Recently,it was discovered that the entropy-conserving/dissipative high-order split-form discontinuous Galerkin discretizations have robustness issues when trying to solve the sim-ple density wave propagation example ...Recently,it was discovered that the entropy-conserving/dissipative high-order split-form discontinuous Galerkin discretizations have robustness issues when trying to solve the sim-ple density wave propagation example for the compressible Euler equations.The issue is related to missing local linear stability,i.e.,the stability of the discretization towards per-turbations added to a stable base flow.This is strongly related to an anti-diffusion mech-anism,that is inherent in entropy-conserving two-point fluxes,which are a key ingredi-ent for the high-order discontinuous Galerkin extension.In this paper,we investigate if pressure equilibrium preservation is a remedy to these recently found local linear stability issues of entropy-conservative/dissipative high-order split-form discontinuous Galerkin methods for the compressible Euler equations.Pressure equilibrium preservation describes the property of a discretization to keep pressure and velocity constant for pure density wave propagation.We present the full theoretical derivation,analysis,and show corresponding numerical results to underline our findings.In addition,we characterize numerical fluxes for the Euler equations that are entropy-conservative,kinetic-energy-preserving,pressure-equilibrium-preserving,and have a density flux that does not depend on the pressure.The source code to reproduce all numerical experiments presented in this article is available online(https://doi.org/10.5281/zenodo.4054366).展开更多
Objective To investigate the cold preservation effect on rat livers of a modified storage method with self-made HYD solution.Methods The vascular bed of rat livers was expanded with an additional 20 to 40?ml self-ma...Objective To investigate the cold preservation effect on rat livers of a modified storage method with self-made HYD solution.Methods The vascular bed of rat livers was expanded with an additional 20 to 40?ml self-made HYD solution/100?g liver. After resection of the liver, the extra HYD solution (expressed as % liver weight) was entrapped via portal infusion by tying off the supra- and infra-hepatic inferior vena cava. Forty rats were randomly divided into four groups including control group with conventional storage method, and 20%, 30% and 40% groups according to the amount of extra HYD solution. We compared the preservation effect of the modified storage method with that of the conventional storage method using an isolated perfused rat liver model.Results Bile production and all the indices of hepatic microcirculation including portal perfusion pressure, endothelin-1 in the effluent, trypan blue distribution time and histology were significantly superior in the modified method groups compared to those in the control group (P<0.05). The contents of dihydroxybenzoic acid (DHBA) in the modified method groups were significantly lower than those in the control group (P<0.05). Liver enzymes activities in the 30% group were markedly lower than those in the control group (P<0.05). The preservation effect on rat liver in the 30% group was the best among the modified method groups.Conclusion The modified cold storage method is effective and may have potential for clinical application in liver preservation.展开更多
基金Funded by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)under Germany’s Excellence Strategy EXC 2044-390685587Mathematics Münster:Dynamics-Geometry-Structure.Gregor Gassner is supported by the European Research Council(ERC)under the European Union’s Eights Framework Program Horizon 2020 with the research project Extreme,ERC Grant Agreement No.714487.
文摘Recently,it was discovered that the entropy-conserving/dissipative high-order split-form discontinuous Galerkin discretizations have robustness issues when trying to solve the sim-ple density wave propagation example for the compressible Euler equations.The issue is related to missing local linear stability,i.e.,the stability of the discretization towards per-turbations added to a stable base flow.This is strongly related to an anti-diffusion mech-anism,that is inherent in entropy-conserving two-point fluxes,which are a key ingredi-ent for the high-order discontinuous Galerkin extension.In this paper,we investigate if pressure equilibrium preservation is a remedy to these recently found local linear stability issues of entropy-conservative/dissipative high-order split-form discontinuous Galerkin methods for the compressible Euler equations.Pressure equilibrium preservation describes the property of a discretization to keep pressure and velocity constant for pure density wave propagation.We present the full theoretical derivation,analysis,and show corresponding numerical results to underline our findings.In addition,we characterize numerical fluxes for the Euler equations that are entropy-conservative,kinetic-energy-preserving,pressure-equilibrium-preserving,and have a density flux that does not depend on the pressure.The source code to reproduce all numerical experiments presented in this article is available online(https://doi.org/10.5281/zenodo.4054366).
基金theNationalNaturalScienceFoundationof China! (No 3 9470 682 )
文摘Objective To investigate the cold preservation effect on rat livers of a modified storage method with self-made HYD solution.Methods The vascular bed of rat livers was expanded with an additional 20 to 40?ml self-made HYD solution/100?g liver. After resection of the liver, the extra HYD solution (expressed as % liver weight) was entrapped via portal infusion by tying off the supra- and infra-hepatic inferior vena cava. Forty rats were randomly divided into four groups including control group with conventional storage method, and 20%, 30% and 40% groups according to the amount of extra HYD solution. We compared the preservation effect of the modified storage method with that of the conventional storage method using an isolated perfused rat liver model.Results Bile production and all the indices of hepatic microcirculation including portal perfusion pressure, endothelin-1 in the effluent, trypan blue distribution time and histology were significantly superior in the modified method groups compared to those in the control group (P<0.05). The contents of dihydroxybenzoic acid (DHBA) in the modified method groups were significantly lower than those in the control group (P<0.05). Liver enzymes activities in the 30% group were markedly lower than those in the control group (P<0.05). The preservation effect on rat liver in the 30% group was the best among the modified method groups.Conclusion The modified cold storage method is effective and may have potential for clinical application in liver preservation.