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Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis
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作者 Yan Li Li-Na Jiang +7 位作者 Bo-Kang Zhao Mei-Ling Li Yi-Yun Jiang Yi-Si Liu Shu-Hong Liu Li Zhu Xin Ye Jing-Min Zhao 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第8期3651-3671,共21页
BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer mortality worldwide,and metastasis is the main cause of early recurrence and poor prognosis.However,the mechanism of metastasis remains poorly underst... BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer mortality worldwide,and metastasis is the main cause of early recurrence and poor prognosis.However,the mechanism of metastasis remains poorly understood.AIM To determine the possible mechanism affecting HCC metastasis and provide a possible theoretical basis for HCC treatment.METHODS The candidate molecule lecithin-cholesterol acyltransferase(LCAT)was screened by gene microarray and bioinformatics analysis.The expression levels of LCAT in clinical cohort samples was detected by quantitative realtime polymerase chain reaction and western blotting.The proliferation,migration,invasion and tumor-forming ability were measured by Cell Counting Kit-8,Transwell cell migration,invasion,and clonal formation assays,respectively.Tumor formation was detected in nude mice after LCAT gene knockdown or overexpression.The immunohistochemistry for Ki67,E-cadherin,N-cadherin,matrix metalloproteinase 9 and vascular endothelial growth factor were performed in liver tissues to assess the effect of LCAT on HCC.Gene set enrichment analysis(GSEA)on various gene signatures were analyzed with GSEA version 3.0.Three machine-learning algorithms(random forest,support vector machine,and logistic regression)were applied to predict HCC metastasis in The Cancer Genome Atlas and GEO databases.RESULTS LCAT was identified as a novel gene relating to HCC metastasis by using gene microarray in HCC tissues.LCAT was significantly downregulated in HCC tissues,which is correlated with recurrence,metastasis and poor outcome of HCC patients.Functional analysis indicated that LCAT inhibited HCC cell proliferation,migration and invasion both in vitro and in vivo.Clinicopathological data showed that LCAT was negatively associated with HCC size and metastasis(HCC size≤3 cm vs 3-9 cm,P<0.001;3-9 cm vs>9 cm,P<0.01;metastatic-free HCC vs extrahepatic metastatic HCC,P<0.05).LCAT suppressed the growth,migration and invasion of HCC cell lines via PI3K/AKT/mTOR signaling.Our results indicated that the logistic regression model based on LCAT,TNM stage and the serum level of α-fetoprotein in HCC patients could effectively predict high metastatic risk HCC patients.CONCLUSION LCAT is downregulated at translational and protein levels in HCC and might inhibit tumor metastasis via attenuating PI3K/AKT/mTOR signaling.LCAT is a prognostic marker and potential therapeutic target for HCC. 展开更多
关键词 Lecithin-cholesterol acyltransferase Tumor suppressor gene Hepatocellular carcinoma pi3K/AKT/MTOR predicting model
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Multivariable PI Type Generalized Predictive Control 被引量:4
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作者 Chen, Zengqiang Zhao, Tianhang Yuan, Zhuzhi 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1998年第2期8-13,共6页
This paper presents a multivariable generalized predictive controller with proportion and integration structure by modifying the quadratic criterion of the usual MGPC. The control performance has been improved greatl... This paper presents a multivariable generalized predictive controller with proportion and integration structure by modifying the quadratic criterion of the usual MGPC. The control performance has been improved greatly. The effectiveness of the controller is demonstrated by the simulation result. 展开更多
关键词 predictive control Self-tuning control Multivariable control pi control
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Composition control and temperature inferential control of dividing wall column based on model predictive control and PI strategies 被引量:2
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作者 Jianxin Wang Na Yu +2 位作者 Mengqi Chen Lin Cong Lanyi Sun 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2018年第5期1087-1101,共15页
The dividing wall column (DWC) is considered as a major breakthrough in distillation technology and has good prospect of industrialization. Model predictive control (MPC) is an advanced control strategy that has a... The dividing wall column (DWC) is considered as a major breakthrough in distillation technology and has good prospect of industrialization. Model predictive control (MPC) is an advanced control strategy that has acquired extensive applications in various industries. In this study, MPC is applied to the process for separating ethanol, n-propanol, and n-butanol ternary mixture in a fully thermally coupled DWC. Both composition control and tem- perature inferent/al control are considered. The multiobjective genetic algor/thm function "gamult/obj" in Matlab is used for the weight tuning of MPC. Comparisons are made between the control performances of MPC and PI strategies. Simulation results show that although both MPC and PI schemes can stabilize the DWC in case of feed disturbances, MPC generally behaves better than the PI strategy for both composition control and tempera- ture inferential control, resulting in a more stable and superior performance with lower values of integral of squared error (ISE). 展开更多
关键词 dividing wall column Composition control Temperature inferential control pi strategy Model predictive control Genetic algorithm
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Delay Margin for Predictive PI Control System 被引量:1
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作者 ZHUHong-Dong SHAOHui-He 《自动化学报》 EI CSCD 北大核心 2005年第4期530-536,共7页
The variation of plant dead-time deeply a?ects the stability of the predictive PI controlsystem. It is important for designing and applying the PPI controller to calculate the delay margin.A criterion of stability for... The variation of plant dead-time deeply a?ects the stability of the predictive PI controlsystem. It is important for designing and applying the PPI controller to calculate the delay margin.A criterion of stability for the PPI system and the quantitive relationship among the delay margin,the time constant of the closed-loop system, and the dead-time of the model are given. A graphicalgorithm to compute the delay margin is also developed. The phenomenon that there exist morethan one stability delay zones is discussed. The algorithm is shown to be precise by some simulations. 展开更多
关键词 植物 死亡时间 预控系统 稳定性分析
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基于非线性动态重心粒子群优化的分数阶PI^(λ)D^(μ)控制器设计
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作者 王仁明 刘闻仲 +2 位作者 鲍刚 张铭锐 杨婕 《控制工程》 CSCD 北大核心 2024年第6期1067-1074,共8页
针对现有Oustaloup滤波器拟合精度不佳、结构复杂的缺点,提出了最优精简Oustaloup滤波器。针对粒子群优化算法整定分数阶PI^(λ)D^(μ)控制器参数时学习能力不充分、迭代收敛乏力的问题,提出了一种改进的粒子群优化算法。该算法设计了... 针对现有Oustaloup滤波器拟合精度不佳、结构复杂的缺点,提出了最优精简Oustaloup滤波器。针对粒子群优化算法整定分数阶PI^(λ)D^(μ)控制器参数时学习能力不充分、迭代收敛乏力的问题,提出了一种改进的粒子群优化算法。该算法设计了双异步非线性动态学习因子,以提高粒子的思考能力与信息共享能力,并增加了粒子群质量重心项,用以加速收敛过程。将改进的算法结合最优精简Oustaloup滤波器应用于分数阶PI^(λ)D^(μ)控制器的设计过程,选取了2个分数阶系统模型进行仿真验证。结果表明,改进的算法收敛速度更快且不易陷入局部最优,所设计的控制系统超调量更小、调节时间更短、稳态误差更小,提高了系统的抗干扰能力。 展开更多
关键词 分数阶pi^(λ)d^(μ) 粒子群优化算法 Oustaloup滤波器 参数整定
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DAB储能变换器双闭环模型预测控制与PI补偿控制策略研究
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作者 陈桂涛 宋晨飞 +2 位作者 刘飞飞 黄伯雄 孙向东 《太阳能学报》 EI CAS CSCD 北大核心 2024年第8期1-9,共9页
针对直流微电网中分布式电源输入输出功率不稳定造成的直流母线电压波动问题,鉴于双有源桥(DAB)储能变换器具有能量双向流动的特点,提出一种基于内模原理的双闭环模型预测控制策略。在分析DAB变换器扩展移相调制原理与特性基础上,重点... 针对直流微电网中分布式电源输入输出功率不稳定造成的直流母线电压波动问题,鉴于双有源桥(DAB)储能变换器具有能量双向流动的特点,提出一种基于内模原理的双闭环模型预测控制策略。在分析DAB变换器扩展移相调制原理与特性基础上,重点研究电压外环和电流内环的模型预测控制策略。针对模型预测控制性能依赖电路参数准确度问题,分别从电路主要参数失配对功率传输和直流母线稳压的影响两个角度出发,深入分析模型参数敏感度。最终设置直流母线电压稳态误差灵敏度区,在误差灵敏度区外仅采用双闭环模型预测控制以保证系统的动态响应性能,在误差灵敏度区内采用双闭环模型预测控制和PI补偿控制以消除系统稳态误差。搭建实验平台进行实验验证,结果表明:在系统受到扰动时,DAB储能变换器可实现快速地充放电对系统进行补偿,混合控制策略可快速保持母线电压的稳定,实现系统功率均衡,增强系统抗扰能力。 展开更多
关键词 微电网 变换器 直流母线电压波动 双有源桥 扩展移相 双闭环模型预测控制 pi补偿控制
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基于分数阶PID的火电厂烟气脱硝控制系统
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作者 段宇 马敏阳 《能源与环境》 2024年第2期135-137,共3页
针对选择性催化还原(SCR)烟气脱硝控制对象具有大迟延、大惯性的动态特性,采用常规的PID控制器经常不能实现及时和准确的喷氨控制。设计了基于分数阶PIλDμ控制器的火电厂烟气脱硝控制系统,并对人群搜索算法(SOA)的种群进行动态排序和... 针对选择性催化还原(SCR)烟气脱硝控制对象具有大迟延、大惯性的动态特性,采用常规的PID控制器经常不能实现及时和准确的喷氨控制。设计了基于分数阶PIλDμ控制器的火电厂烟气脱硝控制系统,并对人群搜索算法(SOA)的种群进行动态排序和随机变异而提出改进人群搜索算法,采用改进SOA算法对分数阶PIλDμ控制器的参数进行优化。仿真表明,分数阶PIλDμ烟气脱硝串级系统可以在保证控制精确度的前提下有效减少喷氨控制的调节时间,提高控制的稳定性,实现更加稳定和及时的喷氨控制。 展开更多
关键词 分数阶piλdμ控制器 改进SOA算法 选择性催化还原 烟气脱硝
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An adaptive physics-informed deep learning method for pore pressure prediction using seismic data 被引量:2
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作者 Xin Zhang Yun-Hu Lu +2 位作者 Yan Jin Mian Chen Bo Zhou 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期885-902,共18页
Accurate prediction of formation pore pressure is essential to predict fluid flow and manage hydrocarbon production in petroleum engineering.Recent deep learning technique has been receiving more interest due to the g... Accurate prediction of formation pore pressure is essential to predict fluid flow and manage hydrocarbon production in petroleum engineering.Recent deep learning technique has been receiving more interest due to the great potential to deal with pore pressure prediction.However,most of the traditional deep learning models are less efficient to address generalization problems.To fill this technical gap,in this work,we developed a new adaptive physics-informed deep learning model with high generalization capability to predict pore pressure values directly from seismic data.Specifically,the new model,named CGP-NN,consists of a novel parametric features extraction approach(1DCPP),a stacked multilayer gated recurrent model(multilayer GRU),and an adaptive physics-informed loss function.Through machine training,the developed model can automatically select the optimal physical model to constrain the results for each pore pressure prediction.The CGP-NN model has the best generalization when the physicsrelated metricλ=0.5.A hybrid approach combining Eaton and Bowers methods is also proposed to build machine-learnable labels for solving the problem of few labels.To validate the developed model and methodology,a case study on a complex reservoir in Tarim Basin was further performed to demonstrate the high accuracy on the pore pressure prediction of new wells along with the strong generalization ability.The adaptive physics-informed deep learning approach presented here has potential application in the prediction of pore pressures coupled with multiple genesis mechanisms using seismic data. 展开更多
关键词 Pore pressure prediction Seismic data 1d convolution pyramid pooling Adaptive physics-informed loss function High generalization capability
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Three-dimensional Modeling of Ore-forming Elements and Mineralization Prognosis for the Yechangping Mo Deposit,Henan Province,China
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作者 DING Gaoming JI Genyuan +5 位作者 YAN Guolong XU Yongzhong WANG Kunming XIAO Chun WANG Quanle GUO Dongbao 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2024年第3期736-752,共17页
Three-dimensional geochemical modeling of ore-forming elements is crucial for predicting deep mineralization.This approach provides key information for the quantitative prediction of deep mineral localization,three-di... Three-dimensional geochemical modeling of ore-forming elements is crucial for predicting deep mineralization.This approach provides key information for the quantitative prediction of deep mineral localization,three-dimensional fine interpolation,analysis of spatial distribution patterns,and extraction of quantitative mineral-seeking markers.The Yechangping molybdenum(Mo)deposit is a significant and extensive porphyry-skarn deposit in the East Qinling-Dabie Mo polymetallic metallogenic belt at the southern margin of the North China Block.Abundant borehole data on oreforming elements underpin deep geochemical predictions.The methodology includes the following steps:(1)Threedimensional geological modeling of the deposit was established.(2)Correlation,cluster,and factor analyses post delineation of mineralization stages and determination of mineral generation sequence to identify(Cu,Pb,Zn,Ag)and(Mo,W,mfe)assemblages.(3)A three-dimensional geochemical block model was constructed for Mo,W,mfe,Cu,Zn,Pb,and Ag using the ordinary kriging method,and the variational function was developed.(4)Spatial distribution and enrichment characteristics analysis of ore-forming elements are performed to extract geological information,employing the variogram and w(Cu+Pb+Zn+Ag)/w(Mo+W)as predictive indicators.(5)Identifying the western,northwestern,and southwestern areas of the mine with limited mineralization potential,contrasted by the northeastern and southeastern areas favorable for mineral exploration. 展开更多
关键词 3d geochemical model ore-forming elements GEOSTATISTICS deep mineralization prediction Yechangping Mo deposit
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Predictive Functional Controller with a Similar Proportional Integral Optimal Regulator Structure:Comparison with Traditional Predic-tive Functional Controller and Application to Heavy Oil Coking Equipment 被引量:1
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作者 张日东 王树青 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2007年第2期247-253,共7页
By extending the system's state variables,a novel predictive functional controller has been developed.The structure of this controller is similar to that of classical proportional integral(PI)optimal controller an... By extending the system's state variables,a novel predictive functional controller has been developed.The structure of this controller is similar to that of classical proportional integral(PI)optimal controller and in-cludes a control block that can perform a feed-forward control of future P-step set points.It considers both the state variables and the output errors in its cost function,which results in enhanced control performance compared with traditional state space predictive functional control(TSSPFC)methods that consider only the predictive output er-rors.The predictive functional controller(PFC)has been compared with TSSPFC in terms of tracking ability,dis-turbance rejection,and also based on its application to heavy oil coking equipment.The results obtained show the effectiveness of the controller. 展开更多
关键词 state space model pi optimal regulator predictive functional control
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A robotic tele-drill system over network using predictive display 被引量:2
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作者 谢小辉 Sun Lining Du Zhijiang Cai Hegao 《High Technology Letters》 EI CAS 2006年第1期42-46,共5页
Based on a robotic telesurgery system whose function is to liberate doctor from X-ray radiation, a robotic tele-drill system is constructed. The system is in client/server structure. Client part includes main control ... Based on a robotic telesurgery system whose function is to liberate doctor from X-ray radiation, a robotic tele-drill system is constructed. The system is in client/server structure. Client part includes main control interface, video-audio interface and predictive display interface. Server part includes robot control server and video, audio server. For applying to teleoperation, a virtual reality environment of the system developed by using Java, Java 3D, Pro/E, etc. is established. The geometry and kinematics model of serial robot MOTOMAN sv3x, parallel robot, C-type arm and X-ray machine, surgery bed and its work environment are fulfilled in it. Simulation engine and its simulation syntax are finished, which made the environment controllable. This environment is used as predictive display interface in the telerobotics in order to tackling the problem in visualization feedback as ambiguous or time delay. Experiments that verified feasibility of the system have been done. 展开更多
关键词 robotic teleoperation virtual reality predictive display Java 3d
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Runout prediction of potential landslides based on the multi-source data collaboration analysis on historical cases
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作者 Jun Sun Yu Zhuang Ai-guo Xing 《China Geology》 CAS CSCD 2024年第2期264-276,共13页
Long runout landslides involve a massive amount of energy and can be extremely hazardous owing to their long movement distance,high mobility and strong destructive power.Numerical methods have been widely used to pred... Long runout landslides involve a massive amount of energy and can be extremely hazardous owing to their long movement distance,high mobility and strong destructive power.Numerical methods have been widely used to predict the landslide runout but a fundamental problem remained is how to determine the reliable numerical parameters.This study proposes a framework to predict the runout of potential landslides through multi-source data collaboration and numerical analysis of historical landslide events.Specifically,for the historical landslide cases,the landslide-induced seismic signal,geophysical surveys,and possible in-situ drone/phone videos(multi-source data collaboration)can validate the numerical results in terms of landslide dynamics and deposit features and help calibrate the numerical(rheological)parameters.Subsequently,the calibrated numerical parameters can be used to numerically predict the runout of potential landslides in the region with a similar geological setting to the recorded events.Application of the runout prediction approach to the 2020 Jiashanying landslide in Guizhou,China gives reasonable results in comparison to the field observations.The numerical parameters are determined from the multi-source data collaboration analysis of a historical case in the region(2019 Shuicheng landslide).The proposed framework for landslide runout prediction can be of great utility for landslide risk assessment and disaster reduction in mountainous regions worldwide. 展开更多
关键词 Landslide runout prediction drone survey Multi-source data collaboration dAN3d numerical modeling Jianshanying landslide Guizhou Province Geological hazards survey engineering
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Predicting 3D Radiotherapy Dose-Volume Based on Deep Learning
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作者 Do Nang Toan Lam Thanh Hien +2 位作者 Ha Manh Toan Nguyen Trong Vinh Pham Trung Hieu 《Intelligent Automation & Soft Computing》 2024年第2期319-335,共17页
Cancer is one of the most dangerous diseaseswith highmortality.One of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill ... Cancer is one of the most dangerous diseaseswith highmortality.One of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and technicians.In our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer patients.Medical image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction problem.We proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and augmentation.In strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the architecture.The output of the network is added with a rectified linear unit(Re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation doses.Our experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation therapy.The results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the Dose-score and the Dose-volume histogram score(DVH-score).In the best training cases,the Dose-score is 3.08 and the DVH-score is 1.78.In addition,we also conducted a comparison with the results of another study in the same context of using the loss function. 展开更多
关键词 CT image 3d dose prediction data preprocessing augmentation
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ANN Based Predictive Modelling of Weld Shape and Dimensions in Laser Welding of Galvanized Steel in Butt Joint Configurations 被引量:1
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作者 Laurent Jacques Abderrazak El Ouafi 《Journal of Minerals and Materials Characterization and Engineering》 2018年第3期316-332,共17页
The quality assessment and prediction becomes one of the most critical requirements for improving reliability, efficiency and safety of laser welding. Accurate and efficient model to perform non-destructive quality es... The quality assessment and prediction becomes one of the most critical requirements for improving reliability, efficiency and safety of laser welding. Accurate and efficient model to perform non-destructive quality estimation is an essential part of this assessment. This paper presents a structured and comprehensive approach developed to design an effective artificial neural network based model for weld bead geometry prediction and control in laser welding of galvanized steel in butt joint configurations. The proposed approach examines laser welding parameters and conditions known to have an influence on geometric characteristics of the welds and builds a weld quality prediction model step by step. The modelling procedure begins by examining, through structured experimental investigations and exhaustive 3D modelling and simulation efforts, the direct and the interaction effects of laser welding parameters such as laser power, welding speed, fibre diameter and gap, on the weld bead geometry (i.e. depth of penetration and bead width). Using these results and various statistical tools, various neural network based prediction models are developed and evaluated. The results demonstrate that the proposed approach can effectively lead to a consistent model able to accurately and reliably provide an appropriate prediction of weld bead geometry under variable welding conditions. 展开更多
关键词 Laser Welding predictive MOdELING WELd Shape WELd dIMENSIONS Artificial Neural Networks 3d MOdELING Finite Element Method design of Experiments Analysis of Variance
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基于PI3K/AKT/mTOR途径桔梗皂苷D对脑缺血再灌注诱导的血脑屏障的保护作用及机制研究
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作者 苏小明 苏彦果 孙利 《特产研究》 2024年第5期63-71,共9页
本研究旨在探讨桔梗皂苷D (Platycodin D,PLD)通过PI3K/AKT/mTOR途径对脑缺血再灌注诱导的血脑屏障的保护作用及机制研究。试验采用糖尿病Sprague-Dawley大鼠构建大脑中动脉闭塞模型。动物试验分组:sham组、HIR组、PLD组、3-MA组(3-甲... 本研究旨在探讨桔梗皂苷D (Platycodin D,PLD)通过PI3K/AKT/mTOR途径对脑缺血再灌注诱导的血脑屏障的保护作用及机制研究。试验采用糖尿病Sprague-Dawley大鼠构建大脑中动脉闭塞模型。动物试验分组:sham组、HIR组、PLD组、3-MA组(3-甲基腺嘌呤,3-methyladenine)和PLD+3-MA组。分析各组大鼠神经功能缺损评分、脑含水量、脑梗塞体积和血脑屏障渗透性。透射电子显微镜观察血脑屏障超微结构变化和自噬。免疫印迹法分析紧密连接(Tight junction,TJ)蛋白(ZO-1、claudin-5和occludin)免疫荧光染色和蛋白质免疫印迹(Western blot,WB)法,分析自噬相关蛋白(Beclin-1、LC3B和p62)和PI3K/AKT/mTOR通路相关蛋白的表达。结果表明,PLD和自噬抑制剂3-MA治疗显著降低了脑梗死体积、脑含水量和伊文思蓝渗漏,同时增加了TJ蛋白的表达,降低了自噬相关蛋白的表达(P<0.05)。此外,PLD增加了PI3K、AKT和mTOR的磷酸化水平。PLD通过抑制自噬预防高血糖条件下,脑缺血再灌注损伤后的血脑屏障损伤,可能通过调节PI3K/AKT/mTOR信号通路来实现。 展开更多
关键词 桔梗皂苷d pi3K/AKT/mTOR途径 脑缺血再灌注 血脑屏障
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Economical Optimization of Grid Power Factor Using Predictive Data 被引量:1
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作者 Chaojiong Huang Jason Gu +2 位作者 Haiying Liu Yuansheng Lu Jun Luo 《IEEE/CAA Journal of Automatica Sinica》 EI CSCD 2019年第1期258-267,共10页
We present an electrical grid optimization method for economical benefit. After simplifying an IEEE feeder diagram, we build a compact smart grid system including a photovoltaic-inverter system, a shunt capacitor, an ... We present an electrical grid optimization method for economical benefit. After simplifying an IEEE feeder diagram, we build a compact smart grid system including a photovoltaic-inverter system, a shunt capacitor, an on-load tapchanger(OLTC) and transmission lines. The system power factor(PF) regulation and reactive power dispatching are indispensable to improve power quality. Our control method uses predictive weather and load data to decide engaging or tripping the shunt capacitor, or reactive power injection by the photovoltaic-inverter system, ultimately to keep the system PF in a good range. From the perspective of economics, the economical model is considered as a decision maker in our predictive data control method.Capacitor-only control strategy is a common photovoltaic(PV)regulation method, which is treated as a baseline case. Simulations with GridLAB-D on profiled loads and residential loads have been carried out. The comparison results with baseline control strategy and our predictive data control method show the appreciable economical benefit of our method. 展开更多
关键词 GRId OPTIMIZATION GridLAB-d inverter power factor predictive dATA control SHUNT CAPACITOR
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高阶时滞对象的预测PI(D)控制 被引量:11
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作者 任正云 张红 邵惠鹤 《控制理论与应用》 EI CAS CSCD 北大核心 2005年第4期645-648,652,共5页
利用频率域模型降阶理论,提出了高阶时滞对象的预测PI(D)控制器两种设计方法.一种方法是直接将高阶滞后对象在频率域内降阶为低阶滞后对象,针对低阶滞后对象设计预测PI(D)控制器;另一种方法是按照规定的性能指标设计控制器,并将该控制... 利用频率域模型降阶理论,提出了高阶时滞对象的预测PI(D)控制器两种设计方法.一种方法是直接将高阶滞后对象在频率域内降阶为低阶滞后对象,针对低阶滞后对象设计预测PI(D)控制器;另一种方法是按照规定的性能指标设计控制器,并将该控制器在频率域内降阶为具有预测PI(D)控制器的结构形式.这两种方法设计的控制器均具有结构简单、可调参数少、参数调节方便的特点.仿真表明:在模型失配的情况下,此两类预测PI(D)控制器仍然具有良好的控制性能和鲁棒稳定性能. 展开更多
关键词 预测pi(d) 高阶时滞对象 模型降阶
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分数阶系统模糊自适应分数阶PI~λD~μ控制器 被引量:15
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作者 梁涛年 陈建军 +2 位作者 王媛 林智伟 崔星毅 《北京工业大学学报》 CAS CSCD 北大核心 2013年第7期1040-1045,共6页
针对分数阶被控对象,采用分数阶微积分的数值解法,提出了模糊自适应分数阶PIλDμ控制器的数值实现方法与步骤.由于分数阶闭环控制系统的模糊化难以实现,将分数阶PIλDμ控制器与分数阶被控对象构成闭环分数阶控制系统,求其闭环系统在... 针对分数阶被控对象,采用分数阶微积分的数值解法,提出了模糊自适应分数阶PIλDμ控制器的数值实现方法与步骤.由于分数阶闭环控制系统的模糊化难以实现,将分数阶PIλDμ控制器与分数阶被控对象构成闭环分数阶控制系统,求其闭环系统在时域内的表达式,再用分数阶微积分的数值解法并结合模糊推理规则,推导出了模糊分数阶PIλDμ控制器的实现步骤,并对其控制系统的单位阶跃响应性能进行了仿真分析.结果表明:所设计的模糊自适应分数阶PIλDμ控制器比分数阶PIλDμ及传统的整数阶PID控制器表现出较好的控制性能. 展开更多
关键词 模糊控制 piλdμ控制器 分数阶被控对象 模糊逻辑推理
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PI3k/Akt信号通路在维生素D促进神经递质分泌中的作用 被引量:14
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作者 刘淑梅 李丽华 +2 位作者 鲁俊华 高玲娟 郎玉玲 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2020年第11期1597-1602,共6页
目的:探讨维生素D(vitamin D,VD)调节海马神经元细胞促进神经递质分泌的可能机制。方法:采用化学发光法及酶联免疫吸附试验(ELISA)对62例产后抑郁(postpartum depression,PPD)患者以及31例健康产妇分别进行血清25羟基维生素D[25(OH)D]... 目的:探讨维生素D(vitamin D,VD)调节海马神经元细胞促进神经递质分泌的可能机制。方法:采用化学发光法及酶联免疫吸附试验(ELISA)对62例产后抑郁(postpartum depression,PPD)患者以及31例健康产妇分别进行血清25羟基维生素D[25(OH)D]、5-羟色胺(5-hydroxytryptamine,5-HT)以及去甲肾上腺素(norepinephrine,NE)水平检测;对体外培养的海马神经元细胞施加不同作用因素,采用甲基噻唑基四唑(methylthiazolyltetrazolium,MTT)比色法检测海马神经元细胞的增殖率;免疫印迹法检测总Akt(total Akt,T-Akt)及磷酸化Akt(phosphorylated Akt,p-Akt)蛋白的表达情况。结果:轻度抑郁组患者的血清25(OH)D、5-HT和NE水平低于健康对照组(均P<0.05);而重度抑郁组患者的血清25(OH)D、5-HT和NE水平与轻度抑郁组(均P<0.05)。体外实验结果显示,VD能以剂量依赖性方式调节海马神经元细胞增殖率及5-HT、NE的分泌水平;与对照组比较,VD+阴性小干扰RNA(negative siRNA)组神经元细胞增殖率及5-HT、NE分泌水平增高(均P<0.05);而与对照组比较,VD+VD受体小干扰RNA(VDR siRNA)组神经元细胞增殖率及5-HT、NE分泌水平差异无统计学意义(均P>0.05);免疫印迹结果显示,与对照组比较,p-Akt蛋白的表达在VD+negative siRNA组显著增加(P<0.01);而VD+VDR siRNA组与对照组比较,p-Akt蛋白表达无显著变化(均P>0.05);与对照组比较,VD+DMSO组神经元细胞增殖率及5-HT、NE分泌水平显著增加(均P<0.05);而VD+LY294002(PI3k/Akt信号通路抑制剂)组神经元细胞增殖率及5-HT、NE分泌水平,与对照组比较差异无统计学意义(均P>0.05)。结论:VD促进海马神经元细胞活性及促进5-HT和NE的分泌,可能与PI3-k/Akt信号通路的激活有关,此作用可能在PPD的临床防治及产后护理中具有应用价值。 展开更多
关键词 产后抑郁 维生素d pi3K/AKT信号通路 5-羟色胺 去甲肾上腺素
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分数阶PI~λD~μ在高超声速飞行器姿态控制中的应用展望 被引量:6
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作者 齐乃明 秦昌茂 宋志国 《航天控制》 CSCD 北大核心 2010年第5期93-98,共6页
高超声速飞行器的发展是一个必然的趋势,但是其具有强耦合、严重非线性、大范围气动环境变化的特点,这对飞行器的姿态控制系统提出了更高的要求。本文简述了现代控制及智能控制在姿态控制器中的应用,回顾了传统PID及其改进控制技术,针... 高超声速飞行器的发展是一个必然的趋势,但是其具有强耦合、严重非线性、大范围气动环境变化的特点,这对飞行器的姿态控制系统提出了更高的要求。本文简述了现代控制及智能控制在姿态控制器中的应用,回顾了传统PID及其改进控制技术,针对新的被控对象特点,介绍了分数阶PIλDμ及其发展。由于分数阶PIλDμ具有比传统PID更好的鲁棒性和控制性能,展望分数阶PIλDμ控制在高超声速飞行器姿态控制中得到更广泛的应用。 展开更多
关键词 高超声速飞行器 姿态控制 传统pid 分数阶piλdμ
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