Aim:Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to dista nt orga n metastasis.The systemic chemotherapy has a ...Aim:Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to dista nt orga n metastasis.The systemic chemotherapy has a mini mal effect in peritoneal metastasis so new types of treatment have emerged.The authors revised the main studies done in pressurized in traperit on eal aerosol chemotherapy(PIPAC)and prese nted the main con clusi ons.Methods:A PubMed search was con ducted focus ing on PIPAC in gastric can cer.The MeSH database was searched with the terms:"Gastric can cer[MeSH]and in traperit on eal aerosol chemotherapy".Results:Seve n studies were an alyzed.All the studies performed the tech nique with aerosol of doxorubic in and cisplat in.All cases were well tolerated,with minor adverse effects.Patients presented resolution of their abdominal symptoms and regression of macroscopic carcinomatosis.Cytoreductive surgery or hypertermic intraperitoneal chemotherapy could be performed in some patients with good response to PIPAC.The peritonitis caused by the chemotherapy was well tolerated.Conclusion:PIPAC can induce remission in end-stage and resistant disease with acceptable side effects,good safety levels for patients and health professionals,and quality of life improvement.展开更多
文摘Aim:Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to dista nt orga n metastasis.The systemic chemotherapy has a mini mal effect in peritoneal metastasis so new types of treatment have emerged.The authors revised the main studies done in pressurized in traperit on eal aerosol chemotherapy(PIPAC)and prese nted the main con clusi ons.Methods:A PubMed search was con ducted focus ing on PIPAC in gastric can cer.The MeSH database was searched with the terms:"Gastric can cer[MeSH]and in traperit on eal aerosol chemotherapy".Results:Seve n studies were an alyzed.All the studies performed the tech nique with aerosol of doxorubic in and cisplat in.All cases were well tolerated,with minor adverse effects.Patients presented resolution of their abdominal symptoms and regression of macroscopic carcinomatosis.Cytoreductive surgery or hypertermic intraperitoneal chemotherapy could be performed in some patients with good response to PIPAC.The peritonitis caused by the chemotherapy was well tolerated.Conclusion:PIPAC can induce remission in end-stage and resistant disease with acceptable side effects,good safety levels for patients and health professionals,and quality of life improvement.
