Common gastrointestinal diseases such as radiation enteritis(RE),acute pancreatitis,inflammatory bowel diseases(IBD)and drug-induced hepatotoxicity share pathophysiological mechanisms at the molecular level,mostly inv...Common gastrointestinal diseases such as radiation enteritis(RE),acute pancreatitis,inflammatory bowel diseases(IBD)and drug-induced hepatotoxicity share pathophysiological mechanisms at the molecular level,mostly involving the activation of many pathways of the immune response,ultimately leading to tissue injury.Increased oxidative stress,inflammatory cytokine release,inflammatory cell infiltration and activation and the up-regulation of inflammatory transcription factors participate in the pathophysiology of these complex entities.Treatment varies in each specific disease,but at least in the cases of RE and IBD immunosuppressors are effective.However,full therapeutic responses are not always achieved.The pathophysiology of ischemiareperfusion(IR)injury shares many of these mechanisms.Brief and repetitive periods of ischemia in an organ or limb have been shown to protect against subsequent major IR injury in distant organs,a phenomenon called remote ischemic preconditioning(RIP).This procedure has been shown to protect the gut,pancreas and liver by modulating many of the same inflammatory mechanisms.Since RIP is safe and tolerable,and has shown to be effective in some recent clinical trials,I suggest that RIP could be used as a physiologicallyrelevant adjunct treatment for non-ischemic gastrointestinal inflammatory conditions.展开更多
目的探讨脑缺血预适应(BIP)对急性脑梗死(ACI)的神经保护作用。方法收集2005年10月至2007年4月潮州市中心医院门诊及住院收治短暂性脑缺血发作(TIA)后发生 ACI 患者60例,其中30例 TIA 时长≤20 min 为 A1组,30例 TIA 时长>20 min且≤...目的探讨脑缺血预适应(BIP)对急性脑梗死(ACI)的神经保护作用。方法收集2005年10月至2007年4月潮州市中心医院门诊及住院收治短暂性脑缺血发作(TIA)后发生 ACI 患者60例,其中30例 TIA 时长≤20 min 为 A1组,30例 TIA 时长>20 min且≤60 min 为 A2组;同期随机抽取 ACI 前无 TIA 的病例30例为 B组(对照组)。ACI 病例观察梗死病灶大小、神经功能评分、病变程度及疗效等指标。结果 TIA 后 ACI,A1组梗死病灶较小,神经功能评分较低,重度病例少,基本痊愈率、显效率及总有效率较高,优于对照组(P<0.01),而A2组差别则无显著性(P>0.05)。结论持续适当的 BIP 对其后发生的 ACI 能产生神经保护作用。展开更多
In this paper we consider the domain decomposition methods with mortar element Lagrange multipliers to two-dimensional elliptic problems.We shall construct a kind of simple preconditioners for the corresponding interf...In this paper we consider the domain decomposition methods with mortar element Lagrange multipliers to two-dimensional elliptic problems.We shall construct a kind of simple preconditioners for the corresponding interface equation.It will be shown that condition number of the preconditioned interface matrix is almost optimal.展开更多
We present a symbolic-numeric hybrid method, based on sum-of-squares （SOS） relaxation and rational vec- tor recovery, to compute inequality invariants and ranking functions for proving total correctness and generati...We present a symbolic-numeric hybrid method, based on sum-of-squares （SOS） relaxation and rational vec- tor recovery, to compute inequality invariants and ranking functions for proving total correctness and generating pre- conditions for programs. The SOS relaxation method is used to compute approximate invariants and approximate rank- ing functions with floating point coefficients. Then Gauss- Newton refinement and rational vector recovery are applied to approximate polynomials to obtain candidate polynomials with rational coefficients, which exactly satisfy the conditions of invariants and ranking functions. In the end, several exam- ples are given to show the effectiveness of our method.展开更多
文摘Common gastrointestinal diseases such as radiation enteritis(RE),acute pancreatitis,inflammatory bowel diseases(IBD)and drug-induced hepatotoxicity share pathophysiological mechanisms at the molecular level,mostly involving the activation of many pathways of the immune response,ultimately leading to tissue injury.Increased oxidative stress,inflammatory cytokine release,inflammatory cell infiltration and activation and the up-regulation of inflammatory transcription factors participate in the pathophysiology of these complex entities.Treatment varies in each specific disease,but at least in the cases of RE and IBD immunosuppressors are effective.However,full therapeutic responses are not always achieved.The pathophysiology of ischemiareperfusion(IR)injury shares many of these mechanisms.Brief and repetitive periods of ischemia in an organ or limb have been shown to protect against subsequent major IR injury in distant organs,a phenomenon called remote ischemic preconditioning(RIP).This procedure has been shown to protect the gut,pancreas and liver by modulating many of the same inflammatory mechanisms.Since RIP is safe and tolerable,and has shown to be effective in some recent clinical trials,I suggest that RIP could be used as a physiologicallyrelevant adjunct treatment for non-ischemic gastrointestinal inflammatory conditions.
文摘目的探讨脑缺血预适应(BIP)对急性脑梗死(ACI)的神经保护作用。方法收集2005年10月至2007年4月潮州市中心医院门诊及住院收治短暂性脑缺血发作(TIA)后发生 ACI 患者60例,其中30例 TIA 时长≤20 min 为 A1组,30例 TIA 时长>20 min且≤60 min 为 A2组;同期随机抽取 ACI 前无 TIA 的病例30例为 B组(对照组)。ACI 病例观察梗死病灶大小、神经功能评分、病变程度及疗效等指标。结果 TIA 后 ACI,A1组梗死病灶较小,神经功能评分较低,重度病例少,基本痊愈率、显效率及总有效率较高,优于对照组(P<0.01),而A2组差别则无显著性(P>0.05)。结论持续适当的 BIP 对其后发生的 ACI 能产生神经保护作用。
基金This research is supported by Special Funds for Major State Basic Research Projects of China (G1999032804).
文摘In this paper we consider the domain decomposition methods with mortar element Lagrange multipliers to two-dimensional elliptic problems.We shall construct a kind of simple preconditioners for the corresponding interface equation.It will be shown that condition number of the preconditioned interface matrix is almost optimal.
文摘We present a symbolic-numeric hybrid method, based on sum-of-squares （SOS） relaxation and rational vec- tor recovery, to compute inequality invariants and ranking functions for proving total correctness and generating pre- conditions for programs. The SOS relaxation method is used to compute approximate invariants and approximate rank- ing functions with floating point coefficients. Then Gauss- Newton refinement and rational vector recovery are applied to approximate polynomials to obtain candidate polynomials with rational coefficients, which exactly satisfy the conditions of invariants and ranking functions. In the end, several exam- ples are given to show the effectiveness of our method.
