Prevention and Control Strategies of Nosocomial Infection and Effectiveness Evaluation in a Tertiary Teaching Hospital during the Epidemic of COVID-19

Objective: To evaluate the role of prevention and control strategies for nosocomial infection in a tertiary teaching hospital during the sudden outbreak of Corona Virus Disease 2019 (COVID-19). Methods: The hospital initiated an emergency plan involving multi-departmental defense and control. It adopted a series of nosocomial infection prevention and control measures, including strengthening pre-examination and triage, optimizing the consultation process, improving the hospital’s architectural composition, implementing graded risk management, enhancing personal protection, and implementing staff training and supervision. Descriptive research was used to evaluate the short-term effects of these in-hospital prevention and control strategies. The analysis compared changes in related evaluation indicators between January 24, 2020 and February 12, 2020 (Chinese Lunar New Year’s Eve 2020 to lunar January 19) and the corresponding lunar period of the previous year. Results: Compared to the same period last year, the outpatient fever rate increased by 1.85-fold (P P Conclusion: The nosocomial infection prevention and control strategies implemented during this specific period improved the detection and control abilities for the COVID-19 source of infection and enhanced the compliance with measures. This likely contributed significantly to avoiding the occurrence of nosocomial infection.

Determinants of overweight and obesity and preventive strategies in Pacific countries: a systematic review

Objective:This study aimed to explore more on contributing factors and prevention of overweight and obesity among Pacific islanders.Methods:Using Cochrane library guideline,four electronic databases,PubMed,Embase,Scopus and CINAHL,were systematically searched from 2010 to 2020.Search strategy included key concepts,free text terms,and database-controlled vocabulary terms to identify articles on determinants and preventative strategies of overweight and obesity in the Pacific countries.A data extraction sheet was developed to extract relevant information required for analysis and theme development for this study.Results:A total of 22 articles were summarized and categorized.Determinants of overweight and obesity identified two themes:environmental related factors 13.6%(3/22)and sociocultural related factors 27.3%(6/22).The preventative strategies of overweight and obesity was categorized into behavioural change 22.7%(5/22),school-related 18.2%(4/22),and policies 50%(11/22).The quality assessment of articles showed“Good”68.2%(15/22),and“Fair”31.8%(7/22).Conclusion:This study highlighted two contributing,non-medication factors affecting overweight and obesity are both environmental and socio-cultural issues.Overweight and obesity preventative strategies identified in the Pacific context considered behavioural change,knowledge enhancement,and policy development.Further research should aim at exploring the current preventative strategies in-depth,to appreciate the most feasible and recommended preventative approach within the Pacific society.

Infection Prevention Strategy in General Hospital under Regular Epidemic Prevention and Control

New coronavirus pneumonia spread rapidly all over the world in the first half of 2020, which is a new respiratory disease with strong infectiousness. At present, the epidemic situation in China has been effectively controlled, but the global epidemic situation remains grim, and the National Health Commission has instructed that the prevention and control of new coronavirus pneumonia should become normalized. As outposts for surveillance of public health events, hospitals are an important front in the fight against the epidemic. Therefore, it is very crucial to construct infection prevention and control system actively to contain the outbreak. This paper analyzes and summarizes the normal prevention and control management strategy of Infection Control Branch Management (hereinafter referred to as Hospital Infection-Control Dept) in a certain designated comprehensive third-grade hospital in Guangdong Province and transforms the prevention and control means in emergency state into measures for sustainable development, which also provides basis and reference for Hospital Infection-Control Dept of medical institutions to formulate prevention and control guidelines.

基于风险评估和参展流程的大型展会疫情风险防控管理实践:以中国国际进口博览会为例

大型展会易发生传染病暴发等公共卫生风险,尤其是新冠疫情暴发后,平衡疫情防控的要求和展会办展体验度是展会行业高质量发展面临的主要难题,相关先进实践经验须进一步总结与推广。通过对5届中国国际进口博览会疫情风险防控成功经验的探索,从展会的参展流程出发,明确各流程中潜在的疫情风险。基于风险评估理论,提出“风险对象分离原则”“疫情防控和展会服务保障组织体系、运行方案和健康促进措施相结合原则”“基于参展参会流程的多点触发监测和实验室检测原则”。同时,基于对不同疫情形势下大型展会疫情防控目标和重点措施的剖析,提出健全组织体系、加强内外联动、风险分级管理、联动开展应急处置等保障模式,相关经验可为今后大型展会疫情风险防控提供参考。

Comprehensive prevention strategies for retinopathy of prematurity:a literature review

Retinopathy of prematurity(ROP)is a kind of disease that can be seen in premature infants.It may cause a series of short-and longterm complications such as poor vision in premature infants,causing irreversible damage to them.Therefore,if we can prevent this disease,we can solve the above problems.This study summarized some factors that influence ROP,such as low gestational age,low birth weight,irrational oxygen use,anemia,blood transfusion,and thrombocytopenia;and also summarized a series of interventions that can prevent or delay the progression of ROP,such as reducing blood transfusion,the application of antenatal corticosteroids,and delaying clip umbilical cord,which can provide some reference for better clinical practice of preventing ROP.

Analysis of Epidemic Prevention Strategies of Omicron Variant Abroad

Omicron variant was first found in Botswana, southern Africa, on November 9, 2021. The variant has many mutations and spreads quickly. It also has immune escape to existing COVID-19 vaccines, and the infection rate and repeated infection rate have increased worldwide. For such variant, at this stage, foreign countries mainly adopt three strategies to prevent and control the epidemic. First, big data is used to track the potential infection of the epidemic, trace the spread of the epidemic, screen close contacts, and control the scope of infection. The second is to maximum the coverage rate of vaccination, especially the coverage rate of the third injection, so as to reduce the infection level of Omicron variant. At last, they are developing a general coronavirus vaccine to prevent infection caused by SARS-CoV-2 variants, including the Omicron variant, so as to fundamentally eliminate the potential threat of variants to human beings. In this paper, three major epidemic prevention strategies of Omicron variant abroad were summarized in detail.

上海市应对新型冠状病毒肺炎疫情综合防控策略

面对新型冠状病毒肺炎疫情,上海市坚决贯彻中央部署要求,采取了最严格、最全面、最积极的防控措施,在短时间内有效地遏制疫情蔓延势头。在疫情防控过程中,准确把握疫情形势变化,因时因势调整防控策略和措施,在严防境外疫情输入、有效处置本土疫情、统筹推动疫情防控和经济社会发展方面形成了行之有效的防控举措,构建起超大城市科学精准防控工作模式。

上海市新型冠状病毒肺炎防控策略探讨

根据政府公开发布的数据和相关的媒体报道,分析归纳上海市新型冠状病毒肺炎疫情防控方略,探讨超大城市应对突发传染病的防控经验和策略。上海市通过居家隔离、联防联控、群防群治、信息公开和分级复工等防控措施,成功将新型冠状病毒肺炎患者人数控制在1641人(截至2021年1月24日),占全国累计确诊病例数的1.64%,防控效果显著。上海市有效地控制了疫情蔓延,为超大城市应对突发急性传染病等公共卫生事件提供了极有价值的经验和策略。

基于风险评估和流程再造的口岸疫情风险防控管理实践

借助机场疫情防控专班的实际经验,从机场业务流程视角出发,明确各流程中口岸防疫风险,制定详细的空港口岸风险要素评估方案,构建基于风险分级的口岸疫情风险要素管理方法,系统性地将风险阻断和防疫措施集成到机场现有的各项业务中,为我国口岸疫情防控体系建设提供实证依据与理论参考。

面向入境货运业务的口岸疫情防控实践:以浦东国际机场为例

新型冠状病毒肺炎疫情发生以来,在“保供保生产”的防疫需求下,我国空港口岸的入境货运量不降反增,入境货运业务成为当前口岸疫情防控的重点内容之一,各口岸机场的先进实践经验需进一步总结与推广。基于浦东国际机场国际入境货运业务的探索实践,总结出以风险评估与流程再造为主的空港口岸货运疫情管控理论:包括“人、物、环境”同防策略下的货运要素风险评估方法、“风险对象分离原则”和“风险单元最小化原则”;明确基于风险分级的货运流程分类管理策略,提出货物动线设计、货物分离和拆装存运的方案;总结基于风险评估的货运人员动态管理方法与风险单元最小化的实践案例,涵盖机组边检、登记进出、健康监测、就医管理、住宿通勤等方面,为我国口岸货运业务疫情防控的精细化管理提供经验参考。

Gastric cancer: Epidemiology, risk factors and prevention strategies

Gastric cancer(GC) is a global health problem, with more than 1 million people newly diagnosed with GC worldwide each year. GC is more prevalent in less developed countries than in more developed countries. About half of all GC cases worldwide occur in East Asia, notably China. Globally, overall incidence rates of GC are declining, which is potentially attributed to a decrease in Helicobacter pylori(H. pylori) infection and the use of refrigeration to preserve foods rather than salt. GC is a multifactorial disease, and its occurrence and development were impacted by environmental and genetic factors. H. pylori infection is the primary risk factor for GC, especially for non-cardia. The prognosis of GC is poor due to stages at the first diagnosis. The 5-year survival rate is less than 10% when patients are diagnosed at an advanced stage, but the rate is as high as 85% if patients are detected at an earlier stage. Endoscopic screening can potentially prevent GC by early diagnosis and early treatment and has been widely adopted in screening programs in East Asian countries, such as Japan and Korea. This review summarizes updated epidemiological aspects, risk factors, and prevention strategies of GC in recent years to help researchers determine the most effective intervention strategies for reducing risk of GC.

Occurrence and Damage Characteristics of Sugarcane Catastrophic Diseases and Pests in Menglian Sugarcane Area and Their Prevention and Control Strategies

In recent years,the conditions of continuous warm winter,more rain and high humidity are very beneficial to the breeding and survival of sugarcane diseases and pests.Coupled with the degradation of single varieties,more attention on new plants and less on ratoon cane and the unscientific and unreasonable use of chemical pesticides,the types of sugarcane diseases and pests in the Menglian sugarcane area are increasing day by day,and the damage is increasing year by year,resulting in a substantial reduction in production and sugar,and a serious disaster threat to sugarcane production.Based on the field survey and the current sugarcane production practice in Menglian,this paper systematically reviewed the occurrence and damage dynamics and outbreak reasons of catastrophic diseases and pests that seriously influence sugarcane production,and proposed corresponding prevention and control strategies and integrated prevention and control technology according to the occurrence and damage characteristics of catastrophic diseases and pests.

Clinical Characteristics and Prevention Strategies of Falls in Hospitalized Patients with Chronic Kidney Disease

Objectives: To analyze the clinical features of falls in hospitalized patients with chronic kidney disease (CKD), and to provide basis for preventing the occurrence of falls in hospitalized patients with CKD. Method: A retrospective study was conducted to analyze the 27 adverse events of falls in hospitalized patients from the department of nephrology in Peking University Shenzhen Hospital during May 2009 and May 2019. Results: Among the 27 patients with falls, people over 65 years old accounted for 55.56%;74.07% of the patients had caregivers;the peak period of falls was from June to August, accounting for 40.74%, mainly occurring from 7:00 to 8:00, 12:00 to 13:30 and 19:00 to 21:00;the locations of falls were mostly near the bed and in the bathroom, accounting for 33.33% and 22.22%, respectively;suffering from anemia, hypoproteinemia, abnormal serum potassium, calcium-phosphorus metabolism disorders accompanied by abnormal parathyroid hormone and hypertension accounted for 88.89%, 85.19%, 29.63%, 96.30% and 81.48% respectively. The inpatients on dialysis therapy accounted for 66.67%. Conclusion: The occurrence of falls in hospitalized patients with CKD was not only related to age, caregivers, time, months, locations or other conventional factors, but also the complications and dialysis therapies. To effectively reduce the occurrence of falls, it’s necessary to enhance the sense of safety and responsibility of caregivers. Besides, nurses should strengthen the inspection of wards for inpatients engaging in some intensive activities, and nurses should also pay more attention to the inpatients with anemia, hypoproteinemia, calcium-phosphorus metabolism disorders and those on dialysis therapies.

Security of Computer Network and Measures of Defense

Along with the deepening of the reform and opening-up policy and the entering of the WTO,international exchange of economy and culture has become more and more frequent,Internet has become an indispensable part of our life,its rapid development brings great convenience to us,and all of the computers will be connected by Internet in the 21 century,thus the meaning of information security has changed substantially.It not only changes from a general guarding to a common defence,but from a specific field to a public subject as well.However,the opening and sharing of the Internet resource,unefficient supervision as well as various virus make people's information and belongings being in an extremely dangerous environment.The fight between hackers and anti-hackers,destruction and anti-destruction has already affected the stable running of the network and users' legal right,caused great economy damages and it could also threat our country's security.So a right understanding and in-time measures should be paid special attention to.The thesis firstly expatiates the current state of the network security and its importance,and discusses some major factors and threats that affect the network security.And the thesis also introduce some catalogues of the security techniques,some relevant information and their major characters,besides that,I enumerate some popular and effective methods of protecting our network,including the widely used firewall,and the meticulous techniques such as security scan techniques and techniques of intrusion detection.Lastly,some protective measures are stated.

The role of personality,social economic and prevention strategy effects on health-related quality of life among people living with HIV/AIDS

Background::HIV/AIDS has transformed into a chronic controllable but not yet curable infectious disease as other chronic diseases to some extent.The additional of so called fourth 90%that included the improved health-related quality of life(HRQoL)for people living with HIV(PLWHIV)required solutions beyond antiretroviral therapy and viral load suppression.This study will explore the role of personality,social economic and prevention strategy effection on HRQoL among people living with HIV/AIDS.Methods::A cross-sectional study was conducted among PLWHIV aged more than 16 years old in the 10 municipalities in Yunnan Province,China from October 2019 to May 2020,enrolling total 1997 participants.Individual-level HRQoL data were measured by 12-item Short Form Health Survey(SF-12)and EuroQol Five Dimensions Questionnaire(EQ-5D-5L).We assembled municipal-level data about social economic from Yunnan Statistical Yearbook in 2020 and strategy practice information from the self-evaluation system.We used the principal component analysis to build the social economic and strategy effect on each area respectively and one-way ANOVA was used to perform univariate analysis to identify the predictors with significant differences.Finally we used multi-level model(MLM)to explore the personality,social economic and strategy effects in health-related quality of life among PLWHIV.Results::The global score for quality of life measured using EQ-5D-5L had an estimated mean score(standard deviation,SD)of 0.901±0.146.The HRQoL score measured using PCS-12 had an estimated mean score(SD)of 46.62±8.55.The mean MCS-12 score(SD)was estimated to be 47.80±9.71.The area-level predictors explained a proportion of 13.6-17.2%for the between-area variation of the HRQoL scores,regardless of the total HRQoL,physical component and mental component.The impacts of stigma(P<0.01),social support(P<0.001),anxiety(P<0.001),depression(P<0.05)and social economic status(P<0.05)on HRQoL at the individual-level were significantly different.The plots visualized the impact of individual-level factors on a respondent’s HRQoL was modified by the area-level characteristics.Conclusions::The study identified the possible strategy determinant of individual HRQoL of PLWHIV and also the area effect on HRQoL.Stigma,social support,anxiety,depression and social economic status were the individual-level determinants on HRQoL.These could be a valuable resource for evaluating the overall health of the areas and help improve local decision making.

Hydrate Prevention Strategies and the Associated Cost in the Gulf of Mexico

With the petroleum industry endeavoring to develop promising oil and gas in deeper water, gas hydrates prevention is a serious concern for oil and gas producing companies producing at conditions in the hydrate region. This paper details lessons learned from the successful field deployment of AA LDHI and proper implementation strategies used for 3 different practical fields as case studies in the Gulf of Mexico. From the 3 field experiences, the AA LDHI has been used to replace the conventional thermodynamic hydrate inhibitor due to its numerous benefits during steady state operations and transition operations where AA LDHI is injected prior to extended shut in and restart for fields producing at low water cut. However, the strategy to develop a cost effective chemical management of hydrates for fields producing at high water cut is by pumping methanol or diesel to push down the wellbore fluid below the mud line during planned and unplanned shut-ins to delay water production, it also secures the riser with non hydrate fluids. This illustrates how the AA LDHIs are used in conjunction with more conventional hydrate management approaches to reach an optimal cost effective field hydrate management solution. However, this shows that the key to overall success of hydrate prevention is a full integration of a good front end design, a comprehensive deployment and an effective down hole monitoring system.

The Pathology of Primary Familial Brain Calcification:Implications for Treatment

Primary familial brain calcification(PFBC)is an inherited neurodegenerative disorder mainly characterized by progressive calcium deposition bilaterally in the brain,accompanied by various symptoms,such as dystonia,ataxia,parkinsonism,dementia,depression,headaches,and epilepsy.Currently,the etiology of PFBC is largely unknown,and no specific prevention or treatment is available.During the past 10 years,six causative genes(SLC20A2,PDGFRB,PDGFB,XPR1,MYORG,and JAM2)have been identified in PFBC.In this review,considering mechanistic studies of these genes at the cellular level and in animals,we summarize the pathogenesis and potential preventive and therapeutic strategies for PFBC patients.Our systematic analysis suggests a classification for PFBC genetic etiology based on several characteristics,provides a summary of the known composition of brain calcification,and identifies some potential therapeutic targets for PFBC.

COVID-19 and ocular complications:A review of ocular manifestations,diagnostic tools,and prevention strategies

Background:The novel severe acute respiratory syndrome coronavins 2(SARS-CoV-2)led to the severe Corona Virus Disease 2019(COVID-19)outbreak that started in December 2019 in China and caused enormous health and economic problems worldwide.Over time,SARS-CoV-2 has demonstrated the capacity for mutation.As the most prevalent new coronavirus variety worldwide,the Omicron variant has supplanted the Delta variant.The COVID-19 primarily damages the immune system and the lungs,but it can also harm other organs secondarily,depending on the patients'co-existing conditions.Main Text:COVID-19 is associated with ophthalmic manifestations such as conjunctival congestion,tear overflow,and conjunctival edema,with the majority of eye complications occurring in patients with severe infection.The virus may make a patient more susceptible to thrombotic conditions that affect venous and arterial circulation.Meanwhile,it can lead to efferent complications and mucormycosis which is more common in patients with diabetes or who have critical or severe SARS-CoV-2 infection.Significantly,there are a number of ocular side effects following the COVID-19 vaccination,such as herpetic keratitis and facial nerve palsy,which have been reported.These side effects may be caused by the vaccinations'propensity to trigger autoimmune symptoms or thromboembolic events.At present,large-scale nucleic acid testing mainly relies on nasopharyngeal swabs and throat swabs.Tear samples and conjunctival swabs may be helpful samples for the diagnosis of ocular SARS-CoV-2 infection.The eye could be a new route of infection,and finding ways such as effective environmental disinfection,scientific administrative control management,qualified personal protection and other measures to protect the eyes could further reduce the risk of infection.Conclusions:This review aims to sum up the ocular complications of COVID-19,the possible pathogenesis,and preventive strategies to protect ophthalmology practitioners and patients by reviewing the currently available literature on the topic.

黄热病经湛江口岸传入我国的可能性探讨

黄热病是由黄热病毒引起经伊蚊传播的烈性传染病,是国际检疫传染病之一.自古至今,我国没有黄热病记载.但随着我国社会经济的飞速发展,湛江口岸与黄热病疫区的交往将日益频繁,在交通工具高度现代化的情况下,此病的传染源或染疫媒介伊蚊随时有可能从国外输入,加上湛江地区存在有传播黄热病的主要媒介--埃及伊蚊和大量的易感人群,这就有可能导致黄热病的爆发或流行.

Critical thinking on amyloid-beta-targeted therapy:challenges and perspectives

Amyloid-beta(Aβ)plays a pivotal role in the pathogenesis of Alzheimer's disease(AD)and has been regarded as the main therapeutic target for AD.However,most of the Aβ-targeted clinical trials have not succeeded.Therefore,the Aβ-targeted therapeutic strategy on treating this complex disease needs to be re-evaluated.In this review,we analyzed the challenges and critical points of the current anti-Aβtherapeutic strategies.In addition to Aβ,multiple pathological events such as tau hyperphosphorylation,oxidative stress,and neuroinflammation,which are involved in AD pathogenesis and synergistically drive disease progression,could be important targets for AD treatment.Tertiary prevention strategies are needed for the successful management of AD due to its complex and dynamic pathogenesis.Systemic perspective addressing the disease pathogenesis within and outside the brain,as well as the multidomain intervention targeting risk factors and comorbidities,are important approaches for the therapeutic solutions of AD.