Objective:To determine the most common mistakes made during the use of a metered-dose inhaler(MDI),and the effect of the repeated trainings performed with demonstration method by providing one-to-one feedback on these...Objective:To determine the most common mistakes made during the use of a metered-dose inhaler(MDI),and the effect of the repeated trainings performed with demonstration method by providing one-to-one feedback on these mistakes.Methods:This is a quasi-experimental study with a control group.A total of 100 chronic obstructive pulmonary disease(COPD)patients(50 in the control group and 50 in the experimental group)were included in the research.“Patient Information Form(PIF)”(to determine the descriptive characteristics of patients)through the face-to-face interview method,using“MDI Skill Assessment Form”(MDISAF)(it is composed of 10 skill steps about the use of MDI)through observation method was used.Patients in both the groups were asked to use MDI and their abilities regarding use of MDI were assessed.Then in the intervention group,usage of MDI was explained by a nurse via demonstration and placebo MDI.Trainings were repeated on days 1,3,and 5 as from hospitalization of the patient.In the intervention group,three methods were used in this study:“face-to-face training,”“one-to-one,”and“with feedbacks and repeated.”Routine training regarding use of MDI was given by the nurses in the clinic to patients in the control group.The use of an MDI was assessed using MDISAF before training and after the training on the first,third and fifth days of hospitalization.On the seventh day,the last measurement was performed.Percentage,chi square,and mean were used to assess the data.Results:After repetitive training with one-to-one feedback,several differences between the groups in favor of the experimental group were found in 7 of the 10 skill levels of the MDI.There was a significant difference after“training”between the groups in the third,fourth,fifth,sixth,seventh,eighth and ninth MDI steps in posttest measurement(P<0.05).Evaluating the skills of the groups to use MDI from pretest to posttest,it was determined that while the intervention group made less mistakes in steps in which mistakes were made mostly,the control group continued to make mistakes.Conclusions:Inhaler technique intervention with repeated,face to face,and one-to-one feedback trainings can significantly enhance the MDI techniques in COPD patients.The patients in the intervention group made less mistakes during MDI application and their application skills improved.It may be asser ted that the training provided to the intervention group was effective for using the device correctly,while the training provided in the clinic for the control group was inadequate.展开更多
目的:研究布地格福联合K5压力阈值吸气肌训练对慢阻肺急性加重期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者呼吸力学参数及生命质量的影响。方法:选取2022年1月至2024年1月在赣州市第五人民医院就诊的8...目的:研究布地格福联合K5压力阈值吸气肌训练对慢阻肺急性加重期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者呼吸力学参数及生命质量的影响。方法:选取2022年1月至2024年1月在赣州市第五人民医院就诊的80例慢阻肺急性加重期患者作为研究对象,按照随机数字表分为对照组和观察组,各40例。对照组使用布地格福进行治疗,观察组在对照组的基础上联合K5压力阈值吸气肌训练治疗,两组均治疗30d。分别比较患者治疗前后的圣乔治评分(St.George's Respiratory Questionnaire,SGRQ)、6分钟步行试验(6-minute walk test,6MWT)、最大吸气压(Maximum inspiratory pressure,MIP),并通过测量第1秒呼气量(Forced Expiratory Volume in the first second,FEV1)、用力肺活量(Forced Vital Capacity,FVC)、弥散功能血氧饱和度(Oxygen saturation of blood,SaO_(2))、动脉氧分压(Arterial Oxygen Partial Pressure,PO_(2))、动脉二氧化碳分压(Partial pressure of arterial carbon dioxide,PCO_(2))对肺功能和血气指标进行比较分析,对其进行比较分析。结果:观察组的SGRQ三项评分均低于对照组(P<0.05);治疗后观察组的6MWT和MIP两项都比对照组高(P<0.05);观察组的FEV1、FVC和弥散功能三项指标都高于对照组(P<0.05);观察组的SaO_(2)和PO_(2)明显高于对照组,PCO_(2)明显低于对照组(P<0.05)。结论:布地格福吸入气雾剂联合K5压力阈值吸气肌训练能有效减轻患者的症状,改善呼吸力学参数并提高生命质量,延长患者生存时间。展开更多
The formulation and device collectively constitute an inhalation drug product.Development of inhaled drugs must consider the compatibility between formulation and device in order to achieve the intended pharmaceutical...The formulation and device collectively constitute an inhalation drug product.Development of inhaled drugs must consider the compatibility between formulation and device in order to achieve the intended pharmaceutical performance and usability of the product to improve patient compliance with treatment instruction.From the points of formulation,device and patient use,this article summarizes the inhalation drugs,including pressurized metered dose inhaler(pMDI),dry powder inhaler(DPI),and nebulizer that are currently available in the US and UK markets.It also discusses the practical considerations for the development of inhalers and provides an update on the corresponding regulations of the FDA(U.S.Food and Drug Administration)and the EMA(European Medicines Agency).展开更多
Asthma and chronic obstructive airway disease ,（COAD） are chronic inflammatory disorders of the airways which are usually associated with widespread airway obstruction that is often relieved by treatment. β2-adreno...Asthma and chronic obstructive airway disease ,（COAD） are chronic inflammatory disorders of the airways which are usually associated with widespread airway obstruction that is often relieved by treatment. β2-adrenoreceptor agonists and corticosteriods are the mainstay of the management of this disease. The preferred route of administration of these agents is by inhalation. This allows the drug to be delivered directly to the airway with more rapid relief and fewer side effects than systemic route. The main disadvantage of metered-dose inhaler （MDI） use is that the correct use requires good technique;展开更多
文摘Objective:To determine the most common mistakes made during the use of a metered-dose inhaler(MDI),and the effect of the repeated trainings performed with demonstration method by providing one-to-one feedback on these mistakes.Methods:This is a quasi-experimental study with a control group.A total of 100 chronic obstructive pulmonary disease(COPD)patients(50 in the control group and 50 in the experimental group)were included in the research.“Patient Information Form(PIF)”(to determine the descriptive characteristics of patients)through the face-to-face interview method,using“MDI Skill Assessment Form”(MDISAF)(it is composed of 10 skill steps about the use of MDI)through observation method was used.Patients in both the groups were asked to use MDI and their abilities regarding use of MDI were assessed.Then in the intervention group,usage of MDI was explained by a nurse via demonstration and placebo MDI.Trainings were repeated on days 1,3,and 5 as from hospitalization of the patient.In the intervention group,three methods were used in this study:“face-to-face training,”“one-to-one,”and“with feedbacks and repeated.”Routine training regarding use of MDI was given by the nurses in the clinic to patients in the control group.The use of an MDI was assessed using MDISAF before training and after the training on the first,third and fifth days of hospitalization.On the seventh day,the last measurement was performed.Percentage,chi square,and mean were used to assess the data.Results:After repetitive training with one-to-one feedback,several differences between the groups in favor of the experimental group were found in 7 of the 10 skill levels of the MDI.There was a significant difference after“training”between the groups in the third,fourth,fifth,sixth,seventh,eighth and ninth MDI steps in posttest measurement(P<0.05).Evaluating the skills of the groups to use MDI from pretest to posttest,it was determined that while the intervention group made less mistakes in steps in which mistakes were made mostly,the control group continued to make mistakes.Conclusions:Inhaler technique intervention with repeated,face to face,and one-to-one feedback trainings can significantly enhance the MDI techniques in COPD patients.The patients in the intervention group made less mistakes during MDI application and their application skills improved.It may be asser ted that the training provided to the intervention group was effective for using the device correctly,while the training provided in the clinic for the control group was inadequate.
文摘目的:研究布地格福联合K5压力阈值吸气肌训练对慢阻肺急性加重期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者呼吸力学参数及生命质量的影响。方法:选取2022年1月至2024年1月在赣州市第五人民医院就诊的80例慢阻肺急性加重期患者作为研究对象,按照随机数字表分为对照组和观察组,各40例。对照组使用布地格福进行治疗,观察组在对照组的基础上联合K5压力阈值吸气肌训练治疗,两组均治疗30d。分别比较患者治疗前后的圣乔治评分(St.George's Respiratory Questionnaire,SGRQ)、6分钟步行试验(6-minute walk test,6MWT)、最大吸气压(Maximum inspiratory pressure,MIP),并通过测量第1秒呼气量(Forced Expiratory Volume in the first second,FEV1)、用力肺活量(Forced Vital Capacity,FVC)、弥散功能血氧饱和度(Oxygen saturation of blood,SaO_(2))、动脉氧分压(Arterial Oxygen Partial Pressure,PO_(2))、动脉二氧化碳分压(Partial pressure of arterial carbon dioxide,PCO_(2))对肺功能和血气指标进行比较分析,对其进行比较分析。结果:观察组的SGRQ三项评分均低于对照组(P<0.05);治疗后观察组的6MWT和MIP两项都比对照组高(P<0.05);观察组的FEV1、FVC和弥散功能三项指标都高于对照组(P<0.05);观察组的SaO_(2)和PO_(2)明显高于对照组,PCO_(2)明显低于对照组(P<0.05)。结论:布地格福吸入气雾剂联合K5压力阈值吸气肌训练能有效减轻患者的症状,改善呼吸力学参数并提高生命质量,延长患者生存时间。
文摘The formulation and device collectively constitute an inhalation drug product.Development of inhaled drugs must consider the compatibility between formulation and device in order to achieve the intended pharmaceutical performance and usability of the product to improve patient compliance with treatment instruction.From the points of formulation,device and patient use,this article summarizes the inhalation drugs,including pressurized metered dose inhaler(pMDI),dry powder inhaler(DPI),and nebulizer that are currently available in the US and UK markets.It also discusses the practical considerations for the development of inhalers and provides an update on the corresponding regulations of the FDA(U.S.Food and Drug Administration)and the EMA(European Medicines Agency).
文摘Asthma and chronic obstructive airway disease ,（COAD） are chronic inflammatory disorders of the airways which are usually associated with widespread airway obstruction that is often relieved by treatment. β2-adrenoreceptor agonists and corticosteriods are the mainstay of the management of this disease. The preferred route of administration of these agents is by inhalation. This allows the drug to be delivered directly to the airway with more rapid relief and fewer side effects than systemic route. The main disadvantage of metered-dose inhaler （MDI） use is that the correct use requires good technique;
