Drug delivery to the posterior segment of the eye, especially the retina, faces the unique challenges of various anatomical and physiological barriers. Invasive intravitreal injection is currently the mainstream clini...Drug delivery to the posterior segment of the eye, especially the retina, faces the unique challenges of various anatomical and physiological barriers. Invasive intravitreal injection is currently the mainstream clinical approach to posterior eye diseases such as age-related macular degeneration, diabetic retinopathy, uveitis, and cytomegalovirus retinitis. Repeated injections could be complicated by endophthalmitis, intra- ocular pressure elevation, retinal vascular occlusion, and ret- inal detachment, let alone the psychological and economical burdens suffered by patients （Schwartz et al., 2014）. In view of this, several extended release drug delivery systems have been devised and the idea of encapsulated-cell technology （ECT） has gained popularity in recent decades since its first proposal in the 1960s.展开更多
Introduction: The study of the posterior segment of the eye has nowadays become one of the most frequent indications for diagnostic ultrasound in the ophthalmological field. The objective of this work is to contribute...Introduction: The study of the posterior segment of the eye has nowadays become one of the most frequent indications for diagnostic ultrasound in the ophthalmological field. The objective of this work is to contribute to the improvement of the diagnostic management of pathologies of the posterior segment of the eye in the radiology department of the medical clinic “Marie Curie” in Bamako. Material and Methods: This was a cross-sectional study carried out in the medical imaging department from January 2020 to January 2022. It concerned all patients who presented for the study of the ocular posterior segment on ultrasound. Results: Fifty-two (52) patients out of a total of 109 were included in the study, i.e. a frequency of 47.70%. The average age was 33.90 with the extremes ranging from 05 years to 75 years. The male sex dominated with a frequency of 69.23%. Ocular ultrasound was prescribed mainly by ophthalmologists (100%). In the study of the posterior segment, preoperative assessment represented the most frequent indications with respectively 55.76% and 23.10%. Retinal detachment and vitreous hemorrhage were the most found lesions on ultrasound with 50% and 34.61% respectively. Conclusion: Ocular ultrasound is accessible in Bamako and has allowed the study of the posterior segment of the eye. It occupies an important place in the study and management of ocular pathologies of the posterior segment.展开更多
基金supported by the grants from Hong Kong Research Grant Council(GRF 545#HKU773613M)The University of Hong Kong Seed Funding Programme for Basic Research(201011159005)
文摘Drug delivery to the posterior segment of the eye, especially the retina, faces the unique challenges of various anatomical and physiological barriers. Invasive intravitreal injection is currently the mainstream clinical approach to posterior eye diseases such as age-related macular degeneration, diabetic retinopathy, uveitis, and cytomegalovirus retinitis. Repeated injections could be complicated by endophthalmitis, intra- ocular pressure elevation, retinal vascular occlusion, and ret- inal detachment, let alone the psychological and economical burdens suffered by patients （Schwartz et al., 2014）. In view of this, several extended release drug delivery systems have been devised and the idea of encapsulated-cell technology （ECT） has gained popularity in recent decades since its first proposal in the 1960s.
文摘Introduction: The study of the posterior segment of the eye has nowadays become one of the most frequent indications for diagnostic ultrasound in the ophthalmological field. The objective of this work is to contribute to the improvement of the diagnostic management of pathologies of the posterior segment of the eye in the radiology department of the medical clinic “Marie Curie” in Bamako. Material and Methods: This was a cross-sectional study carried out in the medical imaging department from January 2020 to January 2022. It concerned all patients who presented for the study of the ocular posterior segment on ultrasound. Results: Fifty-two (52) patients out of a total of 109 were included in the study, i.e. a frequency of 47.70%. The average age was 33.90 with the extremes ranging from 05 years to 75 years. The male sex dominated with a frequency of 69.23%. Ocular ultrasound was prescribed mainly by ophthalmologists (100%). In the study of the posterior segment, preoperative assessment represented the most frequent indications with respectively 55.76% and 23.10%. Retinal detachment and vitreous hemorrhage were the most found lesions on ultrasound with 50% and 34.61% respectively. Conclusion: Ocular ultrasound is accessible in Bamako and has allowed the study of the posterior segment of the eye. It occupies an important place in the study and management of ocular pathologies of the posterior segment.
