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Identification and fine mapping of qSW2 for leaf slow wilting in soybean
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作者 Shengyou Li Changling Wang +5 位作者 Chunjuan Yan Xugang Sun Lijun Zhang Yongqiang Cao Wenbin Wang Shuhong Song 《The Crop Journal》 SCIE CSCD 2024年第1期244-251,共8页
Drought is one of the abiotic stresses limiting the production of soybean(Glycine max).Elucidation of the genetic and molecular basis of the slow-wilting(SW)trait of this crop offers the prospect of its genetic improv... Drought is one of the abiotic stresses limiting the production of soybean(Glycine max).Elucidation of the genetic and molecular basis of the slow-wilting(SW)trait of this crop offers the prospect of its genetic improvement.A panel of 188 accessions and a set of recombinant inbred lines produced from a cross between cultivars Liaodou 14 and Liaodou 21 were used to identify quantitative-trait loci(QTL)associated with SW.Plants were genotyped by Specific-locus amplified fragment sequencing and seedling leaf wilting was assessed under three water-stress treatments.A genome-wide association study identified 26 SW-associated single-nucleotide polymorphisms(SNPs),including three located in a 248-kb linkage-disequilibrium(LD)block on chromosome 2.Linkage mapping revealed a major-effect QTL,qSW2,associated with all three treatments and adjacent to the LD block.Fine mapping in a BC_(2)F_(3) population derived from a backcross between Liaodou 21 and R26 confined qSW2 to a 60-kb interval.Gene expression and sequence variation analysis identified the gene Glyma.02 g218100,encoding an auxin transcription factor,as a candidate gene for qSW2.Our results will contribute significantly to improving drought-resistant soybean cultivars by providing genetic information and resources. 展开更多
关键词 Drought GWAS Linkage mapping slow wilting Soybean(Glycine max)
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On the functions of astrocyte-mediated neuronal slow inward currents
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作者 Balázs Pál 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第12期2602-2612,共11页
Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of astrocytes.These events a... Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of astrocytes.These events are significantly slower than the excitatory postsynaptic currents.Parameters of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto rs.Astrocytes are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback loop.Mostly as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological conditions.There is a growing body of evidence on the roles of slow inward currents on a single neuron or local network level.These events often occur in synchro ny on neurons located in the same astrocytic domain.Besides synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic plasticity.In addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory inputs.Of note,there might be important regionspecific differences in the roles and actions triggering slow inward currents.In greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological ones.Slow inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural networks.Slow inward currents are significant contributors to paroxysmal depolarizational shifts/interictal spikes.These events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive functions.Events with features overlapping with slow inward currents(excitatory,N-methyl-Daspartate-receptor mediated currents with astrocytic contribution) as ischemic currents and spreading depolarization also have a well-known pathophysiological role in worsening consequences of stroke,traumatic brain injury,or epilepsy.One might assume that slow inward currents occurring with low frequency under physiological conditions might contribute to synaptic plasticity and memory formation.However,to state this,more experimental evidence from greater neuronal networks or the level of the individual is needed.In this review,I aimed to summarize findings on slow inward currents and to speculate on the potential functions of it. 展开更多
关键词 ASTROCYTE cortical spreading depolarization gliotransmission GLUTAMATE neural synchronization NMDA receptor paroxysmal depolarizational shift slow inward current
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基于改进Slow-Only网络的骨骼点动作识别方法研究 被引量:1
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作者 田青 冯赛楠 +3 位作者 魏运 豆飞 赵志强 张超 《工业控制计算机》 2023年第7期54-57,共4页
由于存在人体之间相互遮挡、受环境变化影响较大、时序特征提取能力较弱等问题,现有的动作识别方法在精准度方面仍有不足,因此,提出了一种基于改进Slow-Only网络的骨骼点动作识别方法。首先,将骨骼关键点数据进行预处理,分别在时间和空... 由于存在人体之间相互遮挡、受环境变化影响较大、时序特征提取能力较弱等问题,现有的动作识别方法在精准度方面仍有不足,因此,提出了一种基于改进Slow-Only网络的骨骼点动作识别方法。首先,将骨骼关键点数据进行预处理,分别在时间和空间维度减少冗余信息;其次,基于Slow-Only网络,重新设计了时间卷积模块,以更好地提取视频帧所包含的时序信息;最后,增加了改进的注意力机制模块,以降低遮挡问题带来的影响。在NTU RGB+D数据集上进行了实验,实验结果表明该方法能有效地提升检测精度,并且在实际场景中具有应用价值。 展开更多
关键词 骨骼关键点 slow-Only网络 动作识别 时序特征 通道注意力
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Tunable magnomechanically induced transparency and fast-slow light in a hybrid cavity magnomechanical system 被引量:1
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作者 廖庆洪 彭坤 邱海燕 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第5期442-448,共7页
We theoretically explore the tunability of magnomechanically induced transparency(MMIT) phenomenon and fastslow light effect in a hybrid cavity magnomechanical system in which a high-quality yttrium iron garnet(YIG) s... We theoretically explore the tunability of magnomechanically induced transparency(MMIT) phenomenon and fastslow light effect in a hybrid cavity magnomechanical system in which a high-quality yttrium iron garnet(YIG) sphere and an atomic ensemble are placed inside a microwave cavity. In the probe output spectrum, we can observe magnoninduced transparency(MIT) and MMIT due to the photon-magnon and phonon-magnon couplings. We further investigate the effect of atomic ensemble on the absorption spectrum. The results show that better transparency can be obtained by choosing appropriate atomic ensemble parameters. We give an explicit explanation for the mechanism of the Fano resonance phenomenon. Moreover, we discuss phenomena of slow-light propagation. The maximum group delay increases significantly with the increasing atom–cavity coupling strength, and the conversion between slow light and fast light can also be achieved by adjusting the atom–cavity coupling strength. These results may have potential applications for quantum information processing and high precision measurements. 展开更多
关键词 magnomechanical system atomic ensemble magnomechanically induced transparency fast and slow light
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Modeling of beam ions loss and slowing down with Coulomb collisions in EAST
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作者 郑艺峰 肖建元 +4 位作者 郝保龙 徐立清 王彦鹏 郑江山 庄革 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第7期389-403,共15页
This paper uses the implicit Monte–Carlo full-orbit-following parallel program ISSDE to calculate the prompt loss and slowing down process of neutral beam injection(NBI)-generated fast ions due to Coulomb collisions ... This paper uses the implicit Monte–Carlo full-orbit-following parallel program ISSDE to calculate the prompt loss and slowing down process of neutral beam injection(NBI)-generated fast ions due to Coulomb collisions in the equilibrium configuration of Experimental Advanced Superconducting Tokamak(EAST).This program is based on the weak equivalence of the Fokker–Planck equation under Rosenbluth Mac Donald Judd(RMJ)potential and Stratonovich stochastic differential equation(SDE).The prompt loss with the LCFS boundary and the first wall(FW)boundary of the two co-current neutral injection beams are studied.Simulation results indicate that the loss behavior of fast ions using the FW boundary is very different from that of the LCFS boundary,especially for fast ions with a large gyration radius.According to our calculations,about 5.11%of fast ions generated by perpendicular injection drift out of the LCFS and then return inside the LCFS to be captured by the magnetic field.The prompt loss ratio of fast ions and the ratio of orbital types depend on the initial distribution of fast ions in the Pζ–Λspace.Under the effect of Coulomb collisions,the pitch-angle scattering and stochastic diffusion happens,which will cause more fast ion loss.For short time scales,among the particles lost due to collisions,the fraction of banana ions reaches 92.31%in the perpendicular beam and 58.65%in the tangential beam when the fraction of banana ions in the tangential beam is 3.4%of the total ions,which means that the effect of Coulomb collisions on banana fast ions is more significant.For long time scales,the additional fast ion loss caused by Coulomb collisions of tangential and perpendicular beams accounted for 16.21%and 25.05%of the total particles,respectively.We have also investigated the slowing down process of NBI fast ions. 展开更多
关键词 NBI fast ion loss slowing down process EAST Coulomb collisions
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Impact of interstitial cells of Cajal on slow wave and gallbladder contractility in a guinea pig model of acute cholecystitis 被引量:1
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作者 Fan Ding Run Guo +5 位作者 Fang Chen Li-Ping Liu Zheng-Yu Cui Yi-Xing Wang Gang Zhao Hai Hu 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第6期1068-1079,共12页
BACKGROUND Impaired interstitial cells of Cajal(ICCs)are central to the pathophysiology of acute cholecystitis(AC).Common bile duct ligation is a common model of AC,producing acute inflammatory changes and decrease in... BACKGROUND Impaired interstitial cells of Cajal(ICCs)are central to the pathophysiology of acute cholecystitis(AC).Common bile duct ligation is a common model of AC,producing acute inflammatory changes and decrease in gallbladder contractility.AIM To investigate the origin of slow wave(SW)in the gallbladder and the effect of ICCs on gallbladder contractions during the process of AC.METHODS Methylene blue(MB)with light was used to establish selective impaired ICCs gallbladder tissue.Gallbladder motility was assessed using the frequency of SW and gallbladder muscle contractility in vitro in normal control(NC),AC12h,AC24h,and AC48h groups of guinea pigs.Hematoxylin and eosin and Massonstained gallbladder tissues were scored for inflammatory changes.ICCs pathological changes alterations were estimated using immunohistochemistry and transmission electron microscopy.The alterations of c-Kit,α-SMA,cholecystokinin A receptor(CCKAR),and connexin 43(CX43)were assessed using Western blot.RESULTS Impaired ICCs muscle strips resulted in the decrease in gallbladder SW frequency and contractility.The frequency of SW and gallbladder contractility were significantly lower in the AC12h group.Compared with the NC group,the density and ultrastructure of ICCs were remarkably impaired in the AC groups,especially in the AC12h group.The protein expression levels of c-Kit were significantly decreased in the AC12h group,while CCKAR and CX43 protein expression levels were significantly decreased in the AC48h group.CONCLUSION Loss ICCs could lead to a decrease in gallbladder SW frequency and contractility.The density and ultrastructure of ICCs were clearly impaired in the early stage of AC,while CCKAR and CX43 were significantly reduced at end stage. 展开更多
关键词 Interstitial cells of Cajal Acute cholecystitis slow wave GALLBLADDER CONTRACTILITY
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Empirical six-dimensional framework for slowing and reversing ageing using modern science and ancient wisdom
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作者 Asoka Nimal Jinadasa 《Life Research》 2019年第3期106-112,共7页
There are numerous published theories that cover the different biological processes relating to ageing. No one seems to have integrated such complex and seemingly unrelated information into a holistic framework that e... There are numerous published theories that cover the different biological processes relating to ageing. No one seems to have integrated such complex and seemingly unrelated information into a holistic framework that explains in simple terms the key aspects of ageing and provides a set of daily practices for staying young and healthy. An atiempt is made here to select a 6-dimensional framework symbolized by heart, mind, passion, focus, body and health, and correlate it to the mental, emotional, physical and health aspects of ageing. Based on grounded theory, this paper empirically correlates 30 practical methods that can be used to develop all six dimensions, with 18 key factors that were found to infl uence ageing: Neurogenesis;Epigenetic reprogramming;Removing dying cells;Mitochondria resuscitation;Calorie restriction;Plant-based diet;Regular physical activity;Chi Kung (Qigong);Overcoming anxiety, depression and stress;Positive mind-set;Some worrying;Vitamins and minerals;L-Theanine;Omega-3 and healthy fats;Coenzyme Q-10;Pyrroloquinoline quinone;Nitric oxide;Choline. In this study, 26 references were used to establish that all 18 of these seemingly unrelated key anti-ageing factors can be developed using 30 daily practices derived from the 6-dimensional framework. These simple daily prac-tices can help people of all ages to stay young and healthy, and help older people who are living alone to self-improve their quality of life without needing anyone to look atier them. Since many anti-ageing drugs seem to be ineffective, this study provides a holistic new research direction for using modern science and ancient human energy practices combined with wholesome nutrition to slow ageing and age-related illnesses. 展开更多
关键词 slowing ageing Reversing ageing AGE-RELATED illnesses Prolonging YOUTH Improving health Alzheimer's
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Exact solution of slow quench dynamics and nonadiabatic characterization of topological phases
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作者 邬睿 房盼攀 +1 位作者 孙辰 李福祥 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第8期171-180,共10页
Previous studies have shown that the bulk topology of single-particle systems can be captured by the band inversion surface or by the spin inversion surface emerging on the time-averaged spin polarization.Most of the ... Previous studies have shown that the bulk topology of single-particle systems can be captured by the band inversion surface or by the spin inversion surface emerging on the time-averaged spin polarization.Most of the studies,however,are based on the single-particle picture even though the systems are fermionic and multi-bands.Here,we study the slow quench dynamics of topological systems with all the valence bands fully occupied,and show that the concepts of band inversion surface and spin inversion surface are still valid.More importantly,the many-particle nonadiabatic quench dynamics is shown to be reduced to a new and nontrivial three-level Landau-Zener model.This nontrivial three-level Landau-Zener problem is then solved analytically by applying the integrability condition and symmetry considerations,and thus adds a new member to the few models that are exactly solvable.Based on the analytical results,the topological spin texture revealed by the time-averaged spin polarization can be applied to characterize the bulk topology and thus provides a direct comparison for future experiments. 展开更多
关键词 Landau-Zener slow quench NONADIABATIC
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Just How Much Is the Economy Slowing
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作者 Kathleen Madigan 赵忠德 《语言教育》 1999年第1期66-67,共2页
Is the American economy slowing or growing?WallStreet and Corporate America have different views.FederalReserve Chairman Alan Greespan told Congress that it looksas if the economy is slowing.As real retail sales。
关键词 Just How Much Is the Economy slowing
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Study on Critical Slowing Down Phenomenon before the Two Medium-strong Earthquakes in Xinjiang
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作者 Gao Lijuan Yang Youling +1 位作者 Liu Jianming Zhu Chengying 《Earthquake Research in China》 CSCD 2015年第3期394-403,共10页
We study the critical slowing down phenomenon in deformation and groundwater observations before the Nilka-Gongliu MS6. 0 earthquake on November 1, 2011 and Xinyuan-Hejing M S6. 6 earthquake on June 30,2012. Firstly,w... We study the critical slowing down phenomenon in deformation and groundwater observations before the Nilka-Gongliu MS6. 0 earthquake on November 1, 2011 and Xinyuan-Hejing M S6. 6 earthquake on June 30,2012. Firstly,we remove the annual variation and tendency change of basic data by means of wavelet transform analysis.Secondly,we calculate the autocorrelation coefficients and variance of the critical slowing down phenomenon. Lastly,we try to verify the critical slowing down phenomenon before an earthquake. The result indicates that there was obvious critical slowing down of the records at different stations before earthquakes. 展开更多
关键词 临界速度 减速 强震前 新疆 小波变换分析 地下水观测 地震前 慢化现象
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Evaluation and Improvement Strategies for Slow Traffic Systems Based on Multi-source Big Data:A Case Study of Shijingshan District of Beijing City
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作者 LI Yiwen 《Journal of Landscape Research》 2023年第4期62-64,68,共4页
The slow traffic system is an important component of urban transportation,and the prerequisite and necessary condition for Beijing to continue promoting“green priority”are establishing a good urban slow traffic syst... The slow traffic system is an important component of urban transportation,and the prerequisite and necessary condition for Beijing to continue promoting“green priority”are establishing a good urban slow traffic system.Shijingshan District of Beijing City is taken as a research object.By analyzing and processing population distribution data,POI data,and shared bicycle data,the shortcomings and deficiencies of the current slow traffic system in Shijingshan District are explored,and corresponding solutions are proposed,in order to provide new ideas and methods for future urban planning from the perspective of data. 展开更多
关键词 Multi-source data slow traffic system Shijingshan District
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Effects of a Combination of Fu Zi and Rou Gui on Intestinal Neurotransmitters and Microflora in Rats with Slow Transit Constipation
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作者 Yuchuan LI Yuanzhe ZHANG 《Agricultural Biotechnology》 CAS 2023年第3期79-86,91,共9页
[Objectives] This study was carried out to explore the combined effects of Fu Zi(Radix Aconiti Lateralis Praeparata, the secondary root of perennial herbaceous plant Acontium carmichaeli Dehx. of family Ranunculaceae)... [Objectives] This study was carried out to explore the combined effects of Fu Zi(Radix Aconiti Lateralis Praeparata, the secondary root of perennial herbaceous plant Acontium carmichaeli Dehx. of family Ranunculaceae) and Rou Gui(Cortex Cinnamomi, the bark of Cinnamamunz cassia Presl of family Lauraceae) on intestinal neurotransmitters and microflora in rats with slow transit constipation(STC). [Methods] Experimental rats were given loperamide hydrochloride by gavage to induce STC, and then treated with Fu Zi alone, Rou Gui alone, a combination of Fu Zi and Rou Gui(2:1 w/w), and prucalopride, respectively, for 14 days. Meanwhile, the general condition, the time to first black stool and the rate of intestinal propulsion of rats in each group were observed after STC was induced and after drug treatment, and the pathological changes in rat colon were observed via hematoxylin-eosin(HE) staining, and the levels of colonic 5-hydroxytryptamine(HT), vasoactive intestinal peptide(VIP) and substance P(SP) were detected by ELISA, and the changes in intestinal flora were detected by 16S rRNA Real-time PCR. [Results] Compared with healthy rats, the time to first black stool and the rate of intestinal propulsion, colonic 5-HT and SP levels significantly decreased(p<0.01), while their colonic VIP level significantly increased(p<0.01). Compared with STC rats, the time to first black stool, the rate of intestinal propulsion, colonic 5-HT and SP levels in Fu Zi-Rou Gui(2:1) treated rats and prucalopride treated rats significantly increased(p<0.01), while their colonic VIP level significantly decreased(p<0.01). There was no significant difference in alpha diversity between healthy rats and STC rats. However, analysis on beta diversity revealed that there were differences in microflora structure and composition between them. Compared with healthy rats, the relative abundance of Firmicutes and Proteobacteria in STC rats significantly increased, while that of Bacteroidetes decreased. Compared with STC rats, the relative abundance of Proteobacteria decreased and that of Bacteroidetes and Firmicutes increased in Fu Zi-Rou Gui(2:1) treated rats;the relative abundance of Bacteroidetes and Proteobacteria decreased while that of Firmicutes increased in Fu Zi treated rats;the relative abundance of Proteobacteria decreased while that of Bacteroidetes increased in Rou Gui treated rats;the relative abundance of Firmicutes and Proteobacteria decreased while that of Bacteroidetes increased in prucalopride treated rats. The intestinal flora in rats of all groups was dominated by Lactobacillus spp. and other genera of anaerobic bacteria. Compared with healthy rats, the relative abundance of Lactobacillus spp. and Clostridium spp. in STC rats decreased, while those of Blautia spp. and Ruminococcus spp. and Allobaculum spp. increased. Compared with STC rats, the relative abundance of Lactobacillus spp. in all rats treated with drugs increased. [Conclusions] The combination of Fu Zi and Rou Gui(2:1) can effectively improve intestinal motility in STC rats by regulating intestinal microbial community and the levels of colonic neurotransmitters. 展开更多
关键词 slow transit constipation(STC) Fu Zi-Rou Gui Intestinal motility NEUROTRANSMITTERS Intestinal microflora
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Evaluation of Recreation Service Quality of Slow Traffic Space in Urban Parks Based on IPA-Space Syntax Model
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作者 ZHOU Xi CHU Zuoyong JI Xiang 《Journal of Landscape Research》 2023年第4期21-30,共10页
To build an“ecological and livable city”,it is important to figure out the relationship between human activity and urban park space and create a high-quality urban park through the integration of“people”and“park... To build an“ecological and livable city”,it is important to figure out the relationship between human activity and urban park space and create a high-quality urban park through the integration of“people”and“park”.Taking Longhu Park in Huainan Province as an example,the study quantitatively analyzed and evaluated the characteristics and service quality of slow traffic space using importance-performance analysis(IPA)and space syntax,clarified the key indexes and areas to be optimized,and put forward corresponding design countermeasures and suggestions in combination with human activity demand.The results suggest that:①The mean performance of park recreation service quality is 3.63,less than the mean importance(3.95).Tourists pay special attention to the safety and convenience of slow traffic space,and the diversity and identiability of site functions is the focus“to be improved”.②The accessibility of Longhu Park shows a strong irregular shape in the southwest.The dead-end roads in the far lake area and the flora and fauna area on the northwest side have weak spatial perception,and the composite function carrying potential of slow traffic space is better reflected in a small range.Therefore,an optimization strategy for slow traffic space is proposed to enhance the continuity of road network,site identifiability,and functional diversification.The results will provide new thoughts of governance based on spatial humanism for the high-quality renewal of urban parks in the new era. 展开更多
关键词 IPA analysis Space syntax Urban park slow traffic space Recreation service quality
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Serum neuronal pentraxin 2 is related to cognitive dysfunction and electroencephalogram slow wave/fast wave frequency ratio in epilepsy
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作者 Xiao-Fen Huang Ming-Xia Xu +3 位作者 Yue-Fan Chen Yun-Qing Lin Yuan-Xiang Lin Feng Wang 《World Journal of Psychiatry》 SCIE 2023年第10期714-723,共10页
BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentrax... BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentraxin 2(NPTX2)is thought to play a vital role in neurotransmission and the maintenance of synaptic plasticity.This study explored how serum NPTX2 and electroencephalogram(EEG)slow wave/fast wave frequency ratio relate to cognitive dysfunction in patients with epilepsy.AIM To determine if serum NPTX2 could serve as a potential biomarker for diagnosing cognitive impairment in epilepsy patients.METHODS The participants of this study,conducted from January 2020 to December 2021,comprised 74 epilepsy patients with normal cognitive function(normal group),37 epilepsy patients with cognitive dysfunction[epilepsy patients with cognitive dysfunction(ECD)group]and 30 healthy people(control group).The minimental state examination(MMSE)scale was used to evaluate cognitive function.We determined serum NPTX2 levels using an enzyme-linked immunosorbent kit and calculated the signal value of EEG regions according to the EEG recording.Pearson correlation coefficient was used to analyze the correlation between serum NPTX2 and the MMSE score.RESULTS The serum NPTX2 level in the control group,normal group and ECD group were 240.00±35.06 pg/mL,235.80±38.01 pg/mL and 193.80±42.72 pg/mL,respectively.The MMSE score was lowest in the ECD group among the three,while no significant difference was observed between the control and normal groups.In epilepsy patients with cognitive dysfunction,NPTX2 level had a positive correlation with the MMSE score(r=0.367,P=0.0253)and a negative correlation with epilepsy duration(r=−0.443,P=0.0061)and the EEG slow wave/fast wave frequency ratio value in the temporal region(r=−0.339,P=0.039).CONCLUSION Serum NPTX2 was found to be related to cognitive dysfunction and the EEG slow wave/fast wave frequency ratio in patients with epilepsy.It is thus a potential biomarker for the diagnosis of cognitive impairment in patients with epilepsy. 展开更多
关键词 Serum neuronal pentraxin 2 Cognitive dysfunction EPILEPSY Electroencephalogram slow wave/fast wave frequency ratio Biomarker
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Cinnamic acid regulates the intestinal microbiome and short-chain fatty acids to treat slow transit constipation
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作者 Jin-Guang Jiang Qian Luo +4 位作者 Shuang-Shuang Li Tian-Ying Tan Kai Xiong Tao Yang Tian-Bao Xiao 《World Journal of Gastrointestinal Pharmacology and Therapeutics》 2023年第2期4-21,共18页
BACKGROUND Slow transit constipation(STC)is a disorder with delayed colonic transit.Cinnamic acid(CA)is an organic acid in natural plants,such as Radix Scrophulariae(Xuan Shen),with low toxicity and biological activit... BACKGROUND Slow transit constipation(STC)is a disorder with delayed colonic transit.Cinnamic acid(CA)is an organic acid in natural plants,such as Radix Scrophulariae(Xuan Shen),with low toxicity and biological activities to modulate the intestinal microbiome.AIM To explore the potential effects of CA on the intestinal microbiome and the primary endogenous metabolites-short-chain fatty acids(SCFAs)and evaluate the therapeutic effects of CA in STC.METHODS Loperamide was applied to induce STC in mice.The treatment effects of CA on STC mice were assessed from the 24 h defecations,fecal moisture and intestinal transit rate.The enteric neurotransmitters:5-hydroxytryptamine(5-HT)and vasoactive intestinal peptide(VIP)were determined by the enzyme-linked immunosorbent assay.Hematoxylin-eosin and Alcian blue and Periodic acid Schiff staining were used to evaluate intestinal mucosa's histopathological performance and secretory function.16S rDNA was employed to analyze the composition and abundance of the intestinal microbiome.The SCFAs in stool samples were quantitatively detected by gas chromatography-mass spectrometry.RESULTS CA ameliorated the symptoms of STC and treated STC effectively.CA ameliorated the infiltration of neutrophils and lymphocytes,increased the number of goblet cells and acidic mucus secretion of the mucosa.In addition,CA significantly increased the concentration of 5-HT and reduced VIP.CA significantly improved the diversity and abundance of the beneficial microbiome.Furthermore,the production of SCFAs[including acetic acid(AA),butyric acid(BA),propionic acid(PA)and valeric acid(VA)]was significantly promoted by CA.The changed abundance of Firmicutes,Akkermansia,Lachnoclostridium,Monoglobus,UCG.005,Paenalcaligenes,Psychrobacter and Acinetobacter were involved in the production of AA,BA,PA and VA.CONCLUSION CA could treat STC effectively by ameliorating the composition and abundance of the intestinal microbiome to regulate the production of SCFAs. 展开更多
关键词 slow transit constipation Cinnamic acid Intestinal microbiome Short-chain fatty acids Intestinal motility
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Intramuscular vaccine administrations including the adoption of"Zeta-track technique"&"without aspiration slow injection technique"(ZTT&WASiT):a prospective review
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作者 Elena Sblendorio 《Frontiers of Nursing》 2023年第1期21-42,共22页
Objective:To review the current literature on the practice of intramuscular injections(IMIs),focusing on immunizations.Methods:The present study comprises 2 reviews,characterized by high-quality evidence,per taining t... Objective:To review the current literature on the practice of intramuscular injections(IMIs),focusing on immunizations.Methods:The present study comprises 2 reviews,characterized by high-quality evidence,per taining to the deployment of the slow injection technique without aspiration(referred to in this paper as the without-aspiration slow injection technique[WASi T])and combined with the Zeta-track technique(ZTT).The literature review is oriented toward the analysis of 2 features associated with IMIs techniques:safety and pain,integrating new evidence on vaccinee positioning for each muscle site and general relaxation techniques in the multi-parametric analysis.Results:The rigorous and in-depth reviews in the current study reveal the usefulness of including,among the international guidelines for via intramuscular immunizations,the adoption of WASi T only for compliant vaccinees,and in combination with all validated techniques for IMIs,and the use of ZTT limitedly if specific well-developed muscles are indicated.All the technique's limitations are exposed.Conclusions:Future research directions are presented by including the author's study designs to provide indirect evidence for the validity of the rationale of the slow injection technique using scientific methods,and for the conduction of future randomized controlled trials(RCTs)focused on revisiting the adoption of ZTT in a dynamic and integrated immunizations protocol in anterolateral thigh(ALT),ventrogluteal(VG),and also in the deltoid muscle,in the specific cases analyzed. 展开更多
关键词 local reactogenicity injection site reactions injection technique safety intramuscular injections immunogenicity vaccinal solution leakage without-aspiration slow technique Zeta-track technique
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A review on slow transit constipation
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作者 Shuang Yu Min Cao +6 位作者 Hai-Chao Liu Lu-Lu Xie Yu-Tong Jin Ji-Da Wang Lu Han Yi-Yang Wang Yu-Hong Bian 《Clinical Research Communications》 2023年第1期25-31,共7页
Slow transit constipation(STC),one of the most common chronic constipation in the clinic,is characterized by prolonged colonic transit time.Pathogenesis is unclear,and abnormalities can be found in enteric nervous sys... Slow transit constipation(STC),one of the most common chronic constipation in the clinic,is characterized by prolonged colonic transit time.Pathogenesis is unclear,and abnormalities can be found in enteric nervous system,intestinal neurotransmitters,intestinal smooth muscle,and Cajal stromal cell.Various methods have been used to improve the quality of life of patients with STC,including dietary fiber supplements,various cathartics,prokinetic drugs,and surgical intervention.However,there are still a large number of patients showing poor response to conservative treatment and intolerance to surgical treatment.Patients with STC suffer from severe constipation for long periods of time,faced with heavy economic burden and mental torture.Exploration the pathogenesis of STC to provide a clearer direction for future drug development is needed. 展开更多
关键词 slow transit constipation TREATMENT PATHOGENESIS traditional medicine
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The efficacy and mechanism of fecal microflora transplantation in the treatment of slow transit constipation based on metabonomics anion mode
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作者 Lu Han Chen Xu +8 位作者 Hai-Zhao Liu Yi-Yang Wang Lu-Lu Xie Yu-Wei Li Yu-Tong Jin Jia-Tong Liu Ji-Da Wang Joseph Kofi Abankwah Yu-Hong Bian 《Microenvironment & Microecology Research》 2023年第3期1-9,共9页
Background:Fecal microbiota transplantation(FMT)based on the positive ion mode of metabonomics has a good therapeutic benefit for slow transit constipation(STC)patients.However,a piece of comprehensive metabolomics in... Background:Fecal microbiota transplantation(FMT)based on the positive ion mode of metabonomics has a good therapeutic benefit for slow transit constipation(STC)patients.However,a piece of comprehensive metabolomics information is yet to be established.The aim of the study was to explore the efficacy and mechanism of FMT in the treatment of STC under metabonomics.Methods:Eight STC patients meeting the set inclusion and exclusion criteria were enrolled and treated with FMT(three times).The Patient Assessment of Constipation-Symptoms(PAC-SYM),weekly total defecation times,and defecation frequency scores of these STC patients were compared before and after treatment.Feces and serum of STC patients before and after treatment were analyzed using 16SrDNA and metabolomics.Results:After FMT treatment,the PAC-SYM score of constipated patients decreased[(5.00±2.94)vs(5.20±2.87)],while the number of complete defecations per week increased[(2.00±1.79)vs(1.69±1.80)].The score of defecation frequency decreased[(0.83±1.03)vs(0.86±0.95)].The metabolites in the feces and serum of patients receiving FMT changed significantly(P<0.05).The results from 16SrDNA analysis showed that theαandβdiversity of the fecal microbiome changed significantly(P<0.05)after transplantation,and the contents of genera Lactobacillus,Bacillus,Succiniclasticum,Cellvibrio,and Escherichia increased in FMT treated patients.Conclusion:FMT may treat STC by increasing the beneficial intestinal flora and metabolites in the anion mode of metabolomics. 展开更多
关键词 Fecal microbiota transplantation slow transit constipation metabolomics anion mode LACTOBACILLUS
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一种针对“低慢小”目标的栅格化感知系统设计
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作者 孙智勇 陈建军 +1 位作者 李森 肖军 《空军工程大学学报》 CSCD 北大核心 2024年第2期95-99,109,共6页
针对“低慢小”目标探测面临的问题,提出了一种栅格化理念解决问题思路,给出了栅格化感知系统的定义,设计了栅格化感知系统,包括传感器分系统、通信分系统、管理控制中心和综合保障分系统等组成和工作过程。分析了栅格化感知系统的关键... 针对“低慢小”目标探测面临的问题,提出了一种栅格化理念解决问题思路,给出了栅格化感知系统的定义,设计了栅格化感知系统,包括传感器分系统、通信分系统、管理控制中心和综合保障分系统等组成和工作过程。分析了栅格化感知系统的关键技术,包括传感器低成本设计、“低慢小”目标检测、数据融合处理等技术。研究了栅格化感知系统的部署原则,建立部署原则模型,对于解决“低慢小”目标探测具有现实指导意义。 展开更多
关键词 低慢小 栅格化 航空器 感知系统
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考虑激励幅值慢变的卷绕头转子系统动力学建模
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作者 王东强 史卫士 +2 位作者 于贺春 董学武 姜海芹 《重庆理工大学学报(自然科学)》 CAS 北大核心 2024年第3期230-239,共10页
卷绕头转子系统结构之间的耦合振动和时频变激励使振动问题十分复杂,为了更准确地研究其动力学特性,根据转子动力学理论,使用有限元方法建立了考虑多盘质量慢变的卷绕头非线性转子系统整机动力学模型,运用Newmark-β数值积分方法对其动... 卷绕头转子系统结构之间的耦合振动和时频变激励使振动问题十分复杂,为了更准确地研究其动力学特性,根据转子动力学理论,使用有限元方法建立了考虑多盘质量慢变的卷绕头非线性转子系统整机动力学模型,运用Newmark-β数值积分方法对其动力学特性求解,得到仅存在初始不平衡量以及卷装不良带来的激励频率、幅值慢变下的非线性动力学行为。通过分析轴心轨迹、时域波形和幅频特性曲线等结果,发现卷绕头转子系统对因卷装不良引起的激励幅值慢变较为敏感,出现新的频率成分。进一步对比分析了不同节点处的振动频谱,其结果可为卷绕头转子系统动力学设计和故障识别提供一定理论支持。 展开更多
关键词 卷绕头转子系统 质量慢变 时频分析 有限元模型 激励幅值慢变 动力学特性
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