Objective: The aim of this study is to determine the role of preoperative low dose intravenous MgSO4 when given adjuvant to ultrasound guided transversus abdominis plane (TAP) block in augmenting postcesarean analgesi...Objective: The aim of this study is to determine the role of preoperative low dose intravenous MgSO4 when given adjuvant to ultrasound guided transversus abdominis plane (TAP) block in augmenting postcesarean analgesic effects and reducing opioid requirements during the first 24 hours. Subjects and Methods: In this prospective, randomized double blind study, a total of sixty full term pregnant women were recruited for the study underwent caesarean section. Thirty patients were assigned to MgSO4 group (A) and another thirty to placebo group (B). Participants in group (A) received 50 mg/kg MgSO4 in 100 ml isotonic saline intravenous (IV) over 20 minutes prior to induction of general anesthesia by 30 minutes while participants in group (B) received 100 ml isotonic saline (placebo) by the same route and over the same duration as control. Results: Visual Analogue Scale (VAS) was analysed within 24 hours postoperatively. The mean pain score at 6 and 12 hours postoperatively was significantly lower in MgSO4 group compared to control group (40.4 ± 5.12 vs 53.6 ± 4.92;26.1 ± 3.01 vs 35.5 ± 3.98 respectively, p = 0.012, 0.005). Comparing both groups regarding the mean time interval of first rescue analgesia (morphine sulphate) requested by the patients, it was longer in MgSO4 group compared to control group. The total dose of rescue analgesia consumed during 24 hours was analysed and it was significantly higher in control group compared to MgSO4 group (10.1 ± 0.95 vs 6.2 ± 0.87, p = 0.001). Conclusion: We concluded that preoperative low doses (50 mg/Kg) of MgSO4 with general anesthesia combined with ultrasound guided TAP block offer longer postoperative pain free periods thus reducing total opioid consumption. In addition to the safety of the drug to the mother and fetus so we recommend IV MgSO4 as an adjuvant therapy with TAP block.展开更多
目的:观察四磨汤对剖宫产术后患者胃肠功能恢复及应激反应的影响。方法:选取2012年6月—2014年5月本院行剖宫产患者180例,随机分成试验组和对照组各90例。两组患者术后胃肠功能恢复之前均进行全流食,补液,保证水电解质及酸碱平衡,试验...目的:观察四磨汤对剖宫产术后患者胃肠功能恢复及应激反应的影响。方法:选取2012年6月—2014年5月本院行剖宫产患者180例,随机分成试验组和对照组各90例。两组患者术后胃肠功能恢复之前均进行全流食,补液,保证水电解质及酸碱平衡,试验组在此基础上术后6h给予四磨汤口服液,每天3次,每次用量20 m L直至胃肠功能正常肛门排气。比较两组患者胃肠恢复时间、肛门排气时间和有无腹胀等,测量所有患者手术前后的皮质醇水平。结果:试验组肠鸣音恢复时间明显少于对照组,肛门排气时间试验组小于对照组(P<0.05);两组患者术后腹胀情况比较,试验组发生率为15.6%,对照组发生率为54.4%,两组差异明显,具有统计学意义(P<0.05);术后药物干预后试验组患者的皮质醇水平明显低于对照组,差异有统计学意义(P<0.05)。结论:四磨汤有效增强了患者剖宫产术后胃肠功能恢复,降低术后腹胀几率,减轻应激反应,疗效显著。展开更多
文摘Objective: The aim of this study is to determine the role of preoperative low dose intravenous MgSO4 when given adjuvant to ultrasound guided transversus abdominis plane (TAP) block in augmenting postcesarean analgesic effects and reducing opioid requirements during the first 24 hours. Subjects and Methods: In this prospective, randomized double blind study, a total of sixty full term pregnant women were recruited for the study underwent caesarean section. Thirty patients were assigned to MgSO4 group (A) and another thirty to placebo group (B). Participants in group (A) received 50 mg/kg MgSO4 in 100 ml isotonic saline intravenous (IV) over 20 minutes prior to induction of general anesthesia by 30 minutes while participants in group (B) received 100 ml isotonic saline (placebo) by the same route and over the same duration as control. Results: Visual Analogue Scale (VAS) was analysed within 24 hours postoperatively. The mean pain score at 6 and 12 hours postoperatively was significantly lower in MgSO4 group compared to control group (40.4 ± 5.12 vs 53.6 ± 4.92;26.1 ± 3.01 vs 35.5 ± 3.98 respectively, p = 0.012, 0.005). Comparing both groups regarding the mean time interval of first rescue analgesia (morphine sulphate) requested by the patients, it was longer in MgSO4 group compared to control group. The total dose of rescue analgesia consumed during 24 hours was analysed and it was significantly higher in control group compared to MgSO4 group (10.1 ± 0.95 vs 6.2 ± 0.87, p = 0.001). Conclusion: We concluded that preoperative low doses (50 mg/Kg) of MgSO4 with general anesthesia combined with ultrasound guided TAP block offer longer postoperative pain free periods thus reducing total opioid consumption. In addition to the safety of the drug to the mother and fetus so we recommend IV MgSO4 as an adjuvant therapy with TAP block.
文摘目的:观察四磨汤对剖宫产术后患者胃肠功能恢复及应激反应的影响。方法:选取2012年6月—2014年5月本院行剖宫产患者180例,随机分成试验组和对照组各90例。两组患者术后胃肠功能恢复之前均进行全流食,补液,保证水电解质及酸碱平衡,试验组在此基础上术后6h给予四磨汤口服液,每天3次,每次用量20 m L直至胃肠功能正常肛门排气。比较两组患者胃肠恢复时间、肛门排气时间和有无腹胀等,测量所有患者手术前后的皮质醇水平。结果:试验组肠鸣音恢复时间明显少于对照组,肛门排气时间试验组小于对照组(P<0.05);两组患者术后腹胀情况比较,试验组发生率为15.6%,对照组发生率为54.4%,两组差异明显,具有统计学意义(P<0.05);术后药物干预后试验组患者的皮质醇水平明显低于对照组,差异有统计学意义(P<0.05)。结论:四磨汤有效增强了患者剖宫产术后胃肠功能恢复,降低术后腹胀几率,减轻应激反应,疗效显著。