Grand-multiparity is a serious risk factor in pregnancy and common in developing countries. The objective was to compare the obstetric outcome of grand-multiparous women with that of low parity in our center. The stud...Grand-multiparity is a serious risk factor in pregnancy and common in developing countries. The objective was to compare the obstetric outcome of grand-multiparous women with that of low parity in our center. The study comprised of 150 grand-multiparous women (cases) and 150 multiparous women (para 2 - 4) in this index pregnancy as controls matched for age and admitted for delivery. The mean age of the grand-multiparous women at delivery was 37.0 ± 2.8 years. Grand-multiparity was significantly higher among women with only primary education (48.0% versus 44.7%), polygamous marriages (9.3% versus 3.3%) and Muslims (17.3% versus 6.7%). Pregnancy induced hypertension and primary postpartum hemorrhage were significantly more often seen among grand-multiparous women than among the controls. The mean packed cell volume before delivery in the grand-multiparous women was significantly lower (33.6% ± 2.7%) than in the multiparous group (35.2% ± 2.7%) (P-value = 0.000). Grand-multiparity with its associated complications still occurs frequently in our environment. However, with adequate antenatal surveillance, optimal care during labour and contraceptive use, these problems will be reduced.展开更多
亚临床甲状腺功能减退症(subclinical hypothyroidism,SCH)是妊娠期最常见的甲状腺疾病,SCH患者存在血管内皮功能损伤和自主神经功能障碍,可能会增加心血管疾病的发病风险。妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)...亚临床甲状腺功能减退症(subclinical hypothyroidism,SCH)是妊娠期最常见的甲状腺疾病,SCH患者存在血管内皮功能损伤和自主神经功能障碍,可能会增加心血管疾病的发病风险。妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)使妊娠复杂化,并导致孕产妇和胎儿不良妊娠结局发生率和死亡率升高。已有研究发现SCH与HDP发病率增加有关,但目前没有统一结论,且SCH孕妇应用左旋甲状腺素(levothyroxine,L-T4)治疗对HDP是否有益也尚存争议。综述妊娠期SCH对HDP的影响及L-T4的治疗效果,以规范临床妊娠管理方案,减少孕妇和胎儿围产期不良妊娠结局的发生。展开更多
文摘Grand-multiparity is a serious risk factor in pregnancy and common in developing countries. The objective was to compare the obstetric outcome of grand-multiparous women with that of low parity in our center. The study comprised of 150 grand-multiparous women (cases) and 150 multiparous women (para 2 - 4) in this index pregnancy as controls matched for age and admitted for delivery. The mean age of the grand-multiparous women at delivery was 37.0 ± 2.8 years. Grand-multiparity was significantly higher among women with only primary education (48.0% versus 44.7%), polygamous marriages (9.3% versus 3.3%) and Muslims (17.3% versus 6.7%). Pregnancy induced hypertension and primary postpartum hemorrhage were significantly more often seen among grand-multiparous women than among the controls. The mean packed cell volume before delivery in the grand-multiparous women was significantly lower (33.6% ± 2.7%) than in the multiparous group (35.2% ± 2.7%) (P-value = 0.000). Grand-multiparity with its associated complications still occurs frequently in our environment. However, with adequate antenatal surveillance, optimal care during labour and contraceptive use, these problems will be reduced.
文摘亚临床甲状腺功能减退症(subclinical hypothyroidism,SCH)是妊娠期最常见的甲状腺疾病,SCH患者存在血管内皮功能损伤和自主神经功能障碍,可能会增加心血管疾病的发病风险。妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)使妊娠复杂化,并导致孕产妇和胎儿不良妊娠结局发生率和死亡率升高。已有研究发现SCH与HDP发病率增加有关,但目前没有统一结论,且SCH孕妇应用左旋甲状腺素(levothyroxine,L-T4)治疗对HDP是否有益也尚存争议。综述妊娠期SCH对HDP的影响及L-T4的治疗效果,以规范临床妊娠管理方案,减少孕妇和胎儿围产期不良妊娠结局的发生。