The mining area deformation monitoring theory and method using precise point positioning （PPP） ambi- guity resolution （AR） were studied, and an ambiguity fixing model with satellite and receiver combina- tion phas...The mining area deformation monitoring theory and method using precise point positioning （PPP） ambi- guity resolution （AR） were studied, and an ambiguity fixing model with satellite and receiver combina- tion phase delay （CPD） was proposed for zero-differenced PPP ambiguity fixing and its corresponding formula derivation was given. The data processing results for I h at six IGS stations in China show that 93% of ambiguities can be fixed within 10 min and all ambiguities can be fixed within 15 min. After ambi- guity fixing, the positioning accuracy is improved by more than 85% in the E and N directions, with abso- lute positioning accuracy reaching millimeter level, and it was improved by 70% in the U direction, reaching centimeter level; the proposed zero-differenced ambiguity fixing model can effectively improve the convergence rate and positioning accuracy in PPP. Data monitoring continuously conducted for half a year at four COPS stations of Shanxi China Coal Pingshuo Group validated the feasibility of using PPP in mining area deformation monitoring.展开更多
Inflammatory bowel disease(IBD)is an incurable disease characterized by remission-relapse cycles throughout its course.Both Crohn's disease(CD)and ulcerative colitis(UC),the two main forms of IBD,exhibit tendency ...Inflammatory bowel disease(IBD)is an incurable disease characterized by remission-relapse cycles throughout its course.Both Crohn's disease(CD)and ulcerative colitis(UC),the two main forms of IBD,exhibit tendency to develop complications and substantial heterogeneity in terms of frequency and severity of relapse,thus posing great challenges to the clinical management for IBD.Current treatment strategies are effective in different ways in induction and maintenance therapies for IBD.Recent advances in studies of genetics,pharmacogenetics,proteomics and microbiome provide a strong driving force for identifying molecular markers of prognosis and treatment response,which should help clinicians manage IBD patients more effectively,and then,improve clinical outcomes and reduce treatment costs of patients.In this review,we summarize and discuss precision medicine in IBD,focusing on predictive markers of disease course and treatment response,and monitoring indices during therapeutic drug monitoring.展开更多
基金Financial support from the National Natural Science Foundation of China (No. 41074010)the Jiangsu Innovation Works Fund of Postgraduate (No. CXZZ11-0299)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
文摘The mining area deformation monitoring theory and method using precise point positioning （PPP） ambi- guity resolution （AR） were studied, and an ambiguity fixing model with satellite and receiver combina- tion phase delay （CPD） was proposed for zero-differenced PPP ambiguity fixing and its corresponding formula derivation was given. The data processing results for I h at six IGS stations in China show that 93% of ambiguities can be fixed within 10 min and all ambiguities can be fixed within 15 min. After ambi- guity fixing, the positioning accuracy is improved by more than 85% in the E and N directions, with abso- lute positioning accuracy reaching millimeter level, and it was improved by 70% in the U direction, reaching centimeter level; the proposed zero-differenced ambiguity fixing model can effectively improve the convergence rate and positioning accuracy in PPP. Data monitoring continuously conducted for half a year at four COPS stations of Shanxi China Coal Pingshuo Group validated the feasibility of using PPP in mining area deformation monitoring.
基金supported in part by the Sichuan International Science and Technology Innovation Cooperation/Hong Kong/Macao/Taiwan Science and Technology Innovation Cooperation Project (Grant No.2021YFH0189)the Sichuan International Science Foundation Project (Grant No.2022NSFSC1363)the project for disciplines of excellence-Clinical Research Incubation Project,West China Hospital,Sichuan University (Grant No.2021HXFH065).
文摘Inflammatory bowel disease(IBD)is an incurable disease characterized by remission-relapse cycles throughout its course.Both Crohn's disease(CD)and ulcerative colitis(UC),the two main forms of IBD,exhibit tendency to develop complications and substantial heterogeneity in terms of frequency and severity of relapse,thus posing great challenges to the clinical management for IBD.Current treatment strategies are effective in different ways in induction and maintenance therapies for IBD.Recent advances in studies of genetics,pharmacogenetics,proteomics and microbiome provide a strong driving force for identifying molecular markers of prognosis and treatment response,which should help clinicians manage IBD patients more effectively,and then,improve clinical outcomes and reduce treatment costs of patients.In this review,we summarize and discuss precision medicine in IBD,focusing on predictive markers of disease course and treatment response,and monitoring indices during therapeutic drug monitoring.
