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三色膏联合PRICE疗法治疗急性踝关节Ⅰ和Ⅱ度扭伤的临床效果
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作者 邱承玺 殷苏勤 +5 位作者 蔡晓辉 徐凯捷 牛锋 徐建德 詹红生 高慧 《中国当代医药》 CAS 2024年第27期85-88,共4页
目的探讨三色膏联合PRICE疗法治疗急性踝关节Ⅰ、Ⅱ度扭伤的临床效果。方法选取2022年2月至2023年5月上海市嘉定区中医医院骨伤科收治的52例Ⅰ、Ⅱ度急性踝关节扭伤患者作为研究对象,其中急诊患者35例,门诊患者17例,采用随机数字表法将... 目的探讨三色膏联合PRICE疗法治疗急性踝关节Ⅰ、Ⅱ度扭伤的临床效果。方法选取2022年2月至2023年5月上海市嘉定区中医医院骨伤科收治的52例Ⅰ、Ⅱ度急性踝关节扭伤患者作为研究对象,其中急诊患者35例,门诊患者17例,采用随机数字表法将其分为对照组和观察组,每组均失访1例,两组各25例纳入统计。对照组采用PRICE疗法治疗,观察组采用三色膏联合PRICE疗法,两组患者均治疗1周,治疗结束后,比较两组患者治疗前和治疗后第1、3周的视觉模拟评分法(VAS)评分及Mazur功能评分。结果52例患者中50例得到随访,随访时间不短于4周。治疗1、3周后,两组患者的VAS评分低于本组治疗前,Mazur功能评分高于本组治疗前,观察组的VAS评分低于对照组,Mazur功能评分高于对照组,差异有统计学意义(P<0.05)。结论三色膏联合PRICE疗法治疗急性踝关节Ⅰ、Ⅱ度扭伤可以获得更好的疗效,具有重要的临床价值和推广意义。 展开更多
关键词 三色膏 price疗法 踝关节 急性扭伤
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Understanding the Relationship Between Shrinking Cities and Land Prices:Spatial Pattern,Effectiveness,and Policy Implications 被引量:1
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作者 WANG Xiaohui PENG Li +1 位作者 HUANG Kexin DENG Wei 《Chinese Geographical Science》 SCIE CSCD 2024年第1期1-18,共18页
Urban shrinkage has emerged as a widespread phenomenon globally and has a significant impact on land,particularly in terms of land use and price.This study focuses on 2851 county-level cities in China in 2005–2018(ex... Urban shrinkage has emerged as a widespread phenomenon globally and has a significant impact on land,particularly in terms of land use and price.This study focuses on 2851 county-level cities in China in 2005–2018(excluding Hong Kong,Macao,Taiwan,and‘no data’areas in Qinhai-Tibet Plateau)as the fundamental units of analysis.By employing nighttime light(NTL)data to identify shrinking cities,the propensity score matching(PSM)model was used to quantitatively examine the impact of shrinking cities on land prices,and evaluate the magnitude of this influence.The findings demonstrate the following:1)there were 613 shrinking cities in China,with moderate shrinkage being the most prevalent and severe shrinkage being the least.2)Regional disparities are evident in the spatial distribution of shrinking cities,especially in areas with diverse terrain.3)The spatial pattern of land price exhibits a significant correlated to the economic and administrative levels.4)Shrinking cities significantly negatively impact on the overall land price(ATT=–0.1241,P<0.05).However,the extent of the effect varies significantly among different spatial regions.This study contributes novel insights into the investigation of land prices and shrinking cities,ultimately serving as a foundation for government efforts to promote the sustainable development of urban areas. 展开更多
关键词 shrinking cities land price propensity score matching(PSM) relative effectiveness China
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Brent vs.West Texas Intermediate in the US petro derivatives price formation
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作者 Alejandro Almeida Antonio A.Golpe +1 位作者 Juan Manuel Martín-Alvarez Jose Carlos Vides 《Petroleum Science》 SCIE EI CAS CSCD 2024年第1期729-739,共11页
In this paper,we apply the spatial panel model to explore the relationship between the dynamic of two types of crude oil prices(WTI and Brent crude oil)and their refined products over time.Considering the turbulent mo... In this paper,we apply the spatial panel model to explore the relationship between the dynamic of two types of crude oil prices(WTI and Brent crude oil)and their refined products over time.Considering the turbulent months of 2011,when Cushing Oklahoma had reached capacity and the crude oil export ban removal in 2015 as breakpoints,we apply this method both in the full sample and the three resultant regimes.First,results suggest our results show that both WTI and Brent display very similar behaviour with the refined products.Second,when attending to each regime,results derived from the first and third regimes are quite similar to the full sample results.Therefore,during the second regime,Brent crude oil became the benchmark in the petrol market,and it influenced the distillate products.Furthermore,our model can let us determine the price-setters and price-followers in the price formation mechanism through refined products.These results possess important considerations to policymakers and the market participants and the price formation. 展开更多
关键词 Crude oil prices Spatial panel model Refined products price formation
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Economic Resilience in Bangladesh: Analyzing Household Well-Being amidst Price Hikes through ANOVA and Paired Sample t-Test Insights
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作者 Esita Ghosh 《Open Journal of Statistics》 2024年第1期55-89,共35页
This study delves into the multifaceted impact of price hikes on the standard of living in Bangladesh, with a specific focus on distinct socioeconomic segments. Amidst Bangladesh’s economic growth, the challenges of ... This study delves into the multifaceted impact of price hikes on the standard of living in Bangladesh, with a specific focus on distinct socioeconomic segments. Amidst Bangladesh’s economic growth, the challenges of rising inflation and increased living costs have become pressing concerns. Employing a mixed-methods approach combines quantitative data from a structured survey with qualitative insights from in-depth interviews and focused group discussions to analyze the repercussions of price hikes. Stratified random sampling ensures representation across affluent, middle-class, and economically disadvantaged groups. Utilizing data [1] from 2020 to November 2023 on the yearly change in retail prices of essential commodities, analysis reveals significant demographic shifts, occupational changes, and altered asset ownership patterns among households. The vulnerable population, including daily wage laborers and low-income individuals, is disproportionately affected by adjustments in consumption, income generation, and living arrangements. Statistical analyses, including One-Way ANOVA and Paired Sample t-tests, illuminate significant mean differences in strategies employed during price hikes. Despite challenges, the prioritization of education remains evident, emphasizing its resilience in the face of economic hardships. The result shows that price hikes, especially in essential items, lead to substantial adjustments in living costs, with items like onions, garlic, and ginger experiencing significant increases of 275%, 108%, and 483%, respectively. 展开更多
关键词 price Hike Economic Growth SOCIOECONOMIC Development Households
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Flexible Load Participation in Peaking Shaving and Valley Filling Based on Dynamic Price Incentives
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作者 Lifeng Wang Jing Yu Wenlu Ji 《Energy Engineering》 EI 2024年第2期523-540,共18页
Considering the widening of the peak-valley difference in the power grid and the difficulty of the existing fixed time-of-use electricity price mechanism in meeting the energy demand of heterogeneous users at various ... Considering the widening of the peak-valley difference in the power grid and the difficulty of the existing fixed time-of-use electricity price mechanism in meeting the energy demand of heterogeneous users at various moments or motivating users,the design of a reasonable dynamic pricing mechanism to actively engage users in demand response becomes imperative for power grid companies.For this purpose,a power grid-flexible load bilevel model is constructed based on dynamic pricing,where the leader is the dispatching center and the lower-level flexible load acts as the follower.Initially,an upper-level day-ahead dispatching model for the power grid is established,considering the lowest power grid dispatching cost as the objective function and incorporating the power grid-side constraints.Then,the lower level comprehensively considers the load characteristics of industrial load,energy storage,and data centers,and then establishes a lower-level flexible load operation model with the lowest user power-consuming cost as the objective function.Finally,the proposed method is validated using the IEEE-118 system,and the findings indicate that the dynamic pricing mechanism for peaking shaving and valley filling can effectively guide users to respond actively,thereby reducing the peak-valley difference and decreasing users’purchasing costs. 展开更多
关键词 Demand response fixed time-of-use electricity price mechanism dynamic price incentives mechanism bi-level model flexible load
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Production Chain Length and PPI-CPI Divergence:Analysis Based on the Global Input-output Price Model
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作者 Ni Hongfu Yan Bingqian Wu Liyuan 《China Economist》 2024年第3期49-69,共21页
Productivity and international energy price shocks are reflected in PPI and CPI via industrial chains.China’s in-depth participation into the global value chains has increasingly lengthened its industrial production ... Productivity and international energy price shocks are reflected in PPI and CPI via industrial chains.China’s in-depth participation into the global value chains has increasingly lengthened its industrial production chains.The question is how the changing length of production chains will affect CPI and PPI,as well as CPI-PPI correlation?By constructing a global input-output price model,this paper offers a theoretical discussion on the impact of production chain length on the CPI-PPI divergence.Our findings suggest that the price shock of international bulk commodities has a greater impact on China’s PPI than that on CPI.The effects on both China’s PPI and CPI estimated by using the single-country input-output model are higher than the results estimated with the global input-output model.However,the difference between CPI and PPI variations estimated with the global input-output model is greater than the result estimated with the single-country input-output model,which supports the view that the lengthening of production chains,especially international production chains,leads to a divergence between CPI and PPI.Empirical results based on cross-national panel data also suggest that the lengthening of production chains has reduced the CPI-PPI correlation for countries,i.e.the lengthening of production chains has increased the PPI-CPI divergence.That is to say,policymakers should target not just CPI in maintaining price stability,but instead focus on the stability of both PPI and CPI.Efforts can be made to proactively adjust the price index system,and formulate the industrial chain price index. 展开更多
关键词 Global value chains length of production chains consumer price index producer price index
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Price prediction of power transformer materials based on CEEMD and GRU
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作者 Yan Huang Yufeng Hu +2 位作者 Liangzheng Wu Shangyong Wen Zhengdong Wan 《Global Energy Interconnection》 EI CSCD 2024年第2期217-227,共11页
The rapid growth of the Chinese economy has fueled the expansion of power grids.Power transformers are key equipment in power grid projects,and their price changes have a significant impact on cost control.However,the... The rapid growth of the Chinese economy has fueled the expansion of power grids.Power transformers are key equipment in power grid projects,and their price changes have a significant impact on cost control.However,the prices of power transformer materials manifest as nonsmooth and nonlinear sequences.Hence,estimating the acquisition costs of power grid projects is difficult,hindering the normal operation of power engineering construction.To more accurately predict the price of power transformer materials,this study proposes a method based on complementary ensemble empirical mode decomposition(CEEMD)and gated recurrent unit(GRU)network.First,the CEEMD decomposed the price series into multiple intrinsic mode functions(IMFs).Multiple IMFs were clustered to obtain several aggregated sequences based on the sample entropy of each IMF.Then,an empirical wavelet transform(EWT)was applied to the aggregation sequence with a large sample entropy,and the multiple subsequences obtained from the decomposition were predicted by the GRU model.The GRU model was used to directly predict the aggregation sequences with a small sample entropy.In this study,we used authentic historical pricing data for power transformer materials to validate the proposed approach.The empirical findings demonstrated the efficacy of our method across both datasets,with mean absolute percentage errors(MAPEs)of less than 1%and 3%.This approach holds a significant reference value for future research in the field of power transformer material price prediction. 展开更多
关键词 Power transformer material price prediction Complementary ensemble empirical mode decomposition Gated recurrent unit Empirical wavelet transform
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Spatiotemporal Evolution and Linkage Analysis of Mutton Price in Xinjiang
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作者 Yulin YANG Jian XU Lean YU 《Journal of Systems Science and Information》 CSCD 2024年第5期667-689,共23页
The mutton industry plays a pivotal role in the animal husbandry industry of Xinjiang Uygur Autonomous Region.To better monitor the volatility movement and risk warning of mutton price,the fluctuation characteristics ... The mutton industry plays a pivotal role in the animal husbandry industry of Xinjiang Uygur Autonomous Region.To better monitor the volatility movement and risk warning of mutton price,the fluctuation characteristics of mutton prices and the future trend of prices are analyzed systematically.On the one hand,the Hodrick Prescott(HP)filter method is used to analyze the long-term trends and cyclical characteristics of mutton prices in Xinjiang and explored the spatial evolution characteristics of mutton price fluctuations in various regions of Xinjiang.On the other hand,the Threshold Auto-Regressive(TAR)model is used to analyze the linkage relationship between mutton prices and the prices of other livestock products.The empirical results show that 1)the overall volatility of mutton price in Xinjiang is high,showing a trend of rising first,then falling and then rising from the temporal perspective.2)At the regional level,the price in the south is higher than that of the north,showing a decreasing trend from south to north on the whole from the spatial viewpoint.3)From the linkage relationship perspective,mutton and beef are complementary in the short term,but they are substitutes each other in the long term.This paper explores the characteristics of mutton price fluctuations in Xinjiang from the single time series of mutton prices and the linkage with other livestock products,which provides a reliable basis for the monitoring and risk warning of mutton price fluctuation. 展开更多
关键词 mutton price fluctuation spatiotemporal volution linkage analysis Hodrick Prescott filtering method threshold autoregressive model
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The Influence of Price Discrimination from Airports on the Route Development Behavior of Airlines
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作者 Daniel Schnitzler 《Journal of Civil Engineering and Architecture》 2024年第1期17-29,共13页
Given the prominence and magnitude of airport incentive schemes,it is surprising that literature hitherto remains silent as to their effectiveness.In this paper,the relationship between airport incentive schemes and t... Given the prominence and magnitude of airport incentive schemes,it is surprising that literature hitherto remains silent as to their effectiveness.In this paper,the relationship between airport incentive schemes and the route development behavior of airlines is analyzed.Because of rare and often controversial findings in the extant literature regarding relevant influencing variables for attracting airlines at an airport,expert interviews are used as a complement to formulate testable hypotheses in this regard.A fixed effects regression model is used to test the hypotheses with a dataset that covers all seat capacity offered at the 22 largest German commercial airports in the week 46 from 2004 to 2011.It is found that incentives from primary choice,as well as secondary choice airports,have a significant influence on Low Cost Carriers.Furthermore,Low Cost Carriers,in general,do not leave any of both types of airports when the incentives cease.In the case of Network Carriers,no case is found where one joins a primary choice airport and receives an incentive.Insufficient data between Network Carriers and secondary choice airports in the time when incentives have ceased means that no statement can be given. 展开更多
关键词 AIRLINE rout development price discrimination
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From Finnish Assortment Pricing to Market Economy Using Prices for Sawn Wood and Chips in Reference Bucking
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作者 Juha Lappi 《Open Journal of Forestry》 2024年第3期233-280,共48页
Dominant Finnish assortment pricing gives prices for sawlog and pulp wood volumes. Buyers buck stems to sawlogs using secret price matrices. Agreed dimensions allow wide range of sawlog volumes. Forest owners cannot o... Dominant Finnish assortment pricing gives prices for sawlog and pulp wood volumes. Buyers buck stems to sawlogs using secret price matrices. Agreed dimensions allow wide range of sawlog volumes. Forest owners cannot objectively compare biddings: timber trade is a lottery game. Bucking is analyzed in terms of sawlog, pulp wood, log cylinder, sawn wood, value-weighted sawn wood, and chips. Sawn wood and its value are computed from top diameter of the sawlog. Profit maximization requires buyers to buck logs producing smaller than maximal value, causing dead weight loss. Nominal assortment prices have unpredictable relation to effective stumpage price. Assortment pricing does not meet requirements of market economy. If sawmills linked to pulp mills buck smaller sawlog percentages than independent sawmills, as generally believed, they use higher price for chips in their own harvests than they pay for independent sawmills, indicating imperfect competition for chips. Sawn wood potential pricing is suggested which gives prices for sawn wood and chips coming both from sawlogs and pulp wood in reference bucking which maximizes sawn wood for given minimum and maximum log length and minimum top diameter. Simple algorithm generates feasible bucking schedules from which optimum can be selected using any objective. Pricing produces unit price for all commercial wood utilizing ratio of theoretical sawn wood and commercial volume in stand. Unit price can be compared to stem pricing and could be compared to assortment pricing if assortment pricing would produce predictable sawlog percentages. Sawn wood potential pricing is concrete, transparent, easy to compute, considers stem size and tapering, reduces trading cost and is less risky to buyers than stem pricing. It meets requirements of market economy. Readers can repeat computations using open-source software Jlp22. 展开更多
关键词 Sawmill Pulp Mill Jlp22 Dead Weight Loss Stem price
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Comparative Analysis of Machine Learning Models for Stock Price Prediction: Leveraging LSTM for Real-Time Forecasting
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作者 Bijay Gautam Sanif Kandel +1 位作者 Manoj Shrestha Shrawan Thakur 《Journal of Computer and Communications》 2024年第8期52-80,共29页
The research focuses on improving predictive accuracy in the financial sector through the exploration of machine learning algorithms for stock price prediction. The research follows an organized process combining Agil... The research focuses on improving predictive accuracy in the financial sector through the exploration of machine learning algorithms for stock price prediction. The research follows an organized process combining Agile Scrum and the Obtain, Scrub, Explore, Model, and iNterpret (OSEMN) methodology. Six machine learning models, namely Linear Forecast, Naive Forecast, Simple Moving Average with weekly window (SMA 5), Simple Moving Average with monthly window (SMA 20), Autoregressive Integrated Moving Average (ARIMA), and Long Short-Term Memory (LSTM), are compared and evaluated through Mean Absolute Error (MAE), with the LSTM model performing the best, showcasing its potential for practical financial applications. A Django web application “Predict It” is developed to implement the LSTM model. Ethical concerns related to predictive modeling in finance are addressed. Data quality, algorithm choice, feature engineering, and preprocessing techniques are emphasized for better model performance. The research acknowledges limitations and suggests future research directions, aiming to equip investors and financial professionals with reliable predictive models for dynamic markets. 展开更多
关键词 Stock price Prediction Machine Learning LSTM ARIMA Mean Squared Error
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The Prediction for the Consumer Price Index of Residents in Perspective of Time Series Method in Case of Chongqing
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作者 Chunhuan Xiang 《Journal of Applied Mathematics and Physics》 2024年第1期226-233,共8页
The consumer price index (CPI) measures the relative number of changes in the price level of consumer goods and services over time, reflecting the trend and degree of changes in the price level of goods and services p... The consumer price index (CPI) measures the relative number of changes in the price level of consumer goods and services over time, reflecting the trend and degree of changes in the price level of goods and services purchased by residents. This article uses the ARMA model to analyze the fluctuation trend of the CPI (taking Chongqing as an example) and make short-term predictions. To test the predictive performance of the model, the observation values from January to December 2023 were retained as the reference object for evaluating the predictive accuracy of the model. Finally, through trial predictions of the data from May to August 2023, it was found that the constructed model had good fitting performance. 展开更多
关键词 Consumer price Index of Residents PREDICTION ARMA Model
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Stock Price Prediction Based on the Bi-GRU-Attention Model
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作者 Yaojun Zhang Gilbert M. Tumibay 《Journal of Computer and Communications》 2024年第4期72-85,共14页
The stock market, as one of the hotspots in the financial field, forms a data system with a huge volume of data and complex relationships between various factors, making stock price prediction an area of keen interest... The stock market, as one of the hotspots in the financial field, forms a data system with a huge volume of data and complex relationships between various factors, making stock price prediction an area of keen interest for further in-depth mining and research. Mathematical statistics methods struggle to deal with nonlinear relationships in practical applications, making it difficult to explore deep information about stocks. Meanwhile, machine learning methods, particularly neural network models and composite models, which have achieved outstanding results in other fields, are being applied to the stock market with significant results. However, researchers have found that these methods do not grasp the essential information of the data as well as expected. In response to these issues, researchers are exploring better neural network models and combining them with other methods to analyze stock data. Thus, this paper proposes the ABiGRU composite model, which combines the attention mechanism and bidirectional gated recurrent unit (GRU) that can effectively extract data features for stock price prediction research. Models such as LSTM, GRU, and Bi-LSTM are selected for comparative experiments. To ensure the credibility and representativeness of the research data, daily stock price indices of BYD are chosen for closing price prediction studies across different models. The results show that the ABiGRU model has a lower prediction error and better fitting effect on three index-based stock prices, enhancing the learning efficiency of the neural network model and demonstrating good prediction stability. This suggests that the ABiGRU model is highly adaptable for stock price prediction. 展开更多
关键词 Machine Learning Attention Mechanism LSTM Neural Network ABiGRU Model Stock price Prediction
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Fuzzy Inventory Model under Selling Price Dependent Demand and Variable Deterioration with Fully Backlogged Shortages
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作者 Tanzim S. Shaikh Santosh P. Gite 《American Journal of Operations Research》 2024年第2期87-103,共17页
The objective is to develop a model considering demand dependent on selling price and deterioration occurs after a certain period of time, which follows two-parameter Weibull distribution. Shortages are allowed and fu... The objective is to develop a model considering demand dependent on selling price and deterioration occurs after a certain period of time, which follows two-parameter Weibull distribution. Shortages are allowed and fully backlogged. Fuzzy optimal solution is obtained by considering hexagonal fuzzy numbers and for defuzzification Graded Mean Integration Representation Method. A numerical example is provided for the illustration of crisp and fuzzy, both models. To observe the effect of changes in parameters, sensitivity analysis is carried out. 展开更多
关键词 DETERIORATION Selling price Dependent Demand Fully Backlogged Hexagonal Fuzzy Numbers Graded Mean Integration Representation Method
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Does US Dollar Supply Trigger House Price Fluctuations?An International Comparison
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作者 Zihan Wang Yikun Huang 《Proceedings of Business and Economic Studies》 2024年第5期55-60,共6页
Cyclical fluctuations in asset prices are closely related to the overall stability of the macroeconomy and have thus become a significant topic in academic and professional exploration.Among these fluctuations,changes... Cyclical fluctuations in asset prices are closely related to the overall stability of the macroeconomy and have thus become a significant topic in academic and professional exploration.Among these fluctuations,changes in the supply of the U.S.dollar,the global reserve,and primary settlement currency have a broad and far-reaching impact on international financial markets.Since COVID-19,asset prices across various countries have shown differing trends due to fluctuations in the U.S.dollar supply.Housing prices,a key focus in asset pricing research,have been affected to varying degrees.This thesis utilizes seven house price indices from representative cities worldwide from 2020 to 2023 to compare the differential impacts across various countries using an empirical approach.The results indicate that the impact of the U.S.dollar money supply(M2)diminishes in a gradient from the U.S.to East Asia,and then to Europe. 展开更多
关键词 Dollar supply Quantitative easing Property prices International comparisons
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The Effects of Infrastructure Projects on House Prices and Rents:Evidence from the HS2 Extension Cancellation in the UK
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作者 Wentao Zhu 《Journal of Sustainable Business and Economics》 2024年第2期76-94,共19页
This paper uses the HS2 extension cancellation in November 2021 as a quasi-experiment to study its impact on house prices and rents in Leeds.Using a DiD approach on repeat sales and monthly rents,I compare property va... This paper uses the HS2 extension cancellation in November 2021 as a quasi-experiment to study its impact on house prices and rents in Leeds.Using a DiD approach on repeat sales and monthly rents,I compare property values near the HS2 station and proposed construction site before and after the announcement.Results show a 3.6%decrease in house prices and a 3.9%decline in rents near the station,while properties near the construction site experienced a 2.4%increase in prices and a 2.1%rise in rents.This is the first paper to analyse the HS2 cancellation effect using panel data methods. 展开更多
关键词 HS2 extension cancellation Externalities House price effects Transport infrastructure Difference-in-Differences Model
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基于Morgenstern-price法的粘土心墙土石坝坡面稳定计算分析
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作者 张鑫华 许刚 《粘接》 CAS 2024年第8期64-67,共4页
土石坝的坝坡面是否稳定一直是土石坝结构设计研究的重点问题,尤其是在渗流场的影响作用下尤为显著,研究以某水库工程坝体坡面在不同使用工况下的的安全稳定计算为例,通过软件建立坝体的模型,基于不同运行条件下的渗流数据,选用内嵌于... 土石坝的坝坡面是否稳定一直是土石坝结构设计研究的重点问题,尤其是在渗流场的影响作用下尤为显著,研究以某水库工程坝体坡面在不同使用工况下的的安全稳定计算为例,通过软件建立坝体的模型,基于不同运行条件下的渗流数据,选用内嵌于计算软件Geostudio中的LOPE/W计算模块中的极限平衡算法(Morgenstern-Price)进行计算,计算结果满足规范要求,说明大坝坡面安全稳定。由于渗流场的引入,能更好的反映工程中的真实运行状况,为工程的建设提供建设依据和数据支持。 展开更多
关键词 粘土心墙坝 Morgenstern-price 稳定计算 极限平衡法
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YAP、p-STAT3、LMP2A在鼻咽癌中的表达及临床意义 被引量:1
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作者 王赟 王芹 徐亮 《分子诊断与治疗杂志》 2023年第8期1435-1439,共5页
目的探讨Yes相关蛋白(YAP)、磷酸化信号转导与转录激活因子3(p-STAT3)、外源性表达潜伏膜蛋白2A(LMP2A)在鼻咽癌(NPC)中的表达及临床意义。方法收集2020年12月至2021年12月于临沂市人民医院接受治疗的202例NPC患者的活检术石蜡标本作为... 目的探讨Yes相关蛋白(YAP)、磷酸化信号转导与转录激活因子3(p-STAT3)、外源性表达潜伏膜蛋白2A(LMP2A)在鼻咽癌(NPC)中的表达及临床意义。方法收集2020年12月至2021年12月于临沂市人民医院接受治疗的202例NPC患者的活检术石蜡标本作为观察组,同时收集本院98例鼻咽黏膜慢性炎组织标本作为对照组。分析两组YAP、p-STAT3及LMP2A的表达,并分析YAP、p-STAT3及LMP2A三指标与NPC患者的临床病理参数、预后关系。结果观察组YAP、p-STAT3、LMP2A蛋白高表达率均高于对照组,差异有统计学意义(P<0.05)。不同TNM分期、组织分化以及有无远处转移NPC患者之间YAP表达比较差异有统计学意义(P<0.05);不同TNM分期和有无淋巴结、远处转移NPC患者之间p-STAT3表达比较差异有统计学意义(P<0.05);不同TNM分期、组织分化以及有无淋巴结转移NPC患者之间LMP2A表达比较差异有统计学意义(P<0.05)。经随访后发现,预后良好组181例,预后不良组21例;两组年龄、性别比较差异无统计学意义(P>0.05)。不同预后患者TNM分期、淋巴结及远处转移情况、YAP、p-STAT3、LMP2A高表达率比较差异均有统计学意义(P<0.05)。经Logistic回归分析可知,TNM分期为Ⅲ+Ⅳ期、有淋巴结及远处转移、YAP、p-STAT3及LMP2A高表达是影响NPC患者预后不良的独立危险因素(P<0.05)。结论NPC患者中YAP、p-STAT3、LMP2A呈上升表达,且三指标高表达与NPC病情的发生发展以及预后之间存在密切联系,对预测患者预后不良具有重要意义。 展开更多
关键词 YAP P-STAT3 lmp2A 鼻咽癌
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鼻咽癌组织中miR-200c、LMP1、ZEB2和E-cadherin的表达及调控作用 被引量:2
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作者 李晓雪 李鹏 +3 位作者 卢永校 汤素琴 钟玉红 王广林 《黑龙江医药科学》 2023年第1期154-156,共3页
目的:观察鼻咽癌(nasopharyngeal carcinoma,NPC)组织中miR-200c、潜伏期膜蛋白1(LMP1)、E盒结合锌指蛋白2(zinc finger E-box-binding protein 2,ZEB2)和E-cadherin的表达变化,并探讨其调控作用。方法:选取2021-05~2022-06于广州市花... 目的:观察鼻咽癌(nasopharyngeal carcinoma,NPC)组织中miR-200c、潜伏期膜蛋白1(LMP1)、E盒结合锌指蛋白2(zinc finger E-box-binding protein 2,ZEB2)和E-cadherin的表达变化,并探讨其调控作用。方法:选取2021-05~2022-06于广州市花都区人民医院住院的NPC患者62例和鼻咽炎患者41例为研究对象。分别采用RT-PCR法检测两组患者组织中的miR-200c、LMP1、ZEB2和E-cadherin mRNA的表达和免疫印迹的方法检测两组组织中LMP1、ZEB2和E-cadherin蛋白表达,并对miR-200c、LMP1、ZEB2和E-cadherin mRNA的表达进行Pearson线性相关分析。结果:NPC组织中miR-200c的表达水平低于鼻咽炎组(P<0.05),LMP1和ZEB2 mRNA和蛋白的表达水平均高于鼻咽炎组(P<0.05),E-cadherin mRNA和蛋白的表达水平低于鼻咽炎组(P<0.05);NPC组织中LMP1 mRNA与miR-200c的表达呈负相关(r=-0.853,P<0.05),miR-200c与ZEB2 mRNA的表达呈负相关(r=-0.842,P<0.05),ZEB2 mRNA与E-cadherin mRNA表达呈负相关(r=-0.590,P<0.05)。结论:NPC组织中LMP1和ZEB2表达升高,而miR-200c和E-cadherin表达水平降低,有望成为NPC诊疗新靶点;LMP1可能通过诱导下调miR-200c的表达,使得ZEB2转录因子表达上调,最终抑制E-cadherin的表达,从而促进NPC的侵袭和转移。 展开更多
关键词 鼻咽癌 MIR-200C lmp1 ZEB2 E-CADHERIN
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Asymmetric Price Transmission Analysis of the International Soybean Market
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作者 G.M. Barboza Martignone Dimitrios Paparas Karl Behrendt 《Agricultural Sciences》 CAS 2023年第3期317-334,共18页
This study analyzed the asymmetric price transmission in the international soybean market, using data from the US (Chicago Futures), European (Rotterdam), Brazilian (Paranaguá), Argentinian (Rosario Futures and R... This study analyzed the asymmetric price transmission in the international soybean market, using data from the US (Chicago Futures), European (Rotterdam), Brazilian (Paranaguá), Argentinian (Rosario Futures and Rosario Spot), and Chinese (Spot and Futures) markets. The study looked at the price transmission between these markets over a period of almost 10 years, from September 2009 to May 2019. The Phillips-Perron unit root test was used to determine the order of integration of the time series. The Engle-Granger cointegration test failed to find any evidence of cointegration between the Chinese and Argentinian markets with any others of the international markets. The lack of cointegration was associated with highly government intervened markets. The cointegration and threshold test proposed by Enders and Siklos, succeeded in rejecting the Null hypothesis and finding cointegration among the series after structural breaks had been taken into account. The BDS test for nonlinearity showed that most of the time series were nonlinear, which prompted the investigation to look into nonlinear modelling. To evaluate asymmetric price transmission, the study used the Threshold autoregressive (TAR) model and the momentum threshold model (MTAR). The Argentine and Chinese markets were primarily suspected of exhibiting asymmetric price transmission due to structural government intervention. However, the test results failed to reject the null hypothesis and revealed asymmetric price transmission between these markets and the international market. As expected, the results found no evidence of asymmetric price transmission in the Paranaguá, Rotterdam, and Chicago markets. Hence, it can be concluded that symmetric price transmission is more prevalent in the global soybean market than asymmetric price transmission. 展开更多
关键词 Agricultural Economics ECONOMETRICS price Transmission Soybean Market Asymmetric price Transmission TAR MTAR BDS
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