Objective： To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque （OAAP） in patients with primary hypertension and coronary heart disease （PHT-OHD）. Methods： Seventynine patients...Objective： To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque （OAAP） in patients with primary hypertension and coronary heart disease （PHT-OHD）. Methods： Seventynine patients with PHT-OHD were randomly divided into the treated group （39 patients） treated with garlicin and fosinopril and the control group （40 patients） treated with fosinopril alone. The change of OAAP was evaluated by high frequency ultrasonic examination every six months, and the changes of intercellular adhesion molecule-1 （IOAM-1） and high sensitive O-reactive protein （hs-ORP） were measured by ELISA, with the observation proceeding for 52 weeks totally. Results： By the end of the experiment, the number of complex plaques, Orouse integrals, intima-media thickness, serum IOAM-1 and hs-ORP were significantly lower in the treated group than those in the control group with significant difference （P〈0.05）. Conclusion： Garlicin could stabilize CAAP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD.展开更多
目的探讨原发性高血压及原发性高血压合并冠心病患者血同型半胱氨酸(Hcy)、血压变异(BPV)与心率变异(HRV)的关系。方法 59例非高血压、冠心病患者(A组),119例原发性高血压患者(B组),65例原发性高血压合并冠心病患者(C组),检测Hcy水平,...目的探讨原发性高血压及原发性高血压合并冠心病患者血同型半胱氨酸(Hcy)、血压变异(BPV)与心率变异(HRV)的关系。方法 59例非高血压、冠心病患者(A组),119例原发性高血压患者(B组),65例原发性高血压合并冠心病患者(C组),检测Hcy水平,行动态血压监测,取24 h平均收缩压标准差(24 h SSD)作为BPV分析指标,行动态心电图检查,取时域指标中的全部窦性心搏RR间期(简称NN间期)的标准差(SDNN)代表HRV,分析单纯原发性高血压患者及原发性高血压合并冠心病患者Hcy、HRV的相关性。结果 A组Hcy为(9.37±1.03)μmol/L低于B组的(11.61±4.27)μmol/L和C组的(13.23±5.02)μmol/L,差异有统计学意义(P<0.05),且B、C组比较差异有统计学意义(P<0.05)。A组BPV为(11.71±3.17)mm Hg(1 mm Hg=0.133 k Pa)低于B组的(13.83±3.46)mm Hg和C组的(13.82±3.58)mm Hg,差异有统计学意义(P<0.05),B、C两组比较,差异无统计学意义(P>0.05)。三组HRV比较,差异无统计学意义(P>0.05)。A、B组Hcy、BPV、HRV间并无明显相关性;C组中BPV与Hcy无明显相关性,而HRV与Hcy呈正相关(r=0.325,P=0.020<0.05)。结论高血压合并冠心病患者血Hcy、BPV高于单纯高血压患者;其Hcy水平与HRV呈正相关,与BRV无相关性,提示Hcy水平对高血压合并冠心病患者的预后影响与HRV的变化相关,可以通过Hcy水平及HRV的变化初步评估高血压合并冠心病患者的预后。展开更多
目的:探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染所致胃蛋白酶原(pepsinogen,PG)Ⅰ/Ⅱ比值对原发性高血压患者器官损害的筛查价值.方法:选择原发性高血压患者272例,分析其甘油三酯、总胆固醇、高密度脂蛋白与PGⅠ/Ⅱ比值的相关...目的:探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染所致胃蛋白酶原(pepsinogen,PG)Ⅰ/Ⅱ比值对原发性高血压患者器官损害的筛查价值.方法:选择原发性高血压患者272例,分析其甘油三酯、总胆固醇、高密度脂蛋白与PGⅠ/Ⅱ比值的相关;高血压心脏病、高血压肾病、眼底病变患者PGⅠ/Ⅱ比值的变化;受试者工作曲线(receiver operating characteristic,ROC)曲线面积分析PG比值对肾损害、眼底病变的诊断效能.结果:(1)与H.pylori阴性组相比,H.pylori阳性组的甘油三酯(190.6 mg/dL±72.1 mg/dL vs 141.4 mg/dL±56.8 mg/dL)、总胆固醇(257.8 mg/dL±124.7 mg/dL vs 198.6 mg/dL±99.5 mg/dL)升高,而PGⅠ/Ⅱ比值(8.2±3.6 vs 12.4±4.9)降低(P<0.05).原发性高血压患者的甘油三酯(r=-0.302)、总胆固醇(r=-0.395)与PGⅠ/Ⅱ比值均呈负相关(P<0.05);(2)原发性高血压伴有高血压心脏病[81.6%(44/49)vs 40.8%(91/223)]、肾病[84.6%(44/52)vs 45.5%(100/220)]、眼底病变[67.7%(84/124)vs 40.5%(60/148)]患者的H.pylori感染率均高于无高血压心脏病与肾病、无眼底病变,而PGⅠ/Ⅱ比值低于无高血压心脏病(6.9±2.6 vs 11.3±3.2)与肾病(6.3±1.7 vs 10.8±3.4)、无眼底病变(7.4±1.9 vs 12.2±3.5)(P<0.05);(3)PGⅠ/Ⅱ比值筛查心脏病诊断效能的ROC曲线下面积为0.811,肾病损害诊断效能的ROC曲线下面积为0.802,眼底病变诊断效能的ROC曲线下面积为0.831.结论:原发性高血压患者并发心、肾损害以及眼底病变时的PGⅠ/Ⅱ比值降低,PGⅠ/Ⅱ比值可能是原发性高血压患者器官损害的一种筛查指标.展开更多
文摘Objective： To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque （OAAP） in patients with primary hypertension and coronary heart disease （PHT-OHD）. Methods： Seventynine patients with PHT-OHD were randomly divided into the treated group （39 patients） treated with garlicin and fosinopril and the control group （40 patients） treated with fosinopril alone. The change of OAAP was evaluated by high frequency ultrasonic examination every six months, and the changes of intercellular adhesion molecule-1 （IOAM-1） and high sensitive O-reactive protein （hs-ORP） were measured by ELISA, with the observation proceeding for 52 weeks totally. Results： By the end of the experiment, the number of complex plaques, Orouse integrals, intima-media thickness, serum IOAM-1 and hs-ORP were significantly lower in the treated group than those in the control group with significant difference （P〈0.05）. Conclusion： Garlicin could stabilize CAAP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD.
文摘目的探讨原发性高血压及原发性高血压合并冠心病患者血同型半胱氨酸(Hcy)、血压变异(BPV)与心率变异(HRV)的关系。方法 59例非高血压、冠心病患者(A组),119例原发性高血压患者(B组),65例原发性高血压合并冠心病患者(C组),检测Hcy水平,行动态血压监测,取24 h平均收缩压标准差(24 h SSD)作为BPV分析指标,行动态心电图检查,取时域指标中的全部窦性心搏RR间期(简称NN间期)的标准差(SDNN)代表HRV,分析单纯原发性高血压患者及原发性高血压合并冠心病患者Hcy、HRV的相关性。结果 A组Hcy为(9.37±1.03)μmol/L低于B组的(11.61±4.27)μmol/L和C组的(13.23±5.02)μmol/L,差异有统计学意义(P<0.05),且B、C组比较差异有统计学意义(P<0.05)。A组BPV为(11.71±3.17)mm Hg(1 mm Hg=0.133 k Pa)低于B组的(13.83±3.46)mm Hg和C组的(13.82±3.58)mm Hg,差异有统计学意义(P<0.05),B、C两组比较,差异无统计学意义(P>0.05)。三组HRV比较,差异无统计学意义(P>0.05)。A、B组Hcy、BPV、HRV间并无明显相关性;C组中BPV与Hcy无明显相关性,而HRV与Hcy呈正相关(r=0.325,P=0.020<0.05)。结论高血压合并冠心病患者血Hcy、BPV高于单纯高血压患者;其Hcy水平与HRV呈正相关,与BRV无相关性,提示Hcy水平对高血压合并冠心病患者的预后影响与HRV的变化相关,可以通过Hcy水平及HRV的变化初步评估高血压合并冠心病患者的预后。
文摘目的:探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染所致胃蛋白酶原(pepsinogen,PG)Ⅰ/Ⅱ比值对原发性高血压患者器官损害的筛查价值.方法:选择原发性高血压患者272例,分析其甘油三酯、总胆固醇、高密度脂蛋白与PGⅠ/Ⅱ比值的相关;高血压心脏病、高血压肾病、眼底病变患者PGⅠ/Ⅱ比值的变化;受试者工作曲线(receiver operating characteristic,ROC)曲线面积分析PG比值对肾损害、眼底病变的诊断效能.结果:(1)与H.pylori阴性组相比,H.pylori阳性组的甘油三酯(190.6 mg/dL±72.1 mg/dL vs 141.4 mg/dL±56.8 mg/dL)、总胆固醇(257.8 mg/dL±124.7 mg/dL vs 198.6 mg/dL±99.5 mg/dL)升高,而PGⅠ/Ⅱ比值(8.2±3.6 vs 12.4±4.9)降低(P<0.05).原发性高血压患者的甘油三酯(r=-0.302)、总胆固醇(r=-0.395)与PGⅠ/Ⅱ比值均呈负相关(P<0.05);(2)原发性高血压伴有高血压心脏病[81.6%(44/49)vs 40.8%(91/223)]、肾病[84.6%(44/52)vs 45.5%(100/220)]、眼底病变[67.7%(84/124)vs 40.5%(60/148)]患者的H.pylori感染率均高于无高血压心脏病与肾病、无眼底病变,而PGⅠ/Ⅱ比值低于无高血压心脏病(6.9±2.6 vs 11.3±3.2)与肾病(6.3±1.7 vs 10.8±3.4)、无眼底病变(7.4±1.9 vs 12.2±3.5)(P<0.05);(3)PGⅠ/Ⅱ比值筛查心脏病诊断效能的ROC曲线下面积为0.811,肾病损害诊断效能的ROC曲线下面积为0.802,眼底病变诊断效能的ROC曲线下面积为0.831.结论:原发性高血压患者并发心、肾损害以及眼底病变时的PGⅠ/Ⅱ比值降低,PGⅠ/Ⅱ比值可能是原发性高血压患者器官损害的一种筛查指标.
