Cardiovascular disease is the leading cause of death worldwide.Stroke is the second leading cause of death above the age of 60 years and the leading cause of acquired disability in adults.The main type of stroke is is...Cardiovascular disease is the leading cause of death worldwide.Stroke is the second leading cause of death above the age of 60 years and the leading cause of acquired disability in adults.The main type of stroke is ischemic stroke(80%)and it is subclassified as thrombotic or embolic in nature.展开更多
This paper provides a comprehensive overview on coastal protection and hazard mitigation by mangroves.Previous stud-ies have made great strides to understand the mechanisms and influencing factors of mangroves’protec...This paper provides a comprehensive overview on coastal protection and hazard mitigation by mangroves.Previous stud-ies have made great strides to understand the mechanisms and influencing factors of mangroves’protection function,including wave energy dissipation,storm surge damping,tsunami mitigation,adjustment to sea level rise and wind speed reduction,which are sys-tematically summarized in this study.Moreover,the study analyzes the extensive physical models,based on indoor flume experi-ments and numerical models,that consider the interaction between mangroves and hydrodynamics,to help our understanding of mangrove-hydrodynamic interactions.Additionally,quantitative approaches for valuing coastal protection services provided by man-groves,including index-based and process-resolving approaches,are introduced in detail.Finally,we point out the limitations of previous studies,indicating that efforts are still required for obtaining more long-term field observations during extreme weather events,to create more real mangrove models for physical experiments,and to develop numerical models that consider the flexible properties of mangroves to better predict wave propagation in mangroves having complex morphology and structures.展开更多
Mucosal ulcers are a common yet often overlooked complication during orthodontic treatment,significantly impacting patient comfort and compliance.This letter aims to highlight the prevalence,potential causes,and manag...Mucosal ulcers are a common yet often overlooked complication during orthodontic treatment,significantly impacting patient comfort and compliance.This letter aims to highlight the prevalence,potential causes,and management strategies for mucosal ulcers in orthodontic patients.By reviewing recent literature and clinical observations,we underscore the necessity for proactive measures and tailored interventions to mitigate the incidence and severity of these lesions.Emphasizing the role of patient education and the use of protective devices,we call for a multidisciplinary approach to enhance patient care and treatment outcomes.This discussion is particularly relevant in the context of evolving orthodontic techniques and materials,which necessitate continuous adaptation of clinical practices to ensure patient safety and well-being.展开更多
The three important historical development stages of China from"standing up","getting rich"to"becoming strong"were analyzed deeply.Regional coordinated development policies and strategies...The three important historical development stages of China from"standing up","getting rich"to"becoming strong"were analyzed deeply.Regional coordinated development policies and strategies have also gone through the"enlightenment stage","development stage"and"mature stage".On this basis,the problems of the coordination of China s regional coordinated development and joint prevention and control for environmental protection in the new era,as well as suggestions for the next step were further analyzed.展开更多
In this paper, we conduct research on the prevention methodologies and environmental protection countermeasures for oil pollution based on latest techniques from China and abroad. Petroleum and petrochemical industry ...In this paper, we conduct research on the prevention methodologies and environmental protection countermeasures for oil pollution based on latest techniques from China and abroad. Petroleum and petrochemical industry will also be able to have serious water pollution. Against oil pollution increasingly serious phenomenon, about how to control oil pollution has also carried on the thorough research and accumulated in the process of specific management experiences and lessons. We conduct theoretical analysis between the state-of-the-art methods of environmental protection countermeasures with examples, We firmly believe that more advances will occur in the future.展开更多
Protected vegetable production made the traditional agriculture gradually get rid of the shackles of nature, broke the seasonal traditional agriculture and realized the anti season list of agricultural products. While...Protected vegetable production made the traditional agriculture gradually get rid of the shackles of nature, broke the seasonal traditional agriculture and realized the anti season list of agricultural products. While protected vegetables often encountered sudden disasters in production and were restricted with the conditions of low temperature and weak light. Aimed at the sudden disasters of protected vegetable production in Hebei Province,the countermeasures for disaster prevention and control were put forward from the aspects of variety selection, seedling treatment technology,grafting technique,cultivation and management,flower and fruit retention technology,application of exogenous substance,rational fertilization,transgenic technology and so on,in order to reduce production risks and cut loss,realize that protected vegetable production is safe,good-quality and efficient.展开更多
In a context of a virus that is transmissive by sputtering,wearing masks appear necessary to protect the wearer and to limit the propagation of the disease.Currently,we are facing the 2019-2020 coronavirus pandemic.Co...In a context of a virus that is transmissive by sputtering,wearing masks appear necessary to protect the wearer and to limit the propagation of the disease.Currently,we are facing the 2019-2020 coronavirus pandemic.Coronavirus disease 2019(COVID-19)is an infectious disease with first symptoms similar to the flu.The symptom of COVID-19 was reported first in China and very quickly spreads to the rest of the world.The COVID-19 contagiousness is known to be high by comparison with the flu.In this paper,we propose a design of a mobile application for permitting everyone having a smartphone and being able to take a picture to verify that his/her protection mask is correctly positioned on his/her face.Such application can be particularly useful for people using face protection mask for the first time and notably for children and old people.The designed method exploits Haar-like feature descriptors to detect key features of the face and a decision-making algorithm is applied.Experimental results show the potential of this method in the validation of the correct mask wearing.To the best of our knowledge,our work is the only one that currently proposes a mobile application design“CheckYourMask”for validating the correct wearing of protection mask.展开更多
Starting from the historical evolution of China s regional coordinated development policy and practice,three stages of"enlightenment stage","development stage"and"maturity stage",as well ...Starting from the historical evolution of China s regional coordinated development policy and practice,three stages of"enlightenment stage","development stage"and"maturity stage",as well as the connotation,characteristics and content of implementing regional coordinated development strategy were analyzed.On this basis,from different aspects of industrial distribution,pollutant characteristics and regional environmental protection policy,the existing ecological and environmental protection problems in China s regional coordinated development in the new era were analyzed,and some suggestions for the next step were put forward.It is necessary to follow the"four ones"concept from the overall point of view,implement"three lines and one list"from the perspective of the width of the access red line,strengthen"joint prevention and control"from the perspective of the depth of regional regulation,deepen the"planning environmental impact assessment"from the perspective of the breadth of industrial distribution,and promote the"green-way model"from the perspective of ecological low carbon.展开更多
The paper deals with China’s involvement in the process of international environmental protection. The cooperation between China and international environmental organizations is analyzed. This article stresses on suc...The paper deals with China’s involvement in the process of international environmental protection. The cooperation between China and international environmental organizations is analyzed. This article stresses on such issues as China’s cooperation with United Nations Environment Program, Asia-Pacific Economic Cooperation, Association of Southeast Asian Nations, China-Europe and China-Africa Cooperation. The key spheres of China’s activity in international environmental protection are examined in this paper. Thus, Chinese government attaches great importance to environmental protection and believes that environmental protection will have a direct impact on the overall situation of China’s modernization drive and its long-term development. While promoting economic growth, it has adopted a wide range of measures to strengthen environmental protection.展开更多
The concept of facial impact protection mask for cyclists is proposed in response to increased participation in cycling and the need for injury prevention. The research aims to develop an approach for design of facial...The concept of facial impact protection mask for cyclists is proposed in response to increased participation in cycling and the need for injury prevention. The research aims to develop an approach for design of facial impact protection gear to reduce the risk of severe injury. Impact test equipment and procedure, face surrogate and protection material performance criteria are developed. Three groups of protective materials – rigid crushable, semi rigid, and soft cushion foams are tested and assessed according to criteria. The criteria are linked to measures of the risk of facial and brain injuries: HIC (Head Injury Criterion), peak deceleration, Face-bone damage and energy absorption. The impact energy is simulated by a drop test using a 48 mm-radius-steel hemispherical impactor, with a weight of 4.63 kg similar to that of headform J specified in AS/NZS standard. The drop-height is 1500 mm, and the linear deceleration force of the impactor is recorded and used to establish the performance of the materials. The HIC is used to predict the risk of brain injury, whereas the developed face surrogate is used to assess facial bone injury. A 5.4 m/s facial impact to the unprotected-face of a cyclist can result in the risk of severe facial bone fracture and mild brain injury. The impact test results for rigid foam protection of 40 mm thickness shows no densification (bottom out) and absorbs the impact energy without damage to the Foam-bone of the face surrogate. At 20 mm thickness, rigid polyurethane foams performed best with Foam-bone damage ranging from 15.1% to 20.5%. Other materials with thicknesses of 20 to 28 mm showed Foam-bone damage between 21.8% and 35.1%. The HIC values ranged from 267 to 522, with memory foams and expanded polystyrene foam having the lowest values. Peak deceleration ranged from 71 g to 105 g for the materials tested. It is concluded that the impact energy can be dissipated by the protection material thereby reducing the risk of severe facial injury to the protected area.展开更多
COVID-19 has swept the whole our country and the world in the beginning of 2020.31 provinces and municipalities across the country have launched the first-level response to major public health emergencies since Januar...COVID-19 has swept the whole our country and the world in the beginning of 2020.31 provinces and municipalities across the country have launched the first-level response to major public health emergencies since January 24,and China has carried out intensive epidemic control.It is critical for effectively responding to COVID-19 to collect,collate and analyze people’s personal data.What’s more,obtaining identity information,travel records and health information of confirmed cases,suspected cases and close contacts has become a crucial step in epidemic investigation.All regions have made full use of big data to carry out personnel screening,travel records analysis and other related work in epidemic prevention and control,effectively improving the efficiency of epidemic prevention and control.However,data leakage,personnel privacy data exposure,and personal attack frequently occurred in the process of personnel travel records analysis and epidemic prevention and control.It even happened in the WeChat group to forward a person’s name,phone number,address,ID number and other sensitive information.It brought discrimination,telephone and SMS harassment to the parties,which caused great harm to individuals.Based on these,lack of information security and data security awareness and other issues were exposed.Therefore,while big data has been widely concerned and applied,attention should be paid to protecting personal privacy.It is urgent to pay more attention to data privacy and information security in order to effectively protect the legitimate rights of the people.Therefore,measures can be taken to achieve this goal,such as improving the relevant legal system,strengthening technical means to enhance the supervision and management of information security and data protection.展开更多
Radiotherapy is a critical component of cancer care but can cause osteoporosis and pathological insufficiency fractures in surrounding and otherwise healthy bone.Presently,no effective countermeasure exists,and ionizi...Radiotherapy is a critical component of cancer care but can cause osteoporosis and pathological insufficiency fractures in surrounding and otherwise healthy bone.Presently,no effective countermeasure exists,and ionizing radiation-induced bone damage continues to be a substantial source of pain and morbidity.The purpose of this study was to investigate a small molecule aminopropyl carbazole named P7C3 as a novel radioprotective strategy.Our studies revealed that P7C3 repressed ionizing radiation(IR)-induced osteoclastic activity,inhibited adipogenesis,and promoted osteoblastogenesis and mineral deposition in vitro.We also demonstrated that rodents exposed to clinically equivalent hypofractionated levels of IR in vivo develop weakened,osteoporotic bone.However,the administration of P7C3 significantly inhibited osteoclastic activity,lipid formation and bone marrow adiposity and mitigated tissue loss such that bone maintained its area,architecture,and mechanical strength.Our findings revealed significant enhancement of cellular macromolecule metabolic processes,myeloid cell differentiation,and the proteins LRP-4,TAGLN,ILK,and Tollip,with downregulation of GDF-3,SH2B1,and CD200.These proteins are key in favoring osteoblast over adipogenic progenitor differentiation,cell matrix interactions,and shape and motility,facilitating inflammatory resolution,and suppressing osteoclastogenesis,potentially via Wnt/β-catenin signaling.A concern was whether P7C3 afforded similar protection to cancer cells.Preliminarily,and remarkably,at the same protective P7C3 dose,a significant reduction in triple-negative breast cancer and osteosarcoma cell metabolic activity was found in vitro.Together,these results indicate that P7C3 is a previously undiscovered key regulator of adipo-osteogenic progenitor lineage commitment and may serve as a novel multifunctional therapeutic strategy,leaving IR an effective clinical tool while diminishing the risk of adverse post-IR complications.Our data uncover a new approach for the prevention of radiation-induced bone damage,and further work is needed to investigate its ability to selectively drive cancer cell death.展开更多
Due to the effective control of the local COVID-19 pandemic,and the previous related production capacity has been greatly improved,China has become the largest producer and exporter of anti-pandemic products such as m...Due to the effective control of the local COVID-19 pandemic,and the previous related production capacity has been greatly improved,China has become the largest producer and exporter of anti-pandemic products such as masks and protective clothing,helping many countries in the world to fight against pandemics.Except for China,reporters from the Global Times have reported that there are not many countries or regions that continue to export medical supplies.展开更多
文摘Cardiovascular disease is the leading cause of death worldwide.Stroke is the second leading cause of death above the age of 60 years and the leading cause of acquired disability in adults.The main type of stroke is ischemic stroke(80%)and it is subclassified as thrombotic or embolic in nature.
基金funded by the National Key R&D Program of China(No.2023YFC3007900)the Young Scientists Fund of the National Natural Science Foundation of China(No.42106204)+2 种基金the Jiangsu Basic Research Program(Natural Science Foundation)(No.BK20220082)the National Natural Science Foundation of China(No.52271271)the Major Science&Technology Projects of the Ministry of Water Resources(No.SKS-2022025).
文摘This paper provides a comprehensive overview on coastal protection and hazard mitigation by mangroves.Previous stud-ies have made great strides to understand the mechanisms and influencing factors of mangroves’protection function,including wave energy dissipation,storm surge damping,tsunami mitigation,adjustment to sea level rise and wind speed reduction,which are sys-tematically summarized in this study.Moreover,the study analyzes the extensive physical models,based on indoor flume experi-ments and numerical models,that consider the interaction between mangroves and hydrodynamics,to help our understanding of mangrove-hydrodynamic interactions.Additionally,quantitative approaches for valuing coastal protection services provided by man-groves,including index-based and process-resolving approaches,are introduced in detail.Finally,we point out the limitations of previous studies,indicating that efforts are still required for obtaining more long-term field observations during extreme weather events,to create more real mangrove models for physical experiments,and to develop numerical models that consider the flexible properties of mangroves to better predict wave propagation in mangroves having complex morphology and structures.
文摘Mucosal ulcers are a common yet often overlooked complication during orthodontic treatment,significantly impacting patient comfort and compliance.This letter aims to highlight the prevalence,potential causes,and management strategies for mucosal ulcers in orthodontic patients.By reviewing recent literature and clinical observations,we underscore the necessity for proactive measures and tailored interventions to mitigate the incidence and severity of these lesions.Emphasizing the role of patient education and the use of protective devices,we call for a multidisciplinary approach to enhance patient care and treatment outcomes.This discussion is particularly relevant in the context of evolving orthodontic techniques and materials,which necessitate continuous adaptation of clinical practices to ensure patient safety and well-being.
基金Supported by National Key Research and Development Plan(2016YFC0208102)Special Project for Transformation of Scientific and Technological Achievements in Jiangsu Province(BA2020001)Special Project for Prevention and Control of Air Pollution from Fixed Sources of Ministry of Ecology and Environment,China in 2020(2020A060).
文摘The three important historical development stages of China from"standing up","getting rich"to"becoming strong"were analyzed deeply.Regional coordinated development policies and strategies have also gone through the"enlightenment stage","development stage"and"mature stage".On this basis,the problems of the coordination of China s regional coordinated development and joint prevention and control for environmental protection in the new era,as well as suggestions for the next step were further analyzed.
文摘In this paper, we conduct research on the prevention methodologies and environmental protection countermeasures for oil pollution based on latest techniques from China and abroad. Petroleum and petrochemical industry will also be able to have serious water pollution. Against oil pollution increasingly serious phenomenon, about how to control oil pollution has also carried on the thorough research and accumulated in the process of specific management experiences and lessons. We conduct theoretical analysis between the state-of-the-art methods of environmental protection countermeasures with examples, We firmly believe that more advances will occur in the future.
文摘Protected vegetable production made the traditional agriculture gradually get rid of the shackles of nature, broke the seasonal traditional agriculture and realized the anti season list of agricultural products. While protected vegetables often encountered sudden disasters in production and were restricted with the conditions of low temperature and weak light. Aimed at the sudden disasters of protected vegetable production in Hebei Province,the countermeasures for disaster prevention and control were put forward from the aspects of variety selection, seedling treatment technology,grafting technique,cultivation and management,flower and fruit retention technology,application of exogenous substance,rational fertilization,transgenic technology and so on,in order to reduce production risks and cut loss,realize that protected vegetable production is safe,good-quality and efficient.
文摘In a context of a virus that is transmissive by sputtering,wearing masks appear necessary to protect the wearer and to limit the propagation of the disease.Currently,we are facing the 2019-2020 coronavirus pandemic.Coronavirus disease 2019(COVID-19)is an infectious disease with first symptoms similar to the flu.The symptom of COVID-19 was reported first in China and very quickly spreads to the rest of the world.The COVID-19 contagiousness is known to be high by comparison with the flu.In this paper,we propose a design of a mobile application for permitting everyone having a smartphone and being able to take a picture to verify that his/her protection mask is correctly positioned on his/her face.Such application can be particularly useful for people using face protection mask for the first time and notably for children and old people.The designed method exploits Haar-like feature descriptors to detect key features of the face and a decision-making algorithm is applied.Experimental results show the potential of this method in the validation of the correct mask wearing.To the best of our knowledge,our work is the only one that currently proposes a mobile application design“CheckYourMask”for validating the correct wearing of protection mask.
基金Supported by Special Project for Prevention and Control of Air Pollution from Fixed Sources of Ministry of Ecology and Environment,China(2020A060).
文摘Starting from the historical evolution of China s regional coordinated development policy and practice,three stages of"enlightenment stage","development stage"and"maturity stage",as well as the connotation,characteristics and content of implementing regional coordinated development strategy were analyzed.On this basis,from different aspects of industrial distribution,pollutant characteristics and regional environmental protection policy,the existing ecological and environmental protection problems in China s regional coordinated development in the new era were analyzed,and some suggestions for the next step were put forward.It is necessary to follow the"four ones"concept from the overall point of view,implement"three lines and one list"from the perspective of the width of the access red line,strengthen"joint prevention and control"from the perspective of the depth of regional regulation,deepen the"planning environmental impact assessment"from the perspective of the breadth of industrial distribution,and promote the"green-way model"from the perspective of ecological low carbon.
文摘The paper deals with China’s involvement in the process of international environmental protection. The cooperation between China and international environmental organizations is analyzed. This article stresses on such issues as China’s cooperation with United Nations Environment Program, Asia-Pacific Economic Cooperation, Association of Southeast Asian Nations, China-Europe and China-Africa Cooperation. The key spheres of China’s activity in international environmental protection are examined in this paper. Thus, Chinese government attaches great importance to environmental protection and believes that environmental protection will have a direct impact on the overall situation of China’s modernization drive and its long-term development. While promoting economic growth, it has adopted a wide range of measures to strengthen environmental protection.
文摘The concept of facial impact protection mask for cyclists is proposed in response to increased participation in cycling and the need for injury prevention. The research aims to develop an approach for design of facial impact protection gear to reduce the risk of severe injury. Impact test equipment and procedure, face surrogate and protection material performance criteria are developed. Three groups of protective materials – rigid crushable, semi rigid, and soft cushion foams are tested and assessed according to criteria. The criteria are linked to measures of the risk of facial and brain injuries: HIC (Head Injury Criterion), peak deceleration, Face-bone damage and energy absorption. The impact energy is simulated by a drop test using a 48 mm-radius-steel hemispherical impactor, with a weight of 4.63 kg similar to that of headform J specified in AS/NZS standard. The drop-height is 1500 mm, and the linear deceleration force of the impactor is recorded and used to establish the performance of the materials. The HIC is used to predict the risk of brain injury, whereas the developed face surrogate is used to assess facial bone injury. A 5.4 m/s facial impact to the unprotected-face of a cyclist can result in the risk of severe facial bone fracture and mild brain injury. The impact test results for rigid foam protection of 40 mm thickness shows no densification (bottom out) and absorbs the impact energy without damage to the Foam-bone of the face surrogate. At 20 mm thickness, rigid polyurethane foams performed best with Foam-bone damage ranging from 15.1% to 20.5%. Other materials with thicknesses of 20 to 28 mm showed Foam-bone damage between 21.8% and 35.1%. The HIC values ranged from 267 to 522, with memory foams and expanded polystyrene foam having the lowest values. Peak deceleration ranged from 71 g to 105 g for the materials tested. It is concluded that the impact energy can be dissipated by the protection material thereby reducing the risk of severe facial injury to the protected area.
基金This paper is support by:In 2019,Liaoning Provincial Department of Education Project named“Study on the Path Selection of Rural Revitalization in Ethnic Autonomous Areas of Liaoning Province”The 3rd Azure Talent Project of Dalian Ocean University in 2018+1 种基金In 2019,Liaoning Province’s overseas training project“China-Canada Cooperation Research Plan on Marine Law and Policy”(2019GJWYB019)The Ministry of Education filed the 2017 National and Regional Research Center Project“Northeast Asia Research Center for Marine Law and Policy”(GQ17091).
文摘COVID-19 has swept the whole our country and the world in the beginning of 2020.31 provinces and municipalities across the country have launched the first-level response to major public health emergencies since January 24,and China has carried out intensive epidemic control.It is critical for effectively responding to COVID-19 to collect,collate and analyze people’s personal data.What’s more,obtaining identity information,travel records and health information of confirmed cases,suspected cases and close contacts has become a crucial step in epidemic investigation.All regions have made full use of big data to carry out personnel screening,travel records analysis and other related work in epidemic prevention and control,effectively improving the efficiency of epidemic prevention and control.However,data leakage,personnel privacy data exposure,and personal attack frequently occurred in the process of personnel travel records analysis and epidemic prevention and control.It even happened in the WeChat group to forward a person’s name,phone number,address,ID number and other sensitive information.It brought discrimination,telephone and SMS harassment to the parties,which caused great harm to individuals.Based on these,lack of information security and data security awareness and other issues were exposed.Therefore,while big data has been widely concerned and applied,attention should be paid to protecting personal privacy.It is urgent to pay more attention to data privacy and information security in order to effectively protect the legitimate rights of the people.Therefore,measures can be taken to achieve this goal,such as improving the relevant legal system,strengthening technical means to enhance the supervision and management of information security and data protection.
基金funded by the Department of Internal Medicine,College of Medicine,University of Central Florida (Award#2508074)supported by the National Aeronautics and Space Administration [grant No.80NSSC21M0309]issued through the NASA Office of STEM Engagement。
文摘Radiotherapy is a critical component of cancer care but can cause osteoporosis and pathological insufficiency fractures in surrounding and otherwise healthy bone.Presently,no effective countermeasure exists,and ionizing radiation-induced bone damage continues to be a substantial source of pain and morbidity.The purpose of this study was to investigate a small molecule aminopropyl carbazole named P7C3 as a novel radioprotective strategy.Our studies revealed that P7C3 repressed ionizing radiation(IR)-induced osteoclastic activity,inhibited adipogenesis,and promoted osteoblastogenesis and mineral deposition in vitro.We also demonstrated that rodents exposed to clinically equivalent hypofractionated levels of IR in vivo develop weakened,osteoporotic bone.However,the administration of P7C3 significantly inhibited osteoclastic activity,lipid formation and bone marrow adiposity and mitigated tissue loss such that bone maintained its area,architecture,and mechanical strength.Our findings revealed significant enhancement of cellular macromolecule metabolic processes,myeloid cell differentiation,and the proteins LRP-4,TAGLN,ILK,and Tollip,with downregulation of GDF-3,SH2B1,and CD200.These proteins are key in favoring osteoblast over adipogenic progenitor differentiation,cell matrix interactions,and shape and motility,facilitating inflammatory resolution,and suppressing osteoclastogenesis,potentially via Wnt/β-catenin signaling.A concern was whether P7C3 afforded similar protection to cancer cells.Preliminarily,and remarkably,at the same protective P7C3 dose,a significant reduction in triple-negative breast cancer and osteosarcoma cell metabolic activity was found in vitro.Together,these results indicate that P7C3 is a previously undiscovered key regulator of adipo-osteogenic progenitor lineage commitment and may serve as a novel multifunctional therapeutic strategy,leaving IR an effective clinical tool while diminishing the risk of adverse post-IR complications.Our data uncover a new approach for the prevention of radiation-induced bone damage,and further work is needed to investigate its ability to selectively drive cancer cell death.
文摘Due to the effective control of the local COVID-19 pandemic,and the previous related production capacity has been greatly improved,China has become the largest producer and exporter of anti-pandemic products such as masks and protective clothing,helping many countries in the world to fight against pandemics.Except for China,reporters from the Global Times have reported that there are not many countries or regions that continue to export medical supplies.