Objective: To observe the clinical application of olopatadine eye drops alone or combination with pranoprofen eye drops in the treatment of allergic conjunctivitis (AC). The levels of serum immunoglobulin, histamine (...Objective: To observe the clinical application of olopatadine eye drops alone or combination with pranoprofen eye drops in the treatment of allergic conjunctivitis (AC). The levels of serum immunoglobulin, histamine (HA) and eosinophil cationic protein (ECP) were analyzed. Methods: A total of 90 AC patients were randomly divided into control group (n=45) and observation group (n=45) according to the lottery method. The control group was treated with olopatadine hydrochloride eye drops. On the basis of the control group, the observation group was treated with pranoprofen eye drops. The levels of serum immunoglobulin, HA and ECP were measured in all subjects. Results: There was no significant difference in serum immunoglobulin level between the observation group and the control group before treatment. After treatment, the levels of serum IgG, IgA and IgE in the observation group and the control group were significantly lower than those before treatment. And the observation group was significantly lower than the control group after treatment. There were no significant differences in serum HA and ECP levels between the observation group and the control group before treatment. After treatment, the levels of serum HA and ECP in the observation group and the control group were significantly lower than those before treatment. And the observation group was significantly lower than the control group after treatment. Conclusion: Compared with olopatadine eye drops, olopatadine eye drops combined with pranoprofen eye drops in the treatment of AC patients, can effectively reduce the serum immunoglobulin, HA and ECP levels, which may be the clinical treatment of AC patients Of the effective reference program.展开更多
Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus ...Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases;20 eyes).The patients in the control group were given fluorometholone eye drops,and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops.Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results:At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P<0.05), but there was no significant difference on 5 to 7 days postoperatively (P>0.05). The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P<0.05), but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with >20 mmHg intraocular pressure in the control group. Conclusion:The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response,alleviate corneal irritation at early stage after CXL,effectively prevent and control the average of haze,and reduce the incidence of steroid-induced ocular hypertension after surgery.展开更多
目的 观察普拉洛芬滴眼液对实施白内障超声乳化抽吸联合房角分离术的原发性闭角型青光眼合并白内障患者预后的影响。方法 选取2022年1月至2023年12月在合肥市第二人民医院眼科予以针对性治疗的原发性闭角型青光眼伴白内障患者共103例为...目的 观察普拉洛芬滴眼液对实施白内障超声乳化抽吸联合房角分离术的原发性闭角型青光眼合并白内障患者预后的影响。方法 选取2022年1月至2023年12月在合肥市第二人民医院眼科予以针对性治疗的原发性闭角型青光眼伴白内障患者共103例为此次试验的对象,通过随机数字表法分为两组,所有患者均予以白内障超声乳化抽吸联合房角分离术治疗,对照组52例患者术后予以重组牛碱性成纤维细胞生长因子眼用凝胶结合妥布霉素地塞米松滴眼液治疗,观察组51例患者术后加用普拉洛芬滴眼液治疗。比较两组并发症发生情况,手术后1个月的结膜充血和眼压、视功能相关生命质量量表(NEI-VFQ-25)评分和治疗满意度。结果 观察组术后并发症发生率[1.96%(1/51)]低于对照组[15.38%(8/52)],差异有统计学意义(χ^(2)=4.257,P=0.039);观察组术后NEI-VFQ-25得分、眼压和结膜充血评分[分别为(44.23±2.04)分、(15.22±1.89) mm Hg(1 mm Hg≈0.133 kPa)、(1.04±0.27)分]优于对照组[分别为(32.26±2.84)分、(18.45±2.00) mm Hg、(1.42±0.33)分],差异有统计学意义(t=24.526、8.421、6.389,均P<0.05)。在满意度方面,观察组(96.07%,49/51)相较于对照组(84.61%,44/52)更高(χ^(2)=3.859,P<0.05)。结论 原发性闭角型青光眼伴白内障患者实施白内障超声乳化抽吸联合房角分离术术后应用普拉洛芬滴眼液能够降低并发症出现概率,改善日常生活质量以及眼部压力。展开更多
文摘Objective: To observe the clinical application of olopatadine eye drops alone or combination with pranoprofen eye drops in the treatment of allergic conjunctivitis (AC). The levels of serum immunoglobulin, histamine (HA) and eosinophil cationic protein (ECP) were analyzed. Methods: A total of 90 AC patients were randomly divided into control group (n=45) and observation group (n=45) according to the lottery method. The control group was treated with olopatadine hydrochloride eye drops. On the basis of the control group, the observation group was treated with pranoprofen eye drops. The levels of serum immunoglobulin, HA and ECP were measured in all subjects. Results: There was no significant difference in serum immunoglobulin level between the observation group and the control group before treatment. After treatment, the levels of serum IgG, IgA and IgE in the observation group and the control group were significantly lower than those before treatment. And the observation group was significantly lower than the control group after treatment. There were no significant differences in serum HA and ECP levels between the observation group and the control group before treatment. After treatment, the levels of serum HA and ECP in the observation group and the control group were significantly lower than those before treatment. And the observation group was significantly lower than the control group after treatment. Conclusion: Compared with olopatadine eye drops, olopatadine eye drops combined with pranoprofen eye drops in the treatment of AC patients, can effectively reduce the serum immunoglobulin, HA and ECP levels, which may be the clinical treatment of AC patients Of the effective reference program.
文摘Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases;20 eyes).The patients in the control group were given fluorometholone eye drops,and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops.Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results:At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P<0.05), but there was no significant difference on 5 to 7 days postoperatively (P>0.05). The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P<0.05), but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with >20 mmHg intraocular pressure in the control group. Conclusion:The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response,alleviate corneal irritation at early stage after CXL,effectively prevent and control the average of haze,and reduce the incidence of steroid-induced ocular hypertension after surgery.
文摘目的 观察普拉洛芬滴眼液对实施白内障超声乳化抽吸联合房角分离术的原发性闭角型青光眼合并白内障患者预后的影响。方法 选取2022年1月至2023年12月在合肥市第二人民医院眼科予以针对性治疗的原发性闭角型青光眼伴白内障患者共103例为此次试验的对象,通过随机数字表法分为两组,所有患者均予以白内障超声乳化抽吸联合房角分离术治疗,对照组52例患者术后予以重组牛碱性成纤维细胞生长因子眼用凝胶结合妥布霉素地塞米松滴眼液治疗,观察组51例患者术后加用普拉洛芬滴眼液治疗。比较两组并发症发生情况,手术后1个月的结膜充血和眼压、视功能相关生命质量量表(NEI-VFQ-25)评分和治疗满意度。结果 观察组术后并发症发生率[1.96%(1/51)]低于对照组[15.38%(8/52)],差异有统计学意义(χ^(2)=4.257,P=0.039);观察组术后NEI-VFQ-25得分、眼压和结膜充血评分[分别为(44.23±2.04)分、(15.22±1.89) mm Hg(1 mm Hg≈0.133 kPa)、(1.04±0.27)分]优于对照组[分别为(32.26±2.84)分、(18.45±2.00) mm Hg、(1.42±0.33)分],差异有统计学意义(t=24.526、8.421、6.389,均P<0.05)。在满意度方面,观察组(96.07%,49/51)相较于对照组(84.61%,44/52)更高(χ^(2)=3.859,P<0.05)。结论 原发性闭角型青光眼伴白内障患者实施白内障超声乳化抽吸联合房角分离术术后应用普拉洛芬滴眼液能够降低并发症出现概率,改善日常生活质量以及眼部压力。
文摘目的 探讨普拉洛芬滴眼液联合高浓度玻璃酸钠在老年干眼症患者中的应用价值。方法 目的选取2023年3—12月苏州工业园区星塘医院收治的60例(120眼)干眼症老年患者为研究对象,根据治疗方法不同分为两组,各30例(60眼)。对照组给予0.3%玻璃酸钠治疗,观察组在对照组基础上给予普拉洛芬。比较两组临床疗效、泪膜破裂时间(Tear Film Break Up Time,BUT)、荧光素染色评分(Fluorescent,FL)、泪液分泌实验情况、不良反应发生情况。结果 观察组总有效率为98.33%,高于对照组的88.33%,差异有统计学意义(χ^(2)=4.821,P<0.05)。观察组BUT、FL评分、泪液分泌实验结果均优于对照组,差异有统计学意义(P均<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 在老年干眼症患者采用普拉洛芬滴眼液联合高浓度玻璃酸钠滴眼液能够提升总有效率,改善泪膜稳定性,且安全性良好。
