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Short─Term Therapeutic Efficacy of Recombinant Alpha─2b Interferon on Patients with Posttransfusion Hepatitis C
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作者 黄祖瑚 唐保元 +2 位作者 周东辉 李军 孙南雄 《The Journal of Biomedical Research》 CAS 1996年第1期18-22,共5页
Thebiochemicalandvirologicalefficaciesofrecombinantalpha-2bin-terferon(rINFα-2b)wereobservedon30patientswithpostransfusionhepatitisC.Theresultsshowedthatupto3monthsaftertheendoftherapytheALTnormalizationratewas72%and... Thebiochemicalandvirologicalefficaciesofrecombinantalpha-2bin-terferon(rINFα-2b)wereobservedon30patientswithpostransfusionhepatitisC.Theresultsshowedthatupto3monthsaftertheendoftherapytheALTnormalizationratewas72%andHCV-RNAdisappearanceratewas53.3%.Theresponsepredictoranal-ysisrevealedthatpatients′sex,ageandthedurationbetweenclinicalonsetandbegin-ningofIFNtherapywerenotmeaningfulfactors,whiletheinitialtiterofHCV-RNAandthedurationbetwenblodtransfusionandclinicalonsetbothafectedtheefficacysignificantly.HCVgenotypingshowedthat30patientswerealinfectedwithHCVgenotypeⅡ,indicatingthattheresponsetoIFNcouldbeinconsistentevenamongpa-tientswhoinfectedwithsamegenotypeofHCV.ItwasalsofoundthatthediscrepancybetwenbiochemicalandvirologicalresponsestoINFexistedandthatanti-HCVdetect-edbythesecondgenerationkitwasoflitlevalueinevaluatingtheeficacyofINFtherapy. 展开更多
关键词 hepatitisCvirus postransfusion HEPATITISC interferontherapy
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