We proposed a modified ratchet model including power-stroke and elastic coupling to study the efficiency of collective non-processive motors such as myosin Ⅱ in muscle. Our theoretical results are in good agreement w...We proposed a modified ratchet model including power-stroke and elastic coupling to study the efficiency of collective non-processive motors such as myosin Ⅱ in muscle. Our theoretical results are in good agreement with the experimental data. Our study not only reveals that the maximum efficiency depends on elasticity and is independent of transition rates but also indicates that the parameters fitted to fast muscle are different from those fitted to a slow one. The latter may imply that the structure of the fast muscle is different from that of the slow one. The main reason that our model succeeds is that velocity in this model is an independent variable.展开更多
基金Project supported by the Key Research Program of Frontier Sciences of Chinese Academy of Sciences(Grant No.Y7Y1472Y61)the National Natural Science Foundation of China(Grant Nos.11205123,11574329,11774358,11747601,and 11675017)+3 种基金the Joint NSFC–ISF Research Program(Grant No.51561145002)the CAS Biophysics Interdisciplinary Innovation Team Project(Grant No.2060299)the CAS Strategic Priority Research Program(Grant No.XDA17010504)the Fundamental Research Funds for the Central Universities(Grant No.2017EYT24)
文摘We proposed a modified ratchet model including power-stroke and elastic coupling to study the efficiency of collective non-processive motors such as myosin Ⅱ in muscle. Our theoretical results are in good agreement with the experimental data. Our study not only reveals that the maximum efficiency depends on elasticity and is independent of transition rates but also indicates that the parameters fitted to fast muscle are different from those fitted to a slow one. The latter may imply that the structure of the fast muscle is different from that of the slow one. The main reason that our model succeeds is that velocity in this model is an independent variable.
