Soluble receptor for advanced glycation end products（s RAGE） can decoy the toxic AGEs and is considered to be a protective factor.This study aimed to evaluate the correlation between intrafollicular s RAGE levels an...Soluble receptor for advanced glycation end products（s RAGE） can decoy the toxic AGEs and is considered to be a protective factor.This study aimed to evaluate the correlation between intrafollicular s RAGE levels and clinical outcomes in infertile women of young or advanced maternal age（AMA） undergoing in vitro fertilization（IVF）.A total of 62 young women and 62 AMA women who would undergo IVF were included in this prospective study.The intrafollicular s RAGE concentration was measured to determine its association with the number of retrieved oocytes,fertilized oocytes,high-quality embryos or achievement of clinical pregnancy in young and AMA women,respectively.Besides,correlations between sR AGE and age or follicle-stimulating hormone（FSH） were examined.We found that the intrafollicular s RAGE levels were higher in young patients than those in AMA patients,suggesting that the s RAGE levels were inversely correlated with age.In young patients,sR AGE showed no correlation with the number of retrieved oocytes,fertilized oocytes,high-quality embryos or achievement of clinical pregnancy.But it was found that AMA patients with more retrieved oocytes,fertilized oocytes and high-quality embryos demonstrated higher sR AGE levels,which were a prognostic factor for getting clinical pregnancy independent of age or FSH level.In conclusion,the s RAGE levels decrease with age.Elevated intrafollicular s RAGE levels indicate good follicular growth,fertilization and embryonic development,and successful clinical pregnancy in AMA women,while in young women,the role of s RAGE may not be so predominant.展开更多
Background:Seizure control during pregnancy and obstetric outcomes are of important concerns for women with epilepsy(WWE)and their families.Advanced maternal age(≥35 years)shows a growing trend in the society with ch...Background:Seizure control during pregnancy and obstetric outcomes are of important concerns for women with epilepsy(WWE)and their families.Advanced maternal age(≥35 years)shows a growing trend in the society with changes of lifestyle,which also occurs in diseased populations.The advanced maternal age is an independent factor for some unsatisfying obstetric outcomes.In this study we explored the seizure control and obstetric complications associated with advanced maternal age in WWE.Methods:This study was based on the epilepsy pregnancy registry at West China Hospital.Patients with epilepsy in this registry who were aged 35 or older when starting pregnancy were included in this study.Their basic demographics and detailed information on epilepsy management and obstetric issues in all trimesters and during 1-year follow-up after birth were documented and reviewed.Data were processed by IBM SPSS version 22.0.The demographic characteristics,seizure frequency,treatment change,obstetric complications,and outcomes were analyzed and compared.Results:Fifteen patients were included in this study,with an average age of 36.32±2.39 years at pregnancy,and 73.33%of them were primiparas.The change of seizure frequency during pregnancy was not in a clear pattern,but there was an increased incidence of tonic-clonic seizures during the mid-and last trimesters.More than 20%of the patients had obstetric complications throughout the trimesters,including vaginal bleeding,hypothyroidism,and pre-eclampsia.The pre-eclampsia seemed extraordinarily complicated with other conditions.However,none of the complications were related with malformations or poor outcome of babies after 1-year follow-up.Conclusion:Advanced maternal age combined with WWE is associated with frequent common obstetric complications.Future controlled studies with large sample sizes are needed to explore the related risks in comparison with other WWE and non-epileptic populations.展开更多
目的通过分析比较不同类型妊娠期高血压疾病(HDCP)的高龄孕妇心电图及心肌肌钙蛋白Ⅰ(cTnⅠ)水平,以探讨该类孕妇心肌损伤情况。方法选取合并HDCP的妊娠晚期高龄孕妇95例作为观察组(A组),参照HDCP分类标准分为妊娠期高血压孕妇35例(A1组...目的通过分析比较不同类型妊娠期高血压疾病(HDCP)的高龄孕妇心电图及心肌肌钙蛋白Ⅰ(cTnⅠ)水平,以探讨该类孕妇心肌损伤情况。方法选取合并HDCP的妊娠晚期高龄孕妇95例作为观察组(A组),参照HDCP分类标准分为妊娠期高血压孕妇35例(A1组)、轻度子痫前期孕妇25例(A2组)、重度子痫前期孕妇12例(A3组)、慢性高血压合并妊娠孕妇23例(A4组);选取同期正常妊娠孕妇125例作为对照组(B组),其中高龄孕妇58例(B1组),适龄孕妇67例(B2组)。所有研究对象均行心电图、血压、实验室检查,并比较各组各指标水平,分析比较各组孕妇心电图及cTnⅠ异常情况,分析cTnⅠ与收缩压(SBP)、舒张压(DBP)、24 h尿蛋白定量值、肌酸激酶同工酶(CK-MB)的相关性。结果 A1组、A2组、A3组、A4组的SBP、DBP水平均明显高于B组,差异具有统计学意义(P<0.05);A2、A3组的24 h尿蛋白定量明显高于A1、A4组,差异具有统计学意义(P<0.05), A2组、A3组的24 h尿蛋白定量均>0.3 g/24 h。A3组的SBP、DBP、肌酸激酶(CK)、CK-MB、24 h尿蛋白定量、产前及产后24 h cTnⅠ水平均明显高于其他各分组,差异具有统计学意义(P<0.05);A组中除了A3组(A3组仅有2例产后24 h cTnⅠ水平未恢复正常, A1组、A2组及A4组产后24 h cTnⅠ水平均恢复正常)外,各分组间产后24 h cTnⅠ水平比较差异无统计学意义(P>0.05), A3组产后24 h cTnⅠ水平较产前明显下降,差异具有统计学意义(P<0.05)。A组心电图异常率55.8%明显高于B组的16.0%,差异具有统计学意义(P<0.05);心电图异常类型主要包括窦性心动过速、房性早搏、室性早搏、ST-T改变、短P-R间期、左室面高电压。心电图异常率比较:B1组明显高于B2组, A3组明显高于A1组、A2组及A4组, A4组明显高于A1组、A2组,差异具有统计学意义(P<0.05);A1与A2组比较差异无统计学意义(P>0.05)。cTnⅠ异常率比较:产前,A3组cTnⅠ异常率66.7%明显高于其他各分组, A2组明显高于A1组及A4组,差异具有统计学意义(P<0.05);产前A1组及A4组比较差异无统计学意义(P>0.05);各组产后24 h cTnⅠ异常率均较产前明显下降。相关性分析显示,合并HDCP孕妇的cTnⅠ与SBP、DBP、24 h尿蛋白定量值及CK-MB呈正相关(r=0.713、0.635、0.664、0.509, P<0.05)。结论重度子痫前期高龄孕妇并发心肌损伤几率高,合并HDCP高龄孕妇应定期监测心电图及cTnⅠ水平,以尽早发现该类孕妇心肌损伤情况。展开更多
基金supported by the National Natural Science Foundation of China(No.81471507)
文摘Soluble receptor for advanced glycation end products（s RAGE） can decoy the toxic AGEs and is considered to be a protective factor.This study aimed to evaluate the correlation between intrafollicular s RAGE levels and clinical outcomes in infertile women of young or advanced maternal age（AMA） undergoing in vitro fertilization（IVF）.A total of 62 young women and 62 AMA women who would undergo IVF were included in this prospective study.The intrafollicular s RAGE concentration was measured to determine its association with the number of retrieved oocytes,fertilized oocytes,high-quality embryos or achievement of clinical pregnancy in young and AMA women,respectively.Besides,correlations between sR AGE and age or follicle-stimulating hormone（FSH） were examined.We found that the intrafollicular s RAGE levels were higher in young patients than those in AMA patients,suggesting that the s RAGE levels were inversely correlated with age.In young patients,sR AGE showed no correlation with the number of retrieved oocytes,fertilized oocytes,high-quality embryos or achievement of clinical pregnancy.But it was found that AMA patients with more retrieved oocytes,fertilized oocytes and high-quality embryos demonstrated higher sR AGE levels,which were a prognostic factor for getting clinical pregnancy independent of age or FSH level.In conclusion,the s RAGE levels decrease with age.Elevated intrafollicular s RAGE levels indicate good follicular growth,fertilization and embryonic development,and successful clinical pregnancy in AMA women,while in young women,the role of s RAGE may not be so predominant.
基金supported by Key Research project of Sichuan Department of Science and Technology(No.2019YFS0211)National Natural Science Foundation of China(No.81901327)+1 种基金China Postdoctoral Science Foundation(No.208973)1.3.5 project for disciplines and excellence of West China Hospital,Sichuan University(No.2017305).
文摘Background:Seizure control during pregnancy and obstetric outcomes are of important concerns for women with epilepsy(WWE)and their families.Advanced maternal age(≥35 years)shows a growing trend in the society with changes of lifestyle,which also occurs in diseased populations.The advanced maternal age is an independent factor for some unsatisfying obstetric outcomes.In this study we explored the seizure control and obstetric complications associated with advanced maternal age in WWE.Methods:This study was based on the epilepsy pregnancy registry at West China Hospital.Patients with epilepsy in this registry who were aged 35 or older when starting pregnancy were included in this study.Their basic demographics and detailed information on epilepsy management and obstetric issues in all trimesters and during 1-year follow-up after birth were documented and reviewed.Data were processed by IBM SPSS version 22.0.The demographic characteristics,seizure frequency,treatment change,obstetric complications,and outcomes were analyzed and compared.Results:Fifteen patients were included in this study,with an average age of 36.32±2.39 years at pregnancy,and 73.33%of them were primiparas.The change of seizure frequency during pregnancy was not in a clear pattern,but there was an increased incidence of tonic-clonic seizures during the mid-and last trimesters.More than 20%of the patients had obstetric complications throughout the trimesters,including vaginal bleeding,hypothyroidism,and pre-eclampsia.The pre-eclampsia seemed extraordinarily complicated with other conditions.However,none of the complications were related with malformations or poor outcome of babies after 1-year follow-up.Conclusion:Advanced maternal age combined with WWE is associated with frequent common obstetric complications.Future controlled studies with large sample sizes are needed to explore the related risks in comparison with other WWE and non-epileptic populations.
文摘目的通过分析比较不同类型妊娠期高血压疾病(HDCP)的高龄孕妇心电图及心肌肌钙蛋白Ⅰ(cTnⅠ)水平,以探讨该类孕妇心肌损伤情况。方法选取合并HDCP的妊娠晚期高龄孕妇95例作为观察组(A组),参照HDCP分类标准分为妊娠期高血压孕妇35例(A1组)、轻度子痫前期孕妇25例(A2组)、重度子痫前期孕妇12例(A3组)、慢性高血压合并妊娠孕妇23例(A4组);选取同期正常妊娠孕妇125例作为对照组(B组),其中高龄孕妇58例(B1组),适龄孕妇67例(B2组)。所有研究对象均行心电图、血压、实验室检查,并比较各组各指标水平,分析比较各组孕妇心电图及cTnⅠ异常情况,分析cTnⅠ与收缩压(SBP)、舒张压(DBP)、24 h尿蛋白定量值、肌酸激酶同工酶(CK-MB)的相关性。结果 A1组、A2组、A3组、A4组的SBP、DBP水平均明显高于B组,差异具有统计学意义(P<0.05);A2、A3组的24 h尿蛋白定量明显高于A1、A4组,差异具有统计学意义(P<0.05), A2组、A3组的24 h尿蛋白定量均>0.3 g/24 h。A3组的SBP、DBP、肌酸激酶(CK)、CK-MB、24 h尿蛋白定量、产前及产后24 h cTnⅠ水平均明显高于其他各分组,差异具有统计学意义(P<0.05);A组中除了A3组(A3组仅有2例产后24 h cTnⅠ水平未恢复正常, A1组、A2组及A4组产后24 h cTnⅠ水平均恢复正常)外,各分组间产后24 h cTnⅠ水平比较差异无统计学意义(P>0.05), A3组产后24 h cTnⅠ水平较产前明显下降,差异具有统计学意义(P<0.05)。A组心电图异常率55.8%明显高于B组的16.0%,差异具有统计学意义(P<0.05);心电图异常类型主要包括窦性心动过速、房性早搏、室性早搏、ST-T改变、短P-R间期、左室面高电压。心电图异常率比较:B1组明显高于B2组, A3组明显高于A1组、A2组及A4组, A4组明显高于A1组、A2组,差异具有统计学意义(P<0.05);A1与A2组比较差异无统计学意义(P>0.05)。cTnⅠ异常率比较:产前,A3组cTnⅠ异常率66.7%明显高于其他各分组, A2组明显高于A1组及A4组,差异具有统计学意义(P<0.05);产前A1组及A4组比较差异无统计学意义(P>0.05);各组产后24 h cTnⅠ异常率均较产前明显下降。相关性分析显示,合并HDCP孕妇的cTnⅠ与SBP、DBP、24 h尿蛋白定量值及CK-MB呈正相关(r=0.713、0.635、0.664、0.509, P<0.05)。结论重度子痫前期高龄孕妇并发心肌损伤几率高,合并HDCP高龄孕妇应定期监测心电图及cTnⅠ水平,以尽早发现该类孕妇心肌损伤情况。
