β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L ...β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L 0-CD phosphate with the pH adjusted to 7.0 was used as the background electrolyte (BGE), and a small amount of analyte was injected (600v/1s). Triethylamine, diethylamine, triethanolamine, diethanolamine, Tris added as modifier were compared. Isoprenaline, methoxamine, oxprenolol, practolol were successfully resolved.展开更多
目的探讨心得宁口服液对大鼠慢性心衰模型血清中血管紧张素Ⅱ(Ang-Ⅱ)、B型脑钠肽(BNP)、心肌肌钙蛋白Ⅰ(cTnⅠ)、C-反应蛋白(CRP)、肿瘤坏死因子(TNF-a(8)、磷酸腺苷(ATP)和白介素-6(IL-6)水平的影响。方法采用每周腹腔注射盐酸多柔比...目的探讨心得宁口服液对大鼠慢性心衰模型血清中血管紧张素Ⅱ(Ang-Ⅱ)、B型脑钠肽(BNP)、心肌肌钙蛋白Ⅰ(cTnⅠ)、C-反应蛋白(CRP)、肿瘤坏死因子(TNF-a(8)、磷酸腺苷(ATP)和白介素-6(IL-6)水平的影响。方法采用每周腹腔注射盐酸多柔比星(2 mL·kg^(-1)腹腔注射,每周1次,共6周,累积总量24 mg·kg-1)建立大鼠慢性心衰模型,观察20,10,5 m L·kg^(-1)心得宁口服液对慢性心衰模型大鼠血清Ang-Ⅱ、BNP、cTnⅠ、CRP、TNF-a、ATP和IL-6水平的影响。结果大鼠慢性心衰模型造模成功。与模型组相比,20,10,5 m L·kg^(-1)心得宁口服液能显著降低血清Ang-Ⅱ、BNP、cTnⅠ、CRP、TNF-α水平(P<0.01);显著升高ATP水平(P<0.01),20,10 mL·kg^(-1)心得宁口服液能显著降低血清IL-6水平(P<0.01),5 m L·kg^(-1)心得宁口服液能明显降低血清IL-6水平(P<0.05)。结论心得宁口服液可明显改善大鼠慢性心衰模型的作用。展开更多
文摘β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L 0-CD phosphate with the pH adjusted to 7.0 was used as the background electrolyte (BGE), and a small amount of analyte was injected (600v/1s). Triethylamine, diethylamine, triethanolamine, diethanolamine, Tris added as modifier were compared. Isoprenaline, methoxamine, oxprenolol, practolol were successfully resolved.
文摘目的探讨心得宁口服液对大鼠慢性心衰模型血清中血管紧张素Ⅱ(Ang-Ⅱ)、B型脑钠肽(BNP)、心肌肌钙蛋白Ⅰ(cTnⅠ)、C-反应蛋白(CRP)、肿瘤坏死因子(TNF-a(8)、磷酸腺苷(ATP)和白介素-6(IL-6)水平的影响。方法采用每周腹腔注射盐酸多柔比星(2 mL·kg^(-1)腹腔注射,每周1次,共6周,累积总量24 mg·kg-1)建立大鼠慢性心衰模型,观察20,10,5 m L·kg^(-1)心得宁口服液对慢性心衰模型大鼠血清Ang-Ⅱ、BNP、cTnⅠ、CRP、TNF-a、ATP和IL-6水平的影响。结果大鼠慢性心衰模型造模成功。与模型组相比,20,10,5 m L·kg^(-1)心得宁口服液能显著降低血清Ang-Ⅱ、BNP、cTnⅠ、CRP、TNF-α水平(P<0.01);显著升高ATP水平(P<0.01),20,10 mL·kg^(-1)心得宁口服液能显著降低血清IL-6水平(P<0.01),5 m L·kg^(-1)心得宁口服液能明显降低血清IL-6水平(P<0.05)。结论心得宁口服液可明显改善大鼠慢性心衰模型的作用。