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德国生物类似药参考价格组形成机制
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作者 王欣悦 蒋蓉 +2 位作者 何静雯 吴艺 邵蓉 《中国卫生资源》 北大核心 2022年第6期701-709,共9页
采用案例分析法分析德国已分组生物类似药的《决议》《决议理由》《决议摘要》,总结其分组原则、分组契机、关键问题。德国已上市的19种生物类似药中,3种按通用名分组管理,6种按药理学及疗效可比分组管理,10种药品未进行分组。分组主要... 采用案例分析法分析德国已分组生物类似药的《决议》《决议理由》《决议摘要》,总结其分组原则、分组契机、关键问题。德国已上市的19种生物类似药中,3种按通用名分组管理,6种按药理学及疗效可比分组管理,10种药品未进行分组。分组主要关注生物类似药与原研药差异、药理学可比性、临床疗效、儿童用药等方面。分组过程中各利益相关方参与程度较高,分组根据市场情况适时调整。建议我国在生物类似药价格管理过程中提高利益相关方参与程度,关注儿童用药情况,探索建立精细长效的分组方式。 展开更多
关键词 生物类似药biosimilar 定价管理pricing management 参考价格组reference pricing 通用名参考价格组generic reference pricing 药理学参考价格组pharmacological reference pricing 疗效参考价格组therapeutic reference pricing 德国Germany
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Joint slot allocation and dynamic pricing of container sea-rail multimodal transportation 被引量:4
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作者 Di Liu Hualong Yang 《Journal of Traffic and Transportation Engineering(English Edition)》 2015年第3期198-208,共11页
The container sea-rail multimodal transport system faces complex challenges with de- mand uncertainties for joint slot allocation and dynamic pricing. The challenge is formulated as a two-stage optimal model based on ... The container sea-rail multimodal transport system faces complex challenges with de- mand uncertainties for joint slot allocation and dynamic pricing. The challenge is formulated as a two-stage optimal model based on revenue management (RM) as actual slots sale of multi-node container sea-rail multimodal transport usually includes contract sale to large shippers and free sale to scattered shippers. First stage in the model utilizes an origin-destination control approach, formulated as a stochastic integer programming equation, to settle long-term slot allocation in the contract market and empty container allocation. Second stage in the model is formulated as a stochastic nonlinear programming equation to solve a multiproduct joint dynamic pricing and inventory control problem for price settling and slot allocation in each period of free market. Considering the random nature of demand, the methods of chance constrained programming and robust optimi- zation are utilized to transform stochastic models into deterministic models. A numerical experiment is presented to verify the availability of models and solving methods. Results of considering uncertain/certain demand are compared, which show that the two-stage optimal strategy integrating slot allocation with dynamic pricing considering random de- mand is revealed to increase the revenue for multimodal transport operators (MTO) while concurrently satisfying shippers' demand. Research resulting from this paper will contribute to the theory and practice of container sea-rail multimodal transport revenue management and provide a scientific decision-making tool for MTO. 展开更多
关键词 Container transportation Sea-rail multimodal transport Dynamic pricing Slot allocation Revenue management
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