Regulative Effect of Traditional Chinese Medicine on Gene-expression Related to Precancerous Lesion of Gastric Cancer

The gene-expression changes related with precancerous lesion of gastric cancer (PLGC) are surveyed. Not only the regulative effect of traditional Chinese medicine (TCM) on oncogene, antioncogene and anti-apoptosis gene that are related with PLGC is analyzed, but also current research state is presented. It's showed that TCM has effects of therapy and inversion on PLGC. These effects are related with the inhibition to related oncogene expression, the regulation and activation to the deletion of antioncogene, the inhibition to the high-expression of mutant gene-protein about antioncogene, and the regulative function to anti-apoptosis gene.

Traditional Chinese medicine for transformation of gastric precancerous lesions to gastric cancer:A critical review

Gastric cancer(GC)is a common gastrointestinal tumor.Gastric precancerous lesions(GPL)are the last pathological stage before normal gastric mucosa transforms into GC.However,preventing the transformation from GPL to GC remains a challenge.Traditional Chinese medicine(TCM)has been used to treat gastric disease for millennia.A series of TCM formulas and active compounds have shown therapeutic effects in both GC and GPL.This article reviews recent progress on the herbal drugs and pharmacological mechanisms of TCM in preventing the transformation from GPL to GC,especially focusing on antiinflammatory,anti-angiogenesis,proliferation,and apoptosis.This review may provide a meaningful reference for the prevention of the transformation from GPL to GC using TCM.

Review on the progress of treating gastric precancerous lesions with traditional Chinese medicine based on regulatory genes

In recent years,the incidence of Precancerous lesions of gastric cancer(PLGC)has gradually increased,and it is difficult to be cured and easy to recur.Traditional Chinese Medicine(TCM)emphasizes the prevention before the disease.The regulation of PLGC related tumor genes by Chinese medicine has become a research hotspot.This paper summarized PLGC related proto-oncogenes,tumor suppressor genes and apoptosis related genes,and discussed the mechanism of Chinese Medicine Therapy PLGC from the perspective of gene expression,providing new ideas and methods for clinical treatment of PLGC.

A cross-sectional study on traditional Chinese medicine syndromes distribution for chronic atrophic gastritis based on data mining

Background:Chronic atrophic gastritis(CAG)is a common digestive system disease characterized by reduced gastric mucosa inherent glands and often accompanied by intestinal metaplasia and dysplasia.Traditional Chinese medicine believes that syndrome elements dampness and blood stasis are closely related to the occurrence and development of CAG and promote the occurrence of precancerous lesions of gastric cancer.However,there is a lacking of more in-depth and detailed study on the above syndrome elements.This study aimed to made a quantitative description by cross-sectional study on the frequency of key syndrome elements dampness and blood stasis of CAG.Methods:201 CAG patients who met with inclusion criteria were divided into 4 groups including:only dampness group,only blood stasis group,none of dampness and blood stasis group,dampness and blood stasis group according to their four diagnostic information.The severities and levels of patients’clinical symptoms,pathological signs and patient-reported outcome scale used as evaluation indexes were collected.Data mining method of exploratory factor analysis was used for statistics.Results:The results suggested that the frequencies of dampness and blood stasis were reflected in the severity and levels of gastric symptoms,helicobacter pylori infection and the distribution and severity of dysplasia.And blood stasis played a more prominent role in promoting the progression of the CAG to cancer.Conclusion:Our results might provide a quantitative syndrome description for the traditional Chinese medicine differentiation in treating precancerous lesions of gastric cancer and preventing gastric cancer.

A comprehensive update:gastrointestinal microflora,gastric cancer and gastric premalignant condition,and intervention by traditional Chinese medicine

With the recent upsurge of studies in the field of microbiology,we have learned more about the complexity of the gastrointestinal microecosystem.More than 30 genera and 1000 species of gastrointestinal microflora have been found.The structure of the normal microflora is relatively stable,and is in an interdependent and restricted dynamic equilibrium with the body.In recent years,studies have shown that there is a potential relationship between gastrointestinal microflora imbalance and gastric cancer(GC)and precancerous lesions.So,restoring the balance of gastrointestinal microflora is of great significance.Moreover,intervention in gastric premalignant condition(GPC),also known as precancerous lesion of gastric cancer(PLGC),has been the focus of current clinical studies.The holistic view of traditional Chinese medicine(TCM)is consistent with the microecology concept,and oral TCM can play a two-way regulatory role directly with the microflora in the digestive tract,restoring the homeostasis of gastrointestinal microflora to prevent canceration.However,large gaps in knowledge remain to be addressed.This review aims to provide new ideas and a reference for clinical practice.

中医治未病思想应用于胃癌防治的研究进展

胃癌是临床常见的恶性肿瘤之一,具有发病率高,病死率高的特点,严重危害人类生命健康。虽然针对胃癌的治疗手段不断进步,但其防治工作仍是棘手的问题。治未病思想最早见于《黄帝内经》,延至今日对临床仍具有重要指导意义。因此根据中医治未病思想,对中医药应用于胃癌防治的现状进行归纳总结,结果表明中医药在预防胃癌发生、防治胃癌治疗引起的并发症、控制疾病进展、维持带瘤生存状态、预防胃癌复发转移等方面已取得良好成果。

中药干预肿瘤及胃癌前病变上皮间质转化的研究进展

上皮间质转化(EMT)是指上皮细胞失去极性,转变为间质样细胞的过程。在肿瘤及胃癌前病变治疗中,EMT已成为近年来研究热点。本文中查阅近年来相关文献,综述中药干预肿瘤及胃癌前病变的实验研究,以推动中药治疗肿瘤及胃癌前病变研究进展。

从脾论治胃癌前病变的思路与方法

胃癌前病变(Precancerous lesion of gastric carcinoma,PLGC)是胃粘膜“炎-癌转化”发生发展的重要环节。中医以整体调节、辨证论治的独特诊疗模式,在改善临床症状、提高生活质量、逆转病理组织学病变方面显示出良好优势。PLGC病位在脾胃,脾胃虚弱为其发病基础,脾胃运化失常、气机升降异常是症状发生的主要机制,由其演化而生的湿、痰、瘀、毒等胶结积聚久留促发局部病变。脾虚与PLGC发生发展的胃粘膜微环境失衡有关,涉及胃黏膜炎症、胃内菌群、胃黏膜屏障、免疫功能、能量代谢、黏膜分泌等机制。本文从脾入手思考PLGC的病机、治法、用药思路等,对统一认识、开拓临床和科研思路有参考意义。

从“态靶辨治”角度分析蔡淦治疗脾虚瘀热型胃癌前病变经验

从“态靶辨治”角度介绍蔡淦教授治疗脾虚瘀热型胃癌前病变的经验。认为其基本病机为脾失健运,湿阻热蕴,气滞血瘀胶着于胃腑;临证强调“态靶辨治”,把握“基本态”、紧扣“疾病靶”、把控“症状靶”、参考“指标靶”;治疗时灵活运用经验方莪连颗粒健脾益气、化瘀清热以调态,并通过抗幽门螺杆菌、调节炎症因子及肿瘤指标表达水平、提高机体免疫力、影响相关信号通路等途径“精确打靶”,疗效突出。并附验案1则。

顾庆华教授治疗胃癌前病变经验拾粹

胃癌前病变(PLGC)是正常胃黏膜向胃癌发展的关键阶段,发病率较高。因目前对胃癌的预防治疗机理尚不明确,所以对PLGC的治疗是防止其向胃癌发展的关键环节。江苏省名中医顾庆华教授运用中医药方法进行辨病与辨证论治,根据其病因病机以脾胃虚弱为本、气滞血瘀湿浊为标,将本病辨为气滞湿阻、湿热阻中、脾虚夹滞、阴虚内热四个证型辨证施治,取得较为满意的临床效果。现总结顾庆华教授治疗胃癌前病变的经验如下,并附验案1则。

经方治疗胃癌前病变研究进展

经方配伍严谨,用药精当,组方精简,具有很高的实用价值和科学价值。经方治疗胃癌前病变,在临床疗效上显现出极大的优势作用,通过总结近年来各医家的研究,探究经方治疗胃癌前病变的机制。本文将主要论述治疗胃癌前病变的经方及其治疗的作用机制,望有助于明确经方治疗胃癌前病变的机制,为经方广泛应用于临床提供更多医学证据。研究表明,经方能通过增强免疫力、清除幽门螺旋杆菌、调节炎症因子的水平、调控细胞增殖与凋亡平衡等多种途径,多环节、多靶点全面调节胃肠功能,修复胃黏膜损伤,在促进胃黏膜病变组织学逆转方面具有明显作用。

中医药精准靶向治疗胃癌前病变及相关信号通路研究

胃癌前病变(precancerous lesions of gastric cancer,PLGC)是胃癌发展的关键阶段,尽早诊断、及时干预PLGC是预防胃癌发生的重点,如何减缓或逆转PLGC,降低人群中胃癌的发病率、病死率是现阶段消化领域研究的热点问题。当前西医主要采用抑酸、抗幽门螺杆菌(Helicobacter Pylori,HP)感染、内镜下治疗、定期随访等措施来治疗PLGC,但主要是针对病因及症状的治疗,对PLGC的逆转多无确切疗效。许多研究证实中医药治疗PLGC具有独特优势,辨证论治与辨病论治相结合,联合胃镜、组织病理学、血清学、基因组学表现精准靶向治疗PLGC,不仅能有效改善患者临床症状,且能不同程度逆转PLGC,减缓疾病进程,但具体机制尚未完全明确。该文就中医药精准靶向治疗PLGC及其相关信号通路进行概述,以期为中医药治疗该病提供理论基础及机制研究。

基于胃微生态探讨胃癌前病变的中医药防治机制

胃癌是我国常见的恶性肿瘤之一,其发病率和病死率极高,医疗资源消耗巨大,防控形势日益严峻。胃癌前病变是胃癌发生发展的重要环节,具有一定的可逆性,是胃癌早期诊治和预防的关键。大多数胃癌确诊患者处于进展期或晚期,其防治效果尚不理想。因此,寻求积极有效的防治策略极其重要。随着人类元基因组技术的开展和运用,发现胃微生态在胃癌的发生、发展和防治中扮演着重要的角色。胃微生态由肠道菌群、肠道细胞、黏膜化学屏障、免疫屏障和肠内神经等构成,参与机体的物质代谢、免疫调节等方面,已有研究表明,胃微生态失调对胃癌及癌前病变存在潜在的关系,因此,恢复胃微生态平衡极为重要。文章以胃微生态为切入点,阐述了胃微环境失衡与胃癌前病变的相关性,通过调节胃内环境、缓解黏膜炎症和免疫应答等方面,系统总结中医药干预胃癌前病变的发病机制,为中医药防治胃癌前病变提供新的方向。

胃癌癌前病变病因病机及中医药干预相关机制的研究进展

胃癌癌前病变(PLGC)是胃癌二级预防的关键,其病因多为饮食不节、外邪侵袭脾胃、劳倦内伤等,病机在于气阴两虚、胃络失荣、气滞血瘀,早期干预可有效降低胃癌的发生风险。目前,中医药干预被广泛用于PLGC的临床治疗,多将PLGC分为胃阴亏虚、肝胃气滞、胃络瘀血、肝胃郁热、脾胃湿热、脾胃虚弱6型进行辨证论治,疗效可靠,具有一定的预防及逆转作用。但临床暂未有统一的PLGC中医药治疗及疗效评估标准,后续研究中需进一步分析中医治疗PLGC的具体机制,以规范化PLGC的中医治疗方案,并建立统一的中医疗效评估标准,为PLGC的临床治疗提供可靠参考。

谢晶日教授从肝脾论治胃癌前病变经验

谢晶日教授治疗胃癌前病变的经验丰富,认为胃癌前病变以脾胃虚弱为本,气滞、湿阻、血瘀为标,临床症状复杂多变,以本虚标实、虚实夹杂之证多见。临证时,谢晶日教授强调从肝脾论治胃癌前病变的重要性;强调活血解毒,兼化湿浊;重视心理因素在治疗胃癌前病变中的作用,临床多获良效。附验案一则以供参考。

基于Wnt/β-catenin信号通路探讨中医药治疗胃癌前病变研究现状

胃癌前病变(PLGC)是正常胃黏膜组织发生病理学癌变的异常过程,是胃癌发生前的必经阶段,亦是降低胃癌发病率的重要切入点。Wnt/β-catenin信号通路参与了PLGC的发生发展过程,当Wnt信号通路激活时,β-catenin向核内聚集,诱导原癌基因异常表达。中医药治疗PLGC疗效肯定,且查阅大量文献表明中医药对Wnt/β-catenin信号通路具有调控作用。因此,从中药及针灸两方面着手,将中医药基于Wnt/β-catenin信号通路治疗PLGC的理论及研究现状进行综述,从而提出中医药疗法调控该信号通路治疗PLGC的问题及思考,为治疗PLGC及预防胃癌发生的中医药科研工作提供一定的启发,并为PLGC的中医临床应用提供参考依据。

中医药治疗胃癌前病变作用机制研究进展

胃癌前病变是指在萎缩性胃炎基础上伴有肠化生和(或)异型增生,与胃癌的发生密切相关。中医药近年来在治疗胃癌前病变方面发挥了较好的效果,拟对近5年关于中医药治疗胃癌前病变的作用机制研究进行总结,以期为中医药治疗胃癌前病变提供更加科学的依据。

健脾清胃汤在胃癌癌前病变阻断中的应用

目的 观察健脾清胃汤阻断胃癌癌前病变的临床疗效。方法 按随机数字表法将150例纳入对象分为对照组和观察组各75例,对照组给予常规干预及胃乐宁片治疗,观察组在对照组的基础上加用健脾清胃汤,对比2组中医证候、胃镜、病理、幽门螺杆菌(Hp)、胃泌素-17及胃蛋白酶原Ⅰ/Ⅱ指标的变化。结果 治疗后比较中医证候、胃镜及病理疗效指标方面,观察组的总有效率均明显优于对照组(均P<0.05);在胃泌素-17和胃蛋白酶原Ⅰ/Ⅱ方面比较,观察组均优于对照组(均P<0.05);治疗后2组Hp比较,差异无统计学意义(P>0.05)。结论 健脾清胃汤能够有效缓解胃癌癌前病变患者的中医证候及体征,并改善其胃镜和病理结果,为提高胃癌临床阻断率及早期预防提供新思路。

中医药治疗胃癌前病变研究进展

文章通过对近年来中医药对胃癌前病变(PLGC)的病因病机、分型论治、方药治疗及作用机制等方面文献进行研究,表明中医药治疗PLGC具有较好的疗效优势,然而也存在着一些不足,主要有病因病机认识的多样性,辨证分型的杂乱性,临床诊断标准的不统一性,同时对PLGC癌变趋势的预测研究相对较少,以及PLGC模型构建方法存在瑕疵等,这些都是亟待解决的问题。

胃癌癌前病变患者中医体质类型与证型相关性研究

目的探究胃癌癌前病变(precancerous lesion of gastric cancer,PLGC)患者体质与证候的关系。方法运用关联规则的数据挖掘方法,对PLGC患者的中医体质类型与中医证型的相关性进行分析。结果 212例PLGC患者的主要年龄段为34~69岁(占84.43%);偏颇体质依次为阳虚质59例、气虚质30例、气郁质23例、痰湿质11例、湿热质8例、阴虚质7例、血瘀质5例、特禀质2例,平和质67例;中医证型依次为脾胃虚弱证75例、肝气犯胃证56例、气滞痰阻证33例、湿热内蕴证23例、痰瘀互结证17例、胃阴亏耗证8例。湿热内蕴证与湿热质,气滞痰阻型与痰湿质,痰瘀互结证与血瘀质,脾胃虚弱证与阳虚质、气虚质、阴虚质密切相关。结论 PLGC患者多为平和质和正虚体质,证型多为脾胃虚弱证和肝气犯胃证,中医体质类型与中医证候演变具有一定的关系。