The ability of vitamin E to prevent or treat experimental lead intoxication was investigated in rats.Lead ingestion(10 mg/kg,lead as lead acetate,orally fbr 6 weeks)significantly inhibited the activity of blood δ-ami...The ability of vitamin E to prevent or treat experimental lead intoxication was investigated in rats.Lead ingestion(10 mg/kg,lead as lead acetate,orally fbr 6 weeks)significantly inhibited the activity of blood δ-aminolevulinic acid dehydratase(ALAD),reduced the brain dopamine (DA)contents,enhanced the blood zinc protoporphyrin,and enhanced the urinary excretion of δ-aminolevulinic acid(ALA).Lead exposure also elevated brain norepinephrine,homovanillic acid,and 5-hydroxyindole acetic acid(5-HIAA)levels and concentration of lead in blood and tissue.Simultaneous supplementation of vitamin E along with lead significantly reduced the inhibition of blood ALAD activity,brain DA and 5-HIAA levels,and elevation of urinary ALA excretion.Blood and liver lead concentrations were also significantly reduced by simultaneous supplementation with vitamin E.Postlead exposure treatment with vitamin E was ineffective in reducing the lead-induced effects,except that the inhibition of blood ALAD activity was slightly reduced.The present results suggest that vitamin E given simultaneously with lead is effective in reducing the severity of lead intoxication.1989 Academic Press.Inc.展开更多
目的总结骨小梁金属重建棒植入治疗成人早期股骨头缺血性坏死(avascular necrosis of the femoral head,ANFH)的手术方法及临床疗效。方法2005年3月-2007年1月,采用骨小梁金属重建棒植入治疗28例ANFH患者。男18例,女10例;年龄18～56岁,...目的总结骨小梁金属重建棒植入治疗成人早期股骨头缺血性坏死(avascular necrosis of the femoral head,ANFH)的手术方法及临床疗效。方法2005年3月-2007年1月,采用骨小梁金属重建棒植入治疗28例ANFH患者。男18例,女10例;年龄18～56岁,平均30.6岁。致病原因:创伤性7例,激素性10例,酒精性5例,原因不明6例。单侧22例,双侧6例。左侧18髋,右侧16髋。根据1997年世界骨循环研究学会骨坏死分期标准:Ⅰ期16例16髋,Ⅱ期12例15髋,Ⅲ期1例1髋,Ⅳ期2例2髋。Harris评分为(50.3±2.2)分。病程12～24个月,平均16个月。结果术后患者切口均Ⅰ期愈合,无感染等并发症发生。28例均获随访,随访时间18～36个月,平均26个月。患者术前疼痛及功能受限症状均明显缓解。术后18个月Harris评分为(85.7±2.4)分,与术前比较差异有统计学意义(P<0.05);获优23例,良3例,中2例,优良率92.86%。结论骨小梁金属重建棒植入是治疗早期ANFH的有效方法之一,可最大限度减少并发症,但远期疗效尚待随访观察。展开更多
文摘The ability of vitamin E to prevent or treat experimental lead intoxication was investigated in rats.Lead ingestion(10 mg/kg,lead as lead acetate,orally fbr 6 weeks)significantly inhibited the activity of blood δ-aminolevulinic acid dehydratase(ALAD),reduced the brain dopamine (DA)contents,enhanced the blood zinc protoporphyrin,and enhanced the urinary excretion of δ-aminolevulinic acid(ALA).Lead exposure also elevated brain norepinephrine,homovanillic acid,and 5-hydroxyindole acetic acid(5-HIAA)levels and concentration of lead in blood and tissue.Simultaneous supplementation of vitamin E along with lead significantly reduced the inhibition of blood ALAD activity,brain DA and 5-HIAA levels,and elevation of urinary ALA excretion.Blood and liver lead concentrations were also significantly reduced by simultaneous supplementation with vitamin E.Postlead exposure treatment with vitamin E was ineffective in reducing the lead-induced effects,except that the inhibition of blood ALAD activity was slightly reduced.The present results suggest that vitamin E given simultaneously with lead is effective in reducing the severity of lead intoxication.1989 Academic Press.Inc.
文摘目的总结骨小梁金属重建棒植入治疗成人早期股骨头缺血性坏死(avascular necrosis of the femoral head,ANFH)的手术方法及临床疗效。方法2005年3月-2007年1月,采用骨小梁金属重建棒植入治疗28例ANFH患者。男18例,女10例;年龄18～56岁,平均30.6岁。致病原因:创伤性7例,激素性10例,酒精性5例,原因不明6例。单侧22例,双侧6例。左侧18髋,右侧16髋。根据1997年世界骨循环研究学会骨坏死分期标准:Ⅰ期16例16髋,Ⅱ期12例15髋,Ⅲ期1例1髋,Ⅳ期2例2髋。Harris评分为(50.3±2.2)分。病程12～24个月,平均16个月。结果术后患者切口均Ⅰ期愈合,无感染等并发症发生。28例均获随访,随访时间18～36个月,平均26个月。患者术前疼痛及功能受限症状均明显缓解。术后18个月Harris评分为(85.7±2.4)分,与术前比较差异有统计学意义(P<0.05);获优23例,良3例,中2例,优良率92.86%。结论骨小梁金属重建棒植入是治疗早期ANFH的有效方法之一,可最大限度减少并发症,但远期疗效尚待随访观察。
