Therapeutic and recurrence-preventing effects of Qi-Replenishing and Blood-Activating Formula in rats with acetic acid-induced gastric ulcer

Objective:To explore the therapeutic and recurrence-preventing effects of Qi-Replenishing and Blood-Activating Formula in rats with acetic acid-induced gastric ulcer.Methods:A total of 138 SD rats were selected to make rat models with gastric ulcer induced by acetic acid(24 rats with sham operation served as sham operation group),and were randomly divided into model group(n=30),western medicine group(n=30),traditional Chinese medicine(TCM) group(n=24) and combination group(combined western medicine and TCM group,n=30).Western medicine group was gavaged with omeprazole in the morning and with iso-volumetric distilled water in the afternoon;TCM group and TCM sham operation group were gavaged with iso-volumetric distilled water in the morning and with Qi-Replenishing and Blood-Activating Formula in the afternoon;combination group was gavaged with omeprazole in the morning and with Qi-Replenishing and Blood-Activating Formula in the afternoon;sham operation group and model group were gavaged with iso-volumetric distilled water both in the morning and afternoon.Ulcer indexes and degree of mucosal degree in rats at different time points after gavage were observed.Twentyeight days after gavage,interleukin(IL)-1β was given to induce ulcer recurrence so as to observe the recurrent severity and rate of ulcer in each group.Results:Compared with model group and western medicine group,treatment in combination group could prominently reduce the ulcer index of rats with peptic ulcer,and increase the healing rate and inhibition rate of peptic ulcer.After IL-1β-induced ulcer recurrence,combination group was significantly superior to model group and western medicine group in ulcer recurrent rate[50%(3/6) vs.100%(6/6)]and severity.Conclusions:Basic acid-suppression therapy combined with Qi-Replenishing and BloodActivating Formula can effectually improve the ulcer healing quality and reduce ulcer recurrence.

Prevention and Control Measures of the Occurrence of Ceracris kiangsu Tsai in Sugarcane Areas of Yunnan Province

Ceracris kiangsu Tsai is one of the most widely distributed forest pest.C.kiangsu has migrated from Laos to China this year,with many migration peaks and large population numbers.The main sources of C.kiangsu were from abroad and a small number of native insect sources exist.Most of the immigration sources were from Laos,and a small part originated from Vietnam.The frontier region of Yunnan Province is suitable for the growth of C.kiangsu.It is speculated that the migration frequency of the C.kiangsu from abroad may increase in recent years.In this paper,the typical morphological characteristics,life history,biological characteristics and prevention and control measures of C.kiangsu were summarized.Based on the characteristics of C.kiangsu,and combining actual sugarcane production condition in Yunnan sugarcane areas,we put forward prevention and control strategies and measures.It is suggested that Yunnan Sugarcane areas should pay close attention to the occurrence of C.kiangsu in neighboring countries,monitor the C.kiangsu population dynamics and update pest forecast information in time,and detect and control C.kiangsu in the early period,in order to effectively prevent C.kiangsu and ensure the safety of sugarcane production.

Prevention and Controll of Diseases and Pest Damages of Siraitia grosvenori

[Objective] The aim was to develop prevention and control approaches of diseases and pests of Siraitia grosvenori. [Method] Long-term observation was con- ducted on cultivation methods of Siraitia grosvenori in the gardens in Longjiang Vil- lage of Yongfu County to conclude the prevention methods. [Result] Siraitia grosvenori yield can be reduced by nine diseases, such as root knot nematode dis- ease, and eight pests, such as Brachytrupes portentosus. [Conclusion] It would be effective for prevention of diseases and pests and guarantee quality and yield of Luohan guo to manage the gardens dominated by biological control and supple- mented by pesticide as per crop rotation.

Integrated Prevention and Control Technology for Coffee Leaf Rust in Yunnan Province

This paper investigates the damage symptoms and occurrence regularity related to coffee leaf rust,and proposes a comprehensive prevention and control strategy grounded in the principle of prioritizing prevention and implementing integrated prevention and control.This strategy encompasses the cultivation of rust-resistant varieties,the implementation of agricultural practices,the application of chemical interventions,the utilization of hyperparasitic fungi,and the protection and utilization of natural enemies.The paper further outlines the necessary requirements for effective prevention and control,emphasizing the importance of enhancing responsibility implementation,fostering systematic prevention and control measures,enhancing guidance services,and increasing publicity and guidance.The aim is to offer technical guidance for the integrated prevention and control of coffee leaf rust in Yunnan Province.

Catastrophic Debris Flows on July 10^(th) 2013 along the Min River in Areas Seriously-hit by the Wenchuan Earthquake

Over 240 debris flows occurred in hill-slopes, gullies （ indicated those with single-channel） and watersheds （indicated those with tributaries and channels） on July 10th 2013 in the Wenchuan county, and caused 29 casualties and about 633×10^6 USD losses. This work aimed to analyze characteristics, hazards and causes of these events and explore mitigating measures based on field investigation and remote sensing images interpretation. The debris flows contained clay content of 0.1%~3.56%, having densities of 1.72-2.14 t/m^3, velocities of 5.0-m.7 m/s, discharges of 335-2353 m^3/s and sediment yields of 0.10-1.26×10^6 m^3, and also numerously occurred in large watersheds with the area over lo km^2. Large debris flows formed 3 hazard-chains in slopes, gullies, watersheds and rivers, which all evolved in dammed lakes and outburst flood, and 26 dammed lakes and lO newly ones were generated along the rivers of Min and Yuzi. The remarkable spatial difference of loose solid materials accumulation and intense rainfall, with the cumulative of about or more than 150 mm and the hourly of over 16mm, caused debris flows in the sections from Yingxiu to Miansi and Gengda. The damages on buildings, reconstructions, highways,factories and hydro power station originated from the impacting, scouring, burying of debris flows, the submerging of dammed lake and the scouring of outburst flood, and the huge losses came from the ruinous destructions of control engineering works of debris flows as well as the irrational location and low- resistant capabilities of reconstructions. For hazards mitigating of debris flows in long term, the feasible measures for short term, including risk-reassessing of foregone and potential hazard sites, regional alarming system establishing and integrated control in disastrous sites, and middle-long term, including improving reconstruction standard, rationally disposing river channel bed rise and selecting appropriate reconstruction time and plans, were strongly suggested.

Identification and Prevention and Control of Scab-anthracnoge of Landscape Plant Fatsia japonica

The pathogenic characteristics of scab-anthracnoge of Fatsia japonica was introduced,and the infection cycle,occurrence regularity and main harmful symptoms of the disease were elaborated.Prevention is the main method to prevent scab-anthracnoge of F.japonica,and disease-free seedlings should be cultivated.Meantime,cultivation management should be strengthened to improve disease resistance of plant,and chemical agents must be timely sprayed in the early incidence stage,in order to achieve the purpose of comprehensive control.

Dietary Conjugated Linoleic Acids Arrest Cell Cycle Progression and Prevent Ovarian Cancer Xenografts Growth Suggesting a Trans-10 Cis-12 Isoform Specific Activity

Therapies for treating ovarian cancer (OvCa) successfully are largely inadequate. Alternative therapies and diet(s) with preventive potential to debilitated onset, and reduced OvCa tumor burden in situ, have not been systematically studied. Preventive role of conjugated linoleic acids (CLAs) has been reported in many other cancers. We report the first systematic in vitro and in vivo study modeling potential preventive mechanism(s) of CLA, an octadecadienolic fatty acid in clear cell OvCa cell line TOV-21G. We demonstrate that a dose and time-dependent down-regulation of cyclin E and A proteins (p 0.05) by CLA (t10,c12) was concomitant with cell cycle arrest of TOV-21G cell lines in S phase. To understand the molecular mechanism underlying CLA (t10,c12) induced S phase arrest, levels of cell cycle regulatory proteins were determined by western blot analyses. Exposure to CLA (t10,c12) increased p21(CIP1/WAF1), and p27(KIP1) protein levels in a time and dose-dependent manner. Interestingly CLA (t10,c12) did not significantly affect protein levels of cyclin-dependent kinase (cdk) 2, and p53, however, hyperphosphorylated form of pRb (p 0.05) was abrogated. Exposure to CLA (c9,t11) indicated a modest increase in p21(CIP1/WAF1) and p27(KIP1) levels, but changes in cyclin A and E levels were statistically insignificant. These results indicate that CLA (t10,c12) mediated p27(KIP1) upregulation and inhibition of hyperphosphorylation of ppRb may be the possible mechanism for the S phase arrest in TOV-21G cell line. Our in vivo data showed that CLA reduced the progression of TOV-21G xenografts by >50%. Together our results provide evidence of CLA exerted preventive effect on OvCa cell and tumor growth. Tumor growth arrest may be resultant from CLA (t10,c12) mediated modulation of cell cycle arrest.

Research of Risk Identification and Prevention of Underground Pressure Pipelines Damage Caused by External Disturbance

External disturbance is an important cause of underground pressure pipeline damage,which leads to accidents,and it is crucial to study the risk of damage caused by external disturbance and come up with proper prevention and control measures.We reviewed literature on risk identification of underground pressure pipelines damage due to external disturbance was conducted,and a list of risk factors was formed.Based on the list of risk factors,fault tree analysis was carried out on underground pressure pipelines damage caused by external disturbances,and risk prevention and control measures were proposed through the calculation of minimum cut sets,minimum path sets,and structural importance,in hopes of providing reference for the normal operation of underground pressure pipelines.

Use of community mobile phone big location data to recognize unusual patterns close to a pipeline which may indicate unauthorized activities and possible risk of damage

Damage caused by people and organizations unconnected with the pipeline management is a major risk faced by pipelines,and its consequences can have a huge impact.However,the present measures to monitor this have major problems such as time delays,overlooking threats,and false alarms.To overcome the disadvantages of these methods,analysis of big location data from mobile phone systems was applied to prevent third-party damage to pipelines,and a third-party damage prevention system was developed for pipelines including encryption mobile phone data,data preprocessing,and extraction of characteristic patterns.By applying this to natural gas pipelines,a large amount of location data was collected for data feature recognition and model analysis.Third-party illegal construction and occupation activities were discovered in a timely manner.This is important for preventing third-party damage to pipelines.

Tight sandstone reservoir sensitivity and damage mechanism analysis: A case study from Ordos Basin, China and implications for reservoir damage prevention

Analysis of reservoir sensitivity to velocity,water,salt,acid,alkali and stress is critical for reservoir protection.To study the tight sandstone reservoir sensitivity at different formation depths(effective stress)and formation water conditions(pH,salinity,and fluid velocity),a series of dynamic core flow tests under different pH,salinity,acid,and effective stress conditions were performed on samples from tight sandstone reservoirs of the Upper Triassic Yanchang 8(T_(3)y^(8))Member and conventional reservoirs of the Middle-Lower Jurassic Yan'an 9(J_(1-2)y^(9))Member in the Ordos Basin.The results indicate that,compared with the conventional reservoirs,the tight sandstone reservoirs are more sensitive to velocity and stress,less sensitive to water,alkali and salinity,and respond better to acid fracturing.In addition,the critical conditions(salinity,velocity,pH,and stress)for pumping drilling,completion,and fracturing fluids into tight sandstone reservoirs were investigated.A combination of scanning electron microscopy coupled with energy-dispersive spectrometry(SEM-EDS),cathodoluminescence(CL),casting thin section(CTS)and nuclear magnetic resonance(NMR)images,high-pressure mercury injection capillary pressure(MICP)measurements as well as X-ray fluorescence spectral(XRF)analyses were employed to analyze the damage mechanisms of the conventional reservoirs(J_(1-2)y^(9))and tight sandstone reservoirs(T_(3)y^(8))caused by fluid invasion.The results suggest that reservoir sensitivity is primarily conditioned by the composition of detrital components and interstitial fillings,petrophysical properties,pore-throat structure,and diagenetic facies.All these factors control the sensitivity types and extent of the reser-voirs.Our results indicate that the poorer the reservoir physical properties,the stronger the reservoir heterogeneity and sensitivity,implying that tight sandstone reservoirs are more susceptible to changes in fluids than conventional reservoirs.This study offers insights into the reservoir damage types and helps to improve the design and implementation of protection measures for tight sandstone reservoir exploration.

NCEES:An Expert System To Nuclear Calamity Evaluation

This paper introduces a nuclear calamity evaluation expert system which is applied to comprehensive evaluation of damage effects of nuclear calamities. It contains hardware environment, overall structure, logical steps and reasoning models, concerning the expert system.

N-terminal 5-mer Peptide Analog P165 of Amyloid Precursor Protein Exert Antioxidant, Anti-Inflammatory and Anti-Apoptotic Effects on UVB-Irradiated HaCaT Cells

Skin is the first line of defense against a wide variety of physical and chemical damages.Photodamage of the skin can have an effect on beauty,while it is correlated with various skin diseases.Accordingly,effective prevention of skin photodamage has constantly been a research hotspot in the field of skin.The precursor protein of amyloidβ-protein(APP)refers to a type of transmembrane protein that has been widely found in numerous types of cells.

A new method of temporary plugging based on andreasen equation

Based on the fractal nature of pore size in sandstone and grindingbody within a certain range and the Andreasen equation in theory, using the optimization theory of traditional tem- porary plugging agent for reference, we established a new temporary plugging method for reservoir protection. This new method emphasizes on the formulation and optimization of solid filling particles and softening particles. It is good in easy operation and strong applicability. Indoor experiments with the natural core from Hailaer area were conducted using this new method. Compared with traditional methods, the filtration reduced significantly and the permeability recovery was improved greatly, which verified the rationality of this new method.

Rodent Damage and Control Methods in Hami Grassland of Xinjiang

Since 2002,Hami City,Xinjiang Province,has implemented"construction project of rodent-free demonstration area".Artificial eagle frames are installed on the grassland to control rodent damage,receiving remarkable control effect.The rodent density in the treatment area is below the threshold of hazard.Moreover,the implementation of the project increases the grassland biomass and improves the vegetation coverage,receiving good economic,ecological and social benefits.

Preventive effect of Fangshuan capsule on PCI-induced myocardial damage and vascular endothelial injury in patients with unstable angina pectoris

Objective To observe the prevention of Fangshuan Capsule(FC)on percutaneous coronary intervention(PCI)induced myocardial damage and vascular endothelial injury in patients with unstable angina pectoris(UAP).Methods Totally 100 UAP patients undergoing PCI were assigned to the control group and the

四川泸定M_(s)6.8地震房屋震害及人员死亡特征分析

在收集整理四川泸定M_(s)6.8地震现场调查资料的基础上,对比九寨沟M_(s)7.0地震,分析房屋震害特征和人员伤亡情况。结果表明,相较九寨沟地震,四川泸定M_(s)6.8地震灾区房屋震害更为严重,遇难人数更多,主要原因是房屋抗震能力不足、选址不合理以及地质灾害较为发育等。灾区房屋结构类型主要有钢混结构、砖混结构、穿斗木结构、石木结构、砖木结构、土木结构等6类。对房屋平均震害指数和易损性曲线的分析表明,未设防的砖混结构、简易结构房屋抗震能力弱,震害比其他结构房屋严重;而人员死亡主要由地震地质灾害造成,集中在高烈度区和地质灾害易发区,死亡人员以中老年为主,人员死亡率与地震烈度、人口密度有明显相关性。灾区房屋破坏及人员伤亡具有高山峡谷地区的震害特征。本文的研究结果可为进一步研究该类地区的地震灾害风险研究提供参考。

中医“正气存内,邪不可干”与机体内源性抗损伤反应的相关性初探

内源性抗损伤反应是生物机体清除体内细菌病毒、维持机体内环境稳态的重要自我保护机制。其通过诱导相关保护蛋白,使机体自身防御系统产生对抗损伤的触发物质和中介物质,从而激活金属硫蛋白、热休克蛋白、一氧化氮、丝裂素活化蛋白激酶等效应物质及相关信号通路,提高机体对疾病的适应能力与抗损伤能力,是防治疾病、维持机体自身稳态的重要途径。中医“正气存内,邪不可干”理论是对人体发挥抗病、祛邪、调节、修复功能和机体对外界刺激适应能力的高度概括,阐明了在疾病的发生发展过程中正气发挥着主导作用,正气不足是疾病发生的先决条件。而且正气发挥正常的生理功能要满足“足”“通”“和”三个基本条件。内源性抗损伤反应与中医“正气存内,邪不可干”理论联系密切,都表明了正气不足、抵抗力下降是机体发病的前提条件,正气与抗损伤物质不能通达患病部位是机体发病的重要原因。本研究基于中医“正气存内,邪不可干”理论与机体内源性抗损伤反应的防治特点、防治通路及物质基础等为契入点,研究机体内源性抗损伤反应与中医“正气存内,邪不可干”理论的相关性,揭示其在疾病预防和诊疗过程中的重要作用。

广东电网遭台风泰利侵袭的输配电设备受损分析及评估

近年来致灾台风频率呈增加趋势,以2023年影响广东电网约百万用户的第4号台风“泰利”为例,分析广东电网遭台风侵袭受灾情况,建立输配电杆塔受损预测模型,识别关键特征变量与因素,为电网防灾减灾提供支持。首先,分析台风“泰利”气象特征,具有“台前对流活跃,风力强度大,降水范围广”等特点,对输配电设备均产生一定程度破坏。其次,利用随机森林、支持向量机、梯度决策树、神经网络等4种机器学习算法建立输配电杆塔受损预测模型,并对比部分算法针对不平衡样本优化前后模型表现。算例表明,随机森林优化后提升最大,综合考虑时间指标及预测质量指标,梯度决策树为最优算法。最后,基于shapley additive explanations法等对最优模型解释性进行评估,分析表明最大风速、温度、杆塔数量等对预测结果有显著影响。所得结论有助于深入理解台风对广东电网的影响机制,为提升区域电网抵御复杂自然灾害能力提供参考。

预防性个人信息保护公益诉讼的机理证成与制度构建

当前,个人信息保护公益诉讼主要依赖于较为单一的事后补偿性救济方式。囿于个人信息侵害具有不可逆转的特殊性,损害救济模式与个人信息公益保护之间难以实现有效协调。损害救济模式泛化适用的成因,主要在于公益诉讼介入的谦抑性、侵权责任适用的约束性以及风险预防原则的补充性。以风险预防原则为理论基础,在法律框架内对潜在个人信息风险实施前瞻性预防的诉讼模式具有规范性、可行性和优越性。为有效预防个人信息风险,从源头制止个人信息公益损害,应当通过重大风险的界定标准、证明责任的理性分配以及诉权主体的厘定,构建救济性与预防性保护模式并存的个人信息保护公益诉讼体系。