AIM:To evaluate the relationship between the signal intensity of hepatobiliary phase images on gadoxetic acid-enhanced magnetic resonance imaging(MRI)and histological grade.METHODS:Fifty-nine patients with 82 hepatoce...AIM:To evaluate the relationship between the signal intensity of hepatobiliary phase images on gadoxetic acid-enhanced magnetic resonance imaging(MRI)and histological grade.METHODS:Fifty-nine patients with 82 hepatocellular lesions were evaluated retrospectively.Hepatobiliary phase images on gadoxetic acid-enhanced MRI were classified into 3 groups:low,iso or high.Angiographyassisted computed tomography(CT)findings were also classified into 3 groups:CT during arterial portography,and CT hepatic arteriography:A:iso,iso or low;B:slightly low,iso or low;;and C:low,high.We correlated angiography-assisted CT,hepatobiliary phase findings during gadoxetic acid-enhanced MRI and histological grades.Furthermore,correlations between MRI findings and histological grade for each hemodynamic pattern were performed.Correlations among radiologicaland pathological findings were statistically evaluated using the chi-square test and Fisher's exact test.RESULTS:There was a significant correlation between histological grade and hemodynamic pattern(P<0.05).There was a significant correlation between histological grade and signal intensity in the hepatobiliary phase(P<0.05)in group A lesions.There was no significant correlation between histological grade and signal intensity in the hepatobiliary phase in group B or C lesions(P>0.05).CONCLUSION:Signal intensity in the hepatobiliary phase correlated with histological grade in the lesions that maintained portal blood flow,but did not correlate in lesions that showed decreased or defective portal blood flow.展开更多
Five types of superparamagnetic iron oxide （SPIO）,i.e. Ferumoxides （Feridex？ Ⅳ, Berlex Laboratories）,Fe r u c a r b o t ra n （ Re s ov i s t？, B aye r H e a l t h c a re ） ,Ferumoxtran-10 （AMI-227 or Code-72...Five types of superparamagnetic iron oxide （SPIO）,i.e. Ferumoxides （Feridex？ Ⅳ, Berlex Laboratories）,Fe r u c a r b o t ra n （ Re s ov i s t？, B aye r H e a l t h c a re ） ,Ferumoxtran-10 （AMI-227 or Code-7227, Combidex？, AMAG Pharma; Sinerem？, Guerbet）, NC100150（Clariscan？, Nycomed,） and （VSOP C184, Ferropharm）have been designed and clinically tested as magneticresonance contrast agents. However, until nowResovist？ is current available in only a few countries.The other four agents have been stopped for furtherdevelopment or withdrawn from the market. AnotherSPIO agent Ferumoxytol （Feraheme） is approved forthe treatment of iron deficiency in adult chronic kidneydisease patients. Ferumoxytol is comprised of ironoxide particles surrounded by a carbohydrate coat, andit is being explored as a potential imaging approach forevaluating lymph nodes and certain liver tumors.展开更多
目的:探索常规屏气方案和优化屏气方案对普美显增强动脉期图像质量和对比度信噪比(CNR)的影响。方法:回顾性分析2020年3—6月在中山大学肿瘤防治中心行普美显增强磁共振(MRI)检查的143例患者的图像。由2位放射专业医师采用双盲法对图像...目的:探索常规屏气方案和优化屏气方案对普美显增强动脉期图像质量和对比度信噪比(CNR)的影响。方法:回顾性分析2020年3—6月在中山大学肿瘤防治中心行普美显增强磁共振(MRI)检查的143例患者的图像。由2位放射专业医师采用双盲法对图像进行评分得到质量评价,然后行一致性检验。由2位放射专业技师共同测量计算图像病灶的CNR。采用SPSS 23.0统计软件,分析患者的性别、年龄、身体质量指数(BMI)、屏气方案与图像质量和CNR的相关性。结果:2位医师对图像质量评价的kappa值为0.794。性别、年龄和BMI分组对图像质量和CNR没有统计学意义(P值均>0.05)。屏气方案对图像质量和C N R有统计学意义(P值均<0.05)。结论:性别、年龄和B M I对普美显增强动脉期图像质量和CNR没有影响,优化屏气方案比常规屏气方案有更好的图像质量和更高的CNR,值得推广应用于其他需要屏气的放射科检查项目。展开更多
文摘AIM:To evaluate the relationship between the signal intensity of hepatobiliary phase images on gadoxetic acid-enhanced magnetic resonance imaging(MRI)and histological grade.METHODS:Fifty-nine patients with 82 hepatocellular lesions were evaluated retrospectively.Hepatobiliary phase images on gadoxetic acid-enhanced MRI were classified into 3 groups:low,iso or high.Angiographyassisted computed tomography(CT)findings were also classified into 3 groups:CT during arterial portography,and CT hepatic arteriography:A:iso,iso or low;B:slightly low,iso or low;;and C:low,high.We correlated angiography-assisted CT,hepatobiliary phase findings during gadoxetic acid-enhanced MRI and histological grades.Furthermore,correlations between MRI findings and histological grade for each hemodynamic pattern were performed.Correlations among radiologicaland pathological findings were statistically evaluated using the chi-square test and Fisher's exact test.RESULTS:There was a significant correlation between histological grade and hemodynamic pattern(P<0.05).There was a significant correlation between histological grade and signal intensity in the hepatobiliary phase(P<0.05)in group A lesions.There was no significant correlation between histological grade and signal intensity in the hepatobiliary phase in group B or C lesions(P>0.05).CONCLUSION:Signal intensity in the hepatobiliary phase correlated with histological grade in the lesions that maintained portal blood flow,but did not correlate in lesions that showed decreased or defective portal blood flow.
文摘Five types of superparamagnetic iron oxide （SPIO）,i.e. Ferumoxides （Feridex？ Ⅳ, Berlex Laboratories）,Fe r u c a r b o t ra n （ Re s ov i s t？, B aye r H e a l t h c a re ） ,Ferumoxtran-10 （AMI-227 or Code-7227, Combidex？, AMAG Pharma; Sinerem？, Guerbet）, NC100150（Clariscan？, Nycomed,） and （VSOP C184, Ferropharm）have been designed and clinically tested as magneticresonance contrast agents. However, until nowResovist？ is current available in only a few countries.The other four agents have been stopped for furtherdevelopment or withdrawn from the market. AnotherSPIO agent Ferumoxytol （Feraheme） is approved forthe treatment of iron deficiency in adult chronic kidneydisease patients. Ferumoxytol is comprised of ironoxide particles surrounded by a carbohydrate coat, andit is being explored as a potential imaging approach forevaluating lymph nodes and certain liver tumors.
文摘目的:探索常规屏气方案和优化屏气方案对普美显增强动脉期图像质量和对比度信噪比(CNR)的影响。方法:回顾性分析2020年3—6月在中山大学肿瘤防治中心行普美显增强磁共振(MRI)检查的143例患者的图像。由2位放射专业医师采用双盲法对图像进行评分得到质量评价,然后行一致性检验。由2位放射专业技师共同测量计算图像病灶的CNR。采用SPSS 23.0统计软件,分析患者的性别、年龄、身体质量指数(BMI)、屏气方案与图像质量和CNR的相关性。结果:2位医师对图像质量评价的kappa值为0.794。性别、年龄和BMI分组对图像质量和CNR没有统计学意义(P值均>0.05)。屏气方案对图像质量和C N R有统计学意义(P值均<0.05)。结论:性别、年龄和B M I对普美显增强动脉期图像质量和CNR没有影响,优化屏气方案比常规屏气方案有更好的图像质量和更高的CNR,值得推广应用于其他需要屏气的放射科检查项目。
