The ability of vitamin E to prevent or treat experimental lead intoxication was investigated in rats.Lead ingestion(10 mg/kg,lead as lead acetate,orally fbr 6 weeks)significantly inhibited the activity of blood δ-ami...The ability of vitamin E to prevent or treat experimental lead intoxication was investigated in rats.Lead ingestion(10 mg/kg,lead as lead acetate,orally fbr 6 weeks)significantly inhibited the activity of blood δ-aminolevulinic acid dehydratase(ALAD),reduced the brain dopamine (DA)contents,enhanced the blood zinc protoporphyrin,and enhanced the urinary excretion of δ-aminolevulinic acid(ALA).Lead exposure also elevated brain norepinephrine,homovanillic acid,and 5-hydroxyindole acetic acid(5-HIAA)levels and concentration of lead in blood and tissue.Simultaneous supplementation of vitamin E along with lead significantly reduced the inhibition of blood ALAD activity,brain DA and 5-HIAA levels,and elevation of urinary ALA excretion.Blood and liver lead concentrations were also significantly reduced by simultaneous supplementation with vitamin E.Postlead exposure treatment with vitamin E was ineffective in reducing the lead-induced effects,except that the inhibition of blood ALAD activity was slightly reduced.The present results suggest that vitamin E given simultaneously with lead is effective in reducing the severity of lead intoxication.1989 Academic Press.Inc.展开更多
Member of Political Bureau of Central Committee of CPC, Vice Premier of State Council concurrently Minister of Health, General Command of National Protecting and Treating Severe Acute Respiratory Syndrome ( SARS) Head...Member of Political Bureau of Central Committee of CPC, Vice Premier of State Council concurrently Minister of Health, General Command of National Protecting and Treating Severe Acute Respiratory Syndrome ( SARS) Headquarters Vice premier WU Yi cordially met the well-known TCM specialists, and held a symposium with them. Sixteen specialists including WANG Yong-yan, CHEN Ke-ji, LI Fu-ren, JIAO Shu-de, HE Pu-ren, LIU展开更多
Herbal bioactives have been shown to influence the pathogenesis of homocysteine associated vascular complications.However,there are no simple cellular models to study their role in preventing angiogenesis impairment b...Herbal bioactives have been shown to influence the pathogenesis of homocysteine associated vascular complications.However,there are no simple cellular models to study their role in preventing angiogenesis impairment by homocysteine and adenosine.Using dipyridamole,an inhibitor for nucleoside transport,we examined its mechanism of action on impaired展开更多
文摘The ability of vitamin E to prevent or treat experimental lead intoxication was investigated in rats.Lead ingestion(10 mg/kg,lead as lead acetate,orally fbr 6 weeks)significantly inhibited the activity of blood δ-aminolevulinic acid dehydratase(ALAD),reduced the brain dopamine (DA)contents,enhanced the blood zinc protoporphyrin,and enhanced the urinary excretion of δ-aminolevulinic acid(ALA).Lead exposure also elevated brain norepinephrine,homovanillic acid,and 5-hydroxyindole acetic acid(5-HIAA)levels and concentration of lead in blood and tissue.Simultaneous supplementation of vitamin E along with lead significantly reduced the inhibition of blood ALAD activity,brain DA and 5-HIAA levels,and elevation of urinary ALA excretion.Blood and liver lead concentrations were also significantly reduced by simultaneous supplementation with vitamin E.Postlead exposure treatment with vitamin E was ineffective in reducing the lead-induced effects,except that the inhibition of blood ALAD activity was slightly reduced.The present results suggest that vitamin E given simultaneously with lead is effective in reducing the severity of lead intoxication.1989 Academic Press.Inc.
文摘Member of Political Bureau of Central Committee of CPC, Vice Premier of State Council concurrently Minister of Health, General Command of National Protecting and Treating Severe Acute Respiratory Syndrome ( SARS) Headquarters Vice premier WU Yi cordially met the well-known TCM specialists, and held a symposium with them. Sixteen specialists including WANG Yong-yan, CHEN Ke-ji, LI Fu-ren, JIAO Shu-de, HE Pu-ren, LIU
文摘Herbal bioactives have been shown to influence the pathogenesis of homocysteine associated vascular complications.However,there are no simple cellular models to study their role in preventing angiogenesis impairment by homocysteine and adenosine.Using dipyridamole,an inhibitor for nucleoside transport,we examined its mechanism of action on impaired
