Mood disorders are the most common mental disorders, affecting approximately350 million people globally. Recent studies have shown that neuroimmuneinteraction regulates mood disorders. Brain-derived neurotrophic facto...Mood disorders are the most common mental disorders, affecting approximately350 million people globally. Recent studies have shown that neuroimmuneinteraction regulates mood disorders. Brain-derived neurotrophic factor (BDNF)and its precursor pro-BDNF, are involved in the neuroimmune crosstalk duringthe development of mood disorders. BDNF is implicated in the pathophysiologyof psychiatric and neurological disorders especially in antidepressant pharmacotherapy.In this review, we describe the functions of BDNF/pro-BDNF signalingin the central nervous system in the context of mood disorders. In addition, wesummarize the developments for BDNF and pro-BDNF functions in mooddisorders. This review aims to provide new insights into the impact ofneuroimmune interaction on mood disorders and reveal a new basis for furtherdevelopment of diagnostic targets and mood disorders.展开更多
目的:探讨三七总皂苷治疗帕金森病(PD)的作用靶标。方法:采用6-羟基多巴胺偏侧损毁黑质制备PD大鼠模型,区层随机分为模型组、三七总皂苷低、高剂量组,另取不造模大鼠为正常对照组,只注射抗坏血酸大鼠为假手术组。观察PD大鼠神经行为学...目的:探讨三七总皂苷治疗帕金森病(PD)的作用靶标。方法:采用6-羟基多巴胺偏侧损毁黑质制备PD大鼠模型,区层随机分为模型组、三七总皂苷低、高剂量组,另取不造模大鼠为正常对照组,只注射抗坏血酸大鼠为假手术组。观察PD大鼠神经行为学、酪氨酸羟化酶(TH)及多巴胺转运体(DAT)m RNA、脑源性神经营养因子前体蛋白(pro-BDNF)蛋白、胶质细胞源性神经营养因子(GDNF)阳性细胞数量的变化及三七总皂苷的治疗作用。结果:三七总皂苷可改善PD大鼠旋转行为(P<0.01);升高TH及DAT m RNA表达(P<0.01);增加pro-BDNF蛋白的含量(P<0.01);升高GDNF阳性细胞表达数(P<0.01)。结论:三七总皂苷的作用靶标是神经行为学、TH及DAT mRNA、pro-BDNF蛋白、GDNF阳性细胞。展开更多
基金Supported by National Natural Science Foundation of China,No. 82071347 and No. 81771354 (to Dai RP)
文摘Mood disorders are the most common mental disorders, affecting approximately350 million people globally. Recent studies have shown that neuroimmuneinteraction regulates mood disorders. Brain-derived neurotrophic factor (BDNF)and its precursor pro-BDNF, are involved in the neuroimmune crosstalk duringthe development of mood disorders. BDNF is implicated in the pathophysiologyof psychiatric and neurological disorders especially in antidepressant pharmacotherapy.In this review, we describe the functions of BDNF/pro-BDNF signalingin the central nervous system in the context of mood disorders. In addition, wesummarize the developments for BDNF and pro-BDNF functions in mooddisorders. This review aims to provide new insights into the impact ofneuroimmune interaction on mood disorders and reveal a new basis for furtherdevelopment of diagnostic targets and mood disorders.
文摘目的:探讨三七总皂苷治疗帕金森病(PD)的作用靶标。方法:采用6-羟基多巴胺偏侧损毁黑质制备PD大鼠模型,区层随机分为模型组、三七总皂苷低、高剂量组,另取不造模大鼠为正常对照组,只注射抗坏血酸大鼠为假手术组。观察PD大鼠神经行为学、酪氨酸羟化酶(TH)及多巴胺转运体(DAT)m RNA、脑源性神经营养因子前体蛋白(pro-BDNF)蛋白、胶质细胞源性神经营养因子(GDNF)阳性细胞数量的变化及三七总皂苷的治疗作用。结果:三七总皂苷可改善PD大鼠旋转行为(P<0.01);升高TH及DAT m RNA表达(P<0.01);增加pro-BDNF蛋白的含量(P<0.01);升高GDNF阳性细胞表达数(P<0.01)。结论:三七总皂苷的作用靶标是神经行为学、TH及DAT mRNA、pro-BDNF蛋白、GDNF阳性细胞。
