Objectives:Allergic rhinitis(AR)has a significant effect on the quality of life and accounts for unproductive times at work and school,causes disturbed sleep patterns and can lead to daytime somnolence.It is fairly pr...Objectives:Allergic rhinitis(AR)has a significant effect on the quality of life and accounts for unproductive times at work and school,causes disturbed sleep patterns and can lead to daytime somnolence.It is fairly prevalent in the world with medical management still being the mainstay of treatment.Patients suffer for a significant number of years before they undergo surgical management for their intractable rhinitis.Thus,this prospective observational study was conducted to reinforce the proficiency of posterior nasal neurectomy in being an effective method for ending this suffering.Methods:Thirty patients with troublesome intractable rhinitis underwent posterior nasal neurectomy.Pre-and postoperative Visual Analogue Scale(VAS)and Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)scores were compared to study the improvement in nasal and ocular symptoms.Each domain of these scores was studied separately.Results:The mean reduction in the VAS was from 6.76±0.884 preoperatively to a mean of 5.33±0.675 at 1 month,3.81±0.462 at 3 months and 2.53±0.405 at 6 months postoperatively.The mean RQLQ score was reduced from preoperative 4.22±1.091 to a mean of 3.82±1.072 at 1 month,3.55±1.063 at 3 months and 3.18±1.173 at 6 months postoperatively.Thus,a statistically significant improvement was seen in both mean VAS and RQLQ scores(P<0.001),and also when each domain was compared separately.Conclusion:Endoscopic posterior nasal neurectomy may be an effective way of improving symptoms in patients with intractable AR and freeing them from long-term medical regimes,thereby improving their quality of life.展开更多
目的通过Meta分析的方法对鼻后神经切断术治疗变应性鼻炎(allergic rhinitis,AR)的有效性与安全性进行分析,以明确该类手术的临床应用价值并提供相关循证学依据。方法通过计算机检索建库至2019年4月,在Embase、Pubmed、Web of Science...目的通过Meta分析的方法对鼻后神经切断术治疗变应性鼻炎(allergic rhinitis,AR)的有效性与安全性进行分析,以明确该类手术的临床应用价值并提供相关循证学依据。方法通过计算机检索建库至2019年4月,在Embase、Pubmed、Web of Science数据库、万方数据库、维普中文科技期刊数据库(VIP)及中国期刊全文数据库(CNKI)公开发表的研究鼻后神经切断术治疗AR的临床研究,根据纳入排除标准对文献进行筛选、质量评价和数据提取后,应用Revman 5.3软件对文献原始数据进行Meta分析。结果总共纳入9篇临床研究,包含1343例患者。Meta分析结果显示,鼻内镜下鼻后神经切断术治疗AR的有效率很高[RD=0.89,95%CI(0.82,0.95),P<0.001],术后鼻通气阻力减小[MD=0.33,95%CI(0.03,0.62),P=0.03],鼻塞症状评分降低[MD=3.30,95%CI(0.60,6.00),P=0.02],喷嚏症状评分减小[MD=3.21,95%CI(1.80,4.62),P<0.001],流涕症状评分减小[MD=3.33,95%CI(0.66,6.00),P=0.01],并发症发生率很低[RD=0.04,95%CI(0.01,0.08),P=0.03],结果均具有统计学意义。结论鼻后神经切断术治疗AR有效率约为89%,术后鼻通气阻力和鼻塞、打喷嚏、流涕等症状明显减轻,且术后并发症的发生率约为4%,因此该术式对于药物治疗无效的中重度AR患者是一种有效可行的治疗方式。展开更多
文摘Objectives:Allergic rhinitis(AR)has a significant effect on the quality of life and accounts for unproductive times at work and school,causes disturbed sleep patterns and can lead to daytime somnolence.It is fairly prevalent in the world with medical management still being the mainstay of treatment.Patients suffer for a significant number of years before they undergo surgical management for their intractable rhinitis.Thus,this prospective observational study was conducted to reinforce the proficiency of posterior nasal neurectomy in being an effective method for ending this suffering.Methods:Thirty patients with troublesome intractable rhinitis underwent posterior nasal neurectomy.Pre-and postoperative Visual Analogue Scale(VAS)and Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)scores were compared to study the improvement in nasal and ocular symptoms.Each domain of these scores was studied separately.Results:The mean reduction in the VAS was from 6.76±0.884 preoperatively to a mean of 5.33±0.675 at 1 month,3.81±0.462 at 3 months and 2.53±0.405 at 6 months postoperatively.The mean RQLQ score was reduced from preoperative 4.22±1.091 to a mean of 3.82±1.072 at 1 month,3.55±1.063 at 3 months and 3.18±1.173 at 6 months postoperatively.Thus,a statistically significant improvement was seen in both mean VAS and RQLQ scores(P<0.001),and also when each domain was compared separately.Conclusion:Endoscopic posterior nasal neurectomy may be an effective way of improving symptoms in patients with intractable AR and freeing them from long-term medical regimes,thereby improving their quality of life.
文摘目的通过Meta分析的方法对鼻后神经切断术治疗变应性鼻炎(allergic rhinitis,AR)的有效性与安全性进行分析,以明确该类手术的临床应用价值并提供相关循证学依据。方法通过计算机检索建库至2019年4月,在Embase、Pubmed、Web of Science数据库、万方数据库、维普中文科技期刊数据库(VIP)及中国期刊全文数据库(CNKI)公开发表的研究鼻后神经切断术治疗AR的临床研究,根据纳入排除标准对文献进行筛选、质量评价和数据提取后,应用Revman 5.3软件对文献原始数据进行Meta分析。结果总共纳入9篇临床研究,包含1343例患者。Meta分析结果显示,鼻内镜下鼻后神经切断术治疗AR的有效率很高[RD=0.89,95%CI(0.82,0.95),P<0.001],术后鼻通气阻力减小[MD=0.33,95%CI(0.03,0.62),P=0.03],鼻塞症状评分降低[MD=3.30,95%CI(0.60,6.00),P=0.02],喷嚏症状评分减小[MD=3.21,95%CI(1.80,4.62),P<0.001],流涕症状评分减小[MD=3.33,95%CI(0.66,6.00),P=0.01],并发症发生率很低[RD=0.04,95%CI(0.01,0.08),P=0.03],结果均具有统计学意义。结论鼻后神经切断术治疗AR有效率约为89%,术后鼻通气阻力和鼻塞、打喷嚏、流涕等症状明显减轻,且术后并发症的发生率约为4%,因此该术式对于药物治疗无效的中重度AR患者是一种有效可行的治疗方式。
