Introduction: Human malaria infection remains a problem of public health importance in many regions of the world. The infection continues to spread particularly in sub-Saharan Africa. In Nigeria, malaria and its treat...Introduction: Human malaria infection remains a problem of public health importance in many regions of the world. The infection continues to spread particularly in sub-Saharan Africa. In Nigeria, malaria and its treatment have been affected by factors like wrong diagnosis, wrong attitude of the people, unavailability of drugs, fake and substandard drugs, attitude and practices of medical and paramedical personnel. Nigeria’s national standard for malaria treatment was recently changed to artemisinin combination therapy. Methods: A descriptive study using a structured questionnaire was administered to all doctors (123) practicing in the three Army hospitals in Lagos. The study was done between March, 2009 and April, 2009. The findings were precoded;data entry and analysis was done using EPI INFO version 3.5.1 statistical software. Results: Presumptive/clinical diagnosis was still a common practice for diagnosing malaria among doctors, as well as the use of microscopy. None of the doctors had the facility for diagnosing malaria with rapid diagnostic test in their hospitals. Fifty one percent of the doctors stated that they utilized the current National antimalarial treatment guidelines. Significant proportion of the doctors used Artemisinin-based Combination Therapy (ACTs) as first line treatment of uncomplicated malaria in adults and children. Chloroquine was the commonest drug for first line treatment of uncomplicated malaria in pregnancy. Only 45.5% of the doctors had correct knowledge of Intermittent Preventive Treatment in pregnancy (IPTp), while 33.3% knew the stage of pregnancy in which a pregnant woman should receive IPTp with sulphadoxine-pyrimethamine. Awareness and the content of knowledge of the current National antimalarial treatment guideline were not affected by the category or current position of the doctors. Thirteen percent of the respondents had attended training/update workshop organized by the Federal Ministry of Health (FMOH) Roll Back Malaria programme on the current National antimalarial treatment guideline. Conclusion: The study showed that there is need to improve use of recommended antimalarial medicines for all categories of patients by doctors in Army Hospitals in Lagos. More effort should be made by the Federal Ministry of Health and other stakeholders to organize training and refresher courses on the current National antimalarial treatment guidelines for all categories of health care providers.展开更多
Taking cadmium pollution in X River as an example, the interaction between National People＇s Congress and local government was de- scribed. How the local government transforms its role in environment protection with ...Taking cadmium pollution in X River as an example, the interaction between National People＇s Congress and local government was de- scribed. How the local government transforms its role in environment protection with the help of several deputies to National People＇s Congress was expounded from the angle of social construction, which also enlightened the way to build an environment protection road with Chinese characteristics.展开更多
Rarely,scientific developments centered around the patient as a whole arepublished.Our multidisciplinary group,headed by gastrointestinal surgeons,applied this research philosophy considering the most important aspect...Rarely,scientific developments centered around the patient as a whole arepublished.Our multidisciplinary group,headed by gastrointestinal surgeons,applied this research philosophy considering the most important aspects of thediseases“colon-and rectal cancer”in the long-term developments.Good expertcooperation/knowledge at the Comprehensive Cancer Center Ulm(CCCU)wereapplied in several phase III trials for multimodal treatments of primary tumors(MMT)and metastatic diseases(involving nearly 2000 patients and 64 centers),fortreatment individualization of MMT and of metastatic disease,for psychooncology/quality of life involving the patients’wishes,and for disease prevention.Most of the targets initially were heavily rejected/discussed in thescientific communities,but now have become standards in treatments andnational guidelines or are topics in modern translational research protocolsinvolving molecular biology for e.g.,“patient centered individualized treatment”.In this context we also describe the paths we had to tread in order to realize ournew goals,which at the end were highly beneficial for the patients from manypoints of view.This description is also important for students and youngresearchers who,with an actual view on our recent developments,might want toknow how medical progress was achieved.展开更多
目的探讨美国国立卫生研究院卒中量表(NIHSS)评分<6分的合并大血管闭塞的急性缺血性卒中(AIS-LVO)患者行血管内治疗(EVT)的预后影响因素。方法回顾性选取2021年1月至2023年1月在浙江省台州医院接受EVT的42例NIHSS评分<6分的AIS-LV...目的探讨美国国立卫生研究院卒中量表(NIHSS)评分<6分的合并大血管闭塞的急性缺血性卒中(AIS-LVO)患者行血管内治疗(EVT)的预后影响因素。方法回顾性选取2021年1月至2023年1月在浙江省台州医院接受EVT的42例NIHSS评分<6分的AIS-LVO患者为研究对象。根据术后90 d改良Rankin量表(mRS)评分评估患者预后,比较预后良好组与预后不良组患者的临床资料,采用多因素logistic回归分析预后影响因素。结果所有患者均成功实现血管再通(100.0%),术中均未发生血栓逃逸、血管损伤、夹层、出血事件;术后发生24 h症状性颅内出血1例(2.4%),恶性脑水肿1例(2.4%)。随访90 d mRS评分显示预后良好33例,预后不良9例(未发生死亡病例)。预后良好组与预后不良组在年龄、术前舒张压、穿刺至再灌注时间等方面比较,差异均有统计学意义(均P<0.05)。穿刺至再灌注时间是影响NIHSS评分<6分的AIS-LVO患者行EVT预后的独立危险因素(OR=1.026,P=0.029)。结论NIHSS评分<6分的AIS-LVO患者行EVT可能是安全有效的,缩短穿刺至再灌注时间可能改善患者预后。展开更多
文摘Introduction: Human malaria infection remains a problem of public health importance in many regions of the world. The infection continues to spread particularly in sub-Saharan Africa. In Nigeria, malaria and its treatment have been affected by factors like wrong diagnosis, wrong attitude of the people, unavailability of drugs, fake and substandard drugs, attitude and practices of medical and paramedical personnel. Nigeria’s national standard for malaria treatment was recently changed to artemisinin combination therapy. Methods: A descriptive study using a structured questionnaire was administered to all doctors (123) practicing in the three Army hospitals in Lagos. The study was done between March, 2009 and April, 2009. The findings were precoded;data entry and analysis was done using EPI INFO version 3.5.1 statistical software. Results: Presumptive/clinical diagnosis was still a common practice for diagnosing malaria among doctors, as well as the use of microscopy. None of the doctors had the facility for diagnosing malaria with rapid diagnostic test in their hospitals. Fifty one percent of the doctors stated that they utilized the current National antimalarial treatment guidelines. Significant proportion of the doctors used Artemisinin-based Combination Therapy (ACTs) as first line treatment of uncomplicated malaria in adults and children. Chloroquine was the commonest drug for first line treatment of uncomplicated malaria in pregnancy. Only 45.5% of the doctors had correct knowledge of Intermittent Preventive Treatment in pregnancy (IPTp), while 33.3% knew the stage of pregnancy in which a pregnant woman should receive IPTp with sulphadoxine-pyrimethamine. Awareness and the content of knowledge of the current National antimalarial treatment guideline were not affected by the category or current position of the doctors. Thirteen percent of the respondents had attended training/update workshop organized by the Federal Ministry of Health (FMOH) Roll Back Malaria programme on the current National antimalarial treatment guideline. Conclusion: The study showed that there is need to improve use of recommended antimalarial medicines for all categories of patients by doctors in Army Hospitals in Lagos. More effort should be made by the Federal Ministry of Health and other stakeholders to organize training and refresher courses on the current National antimalarial treatment guidelines for all categories of health care providers.
基金Supported by Particular Fund for Scientific Research in Universities
文摘Taking cadmium pollution in X River as an example, the interaction between National People＇s Congress and local government was de- scribed. How the local government transforms its role in environment protection with the help of several deputies to National People＇s Congress was expounded from the angle of social construction, which also enlightened the way to build an environment protection road with Chinese characteristics.
文摘Rarely,scientific developments centered around the patient as a whole arepublished.Our multidisciplinary group,headed by gastrointestinal surgeons,applied this research philosophy considering the most important aspects of thediseases“colon-and rectal cancer”in the long-term developments.Good expertcooperation/knowledge at the Comprehensive Cancer Center Ulm(CCCU)wereapplied in several phase III trials for multimodal treatments of primary tumors(MMT)and metastatic diseases(involving nearly 2000 patients and 64 centers),fortreatment individualization of MMT and of metastatic disease,for psychooncology/quality of life involving the patients’wishes,and for disease prevention.Most of the targets initially were heavily rejected/discussed in thescientific communities,but now have become standards in treatments andnational guidelines or are topics in modern translational research protocolsinvolving molecular biology for e.g.,“patient centered individualized treatment”.In this context we also describe the paths we had to tread in order to realize ournew goals,which at the end were highly beneficial for the patients from manypoints of view.This description is also important for students and youngresearchers who,with an actual view on our recent developments,might want toknow how medical progress was achieved.
文摘目的探讨美国国立卫生研究院卒中量表(NIHSS)评分<6分的合并大血管闭塞的急性缺血性卒中(AIS-LVO)患者行血管内治疗(EVT)的预后影响因素。方法回顾性选取2021年1月至2023年1月在浙江省台州医院接受EVT的42例NIHSS评分<6分的AIS-LVO患者为研究对象。根据术后90 d改良Rankin量表(mRS)评分评估患者预后,比较预后良好组与预后不良组患者的临床资料,采用多因素logistic回归分析预后影响因素。结果所有患者均成功实现血管再通(100.0%),术中均未发生血栓逃逸、血管损伤、夹层、出血事件;术后发生24 h症状性颅内出血1例(2.4%),恶性脑水肿1例(2.4%)。随访90 d mRS评分显示预后良好33例,预后不良9例(未发生死亡病例)。预后良好组与预后不良组在年龄、术前舒张压、穿刺至再灌注时间等方面比较,差异均有统计学意义(均P<0.05)。穿刺至再灌注时间是影响NIHSS评分<6分的AIS-LVO患者行EVT预后的独立危险因素(OR=1.026,P=0.029)。结论NIHSS评分<6分的AIS-LVO患者行EVT可能是安全有效的,缩短穿刺至再灌注时间可能改善患者预后。
