Postpartum depression （PPD） is a modified form of major depressive disorders （MDD） that can exert profound negative effects on both mothers and infants than MDD. Within the postpartum period, both mothers and infa...Postpartum depression （PPD） is a modified form of major depressive disorders （MDD） that can exert profound negative effects on both mothers and infants than MDD. Within the postpartum period, both mothers and infants are susceptible; but because PPD typically occurs for short durations and has moderate symptoms, there exists challenges in exploring and addressing the underlying cause of the depression. This fact highlights the need for relevant animal models. In the present study, postpartum adult female cynomolgus monkeys （Macaca fascicularis） living in breeding groups were observed for typical depressive behavior. The huddle posture behavior was utilized as an indicator of behavioral depression postpartum （BDP） as it has been established as the core depressive-like behavior in primates. Monkeys were divided into two groups： A t3DP group （n=6）, which were found to spend more time huddling over the first two weeks postpartum than other individuals that formed a non-depression control group （n=4）. The two groups were then further analyzed for locomotive activity, stressful events, hair cortisol levels and for maternal interactive behaviors. No differences were found between the BDP and control groups in locomotive activity, in the frequencies of stressful events experienced and in hair cortisol levels. These findings suggested that the postpartum depression witnessed in the monkeys was not related to external factors other than puerperium period. Interestingly, the BDP monkeys displayed an abnormal maternal relationship consisting of increased infant grooming. Taken together, these findings suggest that the adult female cynomolgus monkeys provide a natural model of behavioral postpartum depression that holds a number of advantages over commonly used rodent systems in PPD modeling. The cynomolgus monkeys have a highly-organized social hierarchy and reproductive characteristics without seasonal restriction--similar to humans--as well as much greater homology to humans than rodents. As such, this model may provide a greater translational efficiency and research platform for systematically investigating the etiology, treatment, prevention of PPD.展开更多
目的:探讨知-信-行模式产后干预管理对妊娠期糖尿病妇女产后糖尿病的影响。方法:选取100例妊娠期糖尿病病人为研究对象,分为观察组和对照组,观察两组病人的餐后2 h血糖(2 h PBG)、转铁蛋白、前清蛋白、空腹血糖、糖化血红蛋白(HbA1c)、...目的:探讨知-信-行模式产后干预管理对妊娠期糖尿病妇女产后糖尿病的影响。方法:选取100例妊娠期糖尿病病人为研究对象,分为观察组和对照组,观察两组病人的餐后2 h血糖(2 h PBG)、转铁蛋白、前清蛋白、空腹血糖、糖化血红蛋白(HbA1c)、体质指数、空腹胰岛素(FINS)等指标;观察病人产后6个月糖尿病检出率及自我行为管理情况、胰岛素抵抗指数(HOMA-IR)情况。结果:干预后观察组2 h PBG、HbA1c、空腹血糖、体质指数、转铁蛋白、前清蛋白均低于对照组,差异均有统计学意义(P<0.05);干预前两组自我行为管理情况比较,差异无统计学意义(P>0.05),出院后6个月两组病人自我行为管理评分差异有统计学意义(P<0.05)。出院前两组FINS和HOMA-IR评分差异无统计学意义(P>0.05),出院后两组FINS和HOMA-IR评分差异均有统计学意义(P<0.05)。两组产后6个月糖尿病发生率比较,差异有统计学意义(P<0.05)。结论:知-信-行模式产后干预管理可有效地减少妊娠期糖尿病的发生,并能很好地控制体质指数和提高营养水平,有效地促进妊娠病人的产后自我行为管理,促进血糖调节,从而改善胰腺机能的恢复。展开更多
目的通过网状Meta分析评价6种心理干预方法对产后抑郁症患者抑郁情绪的干预效果。方法检索PubMed、Embase、Web of Science、The Cochrane Library、中国生物医学文献数据库(CBM)、中国知网、万方数据库及中国维普全文数据库中关于心理...目的通过网状Meta分析评价6种心理干预方法对产后抑郁症患者抑郁情绪的干预效果。方法检索PubMed、Embase、Web of Science、The Cochrane Library、中国生物医学文献数据库(CBM)、中国知网、万方数据库及中国维普全文数据库中关于心理干预方法对产后抑郁症患者抑郁情绪干预效果的随机对照试验,检索时限为建库至2022年3月20日。根据纳排标准筛选文献,提取文献信息并进行质量评价,使用STATA SE 16.0进行网状Meta分析。结果共纳入35项随机对照试验,包含6种心理干预方法,合计4441例患者。网状Meta分析结果显示,6种心理干预方法对产后抑郁症患者抑郁情绪的干预效果由高到低分别为音乐疗法、基于网络的认知行为疗法、正念疗法、人际心理疗法、面对面认知行为疗法、行为激活疗法。结论音乐疗法对产后抑郁症患者抑郁情绪的改善效果最好,可考虑优先选用。展开更多
基金supported by National Natural Science Foundation of China(31271167,81271495,31070963,30921064)the Yunnan Provincial Project to attract ore-hundred exceptional talents from Overseas
文摘Postpartum depression （PPD） is a modified form of major depressive disorders （MDD） that can exert profound negative effects on both mothers and infants than MDD. Within the postpartum period, both mothers and infants are susceptible; but because PPD typically occurs for short durations and has moderate symptoms, there exists challenges in exploring and addressing the underlying cause of the depression. This fact highlights the need for relevant animal models. In the present study, postpartum adult female cynomolgus monkeys （Macaca fascicularis） living in breeding groups were observed for typical depressive behavior. The huddle posture behavior was utilized as an indicator of behavioral depression postpartum （BDP） as it has been established as the core depressive-like behavior in primates. Monkeys were divided into two groups： A t3DP group （n=6）, which were found to spend more time huddling over the first two weeks postpartum than other individuals that formed a non-depression control group （n=4）. The two groups were then further analyzed for locomotive activity, stressful events, hair cortisol levels and for maternal interactive behaviors. No differences were found between the BDP and control groups in locomotive activity, in the frequencies of stressful events experienced and in hair cortisol levels. These findings suggested that the postpartum depression witnessed in the monkeys was not related to external factors other than puerperium period. Interestingly, the BDP monkeys displayed an abnormal maternal relationship consisting of increased infant grooming. Taken together, these findings suggest that the adult female cynomolgus monkeys provide a natural model of behavioral postpartum depression that holds a number of advantages over commonly used rodent systems in PPD modeling. The cynomolgus monkeys have a highly-organized social hierarchy and reproductive characteristics without seasonal restriction--similar to humans--as well as much greater homology to humans than rodents. As such, this model may provide a greater translational efficiency and research platform for systematically investigating the etiology, treatment, prevention of PPD.
文摘目的:探讨知-信-行模式产后干预管理对妊娠期糖尿病妇女产后糖尿病的影响。方法:选取100例妊娠期糖尿病病人为研究对象,分为观察组和对照组,观察两组病人的餐后2 h血糖(2 h PBG)、转铁蛋白、前清蛋白、空腹血糖、糖化血红蛋白(HbA1c)、体质指数、空腹胰岛素(FINS)等指标;观察病人产后6个月糖尿病检出率及自我行为管理情况、胰岛素抵抗指数(HOMA-IR)情况。结果:干预后观察组2 h PBG、HbA1c、空腹血糖、体质指数、转铁蛋白、前清蛋白均低于对照组,差异均有统计学意义(P<0.05);干预前两组自我行为管理情况比较,差异无统计学意义(P>0.05),出院后6个月两组病人自我行为管理评分差异有统计学意义(P<0.05)。出院前两组FINS和HOMA-IR评分差异无统计学意义(P>0.05),出院后两组FINS和HOMA-IR评分差异均有统计学意义(P<0.05)。两组产后6个月糖尿病发生率比较,差异有统计学意义(P<0.05)。结论:知-信-行模式产后干预管理可有效地减少妊娠期糖尿病的发生,并能很好地控制体质指数和提高营养水平,有效地促进妊娠病人的产后自我行为管理,促进血糖调节,从而改善胰腺机能的恢复。
文摘目的通过网状Meta分析评价6种心理干预方法对产后抑郁症患者抑郁情绪的干预效果。方法检索PubMed、Embase、Web of Science、The Cochrane Library、中国生物医学文献数据库(CBM)、中国知网、万方数据库及中国维普全文数据库中关于心理干预方法对产后抑郁症患者抑郁情绪干预效果的随机对照试验,检索时限为建库至2022年3月20日。根据纳排标准筛选文献,提取文献信息并进行质量评价,使用STATA SE 16.0进行网状Meta分析。结果共纳入35项随机对照试验,包含6种心理干预方法,合计4441例患者。网状Meta分析结果显示,6种心理干预方法对产后抑郁症患者抑郁情绪的干预效果由高到低分别为音乐疗法、基于网络的认知行为疗法、正念疗法、人际心理疗法、面对面认知行为疗法、行为激活疗法。结论音乐疗法对产后抑郁症患者抑郁情绪的改善效果最好,可考虑优先选用。
