Seven oleanene triterpenes were isolated from the roots of Potentilla discolor Bge and their structures were identified as 3-oxoolean-12-en-27-oic acid（1）, gypsogenic acid（2）, 3α-hydroxyolean-12-en-27-oic acid（3...Seven oleanene triterpenes were isolated from the roots of Potentilla discolor Bge and their structures were identified as 3-oxoolean-12-en-27-oic acid（1）, gypsogenic acid（2）, 3α-hydroxyolean-12-en-27-oic acid（3）, 3β-hydroxyolean-12-en-27-oic acid（4）, aceriphyllic acid A（5）, aceriphyllic acid A methyl ester（6）, and oleanolic acid（7）. Compounds 1–7 inhibited protein tyrosine phosphatase 1B（PTP1B） activity, with IC50 values ranging from（7.5±0.5） to（22.7±0.5） μmol/L. Among the isolates, compounds 1, 2, 3 and 7 from the Potentilla discolor Bge were found to exhibit selective PTP1 B inhibitory activity.展开更多
Nonalcoholic fatty liver disease(NAFLD)is characterized by excessive accumulation of hepatic lipids and metabolic stress-induced liver injury.There are currently no approved effective pharmacological treatments for NA...Nonalcoholic fatty liver disease(NAFLD)is characterized by excessive accumulation of hepatic lipids and metabolic stress-induced liver injury.There are currently no approved effective pharmacological treatments for NAFLD.Traditional Chinese medicine(TCM)has been used for centuries to treat patients with chronic liver diseases without clear disease types and mechanisms.More recently,TCM has been shown to have unique advantages in the treatment of NAFLD.We performed a systematic review of the medical literature published over the last two decades and found that many TCM formulas have been reported to be beneficial for the treatment of metabolic dysfunctions,including Potentilla discolor Bunge(PDB).PDB has a variety of active compounds,including flavonoids,terpenoids,organic acids,steroids and tannins.Many compounds have been shown to exhibit a series of beneficial effects for the treatment of NAFLD,including anti-oxidative and anti-inflammatory functions,improvement of lipid metabolism and reversal of insulin resistance.In this review,we summarize potential therapeutic effects of TCM formulas for the treatment of NAFLD,focusing on the medicinal properties of natural active compounds from PDB and their underlying mechanisms.We point out that PDB can be classified as a novel candidate for the treatment and prevention of NAFLD.展开更多
Ten compounds were obtained from the 90% ethanol extract of whole plant of Potentilla discolor Bunge.On the basis of physicochemical properties and spectral data,these compounds are identified as follows: oleanolic ac...Ten compounds were obtained from the 90% ethanol extract of whole plant of Potentilla discolor Bunge.On the basis of physicochemical properties and spectral data,these compounds are identified as follows: oleanolic acid(Ⅰ),kaempferol-7-O-α-L-rhamnoside(Ⅱ),quercetin-7-O-α-L-rhamnoside(Ⅲ),2α,3α-dihydroxyolean-12-ene-28-acid(Ⅳ),brevifolin(Ⅴ),ellagic acid-3,3′-dimethyl ether-4-O-β-D-glucopyranoside(Ⅵ),ellagic acid-3-methyl ether-4′-O-α-rhamnopyranoside(Ⅶ),2α-hydroxy-betulinic acid(Ⅷ),sitosterol(Ⅸ) and daucosterol(Ⅹ).In which,compound Ⅱ,Ⅲ and Ⅴ are isolated from genus Potentilla L.for the first time,and compound Ⅳ is isolated from P.discolor for the first time.展开更多
基金Science and Technology Development Program of Jilin Province(Grant No.20150101225JC)
文摘Seven oleanene triterpenes were isolated from the roots of Potentilla discolor Bge and their structures were identified as 3-oxoolean-12-en-27-oic acid（1）, gypsogenic acid（2）, 3α-hydroxyolean-12-en-27-oic acid（3）, 3β-hydroxyolean-12-en-27-oic acid（4）, aceriphyllic acid A（5）, aceriphyllic acid A methyl ester（6）, and oleanolic acid（7）. Compounds 1–7 inhibited protein tyrosine phosphatase 1B（PTP1B） activity, with IC50 values ranging from（7.5±0.5） to（22.7±0.5） μmol/L. Among the isolates, compounds 1, 2, 3 and 7 from the Potentilla discolor Bge were found to exhibit selective PTP1 B inhibitory activity.
基金partly supported by National Natural Science Foundation of China (Nos. 82074155, 81874436, 81973773, China)“Shuguang Program” supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission (No. 18SG39, China)+5 种基金Program of Shanghai Academic/Technology Research Leader (No. 20XD1423500, China)Clinical Research Plan of SHDC (No. SHDC2020CR3089B, China)Shanghai Key Clinical Specialty Construction Project (No.shslczdzk01201, China)Shanghai Frontier Research Base of Disease and Syndrome Biology of inflammatory cancer transformation (No. 2021KJ03-12, China)Shanghai Sailing Program (No. 20YF1450200, China)Shanghai Collaborative Innovation Center of Industrial Transformation of Hospital TCM Preparation (China)
文摘Nonalcoholic fatty liver disease(NAFLD)is characterized by excessive accumulation of hepatic lipids and metabolic stress-induced liver injury.There are currently no approved effective pharmacological treatments for NAFLD.Traditional Chinese medicine(TCM)has been used for centuries to treat patients with chronic liver diseases without clear disease types and mechanisms.More recently,TCM has been shown to have unique advantages in the treatment of NAFLD.We performed a systematic review of the medical literature published over the last two decades and found that many TCM formulas have been reported to be beneficial for the treatment of metabolic dysfunctions,including Potentilla discolor Bunge(PDB).PDB has a variety of active compounds,including flavonoids,terpenoids,organic acids,steroids and tannins.Many compounds have been shown to exhibit a series of beneficial effects for the treatment of NAFLD,including anti-oxidative and anti-inflammatory functions,improvement of lipid metabolism and reversal of insulin resistance.In this review,we summarize potential therapeutic effects of TCM formulas for the treatment of NAFLD,focusing on the medicinal properties of natural active compounds from PDB and their underlying mechanisms.We point out that PDB can be classified as a novel candidate for the treatment and prevention of NAFLD.
文摘Ten compounds were obtained from the 90% ethanol extract of whole plant of Potentilla discolor Bunge.On the basis of physicochemical properties and spectral data,these compounds are identified as follows: oleanolic acid(Ⅰ),kaempferol-7-O-α-L-rhamnoside(Ⅱ),quercetin-7-O-α-L-rhamnoside(Ⅲ),2α,3α-dihydroxyolean-12-ene-28-acid(Ⅳ),brevifolin(Ⅴ),ellagic acid-3,3′-dimethyl ether-4-O-β-D-glucopyranoside(Ⅵ),ellagic acid-3-methyl ether-4′-O-α-rhamnopyranoside(Ⅶ),2α-hydroxy-betulinic acid(Ⅷ),sitosterol(Ⅸ) and daucosterol(Ⅹ).In which,compound Ⅱ,Ⅲ and Ⅴ are isolated from genus Potentilla L.for the first time,and compound Ⅳ is isolated from P.discolor for the first time.
