks, B1 score and FMA score in the two groups were all significantly higher than that in the same group before treatment（all P〈0.01）. Comparison between two groups after treatment. HAMD score and HAMA sore in group A after treatment for 4 weeks were significantly lower than that in group B（both P〈0.05）; only the HAMA sore in group A after treatment for 8 weeks was lower than that in group B（P〈0.05）, and there was no significant difference in HAMD score in the two groups（P〉0.05）; after treatment for 8 weeks, FMA score in group A was obviously higher than that in group B（P〈0.05）, and there was no significant difference in BI score in the two groups（P〉 0.05）.Conclusion： The curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain on the anxiety state and motor function of the patients with post stroke depression is superior to that of escitalopram. With regard to the improvement of depression, this acupuncture manipulation was provided with the characteristic of rapid onset, and its long-term efficacy is equivalent to that of escitalopram. In terms of the improvement of activities of daily living, the curative effect of the two methods is equally well.
文摘目的探讨脑卒中后抑郁-焦虑共病(post-stroke anxiety combined with depression,PSCAD)患者合用安神合剂与黛力新治疗对其神经功能缺损、负性心理及不良反应的影响。方法选取2019年8月—2021年5月医院收治PSCAD患者146例,随机数字表法分对照组及观察组,各73例。对照组予以黛力新治疗,观察组在对照组基础之上联用安神合剂;比较治疗前与治疗4周后两组中医证候相关积分,酶联免疫分析仪检测血清5-羟色胺(5-hydroxytryptamine,5-HT)、盐酸多巴胺(Dopamine hydrochloride,DA)以及去甲肾上腺素(Norepinephrine,NE)水平,美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评估神经功能缺损现象,选取特质焦虑分量表(Trait anxiety invento⁃ry,T-AI)、状态焦虑分量表(S-AI)和汉密尔顿抑郁量表与(Hamilton Depression Scale,HAMD)进行负性心理评估;比较两组治疗后不良反应的发生率。结果治疗后,观察组中医症候相关积分皆明显优于对照组(P<0.05);治疗后,观察组血清5-HT、DA及NE水平显著高于对照组,观察组NIHSS评分明显低于对照组(P<0.05);治疗后,观察组T-AI、S-AI和HAMD评分皆明显低于对照组(P<0.05)。观察组不良反应发生率低于对照组,但差异不存在统计学意义(P>0.05)。结论安神合剂与黛力新联用改善PSCAD患者神经功能缺损状况,有效调节负性心理,不增加不良反应发生率。
